Ssl1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ssl1-like, putative

Species:

Leishmania braziliensis

UniProt:

A4HDM8_LEIBR

TriTrypDb:

LbrM.24.1740 , LBRM2903_240025100

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	1
GO:0005675	transcription factor TFIIH holo complex	4	1
GO:0032806	carboxy-terminal domain protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	3
GO:0006281	DNA repair	5	3
GO:0006289	nucleotide-excision repair	6	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006950	response to stress	2	3
GO:0006974	DNA damage response	4	3
GO:0008152	metabolic process	1	3
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	3
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0033554	cellular response to stress	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0046483	heterocycle metabolic process	3	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	3
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051716	cellular response to stimulus	2	3
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	3
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.377
CLV_C14_Caspase3-7	9	13	PF00656	0.307
CLV_NRD_NRD_1	224	226	PF00675	0.699
CLV_NRD_NRD_1	425	427	PF00675	0.287
CLV_PCSK_FUR_1	227	231	PF00082	0.708
CLV_PCSK_KEX2_1	224	226	PF00082	0.696
CLV_PCSK_KEX2_1	229	231	PF00082	0.665
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.671
CLV_PCSK_PC7_1	225	231	PF00082	0.659
CLV_PCSK_SKI1_1	3	7	PF00082	0.270
CLV_PCSK_SKI1_1	300	304	PF00082	0.314
CLV_PCSK_SKI1_1	77	81	PF00082	0.428
DEG_APCC_DBOX_1	28	36	PF00400	0.289
DEG_COP1_1	340	350	PF00400	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.399
DEG_SCF_FBW7_1	40	47	PF00400	0.307
DEG_SPOP_SBC_1	267	271	PF00917	0.408
DEG_SPOP_SBC_1	356	360	PF00917	0.311
DOC_CDC14_PxL_1	303	311	PF14671	0.398
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	319	322	PF00134	0.488
DOC_PP2B_LxvP_1	259	262	PF13499	0.485
DOC_PP2B_LxvP_1	290	293	PF13499	0.395
DOC_PP2B_LxvP_1	319	322	PF13499	0.434
DOC_PP4_MxPP_1	28	31	PF00568	0.307
DOC_USP7_MATH_1	109	113	PF00917	0.525
DOC_USP7_MATH_1	115	119	PF00917	0.569
DOC_USP7_MATH_1	13	17	PF00917	0.243
DOC_USP7_MATH_1	209	213	PF00917	0.427
DOC_USP7_MATH_1	267	271	PF00917	0.643
DOC_USP7_MATH_1	322	326	PF00917	0.381
DOC_USP7_MATH_1	377	381	PF00917	0.562
DOC_USP7_MATH_1	390	394	PF00917	0.650
DOC_USP7_MATH_1	396	400	PF00917	0.654
DOC_USP7_MATH_1	411	415	PF00917	0.506
DOC_USP7_MATH_1	44	48	PF00917	0.227
DOC_WW_Pin1_4	386	391	PF00397	0.508
DOC_WW_Pin1_4	40	45	PF00397	0.268
LIG_14-3-3_CanoR_1	330	335	PF00244	0.372
LIG_14-3-3_CanoR_1	95	104	PF00244	0.212
LIG_Actin_WH2_2	18	36	PF00022	0.307
LIG_BRCT_BRCA1_1	274	278	PF00533	0.469
LIG_eIF4E_1	20	26	PF01652	0.212
LIG_FHA_1	141	147	PF00498	0.342
LIG_FHA_1	2	8	PF00498	0.255
LIG_FHA_1	209	215	PF00498	0.357
LIG_FHA_1	369	375	PF00498	0.378
LIG_FHA_2	145	151	PF00498	0.287
LIG_FHA_2	86	92	PF00498	0.328
LIG_LIR_Gen_1	152	163	PF02991	0.300
LIG_LIR_Nem_3	152	158	PF02991	0.275
LIG_LIR_Nem_3	190	195	PF02991	0.312
LIG_MAD2	327	335	PF02301	0.344
LIG_MYND_1	248	252	PF01753	0.531
LIG_SH2_CRK	192	196	PF00017	0.312
LIG_SH2_SRC	258	261	PF00017	0.464
LIG_SH2_SRC	39	42	PF00017	0.243
LIG_SH2_STAP1	310	314	PF00017	0.476
LIG_SH2_STAT5	192	195	PF00017	0.283
LIG_SH2_STAT5	20	23	PF00017	0.214
LIG_SH2_STAT5	24	27	PF00017	0.224
LIG_SH2_STAT5	258	261	PF00017	0.370
LIG_SH2_STAT5	279	282	PF00017	0.314
LIG_SH2_STAT5	39	42	PF00017	0.348
LIG_SH2_STAT5	433	436	PF00017	0.455
LIG_SH3_3	331	337	PF00018	0.623
LIG_SH3_3	384	390	PF00018	0.536
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.252
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.226
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.307
LIG_SUMO_SIM_par_1	138	143	PF11976	0.260
LIG_SUMO_SIM_par_1	3	9	PF11976	0.276
LIG_SUMO_SIM_par_1	70	76	PF11976	0.307
LIG_TRAF2_1	231	234	PF00917	0.576
LIG_TYR_ITIM	195	200	PF00017	0.380
LIG_WRC_WIRS_1	310	315	PF05994	0.410
MOD_CK1_1	208	214	PF00069	0.438
MOD_CK1_1	269	275	PF00069	0.583
MOD_CK1_1	291	297	PF00069	0.309
MOD_CK1_1	315	321	PF00069	0.460
MOD_CK1_1	85	91	PF00069	0.312
MOD_CK2_1	228	234	PF00069	0.647
MOD_CK2_1	85	91	PF00069	0.296
MOD_Cter_Amidation	222	225	PF01082	0.620
MOD_GlcNHglycan	127	130	PF01048	0.632
MOD_GlcNHglycan	132	135	PF01048	0.440
MOD_GlcNHglycan	205	210	PF01048	0.262
MOD_GlcNHglycan	342	345	PF01048	0.630
MOD_GlcNHglycan	383	386	PF01048	0.643
MOD_GlcNHglycan	393	396	PF01048	0.609
MOD_GlcNHglycan	409	412	PF01048	0.295
MOD_GlcNHglycan	84	87	PF01048	0.451
MOD_GSK3_1	140	147	PF00069	0.288
MOD_GSK3_1	205	212	PF00069	0.373
MOD_GSK3_1	228	235	PF00069	0.554
MOD_GSK3_1	267	274	PF00069	0.636
MOD_GSK3_1	288	295	PF00069	0.335
MOD_GSK3_1	308	315	PF00069	0.217
MOD_GSK3_1	377	384	PF00069	0.644
MOD_GSK3_1	386	393	PF00069	0.639
MOD_GSK3_1	40	47	PF00069	0.277
MOD_GSK3_1	407	414	PF00069	0.395
MOD_GSK3_1	82	89	PF00069	0.307
MOD_N-GLC_1	14	19	PF02516	0.412
MOD_N-GLC_1	86	91	PF02516	0.470
MOD_N-GLC_2	418	420	PF02516	0.374
MOD_NEK2_1	1	6	PF00069	0.337
MOD_NEK2_1	110	115	PF00069	0.499
MOD_NEK2_1	142	147	PF00069	0.253
MOD_NEK2_1	308	313	PF00069	0.345
MOD_NEK2_1	368	373	PF00069	0.428
MOD_NEK2_2	162	167	PF00069	0.380
MOD_NEK2_2	322	327	PF00069	0.290
MOD_PIKK_1	132	138	PF00454	0.380
MOD_PIKK_1	357	363	PF00454	0.314
MOD_PK_1	117	123	PF00069	0.472
MOD_PK_1	330	336	PF00069	0.375
MOD_PKA_1	116	122	PF00069	0.643
MOD_PKA_2	329	335	PF00069	0.472
MOD_PKB_1	230	238	PF00069	0.486
MOD_Plk_1	86	92	PF00069	0.212
MOD_Plk_4	144	150	PF00069	0.247
MOD_Plk_4	169	175	PF00069	0.361
MOD_Plk_4	187	193	PF00069	0.249
MOD_Plk_4	209	215	PF00069	0.357
MOD_Plk_4	309	315	PF00069	0.354
MOD_Plk_4	396	402	PF00069	0.539
MOD_ProDKin_1	386	392	PF00069	0.507
MOD_ProDKin_1	40	46	PF00069	0.268
MOD_SUMO_rev_2	231	240	PF00179	0.480
TRG_DiLeu_BaEn_1	106	111	PF01217	0.318
TRG_DiLeu_BaEn_1	246	251	PF01217	0.340
TRG_DiLeu_BaEn_2	75	81	PF01217	0.212
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.232
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.370
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.307
TRG_ENDOCYTIC_2	192	195	PF00928	0.254
TRG_ENDOCYTIC_2	197	200	PF00928	0.238
TRG_ENDOCYTIC_2	310	313	PF00928	0.410
TRG_ER_diArg_1	224	227	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I5	Leptomonas seymouri	61%	96%
A0A0S4JM00	Bodo saltans	35%	100%
A0A1X0NX76	Trypanosomatidae	38%	100%
A0A3S7WYH8	Leishmania donovani	79%	99%
A0A422MXM9	Trypanosoma rangeli	41%	100%
A0JN27	Rattus norvegicus	24%	100%
E9AH75	Leishmania infantum	79%	98%
E9AX13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QAG3	Leishmania major	80%	100%
Q9JIB4	Mus musculus	25%	100%
V5BAZ0	Trypanosoma cruzi	39%	100%