Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative

Species:

Leishmania braziliensis

UniProt:

A4HDQ1_LEIBR

TriTrypDb:

LbrM.24.1970 , LBRM2903_240027500

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	7
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HDQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010992	ubiquitin recycling	3	1
GO:0019538	protein metabolic process	3	1
GO:0019725	cellular homeostasis	2	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0042592	homeostatic process	3	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	751	755	PF00656	0.523
CLV_NRD_NRD_1	376	378	PF00675	0.445
CLV_NRD_NRD_1	506	508	PF00675	0.773
CLV_PCSK_KEX2_1	376	378	PF00082	0.463
CLV_PCSK_KEX2_1	465	467	PF00082	0.312
CLV_PCSK_KEX2_1	506	508	PF00082	0.781
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.312
CLV_PCSK_SKI1_1	348	352	PF00082	0.624
CLV_PCSK_SKI1_1	448	452	PF00082	0.299
CLV_PCSK_SKI1_1	604	608	PF00082	0.291
CLV_PCSK_SKI1_1	623	627	PF00082	0.249
CLV_PCSK_SKI1_1	688	692	PF00082	0.371
CLV_PCSK_SKI1_1	703	707	PF00082	0.195
CLV_PCSK_SKI1_1	711	715	PF00082	0.371
CLV_PCSK_SKI1_1	766	770	PF00082	0.477
DEG_APCC_DBOX_1	758	766	PF00400	0.481
DEG_Nend_UBRbox_4	1	3	PF02207	0.696
DOC_CDC14_PxL_1	496	504	PF14671	0.629
DOC_CKS1_1	121	126	PF01111	0.320
DOC_CYCLIN_RxL_1	601	610	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.543
DOC_MAPK_gen_1	388	398	PF00069	0.479
DOC_MAPK_gen_1	403	411	PF00069	0.457
DOC_MAPK_MEF2A_6	391	398	PF00069	0.502
DOC_MAPK_MEF2A_6	403	411	PF00069	0.457
DOC_MAPK_MEF2A_6	604	611	PF00069	0.468
DOC_MAPK_RevD_3	362	377	PF00069	0.615
DOC_PP2B_LxvP_1	450	453	PF13499	0.499
DOC_PP2B_LxvP_1	497	500	PF13499	0.416
DOC_PP2B_LxvP_1	519	522	PF13499	0.675
DOC_PP2B_LxvP_1	768	771	PF13499	0.331
DOC_USP7_MATH_1	216	220	PF00917	0.534
DOC_USP7_MATH_1	339	343	PF00917	0.515
DOC_USP7_MATH_1	350	354	PF00917	0.572
DOC_USP7_MATH_1	356	360	PF00917	0.510
DOC_USP7_MATH_1	476	480	PF00917	0.510
DOC_USP7_MATH_1	508	512	PF00917	0.776
DOC_USP7_MATH_1	515	519	PF00917	0.764
DOC_USP7_MATH_1	572	576	PF00917	0.487
DOC_USP7_MATH_1	592	596	PF00917	0.434
DOC_USP7_MATH_1	720	724	PF00917	0.542
DOC_USP7_MATH_1	98	102	PF00917	0.581
DOC_USP7_UBL2_3	429	433	PF12436	0.424
DOC_WW_Pin1_4	120	125	PF00397	0.557
DOC_WW_Pin1_4	255	260	PF00397	0.498
DOC_WW_Pin1_4	489	494	PF00397	0.534
DOC_WW_Pin1_4	517	522	PF00397	0.715
DOC_WW_Pin1_4	568	573	PF00397	0.498
DOC_WW_Pin1_4	691	696	PF00397	0.516
DOC_WW_Pin1_4	716	721	PF00397	0.534
DOC_WW_Pin1_4	752	757	PF00397	0.474
DOC_WW_Pin1_4	770	775	PF00397	0.400
LIG_14-3-3_CanoR_1	20	26	PF00244	0.441
LIG_14-3-3_CanoR_1	596	606	PF00244	0.562
LIG_14-3-3_CanoR_1	649	655	PF00244	0.580
LIG_14-3-3_CanoR_1	703	710	PF00244	0.557
LIG_14-3-3_CanoR_1	711	716	PF00244	0.570
LIG_14-3-3_CanoR_1	763	769	PF00244	0.484
LIG_Actin_WH2_1	780	798	PF00022	0.506
LIG_Actin_WH2_2	781	798	PF00022	0.511
LIG_BRCT_BRCA1_1	218	222	PF00533	0.534
LIG_BRCT_BRCA1_1	365	369	PF00533	0.606
LIG_Clathr_ClatBox_1	747	751	PF01394	0.550
LIG_CtBP_PxDLS_1	729	733	PF00389	0.395
LIG_deltaCOP1_diTrp_1	143	151	PF00928	0.408
LIG_FHA_1	145	151	PF00498	0.411
LIG_FHA_1	176	182	PF00498	0.483
LIG_FHA_1	198	204	PF00498	0.479
LIG_FHA_1	228	234	PF00498	0.475
LIG_FHA_1	270	276	PF00498	0.475
LIG_FHA_1	285	291	PF00498	0.408
LIG_FHA_1	314	320	PF00498	0.534
LIG_FHA_1	342	348	PF00498	0.548
LIG_FHA_1	368	374	PF00498	0.583
LIG_FHA_1	38	44	PF00498	0.492
LIG_FHA_1	514	520	PF00498	0.541
LIG_FHA_1	598	604	PF00498	0.583
LIG_FHA_1	606	612	PF00498	0.544
LIG_FHA_1	61	67	PF00498	0.499
LIG_FHA_1	685	691	PF00498	0.554
LIG_FHA_1	704	710	PF00498	0.571
LIG_FHA_1	712	718	PF00498	0.559
LIG_FHA_1	790	796	PF00498	0.468
LIG_FHA_2	127	133	PF00498	0.540
LIG_FHA_2	264	270	PF00498	0.571
LIG_FHA_2	46	52	PF00498	0.554
LIG_FHA_2	578	584	PF00498	0.457
LIG_LIR_Gen_1	321	330	PF02991	0.404
LIG_LIR_Gen_1	402	412	PF02991	0.468
LIG_LIR_Gen_1	436	445	PF02991	0.502
LIG_LIR_Gen_1	586	593	PF02991	0.534
LIG_LIR_Nem_3	402	407	PF02991	0.468
LIG_LIR_Nem_3	436	440	PF02991	0.502
LIG_LIR_Nem_3	586	591	PF02991	0.513
LIG_LIR_Nem_3	63	68	PF02991	0.499
LIG_LIR_Nem_3	653	658	PF02991	0.562
LIG_NRBOX	602	608	PF00104	0.416
LIG_NRBOX	764	770	PF00104	0.487
LIG_PCNA_PIPBox_1	480	489	PF02747	0.534
LIG_Pex14_1	320	324	PF04695	0.498
LIG_SH2_CRK	437	441	PF00017	0.475
LIG_SH2_CRK	588	592	PF00017	0.534
LIG_SH2_STAP1	253	257	PF00017	0.475
LIG_SH2_STAP1	324	328	PF00017	0.410
LIG_SH2_STAP1	437	441	PF00017	0.475
LIG_SH2_STAP1	565	569	PF00017	0.395
LIG_SH2_STAT3	432	435	PF00017	0.571
LIG_SH2_STAT5	121	124	PF00017	0.426
LIG_SH2_STAT5	265	268	PF00017	0.571
LIG_SH2_STAT5	397	400	PF00017	0.571
LIG_SH2_STAT5	419	422	PF00017	0.475
LIG_SH2_STAT5	439	442	PF00017	0.484
LIG_SH2_STAT5	565	568	PF00017	0.395
LIG_SH2_STAT5	605	608	PF00017	0.429
LIG_SH2_STAT5	68	71	PF00017	0.571
LIG_SH3_3	23	29	PF00018	0.544
LIG_SH3_3	519	525	PF00018	0.611
LIG_SH3_3	571	577	PF00018	0.484
LIG_SH3_3	608	614	PF00018	0.571
LIG_SH3_3	632	638	PF00018	0.540
LIG_SH3_3	660	666	PF00018	0.521
LIG_SH3_3	768	774	PF00018	0.587
LIG_SH3_3	814	820	PF00018	0.525
LIG_SUMO_SIM_par_1	145	152	PF11976	0.459
LIG_SUMO_SIM_par_1	605	610	PF11976	0.491
LIG_SUMO_SIM_par_1	713	719	PF11976	0.573
LIG_SUMO_SIM_par_1	728	734	PF11976	0.435
LIG_TRAF2_1	479	482	PF00917	0.534
LIG_UBA3_1	787	796	PF00899	0.409
LIG_WRC_WIRS_1	541	546	PF05994	0.487
MOD_CAAXbox	819	822	PF01239	0.373
MOD_CDK_SPxxK_3	752	759	PF00069	0.515
MOD_CK1_1	126	132	PF00069	0.568
MOD_CK1_1	235	241	PF00069	0.541
MOD_CK1_1	283	289	PF00069	0.543
MOD_CK1_1	310	316	PF00069	0.396
MOD_CK1_1	341	347	PF00069	0.620
MOD_CK1_1	352	358	PF00069	0.612
MOD_CK1_1	49	55	PF00069	0.579
MOD_CK1_1	510	516	PF00069	0.632
MOD_CK1_1	575	581	PF00069	0.456
MOD_CK1_1	682	688	PF00069	0.466
MOD_CK1_1	697	703	PF00069	0.295
MOD_CK1_1	719	725	PF00069	0.457
MOD_CK1_1	761	767	PF00069	0.481
MOD_CK1_1	789	795	PF00069	0.531
MOD_CK2_1	126	132	PF00069	0.527
MOD_CK2_1	263	269	PF00069	0.331
MOD_CK2_1	399	405	PF00069	0.449
MOD_CK2_1	456	462	PF00069	0.410
MOD_CK2_1	476	482	PF00069	0.136
MOD_CK2_1	521	527	PF00069	0.442
MOD_CK2_1	637	643	PF00069	0.365
MOD_CK2_1	728	734	PF00069	0.218
MOD_CK2_1	98	104	PF00069	0.562
MOD_GlcNHglycan	111	114	PF01048	0.409
MOD_GlcNHglycan	140	143	PF01048	0.453
MOD_GlcNHglycan	144	147	PF01048	0.483
MOD_GlcNHglycan	154	157	PF01048	0.399
MOD_GlcNHglycan	178	181	PF01048	0.376
MOD_GlcNHglycan	184	187	PF01048	0.355
MOD_GlcNHglycan	204	207	PF01048	0.476
MOD_GlcNHglycan	223	226	PF01048	0.243
MOD_GlcNHglycan	278	281	PF01048	0.483
MOD_GlcNHglycan	28	32	PF01048	0.482
MOD_GlcNHglycan	309	312	PF01048	0.396
MOD_GlcNHglycan	354	357	PF01048	0.634
MOD_GlcNHglycan	358	361	PF01048	0.618
MOD_GlcNHglycan	48	51	PF01048	0.591
MOD_GlcNHglycan	510	513	PF01048	0.682
MOD_GlcNHglycan	639	642	PF01048	0.466
MOD_GlcNHglycan	743	746	PF01048	0.457
MOD_GlcNHglycan	99	103	PF01048	0.575
MOD_GSK3_1	138	145	PF00069	0.475
MOD_GSK3_1	176	183	PF00069	0.387
MOD_GSK3_1	217	224	PF00069	0.351
MOD_GSK3_1	247	254	PF00069	0.357
MOD_GSK3_1	255	262	PF00069	0.349
MOD_GSK3_1	265	272	PF00069	0.226
MOD_GSK3_1	27	34	PF00069	0.435
MOD_GSK3_1	276	283	PF00069	0.412
MOD_GSK3_1	296	303	PF00069	0.345
MOD_GSK3_1	335	342	PF00069	0.576
MOD_GSK3_1	352	359	PF00069	0.537
MOD_GSK3_1	363	370	PF00069	0.608
MOD_GSK3_1	37	44	PF00069	0.412
MOD_GSK3_1	45	52	PF00069	0.326
MOD_GSK3_1	456	463	PF00069	0.390
MOD_GSK3_1	502	509	PF00069	0.762
MOD_GSK3_1	511	518	PF00069	0.734
MOD_GSK3_1	568	575	PF00069	0.449
MOD_GSK3_1	579	586	PF00069	0.363
MOD_GSK3_1	623	630	PF00069	0.436
MOD_GSK3_1	684	691	PF00069	0.388
MOD_GSK3_1	716	723	PF00069	0.445
MOD_GSK3_1	786	793	PF00069	0.519
MOD_N-GLC_1	176	181	PF02516	0.491
MOD_N-GLC_1	399	404	PF02516	0.468
MOD_N-GLC_1	711	716	PF02516	0.365
MOD_N-GLC_1	752	757	PF02516	0.524
MOD_N-GLC_2	227	229	PF02516	0.413
MOD_NEK2_1	175	180	PF00069	0.488
MOD_NEK2_1	21	26	PF00069	0.523
MOD_NEK2_1	251	256	PF00069	0.331
MOD_NEK2_1	502	507	PF00069	0.712
MOD_NEK2_1	540	545	PF00069	0.588
MOD_NEK2_1	650	655	PF00069	0.466
MOD_NEK2_1	679	684	PF00069	0.466
MOD_NEK2_1	787	792	PF00069	0.345
MOD_PIKK_1	339	345	PF00454	0.514
MOD_PIKK_1	476	482	PF00454	0.341
MOD_PIKK_1	558	564	PF00454	0.428
MOD_PIKK_1	627	633	PF00454	0.324
MOD_PK_1	232	238	PF00069	0.363
MOD_PKA_1	376	382	PF00069	0.441
MOD_PKA_1	506	512	PF00069	0.736
MOD_PKA_2	276	282	PF00069	0.545
MOD_PKA_2	376	382	PF00069	0.466
MOD_PKA_2	417	423	PF00069	0.218
MOD_PKA_2	506	512	PF00069	0.736
MOD_PKA_2	758	764	PF00069	0.495
MOD_Plk_1	176	182	PF00069	0.437
MOD_Plk_1	217	223	PF00069	0.366
MOD_Plk_1	227	233	PF00069	0.285
MOD_Plk_1	269	275	PF00069	0.331
MOD_Plk_1	313	319	PF00069	0.413
MOD_Plk_1	399	405	PF00069	0.218
MOD_Plk_1	711	717	PF00069	0.365
MOD_Plk_1	98	104	PF00069	0.583
MOD_Plk_4	144	150	PF00069	0.287
MOD_Plk_4	247	253	PF00069	0.331
MOD_Plk_4	456	462	PF00069	0.431
MOD_Plk_4	49	55	PF00069	0.533
MOD_Plk_4	583	589	PF00069	0.384
MOD_Plk_4	623	629	PF00069	0.466
MOD_Plk_4	650	656	PF00069	0.421
MOD_Plk_4	711	717	PF00069	0.226
MOD_ProDKin_1	120	126	PF00069	0.557
MOD_ProDKin_1	255	261	PF00069	0.363
MOD_ProDKin_1	489	495	PF00069	0.413
MOD_ProDKin_1	517	523	PF00069	0.700
MOD_ProDKin_1	568	574	PF00069	0.363
MOD_ProDKin_1	691	697	PF00069	0.389
MOD_ProDKin_1	716	722	PF00069	0.413
MOD_ProDKin_1	752	758	PF00069	0.465
MOD_ProDKin_1	770	776	PF00069	0.400
MOD_SUMO_rev_2	341	350	PF00179	0.567
TRG_DiLeu_BaEn_1	527	532	PF01217	0.638
TRG_DiLeu_BaEn_3	481	487	PF01217	0.365
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.466
TRG_DiLeu_LyEn_5	527	532	PF01217	0.391
TRG_ENDOCYTIC_2	324	327	PF00928	0.532
TRG_ENDOCYTIC_2	437	440	PF00928	0.331
TRG_ENDOCYTIC_2	588	591	PF00928	0.384
TRG_ENDOCYTIC_2	68	71	PF00928	0.466
TRG_NES_CRM1_1	601	615	PF08389	0.321
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR3	Leptomonas seymouri	61%	100%
A0A0S4J046	Bodo saltans	36%	100%
A0A3Q8IC13	Leishmania donovani	86%	99%
A4I0Z7	Leishmania infantum	87%	99%
C9ZWB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	93%
E9AX35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
O94289	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P27612	Mus musculus	27%	100%
P54319	Rattus norvegicus	28%	100%
Q4QAE1	Leishmania major	86%	100%
Q6GM65	Xenopus laevis	27%	100%