Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ5_LEIBR

TriTrypDb:

LbrM.24.2010 , LBRM2903_240027800

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0019751	polyol metabolic process	4	8
GO:0032957	inositol trisphosphate metabolic process	5	8
GO:0043647	inositol phosphate metabolic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044281	small molecule metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901615	organic hydroxy compound metabolic process	3	8
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0000287	magnesium ion binding	5	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0047325	inositol tetrakisphosphate 1-kinase activity	6	8
GO:0051765	inositol tetrakisphosphate kinase activity	5	8
GO:0051766	inositol trisphosphate kinase activity	5	8
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	6	8
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	6	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.448
CLV_C14_Caspase3-7	127	131	PF00656	0.291
CLV_C14_Caspase3-7	152	156	PF00656	0.401
CLV_NRD_NRD_1	234	236	PF00675	0.380
CLV_NRD_NRD_1	293	295	PF00675	0.542
CLV_NRD_NRD_1	372	374	PF00675	0.292
CLV_NRD_NRD_1	534	536	PF00675	0.485
CLV_NRD_NRD_1	99	101	PF00675	0.702
CLV_PCSK_FUR_1	97	101	PF00082	0.686
CLV_PCSK_KEX2_1	233	235	PF00082	0.375
CLV_PCSK_KEX2_1	293	295	PF00082	0.542
CLV_PCSK_KEX2_1	372	374	PF00082	0.292
CLV_PCSK_KEX2_1	675	677	PF00082	0.629
CLV_PCSK_KEX2_1	99	101	PF00082	0.697
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.428
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.629
CLV_PCSK_PC7_1	95	101	PF00082	0.586
CLV_PCSK_SKI1_1	18	22	PF00082	0.451
CLV_PCSK_SKI1_1	211	215	PF00082	0.408
CLV_PCSK_SKI1_1	364	368	PF00082	0.491
CLV_PCSK_SKI1_1	432	436	PF00082	0.475
CLV_PCSK_SKI1_1	671	675	PF00082	0.482
CLV_PCSK_SKI1_1	90	94	PF00082	0.531
DEG_APCC_DBOX_1	239	247	PF00400	0.437
DEG_COP1_1	354	362	PF00400	0.381
DEG_SCF_FBW7_1	472	478	PF00400	0.392
DEG_SCF_FBW7_1	492	498	PF00400	0.426
DEG_SCF_FBW7_1	569	576	PF00400	0.544
DEG_SCF_TRCP1_1	152	157	PF00400	0.413
DEG_SPOP_SBC_1	554	558	PF00917	0.489
DOC_CKS1_1	215	220	PF01111	0.433
DOC_CKS1_1	303	308	PF01111	0.345
DOC_CKS1_1	472	477	PF01111	0.403
DOC_CKS1_1	492	497	PF01111	0.423
DOC_CYCLIN_RxL_1	132	142	PF00134	0.373
DOC_MAPK_DCC_7	237	246	PF00069	0.338
DOC_MAPK_gen_1	171	180	PF00069	0.504
DOC_MAPK_gen_1	233	243	PF00069	0.387
DOC_MAPK_MEF2A_6	237	246	PF00069	0.375
DOC_MAPK_MEF2A_6	400	407	PF00069	0.417
DOC_MAPK_MEF2A_6	416	425	PF00069	0.502
DOC_PP1_RVXF_1	430	436	PF00149	0.335
DOC_PP4_FxxP_1	215	218	PF00568	0.437
DOC_PP4_FxxP_1	489	492	PF00568	0.444
DOC_SPAK_OSR1_1	373	377	PF12202	0.248
DOC_USP7_MATH_1	12	16	PF00917	0.617
DOC_USP7_MATH_1	120	124	PF00917	0.615
DOC_USP7_MATH_1	194	198	PF00917	0.525
DOC_USP7_MATH_1	335	339	PF00917	0.517
DOC_USP7_MATH_1	439	443	PF00917	0.569
DOC_USP7_MATH_1	475	479	PF00917	0.455
DOC_USP7_MATH_1	555	559	PF00917	0.622
DOC_USP7_MATH_1	562	566	PF00917	0.681
DOC_USP7_MATH_1	573	577	PF00917	0.711
DOC_USP7_MATH_1	587	591	PF00917	0.628
DOC_USP7_UBL2_3	229	233	PF12436	0.349
DOC_USP7_UBL2_3	671	675	PF12436	0.482
DOC_WW_Pin1_4	214	219	PF00397	0.438
DOC_WW_Pin1_4	275	280	PF00397	0.358
DOC_WW_Pin1_4	3	8	PF00397	0.679
DOC_WW_Pin1_4	302	307	PF00397	0.466
DOC_WW_Pin1_4	471	476	PF00397	0.489
DOC_WW_Pin1_4	491	496	PF00397	0.426
DOC_WW_Pin1_4	565	570	PF00397	0.615
DOC_WW_Pin1_4	581	586	PF00397	0.578
DOC_WW_Pin1_4	81	86	PF00397	0.574
DOC_WW_Pin1_4	90	95	PF00397	0.606
LIG_14-3-3_CanoR_1	176	181	PF00244	0.506
LIG_14-3-3_CanoR_1	18	23	PF00244	0.431
LIG_14-3-3_CanoR_1	286	291	PF00244	0.428
LIG_14-3-3_CanoR_1	416	425	PF00244	0.502
LIG_14-3-3_CanoR_1	447	455	PF00244	0.516
LIG_14-3-3_CanoR_1	464	472	PF00244	0.525
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BIR_III_4	65	69	PF00653	0.499
LIG_BRCT_BRCA1_1	288	292	PF00533	0.439
LIG_BRCT_BRCA1_1	310	314	PF00533	0.363
LIG_BRCT_BRCA1_1	602	606	PF00533	0.398
LIG_Clathr_ClatBox_1	243	247	PF01394	0.404
LIG_deltaCOP1_diTrp_1	225	230	PF00928	0.288
LIG_deltaCOP1_diTrp_1	484	490	PF00928	0.414
LIG_FHA_1	103	109	PF00498	0.672
LIG_FHA_1	17	23	PF00498	0.459
LIG_FHA_1	200	206	PF00498	0.306
LIG_FHA_1	255	261	PF00498	0.326
LIG_FHA_1	342	348	PF00498	0.426
LIG_FHA_1	402	408	PF00498	0.367
LIG_FHA_1	450	456	PF00498	0.617
LIG_FHA_1	566	572	PF00498	0.545
LIG_FHA_1	612	618	PF00498	0.356
LIG_FHA_1	649	655	PF00498	0.334
LIG_FHA_2	117	123	PF00498	0.619
LIG_FHA_2	155	161	PF00498	0.473
LIG_FHA_2	311	317	PF00498	0.638
LIG_FHA_2	323	329	PF00498	0.371
LIG_FHA_2	417	423	PF00498	0.519
LIG_FHA_2	465	471	PF00498	0.614
LIG_FHA_2	472	478	PF00498	0.433
LIG_LIR_Apic_2	214	218	PF02991	0.436
LIG_LIR_Apic_2	281	287	PF02991	0.443
LIG_LIR_Apic_2	487	492	PF02991	0.346
LIG_LIR_Gen_1	142	150	PF02991	0.316
LIG_LIR_Gen_1	225	231	PF02991	0.282
LIG_LIR_Gen_1	311	320	PF02991	0.521
LIG_LIR_Gen_1	34	41	PF02991	0.394
LIG_LIR_Gen_1	473	483	PF02991	0.502
LIG_LIR_Gen_1	484	492	PF02991	0.439
LIG_LIR_Gen_1	603	613	PF02991	0.312
LIG_LIR_Nem_3	225	230	PF02991	0.317
LIG_LIR_Nem_3	34	38	PF02991	0.391
LIG_LIR_Nem_3	484	489	PF02991	0.392
LIG_LIR_Nem_3	508	513	PF02991	0.381
LIG_LIR_Nem_3	548	554	PF02991	0.542
LIG_LIR_Nem_3	603	609	PF02991	0.325
LIG_MYND_1	569	573	PF01753	0.539
LIG_MYND_1	593	597	PF01753	0.455
LIG_Pex14_1	486	490	PF04695	0.330
LIG_Pex14_2	215	219	PF04695	0.302
LIG_PTB_Apo_2	128	135	PF02174	0.419
LIG_PTB_Phospho_1	135	141	PF10480	0.304
LIG_SH2_CRK	382	386	PF00017	0.380
LIG_SH2_CRK	510	514	PF00017	0.352
LIG_SH2_CRK	551	555	PF00017	0.462
LIG_SH2_CRK	633	637	PF00017	0.476
LIG_SH2_SRC	380	383	PF00017	0.385
LIG_SH2_STAP1	141	145	PF00017	0.298
LIG_SH2_STAT3	141	144	PF00017	0.427
LIG_SH2_STAT5	380	383	PF00017	0.353
LIG_SH2_STAT5	391	394	PF00017	0.298
LIG_SH2_STAT5	629	632	PF00017	0.366
LIG_SH3_3	156	162	PF00018	0.511
LIG_SH3_3	242	248	PF00018	0.415
LIG_SH3_3	300	306	PF00018	0.394
LIG_SH3_3	354	360	PF00018	0.427
LIG_SH3_3	418	424	PF00018	0.436
LIG_SH3_3	489	495	PF00018	0.445
LIG_SH3_3	520	526	PF00018	0.382
LIG_SH3_3	593	599	PF00018	0.557
LIG_SH3_3	6	12	PF00018	0.686
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.397
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.324
LIG_SUMO_SIM_par_1	176	182	PF11976	0.502
LIG_SUMO_SIM_par_1	241	247	PF11976	0.357
LIG_SUMO_SIM_par_1	273	278	PF11976	0.375
LIG_SUMO_SIM_par_1	422	429	PF11976	0.328
LIG_SUMO_SIM_par_1	619	626	PF11976	0.344
LIG_SUMO_SIM_par_1	645	651	PF11976	0.415
LIG_TRAF2_1	166	169	PF00917	0.500
LIG_TYR_ITIM	549	554	PF00017	0.537
LIG_UBA3_1	264	272	PF00899	0.353
LIG_UBA3_1	643	650	PF00899	0.421
LIG_WRC_WIRS_1	212	217	PF05994	0.418
LIG_WRC_WIRS_1	309	314	PF05994	0.440
MOD_CAAXbox	678	681	PF01239	0.630
MOD_CDK_SPK_2	275	280	PF00069	0.358
MOD_CDK_SPK_2	569	574	PF00069	0.542
MOD_CDK_SPK_2	90	95	PF00069	0.535
MOD_CDK_SPxxK_3	90	97	PF00069	0.540
MOD_CK1_1	102	108	PF00069	0.792
MOD_CK1_1	113	119	PF00069	0.480
MOD_CK1_1	153	159	PF00069	0.448
MOD_CK1_1	2	8	PF00069	0.781
MOD_CK1_1	299	305	PF00069	0.514
MOD_CK1_1	395	401	PF00069	0.432
MOD_CK1_1	440	446	PF00069	0.634
MOD_CK1_1	451	457	PF00069	0.577
MOD_CK1_1	463	469	PF00069	0.627
MOD_CK1_1	556	562	PF00069	0.678
MOD_CK1_1	565	571	PF00069	0.795
MOD_CK1_1	580	586	PF00069	0.590
MOD_CK2_1	176	182	PF00069	0.734
MOD_CK2_1	322	328	PF00069	0.427
MOD_CK2_1	451	457	PF00069	0.662
MOD_CK2_1	464	470	PF00069	0.533
MOD_CK2_1	471	477	PF00069	0.372
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.531
MOD_GlcNHglycan	112	115	PF01048	0.542
MOD_GlcNHglycan	122	125	PF01048	0.618
MOD_GlcNHglycan	152	155	PF01048	0.532
MOD_GlcNHglycan	298	301	PF01048	0.738
MOD_GlcNHglycan	439	442	PF01048	0.608
MOD_GlcNHglycan	467	470	PF01048	0.639
MOD_GlcNHglycan	507	510	PF01048	0.452
MOD_GlcNHglycan	564	567	PF01048	0.694
MOD_GlcNHglycan	575	578	PF01048	0.742
MOD_GlcNHglycan	589	592	PF01048	0.651
MOD_GlcNHglycan	609	612	PF01048	0.320
MOD_GlcNHglycan	65	69	PF01048	0.636
MOD_GSK3_1	1	8	PF00069	0.746
MOD_GSK3_1	103	110	PF00069	0.671
MOD_GSK3_1	116	123	PF00069	0.688
MOD_GSK3_1	12	19	PF00069	0.601
MOD_GSK3_1	150	157	PF00069	0.515
MOD_GSK3_1	292	299	PF00069	0.597
MOD_GSK3_1	412	419	PF00069	0.517
MOD_GSK3_1	433	440	PF00069	0.514
MOD_GSK3_1	442	449	PF00069	0.629
MOD_GSK3_1	460	467	PF00069	0.651
MOD_GSK3_1	471	478	PF00069	0.437
MOD_GSK3_1	491	498	PF00069	0.385
MOD_GSK3_1	541	548	PF00069	0.531
MOD_GSK3_1	565	572	PF00069	0.674
MOD_GSK3_1	573	580	PF00069	0.611
MOD_GSK3_1	587	594	PF00069	0.625
MOD_GSK3_1	607	614	PF00069	0.271
MOD_GSK3_1	95	102	PF00069	0.667
MOD_LATS_1	414	420	PF00433	0.535
MOD_N-GLC_1	322	327	PF02516	0.539
MOD_N-GLC_1	335	340	PF02516	0.315
MOD_N-GLC_1	505	510	PF02516	0.323
MOD_N-GLC_1	577	582	PF02516	0.548
MOD_N-GLC_1	655	660	PF02516	0.442
MOD_N-GLC_1	88	93	PF02516	0.590
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	24	29	PF00069	0.441
MOD_NEK2_1	254	259	PF00069	0.373
MOD_NEK2_1	264	269	PF00069	0.343
MOD_NEK2_1	292	297	PF00069	0.660
MOD_NEK2_1	462	467	PF00069	0.522
MOD_NEK2_1	529	534	PF00069	0.554
MOD_NEK2_1	617	622	PF00069	0.359
MOD_NEK2_2	577	582	PF00069	0.668
MOD_NEK2_2	648	653	PF00069	0.395
MOD_PIKK_1	194	200	PF00454	0.538
MOD_PIKK_1	426	432	PF00454	0.396
MOD_PK_1	176	182	PF00069	0.502
MOD_PK_1	286	292	PF00069	0.411
MOD_PKA_1	233	239	PF00069	0.457
MOD_PKA_1	99	105	PF00069	0.693
MOD_PKA_2	233	239	PF00069	0.457
MOD_PKA_2	285	291	PF00069	0.479
MOD_PKA_2	292	298	PF00069	0.630
MOD_PKA_2	415	421	PF00069	0.545
MOD_PKA_2	446	452	PF00069	0.508
MOD_PKA_2	463	469	PF00069	0.529
MOD_PKA_2	573	579	PF00069	0.629
MOD_PKA_2	607	613	PF00069	0.412
MOD_PKA_2	99	105	PF00069	0.690
MOD_PKB_1	97	105	PF00069	0.682
MOD_Plk_1	12	18	PF00069	0.545
MOD_Plk_1	355	361	PF00069	0.551
MOD_Plk_1	577	583	PF00069	0.546
MOD_Plk_1	88	94	PF00069	0.532
MOD_Plk_4	124	130	PF00069	0.337
MOD_Plk_4	475	481	PF00069	0.407
MOD_Plk_4	513	519	PF00069	0.386
MOD_Plk_4	591	597	PF00069	0.511
MOD_Plk_4	612	618	PF00069	0.537
MOD_ProDKin_1	214	220	PF00069	0.429
MOD_ProDKin_1	275	281	PF00069	0.356
MOD_ProDKin_1	3	9	PF00069	0.678
MOD_ProDKin_1	302	308	PF00069	0.464
MOD_ProDKin_1	471	477	PF00069	0.416
MOD_ProDKin_1	491	497	PF00069	0.424
MOD_ProDKin_1	565	571	PF00069	0.617
MOD_ProDKin_1	581	587	PF00069	0.577
MOD_ProDKin_1	81	87	PF00069	0.576
MOD_ProDKin_1	90	96	PF00069	0.609
MOD_SUMO_rev_2	168	172	PF00179	0.518
MOD_SUMO_rev_2	266	274	PF00179	0.362
TRG_DiLeu_BaEn_1	250	255	PF01217	0.378
TRG_DiLeu_BaEn_2	369	375	PF01217	0.369
TRG_ENDOCYTIC_2	510	513	PF00928	0.431
TRG_ENDOCYTIC_2	551	554	PF00928	0.531
TRG_ENDOCYTIC_2	633	636	PF00928	0.472
TRG_ER_diArg_1	190	193	PF00400	0.508
TRG_ER_diArg_1	234	237	PF00400	0.383
TRG_ER_diArg_1	292	294	PF00400	0.481
TRG_ER_diArg_1	372	374	PF00400	0.334
TRG_ER_diArg_1	94	97	PF00400	0.719
TRG_ER_diArg_1	99	101	PF00400	0.684
TRG_NES_CRM1_1	645	657	PF08389	0.458
TRG_NLS_MonoExtC_3	232	237	PF00514	0.424
TRG_NLS_MonoExtN_4	671	678	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV4	Leptomonas seymouri	48%	100%
A0A1X0NVY7	Trypanosomatidae	30%	100%
A0A3S5H7D6	Leishmania donovani	68%	95%
A4I101	Leishmania infantum	69%	96%
E9AX39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4QAD7	Leishmania major	69%	99%