SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDM9_LEIBR

TriTrypDb:

LbrM.24.1750 , LBRM2903_240025200

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0042799	histone H4K20 methyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	365	367	PF00675	0.461
CLV_NRD_NRD_1	377	379	PF00675	0.422
CLV_NRD_NRD_1	71	73	PF00675	0.521
CLV_PCSK_KEX2_1	17	19	PF00082	0.414
CLV_PCSK_KEX2_1	365	367	PF00082	0.427
CLV_PCSK_KEX2_1	377	379	PF00082	0.483
CLV_PCSK_KEX2_1	71	73	PF00082	0.546
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.471
CLV_PCSK_SKI1_1	263	267	PF00082	0.311
CLV_PCSK_SKI1_1	311	315	PF00082	0.280
CLV_PCSK_SKI1_1	74	78	PF00082	0.461
DEG_SPOP_SBC_1	230	234	PF00917	0.375
DOC_CDC14_PxL_1	345	353	PF14671	0.545
DOC_CKS1_1	29	34	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.409
DOC_MAPK_MEF2A_6	193	202	PF00069	0.553
DOC_MAPK_MEF2A_6	301	309	PF00069	0.494
DOC_PP1_RVXF_1	251	257	PF00149	0.480
DOC_PP2B_LxvP_1	307	310	PF13499	0.532
DOC_PP4_FxxP_1	98	101	PF00568	0.634
DOC_USP7_MATH_1	127	131	PF00917	0.542
DOC_USP7_MATH_1	157	161	PF00917	0.556
DOC_USP7_MATH_1	164	168	PF00917	0.579
DOC_USP7_MATH_1	76	80	PF00917	0.540
DOC_WW_Pin1_4	134	139	PF00397	0.503
DOC_WW_Pin1_4	254	259	PF00397	0.494
DOC_WW_Pin1_4	28	33	PF00397	0.459
LIG_14-3-3_CanoR_1	121	127	PF00244	0.491
LIG_14-3-3_CanoR_1	128	132	PF00244	0.462
LIG_14-3-3_CanoR_1	18	27	PF00244	0.443
LIG_14-3-3_CanoR_1	229	239	PF00244	0.545
LIG_14-3-3_CanoR_1	253	257	PF00244	0.500
LIG_14-3-3_CanoR_1	277	284	PF00244	0.425
LIG_14-3-3_CanoR_1	293	299	PF00244	0.510
LIG_Actin_WH2_2	261	279	PF00022	0.447
LIG_ActinCP_TwfCPI_2	98	105	PF01115	0.592
LIG_BIR_II_1	1	5	PF00653	0.538
LIG_EVH1_2	32	36	PF00568	0.436
LIG_FHA_1	332	338	PF00498	0.485
LIG_FHA_1	358	364	PF00498	0.481
LIG_FHA_2	109	115	PF00498	0.538
LIG_FHA_2	205	211	PF00498	0.526
LIG_FHA_2	29	35	PF00498	0.433
LIG_FHA_2	331	337	PF00498	0.461
LIG_FHA_2	359	365	PF00498	0.339
LIG_IRF3_LxIS_1	272	279	PF10401	0.375
LIG_LIR_Gen_1	194	203	PF02991	0.502
LIG_LIR_Gen_1	283	292	PF02991	0.466
LIG_LIR_Nem_3	136	142	PF02991	0.511
LIG_LIR_Nem_3	194	198	PF02991	0.526
LIG_LIR_Nem_3	283	287	PF02991	0.486
LIG_LYPXL_yS_3	348	351	PF13949	0.430
LIG_PCNA_yPIPBox_3	218	231	PF02747	0.510
LIG_SH2_NCK_1	56	60	PF00017	0.417
LIG_SH2_SRC	284	287	PF00017	0.375
LIG_SH2_STAP1	269	273	PF00017	0.464
LIG_SH2_STAP1	284	288	PF00017	0.490
LIG_SH2_STAT5	172	175	PF00017	0.474
LIG_SH2_STAT5	50	53	PF00017	0.399
LIG_SH3_3	129	135	PF00018	0.525
LIG_SH3_3	26	32	PF00018	0.503
LIG_TRAF2_1	143	146	PF00917	0.547
LIG_TRAF2_1	283	286	PF00917	0.480
LIG_TYR_ITIM	282	287	PF00017	0.186
MOD_CK1_1	90	96	PF00069	0.637
MOD_CK2_1	108	114	PF00069	0.350
MOD_CK2_1	152	158	PF00069	0.445
MOD_CK2_1	164	170	PF00069	0.416
MOD_CK2_1	204	210	PF00069	0.298
MOD_CK2_1	28	34	PF00069	0.461
MOD_CK2_1	280	286	PF00069	0.269
MOD_CK2_1	358	364	PF00069	0.392
MOD_CK2_1	76	82	PF00069	0.472
MOD_GlcNHglycan	1	4	PF01048	0.455
MOD_GlcNHglycan	241	244	PF01048	0.335
MOD_GlcNHglycan	250	253	PF01048	0.330
MOD_GlcNHglycan	65	68	PF01048	0.480
MOD_GSK3_1	147	154	PF00069	0.382
MOD_GSK3_1	248	255	PF00069	0.399
MOD_GSK3_1	276	283	PF00069	0.252
MOD_GSK3_1	76	83	PF00069	0.569
MOD_GSK3_1	99	106	PF00069	0.508
MOD_N-GLC_1	164	169	PF02516	0.416
MOD_N-GLC_1	314	319	PF02516	0.336
MOD_NEK2_1	103	108	PF00069	0.434
MOD_NEK2_1	231	236	PF00069	0.216
MOD_NEK2_1	261	266	PF00069	0.339
MOD_NEK2_1	276	281	PF00069	0.222
MOD_NEK2_1	314	319	PF00069	0.361
MOD_NEK2_2	164	169	PF00069	0.347
MOD_OFUCOSY	163	168	PF10250	0.416
MOD_PIKK_1	80	86	PF00454	0.462
MOD_PK_1	301	307	PF00069	0.186
MOD_PKA_2	120	126	PF00069	0.395
MOD_PKA_2	127	133	PF00069	0.398
MOD_PKA_2	252	258	PF00069	0.425
MOD_PKA_2	276	282	PF00069	0.323
MOD_PKA_2	292	298	PF00069	0.326
MOD_PKA_2	358	364	PF00069	0.379
MOD_PKA_2	63	69	PF00069	0.611
MOD_Plk_1	157	163	PF00069	0.416
MOD_Plk_2-3	194	200	PF00069	0.312
MOD_Plk_2-3	358	364	PF00069	0.436
MOD_Plk_4	127	133	PF00069	0.386
MOD_Plk_4	277	283	PF00069	0.355
MOD_Plk_4	58	64	PF00069	0.523
MOD_ProDKin_1	134	140	PF00069	0.365
MOD_ProDKin_1	254	260	PF00069	0.352
MOD_ProDKin_1	28	34	PF00069	0.458
TRG_DiLeu_BaEn_3	285	291	PF01217	0.186
TRG_ENDOCYTIC_2	195	198	PF00928	0.436
TRG_ENDOCYTIC_2	269	272	PF00928	0.333
TRG_ENDOCYTIC_2	284	287	PF00928	0.333
TRG_ENDOCYTIC_2	348	351	PF00928	0.428
TRG_ENDOCYTIC_2	43	46	PF00928	0.413
TRG_ENDOCYTIC_2	50	53	PF00928	0.395
TRG_ER_diArg_1	71	74	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P571	Leptomonas seymouri	29%	79%
A0A0N0P874	Leptomonas seymouri	75%	100%
A0A0S4JLZ8	Bodo saltans	49%	100%
A0A0S4JRV8	Bodo saltans	28%	83%
A0A1X0NL17	Trypanosomatidae	30%	84%
A0A1X0NXF7	Trypanosomatidae	56%	100%
A0A3R7KQ99	Trypanosoma rangeli	32%	88%
A0A3S7WPJ6	Leishmania donovani	27%	76%
A0A3S7WYH0	Leishmania donovani	90%	100%
A4H4R3	Leishmania braziliensis	28%	75%
A4HSZ2	Leishmania infantum	27%	76%
C9ZTM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	88%
C9ZWD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AH76	Leishmania infantum	90%	100%
E9AKX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	77%
E9AX14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAG2	Leishmania major	90%	100%
Q4QIX6	Leishmania major	28%	76%
V5AVL1	Trypanosoma cruzi	59%	100%
V5BT58	Trypanosoma cruzi	32%	88%