Inhibitor of cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inhibitor of cysteine peptidase

Species:

Leishmania braziliensis

UniProt:

A4HDN8_LEIBR

TriTrypDb:

LbrM.24.1840 , LBRM2903_240026100

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDN8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002020	protease binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	12	16	PF00082	0.479
CLV_PCSK_SKI1_1	23	27	PF00082	0.386
DOC_MAPK_gen_1	81	90	PF00069	0.342
DOC_MAPK_HePTP_8	14	26	PF00069	0.348
DOC_MAPK_MEF2A_6	17	26	PF00069	0.348
DOC_USP7_MATH_1	62	66	PF00917	0.311
DOC_USP7_UBL2_3	8	12	PF12436	0.503
DOC_WW_Pin1_4	58	63	PF00397	0.368
LIG_BRCT_BRCA1_1	102	106	PF00533	0.239
LIG_FHA_1	11	17	PF00498	0.437
LIG_FHA_1	19	25	PF00498	0.390
LIG_FHA_1	85	91	PF00498	0.411
LIG_FHA_2	4	10	PF00498	0.412
LIG_LIR_Gen_1	89	99	PF02991	0.325
LIG_LIR_Nem_3	89	95	PF02991	0.344
LIG_Pex14_2	106	110	PF04695	0.227
LIG_SH2_PTP2	92	95	PF00017	0.227
LIG_SH2_STAT5	34	37	PF00017	0.290
LIG_SH2_STAT5	58	61	PF00017	0.402
LIG_SH2_STAT5	92	95	PF00017	0.251
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.313
LIG_SUMO_SIM_par_1	3	9	PF11976	0.593
LIG_SUMO_SIM_par_1	73	80	PF11976	0.227
LIG_TYR_ITIM	90	95	PF00017	0.227
LIG_UBA3_1	95	100	PF00899	0.227
MOD_CK1_1	3	9	PF00069	0.381
MOD_CK1_1	56	62	PF00069	0.431
MOD_GlcNHglycan	64	67	PF01048	0.432
MOD_GSK3_1	100	107	PF00069	0.244
MOD_GSK3_1	28	35	PF00069	0.274
MOD_GSK3_1	52	59	PF00069	0.371
MOD_GSK3_1	70	77	PF00069	0.342
MOD_LATS_1	10	16	PF00433	0.327
MOD_N-GLC_1	10	15	PF02516	0.347
MOD_NEK2_1	18	23	PF00069	0.312
MOD_NEK2_1	52	57	PF00069	0.348
MOD_NEK2_1	74	79	PF00069	0.310
MOD_PIKK_1	100	106	PF00454	0.227
MOD_PIKK_1	56	62	PF00454	0.227
MOD_Plk_1	10	16	PF00069	0.339
MOD_Plk_2-3	45	51	PF00069	0.384
MOD_Plk_4	70	76	PF00069	0.377
MOD_ProDKin_1	58	64	PF00069	0.368
TRG_ENDOCYTIC_2	92	95	PF00928	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR0	Leptomonas seymouri	50%	100%
A0A1X0NX79	Trypanosomatidae	30%	98%
A0A3Q8IC64	Leishmania donovani	60%	97%
A0A3R7MAP9	Trypanosoma rangeli	36%	100%
C9ZWC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AH84	Leishmania infantum	60%	97%
E9AX22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q6KCA4	Entamoeba histolytica	33%	100%
Q868G9	Leishmania major	58%	100%
Q966X9	Trypanosoma cruzi	38%	100%