Cyclin 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin 10

Gene product:

cyclin 10

Species:

Leishmania braziliensis

UniProt:

A4HDQ0_LEIBR

TriTrypDb:

LbrM.24.1960 , LBRM2903_240027400

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ0

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	7
GO:0001932	regulation of protein phosphorylation	7	7
GO:0019220	regulation of phosphate metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031399	regulation of protein modification process	6	7
GO:0042325	regulation of phosphorylation	7	7
GO:0043549	regulation of kinase activity	5	7
GO:0045859	regulation of protein kinase activity	6	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051174	regulation of phosphorus metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051338	regulation of transferase activity	4	7
GO:0051726	regulation of cell cycle	4	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071900	regulation of protein serine/threonine kinase activity	7	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0019899	enzyme binding	3	7
GO:0019900	kinase binding	4	7
GO:0019901	protein kinase binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	581	585	PF00656	0.524
CLV_NRD_NRD_1	416	418	PF00675	0.615
CLV_NRD_NRD_1	482	484	PF00675	0.605
CLV_NRD_NRD_1	62	64	PF00675	0.466
CLV_NRD_NRD_1	661	663	PF00675	0.598
CLV_PCSK_FUR_1	414	418	PF00082	0.612
CLV_PCSK_KEX2_1	153	155	PF00082	0.480
CLV_PCSK_KEX2_1	157	159	PF00082	0.526
CLV_PCSK_KEX2_1	264	266	PF00082	0.304
CLV_PCSK_KEX2_1	416	418	PF00082	0.615
CLV_PCSK_KEX2_1	482	484	PF00082	0.604
CLV_PCSK_KEX2_1	661	663	PF00082	0.598
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.493
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.513
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.304
CLV_PCSK_PC7_1	657	663	PF00082	0.594
CLV_PCSK_SKI1_1	265	269	PF00082	0.304
CLV_PCSK_SKI1_1	303	307	PF00082	0.440
CLV_PCSK_SKI1_1	402	406	PF00082	0.604
CLV_PCSK_SKI1_1	444	448	PF00082	0.612
CLV_PCSK_SKI1_1	636	640	PF00082	0.682
CLV_PCSK_SKI1_1	661	665	PF00082	0.600
CLV_Separin_Metazoa	196	200	PF03568	0.570
CLV_Separin_Metazoa	525	529	PF03568	0.524
DEG_SCF_FBW7_1	144	150	PF00400	0.579
DEG_SPOP_SBC_1	111	115	PF00917	0.566
DOC_CKS1_1	144	149	PF01111	0.553
DOC_CYCLIN_yClb1_LxF_4	337	343	PF00134	0.304
DOC_CYCLIN_yClb1_LxF_4	349	354	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.369
DOC_MAPK_gen_1	201	210	PF00069	0.427
DOC_MAPK_MEF2A_6	252	259	PF00069	0.304
DOC_PP1_RVXF_1	349	355	PF00149	0.453
DOC_PP2B_LxvP_1	572	575	PF13499	0.658
DOC_PP2B_LxvP_1	699	702	PF13499	0.669
DOC_PP2B_PxIxI_1	254	260	PF00149	0.304
DOC_PP4_FxxP_1	179	182	PF00568	0.347
DOC_SPAK_OSR1_1	178	182	PF12202	0.364
DOC_USP7_MATH_1	131	135	PF00917	0.524
DOC_USP7_MATH_1	206	210	PF00917	0.600
DOC_USP7_MATH_1	431	435	PF00917	0.641
DOC_USP7_MATH_1	438	442	PF00917	0.577
DOC_USP7_MATH_1	449	453	PF00917	0.520
DOC_USP7_MATH_1	477	481	PF00917	0.669
DOC_USP7_MATH_1	579	583	PF00917	0.660
DOC_USP7_MATH_2	389	395	PF00917	0.692
DOC_USP7_UBL2_3	153	157	PF12436	0.406
DOC_USP7_UBL2_3	264	268	PF12436	0.304
DOC_WW_Pin1_4	105	110	PF00397	0.606
DOC_WW_Pin1_4	123	128	PF00397	0.598
DOC_WW_Pin1_4	143	148	PF00397	0.543
DOC_WW_Pin1_4	210	215	PF00397	0.594
DOC_WW_Pin1_4	225	230	PF00397	0.654
DOC_WW_Pin1_4	238	243	PF00397	0.369
DOC_WW_Pin1_4	270	275	PF00397	0.304
DOC_WW_Pin1_4	39	44	PF00397	0.630
DOC_WW_Pin1_4	434	439	PF00397	0.642
DOC_WW_Pin1_4	488	493	PF00397	0.620
DOC_WW_Pin1_4	504	509	PF00397	0.611
DOC_WW_Pin1_4	545	550	PF00397	0.658
DOC_WW_Pin1_4	655	660	PF00397	0.593
LIG_14-3-3_CanoR_1	12	22	PF00244	0.612
LIG_14-3-3_CanoR_1	356	360	PF00244	0.314
LIG_14-3-3_CanoR_1	416	422	PF00244	0.551
LIG_14-3-3_CanoR_1	455	460	PF00244	0.688
LIG_14-3-3_CanoR_1	568	573	PF00244	0.646
LIG_14-3-3_CanoR_1	636	645	PF00244	0.807
LIG_14-3-3_CanoR_1	679	689	PF00244	0.664
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BIR_III_4	584	588	PF00653	0.664
LIG_EH1_1	341	349	PF00400	0.419
LIG_eIF4E_1	299	305	PF01652	0.437
LIG_EVH1_1	129	133	PF00568	0.480
LIG_EVH1_1	699	703	PF00568	0.667
LIG_FAT_LD_1	340	348	PF03623	0.413
LIG_FHA_1	124	130	PF00498	0.596
LIG_FHA_1	144	150	PF00498	0.579
LIG_FHA_1	192	198	PF00498	0.293
LIG_FHA_1	249	255	PF00498	0.304
LIG_FHA_1	30	36	PF00498	0.543
LIG_FHA_1	316	322	PF00498	0.304
LIG_FHA_1	459	465	PF00498	0.684
LIG_FHA_1	531	537	PF00498	0.658
LIG_FHA_1	603	609	PF00498	0.597
LIG_FHA_2	166	172	PF00498	0.429
LIG_FHA_2	331	337	PF00498	0.304
LIG_FHA_2	356	362	PF00498	0.453
LIG_FHA_2	382	388	PF00498	0.690
LIG_FHA_2	556	562	PF00498	0.610
LIG_FHA_2	638	644	PF00498	0.535
LIG_FHA_2	665	671	PF00498	0.517
LIG_Integrin_isoDGR_2	10	12	PF01839	0.582
LIG_LIR_Apic_2	176	182	PF02991	0.367
LIG_LIR_Apic_2	270	274	PF02991	0.304
LIG_LIR_Gen_1	325	332	PF02991	0.315
LIG_LIR_Gen_1	341	348	PF02991	0.481
LIG_LIR_Nem_3	176	180	PF02991	0.410
LIG_LIR_Nem_3	325	329	PF02991	0.315
LIG_LIR_Nem_3	341	345	PF02991	0.484
LIG_LIR_Nem_3	358	362	PF02991	0.419
LIG_MYND_1	127	131	PF01753	0.570
LIG_NRBOX	283	289	PF00104	0.304
LIG_Pex14_2	179	183	PF04695	0.409
LIG_PTB_Apo_2	320	327	PF02174	0.352
LIG_PTB_Apo_2	347	354	PF02174	0.406
LIG_PTB_Phospho_1	347	353	PF10480	0.373
LIG_REV1ctd_RIR_1	59	65	PF16727	0.435
LIG_SH2_CRK	177	181	PF00017	0.365
LIG_SH2_CRK	269	273	PF00017	0.403
LIG_SH2_GRB2like	537	540	PF00017	0.623
LIG_SH2_PTP2	271	274	PF00017	0.326
LIG_SH2_SRC	537	540	PF00017	0.529
LIG_SH2_STAP1	426	430	PF00017	0.614
LIG_SH2_STAT5	262	265	PF00017	0.346
LIG_SH2_STAT5	269	272	PF00017	0.343
LIG_SH2_STAT5	283	286	PF00017	0.352
LIG_SH2_STAT5	353	356	PF00017	0.401
LIG_SH2_STAT5	362	365	PF00017	0.377
LIG_SH2_STAT5	666	669	PF00017	0.522
LIG_SH2_STAT5	97	100	PF00017	0.524
LIG_SH3_3	124	130	PF00018	0.545
LIG_SH3_3	141	147	PF00018	0.579
LIG_SH3_3	205	211	PF00018	0.604
LIG_SH3_3	32	38	PF00018	0.564
LIG_SH3_3	397	403	PF00018	0.625
LIG_SH3_3	442	448	PF00018	0.636
LIG_SH3_3	489	495	PF00018	0.612
LIG_SH3_3	50	56	PF00018	0.406
LIG_SH3_3	669	675	PF00018	0.513
LIG_SH3_3	697	703	PF00018	0.613
LIG_SUMO_SIM_par_1	555	561	PF11976	0.623
LIG_TRAF2_1	168	171	PF00917	0.425
LIG_TRAF2_1	522	525	PF00917	0.521
LIG_TRAF2_1	558	561	PF00917	0.629
LIG_TRFH_1	143	147	PF08558	0.492
LIG_TYR_ITIM	267	272	PF00017	0.304
LIG_Vh1_VBS_1	592	610	PF01044	0.505
LIG_WW_3	228	232	PF00397	0.502
MOD_CDC14_SPxK_1	228	231	PF00782	0.501
MOD_CDC14_SPxK_1	437	440	PF00782	0.602
MOD_CDK_SPxK_1	225	231	PF00069	0.565
MOD_CDK_SPxK_1	434	440	PF00069	0.605
MOD_CDK_SPxK_1	655	661	PF00069	0.594
MOD_CDK_SPxxK_3	105	112	PF00069	0.539
MOD_CDK_SPxxK_3	210	217	PF00069	0.512
MOD_CDK_SPxxK_3	655	662	PF00069	0.595
MOD_CK1_1	107	113	PF00069	0.619
MOD_CK1_1	122	128	PF00069	0.512
MOD_CK1_1	13	19	PF00069	0.572
MOD_CK1_1	156	162	PF00069	0.494
MOD_CK1_1	209	215	PF00069	0.611
MOD_CK1_1	355	361	PF00069	0.393
MOD_CK1_1	39	45	PF00069	0.637
MOD_CK1_1	415	421	PF00069	0.672
MOD_CK1_1	429	435	PF00069	0.795
MOD_CK1_1	450	456	PF00069	0.730
MOD_CK1_1	458	464	PF00069	0.644
MOD_CK1_1	596	602	PF00069	0.633
MOD_CK1_1	619	625	PF00069	0.610
MOD_CK1_1	649	655	PF00069	0.623
MOD_CK1_1	680	686	PF00069	0.573
MOD_CK2_1	165	171	PF00069	0.469
MOD_CK2_1	210	216	PF00069	0.530
MOD_CK2_1	22	28	PF00069	0.588
MOD_CK2_1	247	253	PF00069	0.304
MOD_CK2_1	355	361	PF00069	0.579
MOD_CK2_1	381	387	PF00069	0.684
MOD_CK2_1	419	425	PF00069	0.620
MOD_CK2_1	519	525	PF00069	0.560
MOD_CK2_1	555	561	PF00069	0.541
MOD_CK2_1	637	643	PF00069	0.534
MOD_CK2_1	664	670	PF00069	0.521
MOD_GlcNHglycan	1	4	PF01048	0.525
MOD_GlcNHglycan	114	117	PF01048	0.630
MOD_GlcNHglycan	158	161	PF01048	0.575
MOD_GlcNHglycan	393	396	PF01048	0.752
MOD_GlcNHglycan	428	431	PF01048	0.614
MOD_GlcNHglycan	43	46	PF01048	0.549
MOD_GlcNHglycan	433	436	PF01048	0.604
MOD_GlcNHglycan	440	443	PF01048	0.608
MOD_GlcNHglycan	449	452	PF01048	0.602
MOD_GlcNHglycan	475	478	PF01048	0.719
MOD_GlcNHglycan	479	482	PF01048	0.735
MOD_GlcNHglycan	515	519	PF01048	0.622
MOD_GlcNHglycan	521	524	PF01048	0.595
MOD_GlcNHglycan	551	554	PF01048	0.820
MOD_GlcNHglycan	572	575	PF01048	0.705
MOD_GlcNHglycan	646	649	PF01048	0.739
MOD_GlcNHglycan	679	682	PF01048	0.722
MOD_GlcNHglycan	691	694	PF01048	0.615
MOD_GlcNHglycan	71	74	PF01048	0.541
MOD_GlcNHglycan	79	82	PF01048	0.667
MOD_GlcNHglycan	89	92	PF01048	0.639
MOD_GSK3_1	107	114	PF00069	0.548
MOD_GSK3_1	119	126	PF00069	0.519
MOD_GSK3_1	13	20	PF00069	0.576
MOD_GSK3_1	143	150	PF00069	0.576
MOD_GSK3_1	206	213	PF00069	0.556
MOD_GSK3_1	306	313	PF00069	0.304
MOD_GSK3_1	375	382	PF00069	0.640
MOD_GSK3_1	39	46	PF00069	0.632
MOD_GSK3_1	408	415	PF00069	0.631
MOD_GSK3_1	434	441	PF00069	0.808
MOD_GSK3_1	449	456	PF00069	0.605
MOD_GSK3_1	469	476	PF00069	0.616
MOD_GSK3_1	545	552	PF00069	0.547
MOD_GSK3_1	566	573	PF00069	0.669
MOD_GSK3_1	579	586	PF00069	0.600
MOD_GSK3_1	615	622	PF00069	0.630
MOD_GSK3_1	623	630	PF00069	0.789
MOD_GSK3_1	632	639	PF00069	0.730
MOD_GSK3_1	646	653	PF00069	0.682
MOD_GSK3_1	680	687	PF00069	0.609
MOD_GSK3_1	77	84	PF00069	0.676
MOD_N-GLC_1	163	168	PF02516	0.459
MOD_N-GLC_1	408	413	PF02516	0.611
MOD_N-GLC_1	627	632	PF02516	0.565
MOD_N-GLC_1	75	80	PF02516	0.633
MOD_NEK2_1	121	126	PF00069	0.604
MOD_NEK2_1	304	309	PF00069	0.331
MOD_NEK2_1	352	357	PF00069	0.313
MOD_NEK2_1	486	491	PF00069	0.641
MOD_NEK2_1	583	588	PF00069	0.637
MOD_NEK2_1	593	598	PF00069	0.582
MOD_NEK2_1	603	608	PF00069	0.529
MOD_NEK2_1	650	655	PF00069	0.717
MOD_NEK2_1	664	669	PF00069	0.527
MOD_NEK2_1	82	87	PF00069	0.631
MOD_NEK2_2	255	260	PF00069	0.304
MOD_NEK2_2	362	367	PF00069	0.301
MOD_PIKK_1	419	425	PF00454	0.620
MOD_PIKK_1	429	435	PF00454	0.607
MOD_PK_1	324	330	PF00069	0.222
MOD_PK_1	417	423	PF00069	0.616
MOD_PK_1	455	461	PF00069	0.678
MOD_PK_1	566	572	PF00069	0.606
MOD_PKA_1	153	159	PF00069	0.415
MOD_PKA_1	416	422	PF00069	0.614
MOD_PKA_2	153	159	PF00069	0.535
MOD_PKA_2	355	361	PF00069	0.458
MOD_PKA_2	415	421	PF00069	0.620
MOD_PKA_2	587	593	PF00069	0.802
MOD_PKA_2	684	690	PF00069	0.535
MOD_PKB_1	414	422	PF00069	0.612
MOD_PKB_1	566	574	PF00069	0.667
MOD_Plk_1	188	194	PF00069	0.345
MOD_Plk_1	324	330	PF00069	0.304
MOD_Plk_1	382	388	PF00069	0.548
MOD_Plk_1	424	430	PF00069	0.619
MOD_Plk_2-3	165	171	PF00069	0.438
MOD_Plk_4	131	137	PF00069	0.449
MOD_Plk_4	267	273	PF00069	0.326
MOD_Plk_4	646	652	PF00069	0.678
MOD_ProDKin_1	105	111	PF00069	0.607
MOD_ProDKin_1	123	129	PF00069	0.588
MOD_ProDKin_1	143	149	PF00069	0.545
MOD_ProDKin_1	210	216	PF00069	0.594
MOD_ProDKin_1	225	231	PF00069	0.656
MOD_ProDKin_1	238	244	PF00069	0.369
MOD_ProDKin_1	270	276	PF00069	0.304
MOD_ProDKin_1	39	45	PF00069	0.630
MOD_ProDKin_1	434	440	PF00069	0.643
MOD_ProDKin_1	488	494	PF00069	0.621
MOD_ProDKin_1	504	510	PF00069	0.613
MOD_ProDKin_1	545	551	PF00069	0.662
MOD_ProDKin_1	655	661	PF00069	0.594
TRG_DiLeu_BaEn_1	176	181	PF01217	0.497
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.557
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.338
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.376
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.638
TRG_ENDOCYTIC_2	177	180	PF00928	0.372
TRG_ENDOCYTIC_2	269	272	PF00928	0.383
TRG_ENDOCYTIC_2	299	302	PF00928	0.343
TRG_ER_diArg_1	198	201	PF00400	0.334
TRG_ER_diArg_1	414	417	PF00400	0.613
TRG_NES_CRM1_1	335	346	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.462
TRG_PTS1	705	708	PF00515	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K2	Leptomonas seymouri	47%	100%
A0A3Q8IG93	Leishmania donovani	79%	100%
A4I0Z6	Leishmania infantum	79%	100%
E9AX34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAE2	Leishmania major	77%	99%