Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ4_LEIBR

TriTrypDb:

LbrM.24.2000 , LBRM2903_240027700

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.610
CLV_NRD_NRD_1	285	287	PF00675	0.534
CLV_NRD_NRD_1	457	459	PF00675	0.496
CLV_NRD_NRD_1	514	516	PF00675	0.547
CLV_PCSK_FUR_1	512	516	PF00082	0.611
CLV_PCSK_KEX2_1	285	287	PF00082	0.538
CLV_PCSK_KEX2_1	457	459	PF00082	0.498
CLV_PCSK_KEX2_1	514	516	PF00082	0.551
CLV_PCSK_PC7_1	281	287	PF00082	0.584
CLV_PCSK_PC7_1	510	516	PF00082	0.602
CLV_PCSK_SKI1_1	461	465	PF00082	0.586
CLV_Separin_Metazoa	476	480	PF03568	0.587
DEG_SPOP_SBC_1	86	90	PF00917	0.804
DOC_CKS1_1	403	408	PF01111	0.689
DOC_CKS1_1	44	49	PF01111	0.553
DOC_CKS1_1	6	11	PF01111	0.799
DOC_MAPK_MEF2A_6	338	345	PF00069	0.443
DOC_MAPK_NFAT4_5	338	346	PF00069	0.498
DOC_PP1_RVXF_1	445	451	PF00149	0.599
DOC_PP2B_LxvP_1	51	54	PF13499	0.565
DOC_PP2B_LxvP_1	7	10	PF13499	0.544
DOC_PP4_FxxP_1	346	349	PF00568	0.522
DOC_USP7_MATH_1	313	317	PF00917	0.679
DOC_USP7_MATH_1	337	341	PF00917	0.346
DOC_USP7_MATH_1	369	373	PF00917	0.671
DOC_USP7_UBL2_3	166	170	PF12436	0.699
DOC_WW_Pin1_4	14	19	PF00397	0.792
DOC_WW_Pin1_4	30	35	PF00397	0.690
DOC_WW_Pin1_4	319	324	PF00397	0.651
DOC_WW_Pin1_4	402	407	PF00397	0.710
DOC_WW_Pin1_4	43	48	PF00397	0.686
DOC_WW_Pin1_4	5	10	PF00397	0.774
DOC_WW_Pin1_4	87	92	PF00397	0.721
DOC_WW_Pin1_4	97	102	PF00397	0.780
LIG_14-3-3_CanoR_1	13	17	PF00244	0.793
LIG_14-3-3_CanoR_1	244	252	PF00244	0.574
LIG_14-3-3_CanoR_1	338	342	PF00244	0.410
LIG_14-3-3_CanoR_1	512	520	PF00244	0.606
LIG_Actin_WH2_2	138	155	PF00022	0.659
LIG_Actin_WH2_2	207	223	PF00022	0.463
LIG_APCC_ABBA_1	343	348	PF00400	0.523
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_Clathr_ClatBox_1	327	331	PF01394	0.645
LIG_Clathr_ClatBox_1	351	355	PF01394	0.565
LIG_deltaCOP1_diTrp_1	344	354	PF00928	0.497
LIG_FHA_1	144	150	PF00498	0.628
LIG_FHA_1	192	198	PF00498	0.653
LIG_FHA_1	254	260	PF00498	0.575
LIG_FHA_1	403	409	PF00498	0.682
LIG_FHA_1	61	67	PF00498	0.703
LIG_FHA_2	112	118	PF00498	0.627
LIG_FHA_2	408	414	PF00498	0.569
LIG_LIR_Apic_2	344	349	PF02991	0.497
LIG_LIR_Nem_3	344	350	PF02991	0.470
LIG_PCNA_yPIPBox_3	332	346	PF02747	0.564
LIG_Rb_pABgroove_1	356	364	PF01858	0.345
LIG_SH2_SRC	474	477	PF00017	0.562
LIG_SH2_SRC	500	503	PF00017	0.620
LIG_SH2_STAP1	474	478	PF00017	0.555
LIG_SH2_STAT5	130	133	PF00017	0.543
LIG_SH2_STAT5	483	486	PF00017	0.556
LIG_SH2_STAT5	85	88	PF00017	0.555
LIG_SH3_2	101	106	PF14604	0.523
LIG_SH3_2	378	383	PF14604	0.512
LIG_SH3_3	153	159	PF00018	0.687
LIG_SH3_3	3	9	PF00018	0.801
LIG_SH3_3	320	326	PF00018	0.449
LIG_SH3_3	375	381	PF00018	0.733
LIG_SH3_3	38	44	PF00018	0.728
LIG_SH3_3	400	406	PF00018	0.649
LIG_SH3_3	95	101	PF00018	0.703
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.549
LIG_SUMO_SIM_par_1	193	199	PF11976	0.384
LIG_SUMO_SIM_par_1	273	278	PF11976	0.543
LIG_TRAF2_1	181	184	PF00917	0.667
LIG_TRAF2_1	54	57	PF00917	0.780
LIG_UBA3_1	484	489	PF00899	0.561
MOD_CDK_SPK_2	14	19	PF00069	0.775
MOD_CDK_SPxxK_3	14	21	PF00069	0.807
MOD_CK1_1	243	249	PF00069	0.537
MOD_CK1_1	29	35	PF00069	0.695
MOD_CK1_1	316	322	PF00069	0.691
MOD_CK1_1	513	519	PF00069	0.598
MOD_CK1_1	90	96	PF00069	0.754
MOD_CK2_1	30	36	PF00069	0.764
MOD_CK2_1	64	70	PF00069	0.704
MOD_GlcNHglycan	10	13	PF01048	0.818
MOD_GlcNHglycan	174	177	PF01048	0.700
MOD_GlcNHglycan	363	366	PF01048	0.610
MOD_GlcNHglycan	66	69	PF01048	0.549
MOD_GSK3_1	1	8	PF00069	0.733
MOD_GSK3_1	126	133	PF00069	0.557
MOD_GSK3_1	19	26	PF00069	0.603
MOD_GSK3_1	313	320	PF00069	0.668
MOD_GSK3_1	42	49	PF00069	0.776
MOD_GSK3_1	506	513	PF00069	0.610
MOD_GSK3_1	60	67	PF00069	0.574
MOD_GSK3_1	86	93	PF00069	0.703
MOD_N-GLC_1	60	65	PF02516	0.793
MOD_NEK2_1	1	6	PF00069	0.773
MOD_NEK2_1	145	150	PF00069	0.594
MOD_NEK2_1	191	196	PF00069	0.655
MOD_NEK2_1	361	366	PF00069	0.610
MOD_PIKK_1	130	136	PF00454	0.603
MOD_PIKK_1	202	208	PF00454	0.473
MOD_PIKK_1	265	271	PF00454	0.544
MOD_PIKK_1	314	320	PF00454	0.735
MOD_PIKK_1	422	428	PF00454	0.558
MOD_PIKK_1	513	519	PF00454	0.660
MOD_PIKK_1	55	61	PF00454	0.815
MOD_PKA_2	12	18	PF00069	0.741
MOD_PKA_2	243	249	PF00069	0.588
MOD_PKA_2	337	343	PF00069	0.409
MOD_PKA_2	369	375	PF00069	0.524
MOD_PKA_2	513	519	PF00069	0.576
MOD_Plk_1	2	8	PF00069	0.797
MOD_Plk_1	422	428	PF00069	0.573
MOD_Plk_4	2	8	PF00069	0.787
MOD_Plk_4	299	305	PF00069	0.619
MOD_Plk_4	337	343	PF00069	0.469
MOD_Plk_4	356	362	PF00069	0.564
MOD_ProDKin_1	14	20	PF00069	0.790
MOD_ProDKin_1	30	36	PF00069	0.691
MOD_ProDKin_1	319	325	PF00069	0.649
MOD_ProDKin_1	402	408	PF00069	0.707
MOD_ProDKin_1	43	49	PF00069	0.688
MOD_ProDKin_1	5	11	PF00069	0.775
MOD_ProDKin_1	87	93	PF00069	0.722
MOD_ProDKin_1	97	103	PF00069	0.777
MOD_SUMO_for_1	488	491	PF00179	0.555
TRG_DiLeu_BaEn_2	445	451	PF01217	0.599
TRG_DiLeu_BaEn_4	247	253	PF01217	0.550
TRG_DiLeu_BaEn_4	422	428	PF01217	0.556
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.548
TRG_ENDOCYTIC_2	474	477	PF00928	0.537
TRG_ER_diArg_1	121	124	PF00400	0.564
TRG_ER_diArg_1	285	287	PF00400	0.513
TRG_ER_diArg_1	427	430	PF00400	0.573
TRG_ER_diArg_1	437	440	PF00400	0.528
TRG_ER_diArg_1	456	458	PF00400	0.336
TRG_ER_diArg_1	512	515	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P7	Leptomonas seymouri	58%	96%
A0A0S4J1F8	Bodo saltans	25%	96%
A0A1X0NW49	Trypanosomatidae	33%	100%
A0A3Q8IMW3	Leishmania donovani	87%	100%
A0A422NWS4	Trypanosoma rangeli	34%	100%
A4I100	Leishmania infantum	87%	100%
C9ZWA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AX38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAD8	Leishmania major	87%	99%