Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDN0_LEIBR

TriTrypDb:

LbrM.24.1760 , LBRM2903_240025300

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HDN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.513
CLV_C14_Caspase3-7	90	94	PF00656	0.721
CLV_NRD_NRD_1	129	131	PF00675	0.431
CLV_NRD_NRD_1	145	147	PF00675	0.384
CLV_NRD_NRD_1	174	176	PF00675	0.516
CLV_NRD_NRD_1	234	236	PF00675	0.528
CLV_NRD_NRD_1	355	357	PF00675	0.292
CLV_NRD_NRD_1	369	371	PF00675	0.335
CLV_NRD_NRD_1	441	443	PF00675	0.411
CLV_PCSK_FUR_1	127	131	PF00082	0.393
CLV_PCSK_FUR_1	143	147	PF00082	0.349
CLV_PCSK_KEX2_1	126	128	PF00082	0.397
CLV_PCSK_KEX2_1	129	131	PF00082	0.400
CLV_PCSK_KEX2_1	145	147	PF00082	0.461
CLV_PCSK_KEX2_1	174	176	PF00082	0.524
CLV_PCSK_KEX2_1	234	236	PF00082	0.445
CLV_PCSK_KEX2_1	355	357	PF00082	0.292
CLV_PCSK_KEX2_1	369	371	PF00082	0.335
CLV_PCSK_KEX2_1	441	443	PF00082	0.412
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.393
CLV_PCSK_SKI1_1	255	259	PF00082	0.442
CLV_PCSK_SKI1_1	355	359	PF00082	0.342
DEG_APCC_DBOX_1	355	363	PF00400	0.620
DEG_SPOP_SBC_1	284	288	PF00917	0.446
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.620
DOC_MAPK_MEF2A_6	238	247	PF00069	0.538
DOC_MAPK_MEF2A_6	289	296	PF00069	0.528
DOC_MAPK_MEF2A_6	302	311	PF00069	0.515
DOC_PP2B_LxvP_1	240	243	PF13499	0.694
DOC_PP4_FxxP_1	15	18	PF00568	0.690
DOC_USP7_MATH_1	158	162	PF00917	0.650
DOC_USP7_MATH_1	32	36	PF00917	0.573
DOC_USP7_UBL2_3	5	9	PF12436	0.609
DOC_WW_Pin1_4	148	153	PF00397	0.620
DOC_WW_Pin1_4	198	203	PF00397	0.778
DOC_WW_Pin1_4	92	97	PF00397	0.606
LIG_14-3-3_CanoR_1	174	182	PF00244	0.712
LIG_14-3-3_CanoR_1	238	243	PF00244	0.706
LIG_14-3-3_CanoR_1	369	377	PF00244	0.577
LIG_14-3-3_CanoR_1	458	468	PF00244	0.687
LIG_14-3-3_CanoR_1	64	72	PF00244	0.677
LIG_Actin_WH2_2	300	317	PF00022	0.555
LIG_AP2alpha_2	274	276	PF02296	0.575
LIG_APCC_ABBA_1	273	278	PF00400	0.585
LIG_CaM_IQ_9	119	135	PF13499	0.637
LIG_FHA_1	234	240	PF00498	0.626
LIG_FHA_1	256	262	PF00498	0.559
LIG_FHA_1	299	305	PF00498	0.551
LIG_FHA_1	338	344	PF00498	0.197
LIG_FHA_1	428	434	PF00498	0.622
LIG_FHA_1	462	468	PF00498	0.533
LIG_FHA_2	88	94	PF00498	0.658
LIG_FHA_2	96	102	PF00498	0.577
LIG_LIR_Gen_1	241	251	PF02991	0.677
LIG_LIR_Gen_1	328	334	PF02991	0.297
LIG_LIR_Gen_1	53	59	PF02991	0.690
LIG_LIR_Nem_3	241	247	PF02991	0.600
LIG_LIR_Nem_3	269	273	PF02991	0.569
LIG_LIR_Nem_3	328	333	PF02991	0.297
LIG_LIR_Nem_3	53	58	PF02991	0.646
LIG_Pex14_1	108	112	PF04695	0.555
LIG_SH2_CRK	360	364	PF00017	0.607
LIG_SH2_NCK_1	33	37	PF00017	0.640
LIG_SH2_NCK_1	360	364	PF00017	0.580
LIG_SH2_STAP1	443	447	PF00017	0.593
LIG_SH2_STAP1	461	465	PF00017	0.576
LIG_SH2_STAP1	55	59	PF00017	0.644
LIG_SH2_STAP1	67	71	PF00017	0.596
LIG_SH2_STAT5	147	150	PF00017	0.664
LIG_SH2_STAT5	33	36	PF00017	0.673
LIG_SH2_STAT5	360	363	PF00017	0.590
LIG_SH2_STAT5	375	378	PF00017	0.272
LIG_SH2_STAT5	461	464	PF00017	0.676
LIG_SH2_STAT5	466	469	PF00017	0.664
LIG_SH2_STAT5	57	60	PF00017	0.674
LIG_SH3_5	266	270	PF00018	0.637
LIG_SUMO_SIM_par_1	424	431	PF11976	0.583
LIG_TRAF2_1	121	124	PF00917	0.608
LIG_TRFH_1	148	152	PF08558	0.526
LIG_TRFH_1	271	275	PF08558	0.531
LIG_TRFH_1	360	364	PF08558	0.474
LIG_TYR_ITIM	268	273	PF00017	0.538
LIG_UBA3_1	353	358	PF00899	0.498
MOD_CK1_1	250	256	PF00069	0.510
MOD_CK1_1	279	285	PF00069	0.426
MOD_CK1_1	43	49	PF00069	0.531
MOD_CK1_1	459	465	PF00069	0.517
MOD_CK1_1	66	72	PF00069	0.621
MOD_CK1_1	95	101	PF00069	0.545
MOD_CK2_1	158	164	PF00069	0.596
MOD_CK2_1	182	188	PF00069	0.623
MOD_CK2_1	50	56	PF00069	0.652
MOD_CK2_1	95	101	PF00069	0.506
MOD_GlcNHglycan	184	187	PF01048	0.468
MOD_GlcNHglycan	210	213	PF01048	0.538
MOD_GlcNHglycan	240	243	PF01048	0.615
MOD_GlcNHglycan	278	281	PF01048	0.557
MOD_GlcNHglycan	316	319	PF01048	0.318
MOD_GlcNHglycan	34	37	PF01048	0.495
MOD_GlcNHglycan	381	384	PF01048	0.322
MOD_GlcNHglycan	405	408	PF01048	0.297
MOD_GlcNHglycan	47	50	PF01048	0.566
MOD_GSK3_1	204	211	PF00069	0.640
MOD_GSK3_1	279	286	PF00069	0.299
MOD_GSK3_1	325	332	PF00069	0.367
MOD_GSK3_1	456	463	PF00069	0.575
MOD_GSK3_1	63	70	PF00069	0.662
MOD_GSK3_1	92	99	PF00069	0.516
MOD_N-GLC_1	325	330	PF02516	0.313
MOD_N-GLC_1	394	399	PF02516	0.466
MOD_NEK2_1	176	181	PF00069	0.563
MOD_NEK2_1	276	281	PF00069	0.454
MOD_NEK2_1	314	319	PF00069	0.334
MOD_NEK2_1	325	330	PF00069	0.318
MOD_NEK2_1	377	382	PF00069	0.287
MOD_NEK2_1	394	399	PF00069	0.358
MOD_NEK2_1	403	408	PF00069	0.240
MOD_NEK2_1	433	438	PF00069	0.418
MOD_NEK2_1	50	55	PF00069	0.686
MOD_PKA_1	369	375	PF00069	0.302
MOD_PKA_2	176	182	PF00069	0.682
MOD_PKA_2	223	229	PF00069	0.754
MOD_PKA_2	233	239	PF00069	0.637
MOD_PKA_2	368	374	PF00069	0.421
MOD_PKA_2	63	69	PF00069	0.642
MOD_PKB_1	175	183	PF00069	0.572
MOD_Plk_1	325	331	PF00069	0.279
MOD_Plk_1	394	400	PF00069	0.321
MOD_Plk_4	279	285	PF00069	0.426
MOD_Plk_4	320	326	PF00069	0.283
MOD_Plk_4	329	335	PF00069	0.311
MOD_Plk_4	67	73	PF00069	0.568
MOD_ProDKin_1	148	154	PF00069	0.521
MOD_ProDKin_1	198	204	PF00069	0.746
MOD_ProDKin_1	92	98	PF00069	0.504
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.364
TRG_ENDOCYTIC_2	107	110	PF00928	0.356
TRG_ENDOCYTIC_2	147	150	PF00928	0.589
TRG_ENDOCYTIC_2	270	273	PF00928	0.536
TRG_ENDOCYTIC_2	443	446	PF00928	0.490
TRG_ENDOCYTIC_2	55	58	PF00928	0.670
TRG_ER_diArg_1	127	130	PF00400	0.536
TRG_ER_diArg_1	143	146	PF00400	0.466
TRG_ER_diArg_1	166	169	PF00400	0.490
TRG_ER_diArg_1	174	177	PF00400	0.470
TRG_ER_diArg_1	233	235	PF00400	0.476
TRG_ER_diArg_1	354	356	PF00400	0.287
TRG_ER_diArg_1	440	442	PF00400	0.514
TRG_NLS_Bipartite_1	113	130	PF00514	0.506
TRG_NLS_MonoExtC_3	125	130	PF00514	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U8	Leptomonas seymouri	62%	99%
A0A0S4JPE5	Bodo saltans	42%	100%
A0A1X0NW21	Trypanosomatidae	51%	100%
A0A3S7WYL2	Leishmania donovani	85%	100%
C9ZWD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AH77	Leishmania infantum	85%	100%
E9AX15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QAG1	Leishmania major	84%	100%
V5DBL9	Trypanosoma cruzi	48%	100%