RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HDP0_LEIBR

TriTrypDb:

LbrM.24.1860 , LBRM2903_240026300

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDP0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	124	128	PF00082	0.312
DEG_Nend_UBRbox_2	1	3	PF02207	0.566
DOC_CKS1_1	79	84	PF01111	0.659
DOC_MAPK_MEF2A_6	197	205	PF00069	0.529
DOC_PP2B_LxvP_1	80	83	PF13499	0.613
DOC_PP4_FxxP_1	220	223	PF00568	0.460
DOC_USP7_MATH_1	105	109	PF00917	0.605
DOC_WW_Pin1_4	108	113	PF00397	0.676
DOC_WW_Pin1_4	135	140	PF00397	0.487
DOC_WW_Pin1_4	205	210	PF00397	0.522
DOC_WW_Pin1_4	73	78	PF00397	0.666
LIG_BRCT_BRCA1_1	207	211	PF00533	0.558
LIG_BRCT_BRCA1_1	67	71	PF00533	0.662
LIG_CtBP_PxDLS_1	143	147	PF00389	0.475
LIG_EH_1	68	72	PF12763	0.662
LIG_FHA_1	165	171	PF00498	0.470
LIG_FHA_1	198	204	PF00498	0.475
LIG_FHA_1	205	211	PF00498	0.451
LIG_FHA_1	42	48	PF00498	0.557
LIG_FHA_2	139	145	PF00498	0.481
LIG_LIR_Gen_1	173	183	PF02991	0.475
LIG_LIR_Gen_1	216	223	PF02991	0.437
LIG_LIR_Nem_3	173	178	PF02991	0.475
LIG_LIR_Nem_3	216	220	PF02991	0.433
LIG_PAM2_1	69	81	PF00658	0.665
LIG_PDZ_Class_2	235	240	PF00595	0.455
LIG_Pex14_2	211	215	PF04695	0.447
LIG_RPA_C_Fungi	6	18	PF08784	0.570
LIG_SH2_STAT3	87	90	PF00017	0.667
LIG_SH2_STAT5	175	178	PF00017	0.352
LIG_SH3_3	57	63	PF00018	0.692
LIG_SH3_3	79	85	PF00018	0.632
LIG_SH3_5	83	87	PF00018	0.518
LIG_TRAF2_1	142	145	PF00917	0.312
LIG_TRFH_1	78	82	PF08558	0.500
MOD_CK1_1	108	114	PF00069	0.655
MOD_CK1_1	118	124	PF00069	0.446
MOD_CK1_1	3	9	PF00069	0.578
MOD_CK2_1	138	144	PF00069	0.322
MOD_CK2_1	229	235	PF00069	0.477
MOD_GlcNHglycan	231	234	PF01048	0.453
MOD_GlcNHglycan	4	8	PF01048	0.622
MOD_GSK3_1	106	113	PF00069	0.673
MOD_GSK3_1	118	125	PF00069	0.436
MOD_GSK3_1	135	142	PF00069	0.348
MOD_GSK3_1	192	199	PF00069	0.241
MOD_N-GLC_1	157	162	PF02516	0.312
MOD_N-GLC_1	192	197	PF02516	0.225
MOD_N-GLC_1	73	78	PF02516	0.666
MOD_NEK2_1	157	162	PF00069	0.314
MOD_NEK2_1	170	175	PF00069	0.379
MOD_NEK2_1	196	201	PF00069	0.339
MOD_NEK2_1	213	218	PF00069	0.605
MOD_NEK2_1	41	46	PF00069	0.661
MOD_PKA_2	164	170	PF00069	0.312
MOD_Plk_1	157	163	PF00069	0.312
MOD_Plk_1	179	185	PF00069	0.414
MOD_Plk_1	192	198	PF00069	0.235
MOD_Plk_1	234	240	PF00069	0.455
MOD_Plk_4	152	158	PF00069	0.363
MOD_Plk_4	197	203	PF00069	0.335
MOD_Plk_4	34	40	PF00069	0.601
MOD_ProDKin_1	108	114	PF00069	0.675
MOD_ProDKin_1	135	141	PF00069	0.328
MOD_ProDKin_1	205	211	PF00069	0.527
MOD_ProDKin_1	73	79	PF00069	0.664
MOD_SUMO_rev_2	164	173	PF00179	0.312
TRG_ENDOCYTIC_2	175	178	PF00928	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMV3	Leishmania donovani	80%	99%
A0A3R7NAM0	Trypanosoma rangeli	54%	100%
E9AH86	Leishmania infantum	80%	98%
E9AX24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	91%
Q4QAF2	Leishmania major	85%	100%