SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDN5_LEIBR

TriTrypDb:

LbrM.24.1810 , LBRM2903_240025800 , LBRM2903_240025900

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDN5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	461	465	PF00656	0.653
CLV_C14_Caspase3-7	63	67	PF00656	0.591
CLV_NRD_NRD_1	158	160	PF00675	0.552
CLV_NRD_NRD_1	268	270	PF00675	0.578
CLV_NRD_NRD_1	393	395	PF00675	0.488
CLV_NRD_NRD_1	594	596	PF00675	0.458
CLV_PCSK_FUR_1	591	595	PF00082	0.301
CLV_PCSK_KEX2_1	158	160	PF00082	0.552
CLV_PCSK_KEX2_1	179	181	PF00082	0.547
CLV_PCSK_KEX2_1	268	270	PF00082	0.578
CLV_PCSK_KEX2_1	393	395	PF00082	0.599
CLV_PCSK_KEX2_1	591	593	PF00082	0.450
CLV_PCSK_KEX2_1	594	596	PF00082	0.452
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.520
CLV_PCSK_SKI1_1	180	184	PF00082	0.505
CLV_PCSK_SKI1_1	341	345	PF00082	0.400
CLV_PCSK_SKI1_1	405	409	PF00082	0.571
CLV_PCSK_SKI1_1	595	599	PF00082	0.562
DEG_APCC_DBOX_1	146	154	PF00400	0.388
DEG_APCC_DBOX_1	179	187	PF00400	0.489
DEG_APCC_DBOX_1	272	280	PF00400	0.458
DEG_APCC_DBOX_1	317	325	PF00400	0.552
DEG_SCF_FBW7_1	95	102	PF00400	0.451
DEG_SPOP_SBC_1	294	298	PF00917	0.597
DOC_ANK_TNKS_1	325	332	PF00023	0.400
DOC_CDC14_PxL_1	385	393	PF14671	0.427
DOC_CKS1_1	164	169	PF01111	0.664
DOC_CYCLIN_RxL_1	280	291	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.405
DOC_MAPK_gen_1	158	164	PF00069	0.523
DOC_MAPK_gen_1	268	276	PF00069	0.484
DOC_MAPK_MEF2A_6	273	281	PF00069	0.408
DOC_PP1_RVXF_1	281	288	PF00149	0.488
DOC_PP2B_LxvP_1	128	131	PF13499	0.554
DOC_PP4_FxxP_1	164	167	PF00568	0.629
DOC_USP7_MATH_1	14	18	PF00917	0.772
DOC_USP7_MATH_1	259	263	PF00917	0.492
DOC_USP7_MATH_1	290	294	PF00917	0.535
DOC_USP7_MATH_1	460	464	PF00917	0.656
DOC_USP7_MATH_1	99	103	PF00917	0.535
DOC_WW_Pin1_4	142	147	PF00397	0.730
DOC_WW_Pin1_4	163	168	PF00397	0.621
DOC_WW_Pin1_4	211	216	PF00397	0.616
DOC_WW_Pin1_4	392	397	PF00397	0.715
DOC_WW_Pin1_4	443	448	PF00397	0.508
DOC_WW_Pin1_4	49	54	PF00397	0.377
DOC_WW_Pin1_4	81	86	PF00397	0.773
DOC_WW_Pin1_4	90	95	PF00397	0.807
LIG_14-3-3_CanoR_1	147	155	PF00244	0.563
LIG_14-3-3_CanoR_1	249	257	PF00244	0.515
LIG_14-3-3_CanoR_1	286	290	PF00244	0.498
LIG_14-3-3_CanoR_1	345	349	PF00244	0.408
LIG_14-3-3_CanoR_1	493	498	PF00244	0.347
LIG_Actin_WH2_1	273	288	PF00022	0.444
LIG_Actin_WH2_2	270	288	PF00022	0.482
LIG_Actin_WH2_2	329	347	PF00022	0.558
LIG_BIR_III_4	464	468	PF00653	0.726
LIG_EVH1_1	128	132	PF00568	0.552
LIG_FHA_1	16	22	PF00498	0.709
LIG_FHA_1	276	282	PF00498	0.430
LIG_FHA_1	363	369	PF00498	0.547
LIG_FHA_1	410	416	PF00498	0.538
LIG_FHA_1	443	449	PF00498	0.502
LIG_FHA_1	466	472	PF00498	0.533
LIG_FHA_1	479	485	PF00498	0.340
LIG_FHA_1	50	56	PF00498	0.371
LIG_FHA_1	571	577	PF00498	0.500
LIG_FHA_2	149	155	PF00498	0.537
LIG_FHA_2	230	236	PF00498	0.444
LIG_FHA_2	317	323	PF00498	0.296
LIG_FHA_2	33	39	PF00498	0.572
LIG_FHA_2	399	405	PF00498	0.696
LIG_FHA_2	613	619	PF00498	0.503
LIG_FHA_2	86	92	PF00498	0.574
LIG_GBD_Chelix_1	281	289	PF00786	0.396
LIG_HP1_1	223	227	PF01393	0.497
LIG_LIR_Apic_2	3	9	PF02991	0.517
LIG_LIR_Gen_1	102	112	PF02991	0.539
LIG_LIR_Gen_1	347	356	PF02991	0.442
LIG_LIR_Gen_1	361	370	PF02991	0.522
LIG_LIR_Gen_1	492	503	PF02991	0.521
LIG_LIR_Gen_1	573	581	PF02991	0.554
LIG_LIR_Nem_3	102	107	PF02991	0.497
LIG_LIR_Nem_3	347	351	PF02991	0.360
LIG_LIR_Nem_3	352	357	PF02991	0.356
LIG_LIR_Nem_3	361	366	PF02991	0.439
LIG_LIR_Nem_3	382	388	PF02991	0.407
LIG_LIR_Nem_3	492	498	PF02991	0.459
LIG_LIR_Nem_3	569	575	PF02991	0.493
LIG_LIR_Nem_3	599	603	PF02991	0.555
LIG_LYPXL_S_1	387	391	PF13949	0.417
LIG_LYPXL_yS_3	388	391	PF13949	0.428
LIG_NRBOX	275	281	PF00104	0.511
LIG_Rb_LxCxE_1	352	371	PF01857	0.463
LIG_SH2_CRK	363	367	PF00017	0.458
LIG_SH2_NCK_1	363	367	PF00017	0.322
LIG_SH2_NCK_1	532	536	PF00017	0.482
LIG_SH2_PTP2	575	578	PF00017	0.409
LIG_SH2_SRC	328	331	PF00017	0.545
LIG_SH2_STAP1	363	367	PF00017	0.458
LIG_SH2_STAT5	149	152	PF00017	0.554
LIG_SH2_STAT5	163	166	PF00017	0.499
LIG_SH2_STAT5	363	366	PF00017	0.551
LIG_SH2_STAT5	428	431	PF00017	0.394
LIG_SH2_STAT5	442	445	PF00017	0.527
LIG_SH2_STAT5	449	452	PF00017	0.498
LIG_SH2_STAT5	495	498	PF00017	0.360
LIG_SH2_STAT5	575	578	PF00017	0.411
LIG_SH2_STAT5	596	599	PF00017	0.461
LIG_SH3_2	129	134	PF14604	0.548
LIG_SH3_3	123	129	PF00018	0.543
LIG_SH3_3	383	389	PF00018	0.560
LIG_SUMO_SIM_anti_2	376	385	PF11976	0.438
LIG_SUMO_SIM_anti_2	487	492	PF11976	0.586
LIG_SUMO_SIM_par_1	364	369	PF11976	0.354
LIG_TRAF2_1	36	39	PF00917	0.551
LIG_TRFH_1	385	389	PF08558	0.584
LIG_TYR_ITSM	571	578	PF00017	0.531
LIG_UBA3_1	276	283	PF00899	0.510
MOD_CDK_SPK_2	142	147	PF00069	0.739
MOD_CK1_1	145	151	PF00069	0.425
MOD_CK1_1	15	21	PF00069	0.775
MOD_CK1_1	216	222	PF00069	0.562
MOD_CK1_1	262	268	PF00069	0.507
MOD_CK1_1	293	299	PF00069	0.581
MOD_CK1_1	395	401	PF00069	0.682
MOD_CK2_1	170	176	PF00069	0.615
MOD_CK2_1	316	322	PF00069	0.550
MOD_CK2_1	32	38	PF00069	0.680
MOD_CK2_1	355	361	PF00069	0.356
MOD_CK2_1	398	404	PF00069	0.669
MOD_CK2_1	455	461	PF00069	0.502
MOD_CK2_1	612	618	PF00069	0.488
MOD_CMANNOS	452	455	PF00535	0.571
MOD_Cter_Amidation	156	159	PF01082	0.385
MOD_Cter_Amidation	177	180	PF01082	0.602
MOD_GlcNHglycan	138	141	PF01048	0.720
MOD_GlcNHglycan	206	209	PF01048	0.691
MOD_GlcNHglycan	218	221	PF01048	0.657
MOD_GlcNHglycan	250	253	PF01048	0.452
MOD_GSK3_1	209	216	PF00069	0.715
MOD_GSK3_1	248	255	PF00069	0.329
MOD_GSK3_1	258	265	PF00069	0.506
MOD_GSK3_1	285	292	PF00069	0.425
MOD_GSK3_1	30	37	PF00069	0.490
MOD_GSK3_1	335	342	PF00069	0.431
MOD_GSK3_1	362	369	PF00069	0.501
MOD_GSK3_1	375	382	PF00069	0.691
MOD_GSK3_1	392	399	PF00069	0.711
MOD_GSK3_1	443	450	PF00069	0.488
MOD_GSK3_1	81	88	PF00069	0.695
MOD_GSK3_1	95	102	PF00069	0.662
MOD_N-GLC_1	538	543	PF02516	0.282
MOD_N-GLC_2	27	29	PF02516	0.539
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	181	186	PF00069	0.598
MOD_NEK2_1	248	253	PF00069	0.353
MOD_NEK2_1	285	290	PF00069	0.474
MOD_NEK2_1	309	314	PF00069	0.440
MOD_NEK2_1	344	349	PF00069	0.370
MOD_NEK2_1	538	543	PF00069	0.531
MOD_NEK2_1	571	576	PF00069	0.579
MOD_NEK2_1	612	617	PF00069	0.579
MOD_NEK2_2	259	264	PF00069	0.536
MOD_NEK2_2	520	525	PF00069	0.227
MOD_PIKK_1	93	99	PF00454	0.592
MOD_PK_1	79	85	PF00069	0.520
MOD_PKA_1	134	140	PF00069	0.540
MOD_PKA_2	248	254	PF00069	0.505
MOD_PKA_2	285	291	PF00069	0.455
MOD_PKA_2	344	350	PF00069	0.367
MOD_PKA_2	373	379	PF00069	0.457
MOD_Plk_1	124	130	PF00069	0.586
MOD_Plk_1	361	367	PF00069	0.453
MOD_Plk_2-3	170	176	PF00069	0.615
MOD_Plk_4	275	281	PF00069	0.323
MOD_Plk_4	301	307	PF00069	0.338
MOD_Plk_4	349	355	PF00069	0.411
MOD_Plk_4	379	385	PF00069	0.664
MOD_Plk_4	447	453	PF00069	0.457
MOD_Plk_4	484	490	PF00069	0.604
MOD_Plk_4	493	499	PF00069	0.458
MOD_Plk_4	555	561	PF00069	0.539
MOD_Plk_4	571	577	PF00069	0.403
MOD_Plk_4	99	105	PF00069	0.425
MOD_ProDKin_1	142	148	PF00069	0.716
MOD_ProDKin_1	163	169	PF00069	0.615
MOD_ProDKin_1	211	217	PF00069	0.614
MOD_ProDKin_1	392	398	PF00069	0.714
MOD_ProDKin_1	443	449	PF00069	0.503
MOD_ProDKin_1	49	55	PF00069	0.376
MOD_ProDKin_1	81	87	PF00069	0.774
MOD_ProDKin_1	90	96	PF00069	0.805
MOD_SUMO_rev_2	173	181	PF00179	0.587
MOD_SUMO_rev_2	32	41	PF00179	0.602
TRG_DiLeu_BaEn_1	272	277	PF01217	0.465
TRG_DiLeu_BaEn_1	339	344	PF01217	0.559
TRG_DiLeu_BaEn_3	176	182	PF01217	0.641
TRG_DiLeu_BaEn_4	60	66	PF01217	0.513
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.623
TRG_ENDOCYTIC_2	363	366	PF00928	0.574
TRG_ENDOCYTIC_2	388	391	PF00928	0.428
TRG_ENDOCYTIC_2	428	431	PF00928	0.457
TRG_ENDOCYTIC_2	495	498	PF00928	0.496
TRG_ENDOCYTIC_2	575	578	PF00928	0.428
TRG_ENDOCYTIC_2	600	603	PF00928	0.501
TRG_ER_diArg_1	317	320	PF00400	0.487
TRG_ER_diArg_1	591	594	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I099	Leptomonas seymouri	43%	86%
A0A1X0NVU7	Trypanosomatidae	28%	100%
A0A3R7RB97	Trypanosoma rangeli	29%	100%
A0A3S7WYH5	Leishmania donovani	73%	84%
C9ZWC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AH82	Leishmania infantum	73%	84%
E9AX20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	83%
Q4QAF6	Leishmania major	72%	100%
V5CZP8	Trypanosoma cruzi	28%	100%