Putative short chain dehydrogenase/reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase/reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDP3_LEIBR

TriTrypDb:

LbrM.24.1890 , LBRM2903_240026600

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HDP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDP3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0016491	oxidoreductase activity	2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.453
CLV_NRD_NRD_1	211	213	PF00675	0.255
CLV_NRD_NRD_1	275	277	PF00675	0.457
CLV_NRD_NRD_1	51	53	PF00675	0.488
CLV_NRD_NRD_1	9	11	PF00675	0.340
CLV_PCSK_KEX2_1	138	140	PF00082	0.212
CLV_PCSK_KEX2_1	275	277	PF00082	0.457
CLV_PCSK_KEX2_1	365	367	PF00082	0.381
CLV_PCSK_KEX2_1	51	53	PF00082	0.542
CLV_PCSK_KEX2_1	9	11	PF00082	0.340
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.212
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.506
CLV_PCSK_SKI1_1	101	105	PF00082	0.302
CLV_PCSK_SKI1_1	138	142	PF00082	0.188
CLV_PCSK_SKI1_1	241	245	PF00082	0.434
CLV_PCSK_SKI1_1	57	61	PF00082	0.455
DEG_APCC_DBOX_1	9	17	PF00400	0.384
DEG_SPOP_SBC_1	122	126	PF00917	0.526
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.470
DOC_MAPK_DCC_7	284	293	PF00069	0.531
DOC_MAPK_gen_1	186	195	PF00069	0.293
DOC_MAPK_gen_1	275	282	PF00069	0.469
DOC_MAPK_gen_1	9	17	PF00069	0.419
DOC_MAPK_MEF2A_6	188	197	PF00069	0.398
DOC_MAPK_MEF2A_6	9	17	PF00069	0.413
DOC_MAPK_NFAT4_5	10	18	PF00069	0.420
DOC_MAPK_RevD_3	37	52	PF00069	0.267
DOC_PP1_RVXF_1	136	143	PF00149	0.266
DOC_PP2B_LxvP_1	11	14	PF13499	0.469
DOC_PP4_FxxP_1	197	200	PF00568	0.335
DOC_USP7_MATH_1	248	252	PF00917	0.481
DOC_USP7_MATH_1	37	41	PF00917	0.459
DOC_USP7_MATH_1	91	95	PF00917	0.441
DOC_USP7_MATH_2	112	118	PF00917	0.442
DOC_USP7_UBL2_3	383	387	PF12436	0.499
DOC_WW_Pin1_4	108	113	PF00397	0.531
DOC_WW_Pin1_4	118	123	PF00397	0.717
DOC_WW_Pin1_4	127	132	PF00397	0.701
DOC_WW_Pin1_4	211	216	PF00397	0.378
LIG_14-3-3_CanoR_1	139	143	PF00244	0.273
LIG_14-3-3_CanoR_1	256	263	PF00244	0.304
LIG_14-3-3_CanoR_1	284	291	PF00244	0.571
LIG_14-3-3_CanoR_1	321	327	PF00244	0.406
LIG_14-3-3_CanoR_1	45	49	PF00244	0.346
LIG_AP2alpha_2	311	313	PF02296	0.364
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.354
LIG_BIR_II_1	1	5	PF00653	0.281
LIG_BRCT_BRCA1_1	309	313	PF00533	0.573
LIG_CSL_BTD_1	11	14	PF09270	0.338
LIG_eIF4E_1	353	359	PF01652	0.372
LIG_eIF4E_1	76	82	PF01652	0.310
LIG_FHA_1	123	129	PF00498	0.704
LIG_FHA_1	202	208	PF00498	0.308
LIG_FHA_1	36	42	PF00498	0.381
LIG_FHA_1	61	67	PF00498	0.317
LIG_FHA_1	68	74	PF00498	0.313
LIG_FHA_2	109	115	PF00498	0.408
LIG_FHA_2	139	145	PF00498	0.194
LIG_LIR_Apic_2	25	30	PF02991	0.437
LIG_LIR_Gen_1	141	148	PF02991	0.315
LIG_LIR_Gen_1	2	11	PF02991	0.401
LIG_LIR_Gen_1	60	66	PF02991	0.373
LIG_LIR_Nem_3	2	6	PF02991	0.343
LIG_LIR_Nem_3	60	65	PF02991	0.380
LIG_Pex14_2	197	201	PF04695	0.279
LIG_PTB_Apo_2	271	278	PF02174	0.522
LIG_PTB_Apo_2	346	353	PF02174	0.358
LIG_PTB_Phospho_1	271	277	PF10480	0.505
LIG_PTB_Phospho_1	346	352	PF10480	0.362
LIG_SH2_CRK	36	40	PF00017	0.322
LIG_SH2_CRK	62	66	PF00017	0.384
LIG_SH2_GRB2like	27	30	PF00017	0.325
LIG_SH2_NCK_1	36	40	PF00017	0.472
LIG_SH2_SRC	27	30	PF00017	0.325
LIG_SH2_STAP1	18	22	PF00017	0.439
LIG_SH2_STAP1	62	66	PF00017	0.384
LIG_SH2_STAT3	147	150	PF00017	0.398
LIG_SH2_STAT3	267	270	PF00017	0.279
LIG_SH2_STAT5	223	226	PF00017	0.323
LIG_SH2_STAT5	27	30	PF00017	0.422
LIG_SH2_STAT5	3	6	PF00017	0.324
LIG_SH2_STAT5	389	392	PF00017	0.461
LIG_SH2_STAT5	62	65	PF00017	0.318
LIG_SH2_STAT5	76	79	PF00017	0.240
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.271
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.333
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.351
LIG_TRAF2_1	94	97	PF00917	0.256
LIG_TYR_ITSM	58	65	PF00017	0.386
LIG_UBA3_1	207	213	PF00899	0.286
LIG_UBA3_1	242	247	PF00899	0.331
MOD_CDC14_SPxK_1	214	217	PF00782	0.154
MOD_CDK_SPxK_1	211	217	PF00069	0.154
MOD_CK1_1	117	123	PF00069	0.674
MOD_CK1_1	124	130	PF00069	0.704
MOD_CK1_1	251	257	PF00069	0.305
MOD_CK1_1	361	367	PF00069	0.356
MOD_CK2_1	108	114	PF00069	0.431
MOD_CK2_1	91	97	PF00069	0.486
MOD_Cter_Amidation	49	52	PF01082	0.544
MOD_GlcNHglycan	24	27	PF01048	0.423
MOD_GlcNHglycan	258	261	PF01048	0.314
MOD_GlcNHglycan	360	363	PF01048	0.358
MOD_GlcNHglycan	70	73	PF01048	0.361
MOD_GlcNHglycan	93	96	PF01048	0.501
MOD_GSK3_1	108	115	PF00069	0.587
MOD_GSK3_1	117	124	PF00069	0.693
MOD_GSK3_1	207	214	PF00069	0.286
MOD_GSK3_1	315	322	PF00069	0.472
MOD_GSK3_1	354	361	PF00069	0.234
MOD_GSK3_1	60	67	PF00069	0.359
MOD_N-GLC_1	248	253	PF02516	0.471
MOD_N-GLC_1	315	320	PF02516	0.527
MOD_N-GLC_2	340	342	PF02516	0.324
MOD_NEK2_1	300	305	PF00069	0.409
MOD_NEK2_1	314	319	PF00069	0.466
MOD_NEK2_1	35	40	PF00069	0.383
MOD_NEK2_1	381	386	PF00069	0.392
MOD_NEK2_1	5	10	PF00069	0.429
MOD_PIKK_1	248	254	PF00454	0.444
MOD_PIKK_1	332	338	PF00454	0.300
MOD_PKA_1	138	144	PF00069	0.262
MOD_PKA_2	138	144	PF00069	0.273
MOD_PKA_2	283	289	PF00069	0.586
MOD_PKA_2	343	349	PF00069	0.318
MOD_PKA_2	44	50	PF00069	0.389
MOD_Plk_1	248	254	PF00069	0.372
MOD_Plk_1	315	321	PF00069	0.424
MOD_Plk_1	354	360	PF00069	0.515
MOD_Plk_4	138	144	PF00069	0.308
MOD_Plk_4	334	340	PF00069	0.299
MOD_Plk_4	354	360	PF00069	0.545
MOD_Plk_4	37	43	PF00069	0.417
MOD_ProDKin_1	108	114	PF00069	0.543
MOD_ProDKin_1	118	124	PF00069	0.716
MOD_ProDKin_1	127	133	PF00069	0.693
MOD_ProDKin_1	211	217	PF00069	0.378
MOD_SUMO_rev_2	364	372	PF00179	0.369
TRG_ENDOCYTIC_2	21	24	PF00928	0.241
TRG_ENDOCYTIC_2	277	280	PF00928	0.493
TRG_ENDOCYTIC_2	3	6	PF00928	0.351
TRG_ENDOCYTIC_2	36	39	PF00928	0.247
TRG_ENDOCYTIC_2	388	391	PF00928	0.412
TRG_ENDOCYTIC_2	62	65	PF00928	0.337
TRG_ENDOCYTIC_2	76	79	PF00928	0.324
TRG_ER_diArg_1	275	277	PF00400	0.457
TRG_ER_diArg_1	9	11	PF00400	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P0	Leptomonas seymouri	26%	95%
A0A0N0P2S5	Leptomonas seymouri	28%	88%
A0A0N0P2S7	Leptomonas seymouri	78%	77%
A0A0N1HZ81	Leptomonas seymouri	30%	71%
A0A0S4IWT0	Bodo saltans	45%	84%
A0A0S4IZG2	Bodo saltans	28%	87%
A0A0S4J1I6	Bodo saltans	29%	90%
A0A0S4JBQ4	Bodo saltans	27%	100%
A0A1J0HSL5	Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)	29%	100%
A0A1V0QS34	Hericium erinaceus	26%	100%
A0A1X0NVT8	Trypanosomatidae	65%	79%
A0A1X0P5Q9	Trypanosomatidae	28%	86%
A0A2H3CZZ2	Armillaria gallica	24%	100%
A0A3Q8ID46	Leishmania donovani	87%	78%
A0A3Q8IM89	Leishmania donovani	29%	90%
A0A3R7K071	Trypanosoma rangeli	31%	82%
A0A3R7K8J6	Trypanosoma rangeli	28%	90%
A0A3R7N7S2	Trypanosoma rangeli	26%	92%
A0A3S5H7D5	Leishmania donovani	32%	90%
A0A422N2B6	Trypanosoma rangeli	62%	82%
A4HDP2	Leishmania braziliensis	32%	100%
A4HMN7	Leishmania braziliensis	30%	90%
C8V3Y7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	83%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
E9AF39	Leishmania major	28%	100%
E9AH88	Leishmania infantum	32%	79%
E9AH89	Leishmania infantum	87%	78%
E9AHV6	Leishmania infantum	29%	90%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	90%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	78%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
G9N4A6	Hypocrea virens (strain Gv29-8 / FGSC 10586)	27%	100%
O13822	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	99%
Q17QU7	Bos taurus	28%	100%
Q17QW3	Bos taurus	29%	100%
Q4QAE9	Leishmania major	87%	100%
Q4QAF0	Leishmania major	34%	100%
Q5R9W5	Pongo abelii	26%	95%
Q5SS80	Mus musculus	28%	100%
Q6UX07	Homo sapiens	29%	100%
Q8BYK4	Mus musculus	26%	100%
Q91WL8	Mus musculus	27%	95%
Q92247	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	96%
Q96NR8	Homo sapiens	27%	100%
Q9ERI6	Mus musculus	28%	100%
Q9HBH5	Homo sapiens	26%	100%
Q9NZC7	Homo sapiens	26%	95%
V5BAF4	Trypanosoma cruzi	62%	83%
V5BJC7	Trypanosoma cruzi	25%	89%