Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDP6_LEIBR

TriTrypDb:

LbrM.24.1920 , LBRM2903_240026900

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HDP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.495
CLV_C14_Caspase3-7	293	297	PF00656	0.583
CLV_NRD_NRD_1	12	14	PF00675	0.717
CLV_NRD_NRD_1	144	146	PF00675	0.719
CLV_NRD_NRD_1	217	219	PF00675	0.783
CLV_NRD_NRD_1	344	346	PF00675	0.654
CLV_NRD_NRD_1	384	386	PF00675	0.474
CLV_PCSK_FUR_1	10	14	PF00082	0.588
CLV_PCSK_FUR_1	215	219	PF00082	0.768
CLV_PCSK_FUR_1	5	9	PF00082	0.603
CLV_PCSK_KEX2_1	12	14	PF00082	0.703
CLV_PCSK_KEX2_1	129	131	PF00082	0.676
CLV_PCSK_KEX2_1	144	146	PF00082	0.719
CLV_PCSK_KEX2_1	217	219	PF00082	0.780
CLV_PCSK_KEX2_1	344	346	PF00082	0.682
CLV_PCSK_KEX2_1	7	9	PF00082	0.754
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.676
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.601
CLV_PCSK_PC7_1	213	219	PF00082	0.756
CLV_PCSK_PC7_1	3	9	PF00082	0.760
CLV_PCSK_SKI1_1	170	174	PF00082	0.739
CLV_PCSK_SKI1_1	301	305	PF00082	0.587
DEG_Nend_UBRbox_3	1	3	PF02207	0.740
DEG_SPOP_SBC_1	229	233	PF00917	0.559
DEG_SPOP_SBC_1	245	249	PF00917	0.388
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.427
DOC_MAPK_gen_1	299	307	PF00069	0.529
DOC_MAPK_MEF2A_6	299	307	PF00069	0.529
DOC_MAPK_MEF2A_6	322	331	PF00069	0.360
DOC_MAPK_MEF2A_6	360	368	PF00069	0.402
DOC_MAPK_RevD_3	371	386	PF00069	0.431
DOC_PP1_RVXF_1	378	385	PF00149	0.672
DOC_PP2B_LxvP_1	102	105	PF13499	0.536
DOC_PP2B_LxvP_1	310	313	PF13499	0.368
DOC_PP4_FxxP_1	100	103	PF00568	0.494
DOC_USP7_MATH_1	132	136	PF00917	0.499
DOC_USP7_MATH_1	223	227	PF00917	0.664
DOC_USP7_MATH_1	229	233	PF00917	0.624
DOC_USP7_MATH_1	235	239	PF00917	0.575
DOC_USP7_MATH_1	297	301	PF00917	0.568
DOC_USP7_MATH_1	91	95	PF00917	0.570
DOC_WW_Pin1_4	186	191	PF00397	0.449
LIG_14-3-3_CanoR_1	144	149	PF00244	0.412
LIG_14-3-3_CanoR_1	344	350	PF00244	0.516
LIG_14-3-3_CanoR_1	354	358	PF00244	0.494
LIG_14-3-3_CanoR_1	385	390	PF00244	0.653
LIG_Actin_WH2_2	375	392	PF00022	0.428
LIG_BRCT_BRCA1_1	96	100	PF00533	0.532
LIG_FHA_1	206	212	PF00498	0.578
LIG_FHA_1	345	351	PF00498	0.506
LIG_FHA_1	376	382	PF00498	0.658
LIG_FHA_1	48	54	PF00498	0.468
LIG_FHA_1	62	68	PF00498	0.434
LIG_FHA_2	229	235	PF00498	0.471
LIG_FHA_2	284	290	PF00498	0.517
LIG_FHA_2	37	43	PF00498	0.473
LIG_GBD_Chelix_1	23	31	PF00786	0.730
LIG_LIR_Apic_2	97	103	PF02991	0.532
LIG_LIR_Gen_1	306	313	PF02991	0.355
LIG_LIR_Gen_1	369	379	PF02991	0.513
LIG_LIR_Gen_1	78	87	PF02991	0.489
LIG_LIR_Nem_3	147	151	PF02991	0.491
LIG_LIR_Nem_3	179	185	PF02991	0.475
LIG_LIR_Nem_3	306	310	PF02991	0.347
LIG_LIR_Nem_3	369	375	PF02991	0.437
LIG_NRBOX	26	32	PF00104	0.669
LIG_NRBOX	51	57	PF00104	0.517
LIG_REV1ctd_RIR_1	170	179	PF16727	0.505
LIG_SH2_PTP2	372	375	PF00017	0.261
LIG_SH2_STAP1	339	343	PF00017	0.544
LIG_SH2_STAT5	290	293	PF00017	0.553
LIG_SH2_STAT5	372	375	PF00017	0.313
LIG_SH3_3	184	190	PF00018	0.429
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.520
LIG_SUMO_SIM_par_1	363	369	PF11976	0.270
LIG_SUMO_SIM_par_1	44	51	PF11976	0.462
LIG_SUMO_SIM_par_1	63	69	PF11976	0.445
LIG_TRAF2_1	152	155	PF00917	0.481
LIG_TRAF2_1	275	278	PF00917	0.620
LIG_TRFH_1	100	104	PF08558	0.536
LIG_WRC_WIRS_1	304	309	PF05994	0.341
MOD_CK1_1	139	145	PF00069	0.541
MOD_CK1_1	189	195	PF00069	0.448
MOD_CK1_1	205	211	PF00069	0.434
MOD_CK1_1	353	359	PF00069	0.395
MOD_CK1_1	388	394	PF00069	0.750
MOD_CK1_1	66	72	PF00069	0.506
MOD_CK1_1	94	100	PF00069	0.543
MOD_CK2_1	149	155	PF00069	0.488
MOD_CK2_1	194	200	PF00069	0.588
MOD_CK2_1	230	236	PF00069	0.648
MOD_CK2_1	283	289	PF00069	0.559
MOD_CK2_1	36	42	PF00069	0.472
MOD_DYRK1A_RPxSP_1	186	190	PF00069	0.415
MOD_GlcNHglycan	196	199	PF01048	0.759
MOD_GlcNHglycan	20	23	PF01048	0.710
MOD_GlcNHglycan	236	240	PF01048	0.772
MOD_GlcNHglycan	248	251	PF01048	0.627
MOD_GlcNHglycan	263	266	PF01048	0.620
MOD_GlcNHglycan	375	378	PF01048	0.406
MOD_GlcNHglycan	390	393	PF01048	0.495
MOD_GlcNHglycan	93	96	PF01048	0.810
MOD_GSK3_1	132	139	PF00069	0.537
MOD_GSK3_1	202	209	PF00069	0.549
MOD_GSK3_1	237	244	PF00069	0.521
MOD_GSK3_1	94	101	PF00069	0.518
MOD_NEK2_1	30	35	PF00069	0.475
MOD_NEK2_1	303	308	PF00069	0.349
MOD_NEK2_1	36	41	PF00069	0.590
MOD_NEK2_1	366	371	PF00069	0.513
MOD_NEK2_1	48	53	PF00069	0.523
MOD_NEK2_1	98	103	PF00069	0.524
MOD_OFUCOSY	28	34	PF10250	0.555
MOD_PIKK_1	223	229	PF00454	0.475
MOD_PIKK_1	86	92	PF00454	0.597
MOD_PKA_1	144	150	PF00069	0.406
MOD_PKA_1	344	350	PF00069	0.461
MOD_PKA_1	385	391	PF00069	0.680
MOD_PKA_2	144	150	PF00069	0.406
MOD_PKA_2	343	349	PF00069	0.542
MOD_PKA_2	353	359	PF00069	0.455
MOD_Plk_1	283	289	PF00069	0.559
MOD_Plk_1	77	83	PF00069	0.421
MOD_Plk_4	353	359	PF00069	0.482
MOD_Plk_4	48	54	PF00069	0.460
MOD_Plk_4	94	100	PF00069	0.527
MOD_ProDKin_1	186	192	PF00069	0.452
MOD_SUMO_rev_2	189	197	PF00179	0.470
TRG_ENDOCYTIC_2	339	342	PF00928	0.545
TRG_ENDOCYTIC_2	372	375	PF00928	0.390
TRG_ER_diArg_1	10	13	PF00400	0.675
TRG_ER_diArg_1	213	216	PF00400	0.580
TRG_ER_diArg_1	343	345	PF00400	0.449
TRG_ER_diLys_1	401	404	PF00400	0.747
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P420	Leptomonas seymouri	37%	96%
A0A3S7WYI6	Leishmania donovani	64%	98%
E9AH92	Leishmania infantum	64%	98%
E9AX30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4QAE6	Leishmania major	63%	100%