Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ6_LEIBR

TriTrypDb:

LbrM.24.2020 , LBRM2903_240027900

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.537
CLV_NRD_NRD_1	283	285	PF00675	0.487
CLV_PCSK_FUR_1	281	285	PF00082	0.403
CLV_PCSK_KEX2_1	134	136	PF00082	0.465
CLV_PCSK_KEX2_1	283	285	PF00082	0.487
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.465
CLV_PCSK_SKI1_1	195	199	PF00082	0.434
DEG_APCC_DBOX_1	291	299	PF00400	0.546
DEG_SPOP_SBC_1	123	127	PF00917	0.831
DEG_SPOP_SBC_1	352	356	PF00917	0.342
DEG_SPOP_SBC_1	54	58	PF00917	0.822
DOC_ANK_TNKS_1	41	48	PF00023	0.652
DOC_MAPK_HePTP_8	216	228	PF00069	0.633
DOC_MAPK_HePTP_8	258	270	PF00069	0.513
DOC_MAPK_MEF2A_6	219	228	PF00069	0.630
DOC_MAPK_MEF2A_6	261	270	PF00069	0.654
DOC_PP2B_PxIxI_1	78	84	PF00149	0.659
DOC_USP7_MATH_1	107	111	PF00917	0.692
DOC_USP7_MATH_1	115	119	PF00917	0.754
DOC_USP7_MATH_1	143	147	PF00917	0.637
DOC_USP7_MATH_1	152	156	PF00917	0.566
DOC_USP7_MATH_1	253	257	PF00917	0.411
DOC_USP7_MATH_1	291	295	PF00917	0.602
DOC_USP7_MATH_1	307	311	PF00917	0.392
DOC_USP7_MATH_1	41	45	PF00917	0.777
DOC_USP7_MATH_1	54	58	PF00917	0.635
DOC_WW_Pin1_4	129	134	PF00397	0.756
DOC_WW_Pin1_4	226	231	PF00397	0.261
DOC_WW_Pin1_4	37	42	PF00397	0.748
DOC_WW_Pin1_4	75	80	PF00397	0.736
DOC_WW_Pin1_4	91	96	PF00397	0.779
LIG_14-3-3_CanoR_1	292	298	PF00244	0.411
LIG_14-3-3_CanoR_1	42	46	PF00244	0.748
LIG_14-3-3_CanoR_1	68	74	PF00244	0.748
LIG_Actin_RPEL_3	239	258	PF02755	0.621
LIG_Actin_WH2_2	255	271	PF00022	0.261
LIG_BRCT_BRCA1_1	255	259	PF00533	0.411
LIG_BRCT_BRCA1_1	293	297	PF00533	0.416
LIG_FHA_1	149	155	PF00498	0.588
LIG_FHA_1	21	27	PF00498	0.776
LIG_FHA_1	258	264	PF00498	0.314
LIG_FHA_1	76	82	PF00498	0.682
LIG_FHA_2	184	190	PF00498	0.624
LIG_FHA_2	196	202	PF00498	0.685
LIG_FHA_2	20	26	PF00498	0.751
LIG_IRF3_LxIS_1	224	229	PF10401	0.261
LIG_LIR_Gen_1	155	164	PF02991	0.618
LIG_LIR_Gen_1	256	266	PF02991	0.411
LIG_LIR_Gen_1	97	107	PF02991	0.621
LIG_LIR_Nem_3	155	159	PF02991	0.627
LIG_LIR_Nem_3	256	262	PF02991	0.411
LIG_LIR_Nem_3	339	345	PF02991	0.385
LIG_LIR_Nem_3	97	102	PF02991	0.735
LIG_Pex14_1	344	348	PF04695	0.396
LIG_Pex14_2	304	308	PF04695	0.407
LIG_SH2_GRB2like	248	251	PF00017	0.500
LIG_SH2_STAT5	238	241	PF00017	0.486
LIG_SH2_STAT5	345	348	PF00017	0.394
LIG_SH3_3	157	163	PF00018	0.638
LIG_SH3_3	224	230	PF00018	0.261
LIG_SH3_3	306	312	PF00018	0.509
LIG_SxIP_EBH_1	103	117	PF03271	0.646
LIG_TRAF2_1	73	76	PF00917	0.652
MOD_CDC14_SPxK_1	132	135	PF00782	0.834
MOD_CDK_SPK_2	129	134	PF00069	0.656
MOD_CDK_SPK_2	37	42	PF00069	0.640
MOD_CDK_SPxK_1	129	135	PF00069	0.837
MOD_CK1_1	125	131	PF00069	0.842
MOD_CK1_1	155	161	PF00069	0.651
MOD_CK1_1	214	220	PF00069	0.568
MOD_CK1_1	296	302	PF00069	0.411
MOD_CK1_1	356	362	PF00069	0.593
MOD_CK1_1	94	100	PF00069	0.717
MOD_CK2_1	115	121	PF00069	0.749
MOD_CK2_1	183	189	PF00069	0.603
MOD_CK2_1	195	201	PF00069	0.613
MOD_GlcNHglycan	113	116	PF01048	0.558
MOD_GlcNHglycan	117	120	PF01048	0.556
MOD_GlcNHglycan	298	301	PF01048	0.472
MOD_GlcNHglycan	355	358	PF01048	0.710
MOD_GlcNHglycan	4	7	PF01048	0.479
MOD_GlcNHglycan	57	60	PF01048	0.491
MOD_GlcNHglycan	63	66	PF01048	0.547
MOD_GlcNHglycan	69	72	PF01048	0.483
MOD_GlcNHglycan	90	94	PF01048	0.429
MOD_GSK3_1	107	114	PF00069	0.729
MOD_GSK3_1	122	129	PF00069	0.792
MOD_GSK3_1	148	155	PF00069	0.625
MOD_GSK3_1	211	218	PF00069	0.636
MOD_GSK3_1	253	260	PF00069	0.355
MOD_GSK3_1	352	359	PF00069	0.444
MOD_GSK3_1	37	44	PF00069	0.745
MOD_GSK3_1	49	56	PF00069	0.678
MOD_GSK3_1	77	84	PF00069	0.762
MOD_GSK3_1	94	101	PF00069	0.665
MOD_N-GLC_1	360	365	PF02516	0.652
MOD_NEK2_1	122	127	PF00069	0.803
MOD_NEK2_1	232	237	PF00069	0.388
MOD_NEK2_1	286	291	PF00069	0.609
MOD_NEK2_1	336	341	PF00069	0.428
MOD_NEK2_1	55	60	PF00069	0.677
MOD_NEK2_1	82	87	PF00069	0.713
MOD_NEK2_2	98	103	PF00069	0.707
MOD_PIKK_1	20	26	PF00454	0.779
MOD_PIKK_1	82	88	PF00454	0.656
MOD_PKA_2	105	111	PF00069	0.754
MOD_PKA_2	176	182	PF00069	0.665
MOD_PKA_2	286	292	PF00069	0.628
MOD_PKA_2	41	47	PF00069	0.777
MOD_PKA_2	50	56	PF00069	0.685
MOD_PKA_2	67	73	PF00069	0.823
MOD_Plk_1	195	201	PF00069	0.613
MOD_Plk_4	233	239	PF00069	0.499
MOD_Plk_4	253	259	PF00069	0.408
MOD_Plk_4	293	299	PF00069	0.408
MOD_Plk_4	77	83	PF00069	0.660
MOD_Plk_4	94	100	PF00069	0.734
MOD_ProDKin_1	129	135	PF00069	0.756
MOD_ProDKin_1	226	232	PF00069	0.261
MOD_ProDKin_1	37	43	PF00069	0.750
MOD_ProDKin_1	75	81	PF00069	0.736
MOD_ProDKin_1	91	97	PF00069	0.778
TRG_DiLeu_BaEn_1	189	194	PF01217	0.610
TRG_DiLeu_BaEn_1	273	278	PF01217	0.720
TRG_ER_diArg_1	266	269	PF00400	0.667
TRG_ER_diArg_1	281	284	PF00400	0.648
TRG_NLS_MonoExtC_3	102	107	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV70	Leptomonas seymouri	48%	100%
A0A3Q8ID58	Leishmania donovani	77%	100%
A4I102	Leishmania infantum	77%	100%
E9AX40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAD6	Leishmania major	75%	100%