Protein prenyltransferase alpha subunit repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ2_LEIBR

TriTrypDb:

LbrM.24.1980

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0018342	protein prenylation	4	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:0097354	prenylation	3	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004659	prenyltransferase activity	4	3
GO:0008318	protein prenyltransferase activity	3	3
GO:0016740	transferase activity	2	4
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.429
CLV_NRD_NRD_1	151	153	PF00675	0.344
CLV_NRD_NRD_1	253	255	PF00675	0.315
CLV_NRD_NRD_1	339	341	PF00675	0.746
CLV_NRD_NRD_1	354	356	PF00675	0.462
CLV_NRD_NRD_1	384	386	PF00675	0.454
CLV_PCSK_KEX2_1	150	152	PF00082	0.333
CLV_PCSK_KEX2_1	253	255	PF00082	0.316
CLV_PCSK_KEX2_1	339	341	PF00082	0.746
CLV_PCSK_KEX2_1	384	386	PF00082	0.479
CLV_PCSK_SKI1_1	122	126	PF00082	0.528
CLV_PCSK_SKI1_1	39	43	PF00082	0.421
CLV_PCSK_SKI1_1	86	90	PF00082	0.365
CLV_PCSK_SKI1_1	97	101	PF00082	0.474
DEG_APCC_DBOX_1	121	129	PF00400	0.437
DEG_Nend_UBRbox_2	1	3	PF02207	0.470
DEG_ODPH_VHL_1	367	378	PF01847	0.414
DEG_SCF_FBW7_1	114	121	PF00400	0.352
DEG_SPOP_SBC_1	64	68	PF00917	0.454
DOC_CKS1_1	30	35	PF01111	0.361
DOC_CYCLIN_RxL_1	250	259	PF00134	0.327
DOC_CYCLIN_RxL_1	408	421	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.523
DOC_MAPK_gen_1	253	262	PF00069	0.331
DOC_MAPK_MEF2A_6	176	185	PF00069	0.397
DOC_MAPK_MEF2A_6	256	264	PF00069	0.266
DOC_PP1_RVXF_1	251	258	PF00149	0.322
DOC_PP1_SILK_1	475	480	PF00149	0.287
DOC_USP7_MATH_1	461	465	PF00917	0.474
DOC_USP7_MATH_1	84	88	PF00917	0.490
DOC_USP7_UBL2_3	356	360	PF12436	0.451
DOC_WW_Pin1_4	114	119	PF00397	0.541
DOC_WW_Pin1_4	29	34	PF00397	0.417
DOC_WW_Pin1_4	326	331	PF00397	0.460
DOC_WW_Pin1_4	359	364	PF00397	0.453
DOC_WW_Pin1_4	406	411	PF00397	0.443
DOC_WW_Pin1_4	441	446	PF00397	0.622
LIG_14-3-3_CanoR_1	256	261	PF00244	0.360
LIG_14-3-3_CanoR_1	339	346	PF00244	0.502
LIG_14-3-3_CanoR_1	355	364	PF00244	0.738
LIG_14-3-3_CanoR_1	413	418	PF00244	0.430
LIG_14-3-3_CanoR_1	425	431	PF00244	0.494
LIG_14-3-3_CanoR_1	432	442	PF00244	0.570
LIG_14-3-3_CanoR_1	479	483	PF00244	0.634
LIG_14-3-3_CanoR_1	79	89	PF00244	0.240
LIG_14-3-3_CanoR_1	95	103	PF00244	0.358
LIG_Actin_WH2_2	410	427	PF00022	0.448
LIG_AP2alpha_1	89	93	PF02296	0.248
LIG_CaM_IQ_9	376	391	PF13499	0.508
LIG_FHA_1	115	121	PF00498	0.479
LIG_FHA_1	220	226	PF00498	0.327
LIG_FHA_1	257	263	PF00498	0.360
LIG_FHA_1	321	327	PF00498	0.523
LIG_FHA_1	58	64	PF00498	0.385
LIG_FHA_1	66	72	PF00498	0.388
LIG_FHA_2	312	318	PF00498	0.359
LIG_FHA_2	377	383	PF00498	0.473
LIG_FHA_2	434	440	PF00498	0.433
LIG_GBD_Chelix_1	474	482	PF00786	0.290
LIG_LIR_Gen_1	144	154	PF02991	0.521
LIG_LIR_Gen_1	177	185	PF02991	0.329
LIG_LIR_Gen_1	2	12	PF02991	0.420
LIG_LIR_Gen_1	300	307	PF02991	0.324
LIG_LIR_Gen_1	427	435	PF02991	0.349
LIG_LIR_Gen_1	459	470	PF02991	0.402
LIG_LIR_Nem_3	144	149	PF02991	0.525
LIG_LIR_Nem_3	177	181	PF02991	0.327
LIG_LIR_Nem_3	182	187	PF02991	0.357
LIG_LIR_Nem_3	2	8	PF02991	0.432
LIG_LIR_Nem_3	300	304	PF02991	0.324
LIG_LIR_Nem_3	427	433	PF02991	0.410
LIG_LIR_Nem_3	459	465	PF02991	0.427
LIG_LIR_Nem_3	72	76	PF02991	0.443
LIG_NRBOX	301	307	PF00104	0.346
LIG_OCRL_FandH_1	256	268	PF00620	0.302
LIG_PAM2_1	128	140	PF00658	0.222
LIG_PCNA_PIPBox_1	411	420	PF02747	0.479
LIG_PCNA_yPIPBox_3	408	418	PF02747	0.479
LIG_Pex14_1	426	430	PF04695	0.491
LIG_Pex14_2	149	153	PF04695	0.234
LIG_Pex14_2	184	188	PF04695	0.231
LIG_Pex14_2	89	93	PF04695	0.396
LIG_PTB_Apo_2	211	218	PF02174	0.442
LIG_PTB_Phospho_1	211	217	PF10480	0.349
LIG_SH2_CRK	252	256	PF00017	0.427
LIG_SH2_CRK	430	434	PF00017	0.400
LIG_SH2_CRK	5	9	PF00017	0.413
LIG_SH2_NCK_1	5	9	PF00017	0.413
LIG_SH2_SRC	217	220	PF00017	0.400
LIG_SH2_STAP1	307	311	PF00017	0.355
LIG_SH2_STAP1	5	9	PF00017	0.413
LIG_SH2_STAT3	470	473	PF00017	0.379
LIG_SH2_STAT5	172	175	PF00017	0.264
LIG_SH2_STAT5	217	220	PF00017	0.400
LIG_SH2_STAT5	26	29	PF00017	0.399
LIG_SH2_STAT5	301	304	PF00017	0.317
LIG_SH2_STAT5	5	8	PF00017	0.409
LIG_SUMO_SIM_par_1	412	419	PF11976	0.460
LIG_SUMO_SIM_par_1	72	78	PF11976	0.347
LIG_TRAF2_1	48	51	PF00917	0.359
LIG_TRFH_1	44	48	PF08558	0.383
LIG_UBA3_1	183	192	PF00899	0.450
LIG_WRC_WIRS_1	146	151	PF05994	0.357
LIG_WRC_WIRS_1	85	90	PF05994	0.349
MOD_CDK_SPxxK_3	406	413	PF00069	0.377
MOD_CK1_1	29	35	PF00069	0.535
MOD_CK1_1	297	303	PF00069	0.390
MOD_CK1_1	3	9	PF00069	0.475
MOD_CK1_1	359	365	PF00069	0.630
MOD_CK1_1	409	415	PF00069	0.538
MOD_CK1_1	416	422	PF00069	0.549
MOD_CK1_1	444	450	PF00069	0.561
MOD_CK1_1	454	460	PF00069	0.498
MOD_CK2_1	190	196	PF00069	0.452
MOD_CK2_1	376	382	PF00069	0.364
MOD_CK2_1	433	439	PF00069	0.515
MOD_GlcNHglycan	20	23	PF01048	0.284
MOD_GlcNHglycan	295	299	PF01048	0.327
MOD_GlcNHglycan	418	421	PF01048	0.483
MOD_GlcNHglycan	446	449	PF01048	0.524
MOD_GlcNHglycan	455	459	PF01048	0.379
MOD_GlcNHglycan	97	100	PF01048	0.551
MOD_GSK3_1	110	117	PF00069	0.651
MOD_GSK3_1	293	300	PF00069	0.397
MOD_GSK3_1	322	329	PF00069	0.733
MOD_GSK3_1	351	358	PF00069	0.621
MOD_GSK3_1	409	416	PF00069	0.497
MOD_GSK3_1	453	460	PF00069	0.435
MOD_GSK3_1	461	468	PF00069	0.332
MOD_GSK3_1	80	87	PF00069	0.370
MOD_N-GLC_1	262	267	PF02516	0.393
MOD_N-GLC_1	465	470	PF02516	0.510
MOD_N-GLC_2	204	206	PF02516	0.331
MOD_NEK2_1	183	188	PF00069	0.330
MOD_NEK2_1	371	376	PF00069	0.361
MOD_NEK2_1	42	47	PF00069	0.557
MOD_NEK2_1	424	429	PF00069	0.329
MOD_NEK2_1	465	470	PF00069	0.445
MOD_NEK2_1	478	483	PF00069	0.450
MOD_NEK2_1	57	62	PF00069	0.511
MOD_NEK2_1	89	94	PF00069	0.412
MOD_NEK2_2	26	31	PF00069	0.361
MOD_NEK2_2	84	89	PF00069	0.232
MOD_OFUCOSY	202	208	PF10250	0.244
MOD_OFUCOSY	56	62	PF10250	0.340
MOD_PIKK_1	165	171	PF00454	0.367
MOD_PIKK_1	376	382	PF00454	0.435
MOD_PKA_1	339	345	PF00069	0.502
MOD_PKA_1	355	361	PF00069	0.449
MOD_PKA_1	384	390	PF00069	0.444
MOD_PKA_2	339	345	PF00069	0.639
MOD_PKA_2	384	390	PF00069	0.444
MOD_PKA_2	424	430	PF00069	0.326
MOD_PKA_2	478	484	PF00069	0.630
MOD_PKB_1	254	262	PF00069	0.369
MOD_Plk_1	232	238	PF00069	0.392
MOD_Plk_1	3	9	PF00069	0.298
MOD_Plk_1	465	471	PF00069	0.495
MOD_Plk_1	58	64	PF00069	0.539
MOD_Plk_4	128	134	PF00069	0.386
MOD_Plk_4	183	189	PF00069	0.305
MOD_Plk_4	190	196	PF00069	0.361
MOD_Plk_4	232	238	PF00069	0.233
MOD_Plk_4	297	303	PF00069	0.366
MOD_Plk_4	3	9	PF00069	0.543
MOD_Plk_4	322	328	PF00069	0.524
MOD_Plk_4	371	377	PF00069	0.403
MOD_Plk_4	413	419	PF00069	0.458
MOD_Plk_4	473	479	PF00069	0.469
MOD_ProDKin_1	114	120	PF00069	0.528
MOD_ProDKin_1	29	35	PF00069	0.415
MOD_ProDKin_1	326	332	PF00069	0.464
MOD_ProDKin_1	359	365	PF00069	0.445
MOD_ProDKin_1	406	412	PF00069	0.448
MOD_ProDKin_1	441	447	PF00069	0.616
MOD_SUMO_rev_2	156	166	PF00179	0.449
TRG_ENDOCYTIC_2	172	175	PF00928	0.466
TRG_ENDOCYTIC_2	252	255	PF00928	0.470
TRG_ENDOCYTIC_2	301	304	PF00928	0.317
TRG_ENDOCYTIC_2	430	433	PF00928	0.435
TRG_ENDOCYTIC_2	5	8	PF00928	0.409
TRG_ER_diArg_1	149	152	PF00400	0.356
TRG_ER_diArg_1	252	254	PF00400	0.300
TRG_ER_diArg_1	339	341	PF00400	0.711
TRG_ER_diArg_1	383	385	PF00400	0.441
TRG_NES_CRM1_1	169	182	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ1	Leptomonas seymouri	39%	100%
A0A0S4JLJ0	Bodo saltans	27%	100%
A0A1X0NWB3	Trypanosomatidae	25%	100%
A0A3Q8IF02	Leishmania donovani	73%	100%
A0A422NWV9	Trypanosoma rangeli	30%	100%
A4I0Z8	Leishmania infantum	73%	100%
C9ZWB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AX36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAE0	Leishmania major	72%	100%