GCV_T domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate-binding protein YgfZ, putative

Species:

Leishmania braziliensis

UniProt:

A4HDN4_LEIBR

TriTrypDb:

LbrM.24.1800 , LBRM2903_240025700

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005759	mitochondrial matrix	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HDN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDN4

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005542	folic acid binding	3	1
GO:0019842	vitamin binding	3	1
GO:0031406	carboxylic acid binding	4	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043177	organic acid binding	3	1
GO:0072341	modified amino acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0004047	aminomethyltransferase activity	5	1
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.638
CLV_C14_Caspase3-7	136	140	PF00656	0.431
CLV_NRD_NRD_1	14	16	PF00675	0.444
CLV_NRD_NRD_1	217	219	PF00675	0.433
CLV_NRD_NRD_1	290	292	PF00675	0.371
CLV_NRD_NRD_1	390	392	PF00675	0.423
CLV_NRD_NRD_1	96	98	PF00675	0.212
CLV_PCSK_KEX2_1	14	16	PF00082	0.444
CLV_PCSK_KEX2_1	217	219	PF00082	0.348
CLV_PCSK_KEX2_1	292	294	PF00082	0.314
CLV_PCSK_KEX2_1	390	392	PF00082	0.362
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.314
CLV_PCSK_PC7_1	10	16	PF00082	0.429
CLV_PCSK_SKI1_1	14	18	PF00082	0.399
CLV_PCSK_SKI1_1	390	394	PF00082	0.461
DEG_SPOP_SBC_1	145	149	PF00917	0.473
DEG_SPOP_SBC_1	196	200	PF00917	0.533
DEG_SPOP_SBC_1	308	312	PF00917	0.474
DOC_ANK_TNKS_1	241	248	PF00023	0.440
DOC_CKS1_1	208	213	PF01111	0.369
DOC_CYCLIN_RxL_1	251	259	PF00134	0.365
DOC_MAPK_DCC_7	360	370	PF00069	0.488
DOC_MAPK_gen_1	291	299	PF00069	0.325
DOC_MAPK_gen_1	95	102	PF00069	0.412
DOC_MAPK_MEF2A_6	291	299	PF00069	0.325
DOC_MAPK_MEF2A_6	71	79	PF00069	0.355
DOC_PP1_RVXF_1	264	271	PF00149	0.322
DOC_PP4_FxxP_1	161	164	PF00568	0.345
DOC_USP7_MATH_1	128	132	PF00917	0.682
DOC_USP7_MATH_1	140	144	PF00917	0.541
DOC_USP7_MATH_1	181	185	PF00917	0.670
DOC_USP7_MATH_1	197	201	PF00917	0.578
DOC_USP7_MATH_1	204	208	PF00917	0.695
DOC_USP7_MATH_1	228	232	PF00917	0.359
DOC_USP7_MATH_1	307	311	PF00917	0.539
DOC_USP7_MATH_1	41	45	PF00917	0.410
DOC_USP7_UBL2_3	95	99	PF12436	0.466
DOC_WW_Pin1_4	146	151	PF00397	0.652
DOC_WW_Pin1_4	170	175	PF00397	0.564
DOC_WW_Pin1_4	207	212	PF00397	0.575
DOC_WW_Pin1_4	371	376	PF00397	0.512
LIG_14-3-3_CanoR_1	141	146	PF00244	0.662
LIG_14-3-3_CanoR_1	156	164	PF00244	0.550
LIG_14-3-3_CanoR_1	291	296	PF00244	0.326
LIG_Actin_WH2_2	341	358	PF00022	0.341
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.440
LIG_BRCT_BRCA1_1	130	134	PF00533	0.478
LIG_BRCT_BRCA1_1	254	258	PF00533	0.365
LIG_FHA_1	196	202	PF00498	0.470
LIG_FHA_1	203	209	PF00498	0.437
LIG_FHA_1	234	240	PF00498	0.470
LIG_FHA_1	292	298	PF00498	0.315
LIG_FHA_1	31	37	PF00498	0.423
LIG_FHA_1	319	325	PF00498	0.550
LIG_FHA_1	360	366	PF00498	0.555
LIG_FHA_1	51	57	PF00498	0.323
LIG_FHA_2	122	128	PF00498	0.530
LIG_FHA_2	150	156	PF00498	0.591
LIG_FHA_2	309	315	PF00498	0.571
LIG_LIR_Apic_2	158	164	PF02991	0.375
LIG_LIR_Apic_2	224	228	PF02991	0.501
LIG_LIR_Gen_1	233	240	PF02991	0.402
LIG_LIR_LC3C_4	108	111	PF02991	0.467
LIG_LIR_Nem_3	233	238	PF02991	0.348
LIG_LIR_Nem_3	382	386	PF02991	0.276
LIG_LIR_Nem_3	44	49	PF02991	0.410
LIG_SH2_CRK	177	181	PF00017	0.463
LIG_SH2_CRK	235	239	PF00017	0.380
LIG_SH2_STAP1	235	239	PF00017	0.359
LIG_SH2_STAT3	275	278	PF00017	0.295
LIG_SH2_STAT5	177	180	PF00017	0.605
LIG_SH2_STAT5	235	238	PF00017	0.379
LIG_SH2_STAT5	275	278	PF00017	0.313
LIG_SH2_STAT5	357	360	PF00017	0.346
LIG_SH2_STAT5	51	54	PF00017	0.483
LIG_SH3_3	168	174	PF00018	0.497
LIG_SH3_3	189	195	PF00018	0.684
LIG_SH3_3	205	211	PF00018	0.635
LIG_SUMO_SIM_anti_2	108	113	PF11976	0.425
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.357
LIG_SUMO_SIM_par_1	320	328	PF11976	0.534
LIG_SUMO_SIM_par_1	74	83	PF11976	0.467
LIG_TRAF2_1	114	117	PF00917	0.510
LIG_TRAF2_1	152	155	PF00917	0.574
LIG_UBA3_1	352	360	PF00899	0.449
LIG_UBA3_1	87	95	PF00899	0.445
LIG_WW_1	174	177	PF00397	0.455
MOD_CDK_SPK_2	146	151	PF00069	0.463
MOD_CK1_1	143	149	PF00069	0.656
MOD_CK1_1	207	213	PF00069	0.501
MOD_CK1_1	310	316	PF00069	0.597
MOD_CK2_1	149	155	PF00069	0.614
MOD_CK2_1	179	185	PF00069	0.459
MOD_CK2_1	80	86	PF00069	0.464
MOD_GlcNHglycan	116	121	PF01048	0.513
MOD_GlcNHglycan	302	305	PF01048	0.488
MOD_GlcNHglycan	331	334	PF01048	0.473
MOD_GSK3_1	129	136	PF00069	0.659
MOD_GSK3_1	140	147	PF00069	0.610
MOD_GSK3_1	234	241	PF00069	0.443
MOD_GSK3_1	287	294	PF00069	0.348
MOD_GSK3_1	371	378	PF00069	0.530
MOD_LATS_1	69	75	PF00433	0.370
MOD_N-GLC_1	252	257	PF02516	0.424
MOD_N-GLC_1	41	46	PF02516	0.256
MOD_NEK2_1	115	120	PF00069	0.497
MOD_NEK2_1	238	243	PF00069	0.391
MOD_NEK2_1	287	292	PF00069	0.379
MOD_NEK2_1	50	55	PF00069	0.410
MOD_NEK2_2	41	46	PF00069	0.466
MOD_PK_1	141	147	PF00069	0.612
MOD_PK_1	71	77	PF00069	0.355
MOD_PKA_1	291	297	PF00069	0.319
MOD_PKA_2	129	135	PF00069	0.726
MOD_PKA_2	140	146	PF00069	0.631
MOD_PKA_2	155	161	PF00069	0.543
MOD_PKA_2	19	25	PF00069	0.487
MOD_Plk_1	252	258	PF00069	0.488
MOD_Plk_1	80	86	PF00069	0.422
MOD_Plk_4	187	193	PF00069	0.477
MOD_Plk_4	234	240	PF00069	0.380
MOD_Plk_4	41	47	PF00069	0.434
MOD_Plk_4	71	77	PF00069	0.433
MOD_ProDKin_1	146	152	PF00069	0.647
MOD_ProDKin_1	170	176	PF00069	0.578
MOD_ProDKin_1	207	213	PF00069	0.555
MOD_ProDKin_1	371	377	PF00069	0.511
MOD_SUMO_rev_2	89	96	PF00179	0.505
TRG_DiLeu_BaEn_1	388	393	PF01217	0.442
TRG_DiLeu_LyEn_5	388	393	PF01217	0.258
TRG_ENDOCYTIC_2	235	238	PF00928	0.320
TRG_ENDOCYTIC_2	46	49	PF00928	0.466
TRG_ER_diArg_1	14	16	PF00400	0.443
TRG_ER_diArg_1	17	20	PF00400	0.528
TRG_ER_diArg_1	216	218	PF00400	0.306
TRG_ER_diArg_1	353	356	PF00400	0.329
TRG_ER_diArg_1	389	391	PF00400	0.271
TRG_NLS_MonoExtN_4	95	101	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM11	Leptomonas seymouri	60%	90%
A0A0S4JL83	Bodo saltans	38%	100%
A0A3Q8IEZ2	Leishmania donovani	77%	100%
A0A3R7K245	Trypanosoma rangeli	45%	100%
B8JMH0	Danio rerio	27%	100%
C9ZWC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AH81	Leishmania infantum	76%	100%
E9AX19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
P0CM52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	100%
P0CM53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	100%
Q2H6N9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	91%
Q4QAF7	Leishmania major	78%	92%
Q54NS1	Dictyostelium discoideum	26%	97%
Q5T440	Homo sapiens	28%	100%
Q6C8Y7	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	83%
Q7RYZ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	90%
V5AJ90	Trypanosoma cruzi	45%	100%