J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ3_LEIBR

TriTrypDb:

LbrM.24.1990 , LBRM2903_240027600

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0001405	PAM complex, Tim23 associated import motor	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A4HDQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.561
CLV_PCSK_KEX2_1	89	91	PF00082	0.488
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.488
CLV_PCSK_SKI1_1	116	120	PF00082	0.327
DOC_MAPK_gen_1	88	97	PF00069	0.276
DOC_PP4_FxxP_1	55	58	PF00568	0.442
DOC_PP4_FxxP_1	79	82	PF00568	0.491
DOC_USP7_UBL2_3	46	50	PF12436	0.595
DOC_WW_Pin1_4	54	59	PF00397	0.372
LIG_14-3-3_CanoR_1	40	48	PF00244	0.590
LIG_BIR_II_1	1	5	PF00653	0.317
LIG_BIR_III_1	1	5	PF00653	0.317
LIG_BIR_III_3	1	5	PF00653	0.317
LIG_BIR_III_4	101	105	PF00653	0.294
LIG_eIF4E_1	62	68	PF01652	0.386
LIG_FHA_1	103	109	PF00498	0.510
LIG_FHA_2	58	64	PF00498	0.450
LIG_LIR_Apic_2	52	58	PF02991	0.458
LIG_LIR_Gen_1	63	70	PF02991	0.404
LIG_LIR_Nem_3	60	65	PF02991	0.398
LIG_Pex14_2	51	55	PF04695	0.468
LIG_SH2_STAP1	62	66	PF00017	0.474
LIG_SH2_STAT5	107	110	PF00017	0.393
LIG_SH2_STAT5	17	20	PF00017	0.366
LIG_SH2_STAT5	65	68	PF00017	0.490
LIG_TRAF2_1	83	86	PF00917	0.392
MOD_CK1_1	100	106	PF00069	0.455
MOD_CK1_1	36	42	PF00069	0.542
MOD_CK1_1	57	63	PF00069	0.419
MOD_CK2_1	57	63	PF00069	0.346
MOD_GlcNHglycan	101	105	PF01048	0.456
MOD_GlcNHglycan	29	32	PF01048	0.514
MOD_GlcNHglycan	35	38	PF01048	0.496
MOD_GlcNHglycan	43	46	PF01048	0.452
MOD_GSK3_1	103	110	PF00069	0.356
MOD_GSK3_1	29	36	PF00069	0.448
MOD_NEK2_1	41	46	PF00069	0.575
MOD_PKA_2	27	33	PF00069	0.569
MOD_Plk_4	103	109	PF00069	0.377
MOD_ProDKin_1	54	60	PF00069	0.368
TRG_DiLeu_BaEn_1	114	119	PF01217	0.329
TRG_DiLeu_BaEn_1	63	68	PF01217	0.315
TRG_ENDOCYTIC_2	48	51	PF00928	0.510
TRG_ENDOCYTIC_2	65	68	PF00928	0.428
TRG_ENDOCYTIC_2	91	94	PF00928	0.362
TRG_NLS_MonoExtC_3	87	92	PF00514	0.482
TRG_NLS_MonoExtN_4	88	93	PF00514	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II15	Leptomonas seymouri	63%	100%
A0A0S4IZD1	Bodo saltans	42%	100%
A0A1X0NXI1	Trypanosomatidae	50%	100%
A0A3Q8IC73	Leishmania donovani	85%	100%
A0A422NWS9	Trypanosoma rangeli	45%	100%
A4I0Z9	Leishmania infantum	85%	100%
C9ZWB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AX37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QAD9	Leishmania major	80%	100%
Q54QN1	Dictyostelium discoideum	34%	100%
Q5RCP4	Pongo abelii	33%	81%
Q759D2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	77%