Putative calcium/calmodulin-dependent protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDN3_LEIBR

TriTrypDb:

LbrM.24.1790 , LBRM2903_240025600

Length:

1429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

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Expansion

Sequence features

A4HDN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0035556	intracellular signal transduction	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	4
GO:0004683	calmodulin-dependent protein kinase activity	5	3
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008270	zinc ion binding	6	5
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1410	1414	PF00656	0.588
CLV_C14_Caspase3-7	236	240	PF00656	0.677
CLV_C14_Caspase3-7	431	435	PF00656	0.463
CLV_C14_Caspase3-7	770	774	PF00656	0.314
CLV_C14_Caspase3-7	945	949	PF00656	0.645
CLV_NRD_NRD_1	1146	1148	PF00675	0.328
CLV_NRD_NRD_1	1267	1269	PF00675	0.428
CLV_NRD_NRD_1	1303	1305	PF00675	0.440
CLV_NRD_NRD_1	149	151	PF00675	0.563
CLV_NRD_NRD_1	551	553	PF00675	0.507

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFR7	Leptomonas seymouri	55%	95%
A0A1X0NVU6	Trypanosomatidae	36%	100%
A0A3Q8IC00	Leishmania donovani	74%	99%
A0A422N1A6	Trypanosoma rangeli	35%	100%
C9ZWD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AH80	Leishmania infantum	74%	99%
E9AX18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAF8	Leishmania major	74%	99%
V5AZK0	Trypanosoma cruzi	37%	100%

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