Putative short chain dehydrogenase/reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-ketoacyl-ACP reductase 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HDP2_LEIBR

TriTrypDb:

LbrM.24.1880 , LBRM2903_240026500

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 33
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	17
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HDP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDP2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.561
CLV_NRD_NRD_1	121	123	PF00675	0.375
CLV_NRD_NRD_1	354	356	PF00675	0.542
CLV_PCSK_KEX2_1	121	123	PF00082	0.396
CLV_PCSK_KEX2_1	205	207	PF00082	0.273
CLV_PCSK_KEX2_1	354	356	PF00082	0.552
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.291
CLV_PCSK_PC7_1	201	207	PF00082	0.265
CLV_PCSK_SKI1_1	127	131	PF00082	0.363
CLV_PCSK_SKI1_1	41	45	PF00082	0.377
DOC_MAPK_gen_1	229	239	PF00069	0.417
DOC_MAPK_MEF2A_6	232	241	PF00069	0.440
DOC_MAPK_MEF2A_6	414	423	PF00069	0.235
DOC_PP4_FxxP_1	243	246	PF00568	0.488
DOC_USP7_MATH_1	13	17	PF00917	0.700
DOC_USP7_MATH_1	179	183	PF00917	0.476
DOC_USP7_MATH_1	319	323	PF00917	0.495
DOC_USP7_MATH_1	326	330	PF00917	0.610
DOC_USP7_MATH_1	353	357	PF00917	0.718
DOC_USP7_MATH_1	366	370	PF00917	0.779
DOC_USP7_MATH_1	408	412	PF00917	0.297
DOC_USP7_UBL2_3	481	485	PF12436	0.364
DOC_WW_Pin1_4	162	167	PF00397	0.588
DOC_WW_Pin1_4	28	33	PF00397	0.697
DOC_WW_Pin1_4	288	293	PF00397	0.512
DOC_WW_Pin1_4	392	397	PF00397	0.525
LIG_14-3-3_CanoR_1	33	42	PF00244	0.612
LIG_14-3-3_CanoR_1	388	396	PF00244	0.490
LIG_14-3-3_CanoR_1	49	54	PF00244	0.632
LIG_14-3-3_CanoR_1	64	68	PF00244	0.550
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_CSL_BTD_1	289	292	PF09270	0.542
LIG_eIF4E_1	417	423	PF01652	0.276
LIG_FHA_1	124	130	PF00498	0.591
LIG_FHA_1	138	144	PF00498	0.467
LIG_FHA_1	189	195	PF00498	0.531
LIG_FHA_1	248	254	PF00498	0.455
LIG_FHA_1	279	285	PF00498	0.452
LIG_FHA_1	64	70	PF00498	0.534
LIG_FHA_2	1	7	PF00498	0.667
LIG_FHA_2	424	430	PF00498	0.320
LIG_FHA_2	465	471	PF00498	0.343
LIG_HCF-1_HBM_1	57	60	PF13415	0.539
LIG_LIR_Apic_2	322	326	PF02991	0.655
LIG_LIR_Gen_1	195	203	PF02991	0.469
LIG_LIR_Gen_1	66	75	PF02991	0.540
LIG_LIR_Nem_3	195	200	PF02991	0.446
LIG_LIR_Nem_3	401	407	PF02991	0.573
LIG_LIR_Nem_3	411	416	PF02991	0.372
LIG_NRBOX	112	118	PF00104	0.423
LIG_Pex14_2	44	48	PF04695	0.530
LIG_PTB_Apo_2	442	449	PF02174	0.297
LIG_PTB_Phospho_1	442	448	PF10480	0.298
LIG_RPA_C_Fungi	110	122	PF08784	0.504
LIG_SH2_CRK	404	408	PF00017	0.490
LIG_SH2_GRB2like	449	452	PF00017	0.346
LIG_SH2_NCK_1	358	362	PF00017	0.572
LIG_SH2_PTP2	420	423	PF00017	0.478
LIG_SH2_SRC	418	421	PF00017	0.224
LIG_SH2_SRC	454	457	PF00017	0.454
LIG_SH2_STAP1	358	362	PF00017	0.688
LIG_SH2_STAT5	174	177	PF00017	0.286
LIG_SH2_STAT5	203	206	PF00017	0.367
LIG_SH2_STAT5	247	250	PF00017	0.367
LIG_SH2_STAT5	266	269	PF00017	0.322
LIG_SH2_STAT5	283	286	PF00017	0.381
LIG_SH2_STAT5	415	418	PF00017	0.279
LIG_SH2_STAT5	420	423	PF00017	0.258
LIG_SH2_STAT5	87	90	PF00017	0.374
LIG_SH3_1	39	45	PF00018	0.437
LIG_SH3_3	286	292	PF00018	0.479
LIG_SH3_3	39	45	PF00018	0.437
LIG_SH3_3	90	96	PF00018	0.433
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.370
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.330
LIG_SUMO_SIM_par_1	250	258	PF11976	0.414
LIG_TYR_ITIM	416	421	PF00017	0.324
LIG_WRC_WIRS_1	97	102	PF05994	0.169
MOD_CDK_SPK_2	28	33	PF00069	0.670
MOD_CDK_SPK_2	288	293	PF00069	0.422
MOD_CK1_1	210	216	PF00069	0.461
MOD_CK1_1	31	37	PF00069	0.598
MOD_CK1_1	329	335	PF00069	0.543
MOD_CK1_1	369	375	PF00069	0.704
MOD_CK2_1	252	258	PF00069	0.169
MOD_CK2_1	369	375	PF00069	0.476
MOD_CK2_1	423	429	PF00069	0.390
MOD_CK2_1	464	470	PF00069	0.350
MOD_CK2_1	49	55	PF00069	0.537
MOD_Cter_Amidation	119	122	PF01082	0.521
MOD_GlcNHglycan	140	143	PF01048	0.315
MOD_GlcNHglycan	15	18	PF01048	0.635
MOD_GlcNHglycan	181	184	PF01048	0.323
MOD_GlcNHglycan	284	287	PF01048	0.482
MOD_GlcNHglycan	3	6	PF01048	0.586
MOD_GlcNHglycan	350	353	PF01048	0.629
MOD_GlcNHglycan	355	358	PF01048	0.664
MOD_GlcNHglycan	371	374	PF01048	0.611
MOD_GSK3_1	123	130	PF00069	0.521
MOD_GSK3_1	134	141	PF00069	0.286
MOD_GSK3_1	20	27	PF00069	0.554
MOD_GSK3_1	278	285	PF00069	0.435
MOD_GSK3_1	326	333	PF00069	0.617
MOD_GSK3_1	87	94	PF00069	0.430
MOD_GSK3_1	9	16	PF00069	0.643
MOD_N-GLC_1	162	167	PF02516	0.277
MOD_N-GLC_1	210	215	PF02516	0.491
MOD_N-GLC_1	464	469	PF02516	0.248
MOD_N-GLC_2	123	125	PF02516	0.325
MOD_N-GLC_2	436	438	PF02516	0.321
MOD_NEK2_1	106	111	PF00069	0.330
MOD_NEK2_1	207	212	PF00069	0.213
MOD_NEK2_1	403	408	PF00069	0.459
MOD_NEK2_1	409	414	PF00069	0.298
MOD_NEK2_1	459	464	PF00069	0.521
MOD_NEK2_1	473	478	PF00069	0.382
MOD_NEK2_1	70	75	PF00069	0.477
MOD_PIKK_1	366	372	PF00454	0.709
MOD_PIKK_1	428	434	PF00454	0.310
MOD_PIKK_1	473	479	PF00454	0.251
MOD_PKA_2	123	129	PF00069	0.463
MOD_PKA_2	13	19	PF00069	0.533
MOD_PKA_2	207	213	PF00069	0.370
MOD_PKA_2	228	234	PF00069	0.186
MOD_PKA_2	333	339	PF00069	0.636
MOD_PKA_2	353	359	PF00069	0.676
MOD_PKA_2	387	393	PF00069	0.369
MOD_PKA_2	63	69	PF00069	0.423
MOD_Plk_1	156	162	PF00069	0.314
MOD_Plk_1	210	216	PF00069	0.439
MOD_Plk_1	326	332	PF00069	0.561
MOD_Plk_4	106	112	PF00069	0.292
MOD_Plk_4	156	162	PF00069	0.209
MOD_Plk_4	252	258	PF00069	0.169
MOD_Plk_4	279	285	PF00069	0.370
MOD_Plk_4	430	436	PF00069	0.316
MOD_Plk_4	49	55	PF00069	0.514
MOD_Plk_4	63	69	PF00069	0.445
MOD_ProDKin_1	162	168	PF00069	0.482
MOD_ProDKin_1	28	34	PF00069	0.633
MOD_ProDKin_1	288	294	PF00069	0.376
MOD_ProDKin_1	392	398	PF00069	0.404
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.334
TRG_ENDOCYTIC_2	404	407	PF00928	0.425
TRG_ENDOCYTIC_2	418	421	PF00928	0.368
TRG_ER_diArg_1	121	124	PF00400	0.390
TRG_ER_diArg_1	353	355	PF00400	0.456
TRG_NES_CRM1_1	150	164	PF08389	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S5	Leptomonas seymouri	27%	100%
A0A0N0P2S7	Leptomonas seymouri	32%	95%
A0A0N1HZ81	Leptomonas seymouri	67%	87%
A0A0S4IWT0	Bodo saltans	31%	100%
A0A0S4IZG2	Bodo saltans	35%	100%
A0A0S4J1I6	Bodo saltans	41%	100%
A0A1X0NVT8	Trypanosomatidae	34%	98%
A0A1X0NVV6	Trypanosomatidae	51%	95%
A0A3Q8ID46	Leishmania donovani	34%	96%
A0A3Q8IM89	Leishmania donovani	26%	100%
A0A3R7K071	Trypanosoma rangeli	51%	100%
A0A3R7N7S2	Trypanosoma rangeli	27%	100%
A0A3S5H7D5	Leishmania donovani	86%	100%
A0A3S7X986	Leishmania donovani	23%	100%
A0A422N2B6	Trypanosoma rangeli	33%	100%
A4HDP3	Leishmania braziliensis	32%	100%
A4HMN7	Leishmania braziliensis	24%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF41	Leishmania major	24%	100%
E9AH88	Leishmania infantum	86%	97%
E9AH89	Leishmania infantum	33%	96%
E9AHV6	Leishmania infantum	25%	100%
E9AHV8	Leishmania infantum	23%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	96%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4QAE9	Leishmania major	33%	100%
Q4QAF0	Leishmania major	85%	100%
V5BAF4	Trypanosoma cruzi	34%	100%
V5BNY6	Trypanosoma cruzi	28%	100%