EKC/KEOPS complex subunit CGI121

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDN7_LEIBR

TriTrypDb:

LbrM.24.1830 , LBRM2903_240026000

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HDN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.535
CLV_NRD_NRD_1	28	30	PF00675	0.656
CLV_PCSK_KEX2_1	27	29	PF00082	0.654
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.654
CLV_PCSK_SKI1_1	108	112	PF00082	0.451
CLV_PCSK_SKI1_1	213	217	PF00082	0.693
DEG_SPOP_SBC_1	131	135	PF00917	0.487
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.626
DOC_USP7_MATH_1	149	153	PF00917	0.775
DOC_USP7_MATH_1	209	213	PF00917	0.545
DOC_USP7_MATH_1	263	267	PF00917	0.482
DOC_USP7_MATH_1	77	81	PF00917	0.762
DOC_WW_Pin1_4	233	238	PF00397	0.484
DOC_WW_Pin1_4	40	45	PF00397	0.476
DOC_WW_Pin1_4	75	80	PF00397	0.671
DOC_WW_Pin1_4	87	92	PF00397	0.580
LIG_14-3-3_CanoR_1	103	111	PF00244	0.389
LIG_14-3-3_CanoR_1	240	245	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_BRCT_BRCA1_1	189	193	PF00533	0.442
LIG_Clathr_ClatBox_1	51	55	PF01394	0.618
LIG_deltaCOP1_diTrp_1	198	206	PF00928	0.722
LIG_EVH1_1	88	92	PF00568	0.601
LIG_FHA_1	131	137	PF00498	0.588
LIG_FHA_1	152	158	PF00498	0.563
LIG_FHA_1	66	72	PF00498	0.553
LIG_GBD_Chelix_1	220	228	PF00786	0.401
LIG_LIR_Nem_3	190	196	PF02991	0.654
LIG_SH3_3	123	129	PF00018	0.507
LIG_SH3_3	86	92	PF00018	0.821
LIG_SUMO_SIM_anti_2	133	140	PF11976	0.435
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.572
LIG_SUMO_SIM_par_1	67	73	PF11976	0.560
LIG_WRC_WIRS_1	5	10	PF05994	0.510
MOD_CDK_SPxxK_3	233	240	PF00069	0.449
MOD_CK1_1	143	149	PF00069	0.522
MOD_CK1_1	67	73	PF00069	0.776
MOD_CK1_1	78	84	PF00069	0.618
MOD_CK1_1	87	93	PF00069	0.558
MOD_GlcNHglycan	142	145	PF01048	0.553
MOD_GlcNHglycan	151	154	PF01048	0.604
MOD_GlcNHglycan	164	167	PF01048	0.575
MOD_GlcNHglycan	203	206	PF01048	0.514
MOD_GlcNHglycan	55	59	PF01048	0.629
MOD_GlcNHglycan	72	75	PF01048	0.590
MOD_GlcNHglycan	80	83	PF01048	0.665
MOD_GSK3_1	158	165	PF00069	0.629
MOD_GSK3_1	183	190	PF00069	0.404
MOD_GSK3_1	60	67	PF00069	0.662
MOD_GSK3_1	77	84	PF00069	0.665
MOD_N-GLC_1	184	189	PF02516	0.399
MOD_N-GLC_1	263	268	PF02516	0.484
MOD_NEK2_1	104	109	PF00069	0.437
MOD_NEK2_1	114	119	PF00069	0.553
MOD_PK_1	158	164	PF00069	0.559
MOD_PK_1	240	246	PF00069	0.437
MOD_PKA_2	102	108	PF00069	0.675
MOD_Plk_1	84	90	PF00069	0.617
MOD_Plk_4	132	138	PF00069	0.454
MOD_Plk_4	158	164	PF00069	0.538
MOD_ProDKin_1	233	239	PF00069	0.485
MOD_ProDKin_1	40	46	PF00069	0.472
MOD_ProDKin_1	75	81	PF00069	0.675
MOD_ProDKin_1	87	93	PF00069	0.573
TRG_NLS_MonoExtC_3	26	32	PF00514	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV6	Leptomonas seymouri	43%	97%
A0A3S7WYI4	Leishmania donovani	77%	100%
A4HDN6	Leishmania braziliensis	98%	100%
E9AH83	Leishmania infantum	78%	100%
E9AX21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAF5	Leishmania major	75%	100%