Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDP4_LEIBR

TriTrypDb:

LbrM.24.1900 , LBRM2903_240026700

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.615
CLV_NRD_NRD_1	193	195	PF00675	0.568
CLV_PCSK_KEX2_1	113	115	PF00082	0.639
CLV_PCSK_KEX2_1	193	195	PF00082	0.592
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.671
CLV_PCSK_SKI1_1	113	117	PF00082	0.603
CLV_PCSK_SKI1_1	30	34	PF00082	0.707
DEG_APCC_KENBOX_2	168	172	PF00400	0.664
DEG_SCF_FBW7_2	51	56	PF00400	0.617
DOC_MAPK_gen_1	113	122	PF00069	0.641
DOC_MAPK_gen_1	88	97	PF00069	0.622
DOC_MAPK_MEF2A_6	88	97	PF00069	0.660
DOC_PP2B_LxvP_1	51	54	PF13499	0.612
DOC_PP4_FxxP_1	57	60	PF00568	0.638
DOC_USP7_MATH_2	98	104	PF00917	0.648
DOC_WW_Pin1_4	17	22	PF00397	0.725
DOC_WW_Pin1_4	49	54	PF00397	0.609
LIG_14-3-3_CanoR_1	10	14	PF00244	0.536
LIG_14-3-3_CanoR_1	80	86	PF00244	0.588
LIG_deltaCOP1_diTrp_1	56	63	PF00928	0.655
LIG_EVH1_2	53	57	PF00568	0.633
LIG_FHA_2	31	37	PF00498	0.649
LIG_LIR_Apic_2	56	60	PF02991	0.651
LIG_PTB_Apo_2	123	130	PF02174	0.693
LIG_PTB_Phospho_1	123	129	PF10480	0.693
LIG_SH2_GRB2like	119	122	PF00017	0.581
LIG_SH2_PTP2	119	122	PF00017	0.637
LIG_SH2_STAP1	14	18	PF00017	0.645
LIG_SH2_STAP1	91	95	PF00017	0.669
LIG_SH2_STAT3	14	17	PF00017	0.589
LIG_SH2_STAT3	143	146	PF00017	0.637
LIG_SH2_STAT5	119	122	PF00017	0.637
LIG_SH2_STAT5	129	132	PF00017	0.641
LIG_SH2_STAT5	157	160	PF00017	0.642
LIG_SH3_3	92	98	PF00018	0.742
LIG_TRAF2_1	67	70	PF00917	0.633
LIG_TRAF2_1	84	87	PF00917	0.592
MOD_CDK_SPxxK_3	17	24	PF00069	0.732
MOD_CK2_1	30	36	PF00069	0.624
MOD_CK2_1	81	87	PF00069	0.597
MOD_CK2_1	9	15	PF00069	0.537
MOD_N-GLC_1	179	184	PF02516	0.596
MOD_PKA_2	146	152	PF00069	0.652
MOD_PKA_2	9	15	PF00069	0.595
MOD_Plk_1	139	145	PF00069	0.650
MOD_Plk_1	86	92	PF00069	0.650
MOD_Plk_4	9	15	PF00069	0.595
MOD_ProDKin_1	17	23	PF00069	0.728
MOD_ProDKin_1	49	55	PF00069	0.610
MOD_SUMO_rev_2	84	89	PF00179	0.591
TRG_ENDOCYTIC_2	119	122	PF00928	0.581
TRG_ER_diArg_1	132	135	PF00400	0.603
TRG_ER_diArg_1	193	195	PF00400	0.592
TRG_NLS_MonoExtN_4	110	117	PF00514	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P367	Leptomonas seymouri	88%	73%
A0A0S4J5N9	Bodo saltans	62%	86%
A0A1X0NVV7	Trypanosomatidae	78%	93%
A0A3Q8ICY8	Leishmania donovani	98%	87%
C9ZWB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	88%
E9AH90	Leishmania infantum	98%	87%
E9AX28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	87%
Q4QAE8	Leishmania major	98%	100%