RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDP7_LEIBR

TriTrypDb:

LbrM.24.1930 , LBRM2903_240027100

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.555
CLV_NRD_NRD_1	259	261	PF00675	0.571
CLV_NRD_NRD_1	73	75	PF00675	0.583
CLV_NRD_NRD_1	97	99	PF00675	0.589
CLV_PCSK_KEX2_1	20	22	PF00082	0.712
CLV_PCSK_KEX2_1	97	99	PF00082	0.589
CLV_PCSK_SKI1_1	260	264	PF00082	0.650
DEG_APCC_DBOX_1	488	496	PF00400	0.555
DEG_SCF_FBW7_2	32	38	PF00400	0.575
DEG_SCF_FBW7_2	421	427	PF00400	0.538
DEG_SPOP_SBC_1	348	352	PF00917	0.576
DOC_CKS1_1	110	115	PF01111	0.738
DOC_CKS1_1	32	37	PF01111	0.574
DOC_CKS1_1	421	426	PF01111	0.540
DOC_CKS1_1	53	58	PF01111	0.579
DOC_MAPK_gen_1	472	480	PF00069	0.538
DOC_MAPK_MEF2A_6	162	169	PF00069	0.549
DOC_PP2B_LxvP_1	15	18	PF13499	0.691
DOC_USP7_MATH_1	117	121	PF00917	0.631
DOC_USP7_MATH_1	237	241	PF00917	0.714
DOC_USP7_MATH_1	330	334	PF00917	0.615
DOC_USP7_MATH_1	348	352	PF00917	0.535
DOC_USP7_MATH_1	372	376	PF00917	0.841
DOC_USP7_MATH_1	85	89	PF00917	0.708
DOC_WW_Pin1_4	109	114	PF00397	0.692
DOC_WW_Pin1_4	157	162	PF00397	0.720
DOC_WW_Pin1_4	176	181	PF00397	0.633
DOC_WW_Pin1_4	220	225	PF00397	0.726
DOC_WW_Pin1_4	265	270	PF00397	0.578
DOC_WW_Pin1_4	31	36	PF00397	0.643
DOC_WW_Pin1_4	325	330	PF00397	0.593
DOC_WW_Pin1_4	337	342	PF00397	0.713
DOC_WW_Pin1_4	349	354	PF00397	0.608
DOC_WW_Pin1_4	420	425	PF00397	0.544
DOC_WW_Pin1_4	46	51	PF00397	0.697
DOC_WW_Pin1_4	52	57	PF00397	0.677
DOC_WW_Pin1_4	61	66	PF00397	0.583
DOC_WW_Pin1_4	90	95	PF00397	0.585
LIG_14-3-3_CanoR_1	135	139	PF00244	0.602
LIG_14-3-3_CanoR_1	238	246	PF00244	0.585
LIG_14-3-3_CanoR_1	25	33	PF00244	0.590
LIG_14-3-3_CanoR_1	428	437	PF00244	0.537
LIG_14-3-3_CanoR_1	439	446	PF00244	0.512
LIG_14-3-3_CanoR_1	472	478	PF00244	0.426
LIG_BRCT_BRCA1_1	514	518	PF00533	0.414
LIG_EVH1_1	15	19	PF00568	0.691
LIG_FHA_1	430	436	PF00498	0.538
LIG_FHA_1	451	457	PF00498	0.674
LIG_FHA_1	7	13	PF00498	0.557
LIG_FHA_2	119	125	PF00498	0.723
LIG_FHA_2	41	47	PF00498	0.636
LIG_Integrin_isoDGR_2	302	304	PF01839	0.590
LIG_Integrin_RGD_1	304	306	PF01839	0.592
LIG_Integrin_RGD_1	57	59	PF01839	0.588
LIG_LIR_Apic_2	265	269	PF02991	0.576
LIG_LIR_Apic_2	354	360	PF02991	0.576
LIG_LIR_Gen_1	515	524	PF02991	0.694
LIG_LIR_Nem_3	515	521	PF02991	0.688
LIG_SH2_CRK	266	270	PF00017	0.579
LIG_SH2_SRC	245	248	PF00017	0.566
LIG_SH2_SRC	357	360	PF00017	0.573
LIG_SH2_STAP1	514	518	PF00017	0.511
LIG_SH2_STAP1	8	12	PF00017	0.558
LIG_SH2_STAT3	272	275	PF00017	0.691
LIG_SH2_STAT5	157	160	PF00017	0.553
LIG_SH2_STAT5	245	248	PF00017	0.566
LIG_SH2_STAT5	357	360	PF00017	0.652
LIG_SH2_STAT5	76	79	PF00017	0.578
LIG_SH2_STAT5	8	11	PF00017	0.558
LIG_SH3_1	13	19	PF00018	0.623
LIG_SH3_2	16	21	PF14604	0.701
LIG_SH3_3	1	7	PF00018	0.617
LIG_SH3_3	13	19	PF00018	0.666
LIG_SH3_3	164	170	PF00018	0.547
LIG_SH3_3	288	294	PF00018	0.702
LIG_SH3_3	29	35	PF00018	0.570
LIG_SH3_3	323	329	PF00018	0.563
LIG_SH3_3	333	339	PF00018	0.557
LIG_SH3_3	44	50	PF00018	0.540
LIG_SH3_3	454	460	PF00018	0.671
LIG_SH3_3	467	473	PF00018	0.465
LIG_SH3_3	526	532	PF00018	0.655
LIG_SH3_3	88	94	PF00018	0.583
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.527
LIG_TRAF2_1	37	40	PF00917	0.576
LIG_TRAF2_1	485	488	PF00917	0.441
LIG_WW_3	17	21	PF00397	0.664
MOD_CDC14_SPxK_1	268	271	PF00782	0.577
MOD_CDK_SPK_2	109	114	PF00069	0.677
MOD_CDK_SPK_2	157	162	PF00069	0.547
MOD_CDK_SPK_2	337	342	PF00069	0.585
MOD_CDK_SPK_2	52	57	PF00069	0.678
MOD_CDK_SPxK_1	265	271	PF00069	0.579
MOD_CDK_SPxxK_3	109	116	PF00069	0.537
MOD_CDK_SPxxK_3	325	332	PF00069	0.567
MOD_CDK_SPxxK_3	90	97	PF00069	0.580
MOD_CK1_1	129	135	PF00069	0.554
MOD_CK1_1	160	166	PF00069	0.605
MOD_CK1_1	175	181	PF00069	0.757
MOD_CK1_1	202	208	PF00069	0.664
MOD_CK1_1	211	217	PF00069	0.642
MOD_CK1_1	24	30	PF00069	0.705
MOD_CK1_1	240	246	PF00069	0.657
MOD_CK1_1	248	254	PF00069	0.604
MOD_CK1_1	325	331	PF00069	0.633
MOD_CK1_1	340	346	PF00069	0.572
MOD_CK1_1	385	391	PF00069	0.667
MOD_CK1_1	433	439	PF00069	0.657
MOD_CK1_1	93	99	PF00069	0.595
MOD_CK2_1	118	124	PF00069	0.727
MOD_CK2_1	280	286	PF00069	0.656
MOD_CK2_1	310	316	PF00069	0.747
MOD_CK2_1	348	354	PF00069	0.642
MOD_CK2_1	437	443	PF00069	0.535
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.612
MOD_GlcNHglycan	173	177	PF01048	0.554
MOD_GlcNHglycan	230	233	PF01048	0.817
MOD_GlcNHglycan	234	237	PF01048	0.791
MOD_GlcNHglycan	282	285	PF01048	0.711
MOD_GlcNHglycan	432	435	PF01048	0.635
MOD_GSK3_1	125	132	PF00069	0.676
MOD_GSK3_1	134	141	PF00069	0.583
MOD_GSK3_1	172	179	PF00069	0.741
MOD_GSK3_1	202	209	PF00069	0.678
MOD_GSK3_1	21	28	PF00069	0.691
MOD_GSK3_1	228	235	PF00069	0.796
MOD_GSK3_1	276	283	PF00069	0.630
MOD_GSK3_1	306	313	PF00069	0.642
MOD_GSK3_1	343	350	PF00069	0.668
MOD_GSK3_1	358	365	PF00069	0.658
MOD_GSK3_1	378	385	PF00069	0.534
MOD_GSK3_1	401	408	PF00069	0.666
MOD_GSK3_1	429	436	PF00069	0.570
MOD_GSK3_1	437	444	PF00069	0.611
MOD_GSK3_1	540	547	PF00069	0.613
MOD_GSK3_1	92	99	PF00069	0.700
MOD_N-GLC_1	126	131	PF02516	0.543
MOD_N-GLC_1	176	181	PF02516	0.582
MOD_N-GLC_1	25	30	PF02516	0.573
MOD_N-GLC_1	343	348	PF02516	0.585
MOD_N-GLC_1	382	387	PF02516	0.574
MOD_NEK2_1	125	130	PF00069	0.543
MOD_NEK2_1	405	410	PF00069	0.587
MOD_NEK2_1	437	442	PF00069	0.548
MOD_NEK2_2	285	290	PF00069	0.586
MOD_NEK2_2	8	13	PF00069	0.558
MOD_PIKK_1	211	217	PF00454	0.671
MOD_PIKK_1	362	368	PF00454	0.731
MOD_PIKK_1	69	75	PF00454	0.737
MOD_PK_1	25	31	PF00069	0.576
MOD_PK_1	441	447	PF00069	0.538
MOD_PKA_2	134	140	PF00069	0.607
MOD_PKA_2	19	25	PF00069	0.675
MOD_PKA_2	237	243	PF00069	0.581
MOD_PKA_2	372	378	PF00069	0.858
MOD_PKA_2	409	415	PF00069	0.706
MOD_PKA_2	96	102	PF00069	0.618
MOD_PKB_1	439	447	PF00069	0.625
MOD_Plk_1	125	131	PF00069	0.544
MOD_Plk_1	25	31	PF00069	0.576
MOD_Plk_1	285	291	PF00069	0.580
MOD_Plk_1	401	407	PF00069	0.551
MOD_Plk_1	502	508	PF00069	0.372
MOD_Plk_4	126	132	PF00069	0.624
MOD_Plk_4	401	407	PF00069	0.538
MOD_ProDKin_1	109	115	PF00069	0.694
MOD_ProDKin_1	157	163	PF00069	0.719
MOD_ProDKin_1	176	182	PF00069	0.635
MOD_ProDKin_1	220	226	PF00069	0.726
MOD_ProDKin_1	265	271	PF00069	0.579
MOD_ProDKin_1	31	37	PF00069	0.639
MOD_ProDKin_1	325	331	PF00069	0.594
MOD_ProDKin_1	337	343	PF00069	0.712
MOD_ProDKin_1	349	355	PF00069	0.609
MOD_ProDKin_1	420	426	PF00069	0.543
MOD_ProDKin_1	46	52	PF00069	0.698
MOD_ProDKin_1	61	67	PF00069	0.581
MOD_ProDKin_1	90	96	PF00069	0.585
MOD_SUMO_rev_2	375	384	PF00179	0.582
MOD_SUMO_rev_2	86	91	PF00179	0.735
TRG_DiLeu_BaEn_1	451	456	PF01217	0.675
TRG_DiLeu_BaEn_4	487	493	PF01217	0.427
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.675
TRG_ENDOCYTIC_2	474	477	PF00928	0.657
TRG_ER_diArg_1	19	21	PF00400	0.552
TRG_NLS_MonoExtN_4	259	264	PF00514	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID03	Leishmania donovani	52%	100%
A4I0Z3	Leishmania infantum	52%	100%
E9AX31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4QAE5	Leishmania major	50%	97%