Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDM7_LEIBR

TriTrypDb:

LbrM.24.1730 , LBRM2903_240025000

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.465
CLV_NRD_NRD_1	151	153	PF00675	0.402
CLV_NRD_NRD_1	174	176	PF00675	0.488
CLV_NRD_NRD_1	198	200	PF00675	0.475
CLV_NRD_NRD_1	201	203	PF00675	0.478
CLV_NRD_NRD_1	206	208	PF00675	0.467
CLV_PCSK_FUR_1	178	182	PF00082	0.531
CLV_PCSK_FUR_1	199	203	PF00082	0.480
CLV_PCSK_KEX2_1	137	139	PF00082	0.429
CLV_PCSK_KEX2_1	180	182	PF00082	0.536
CLV_PCSK_KEX2_1	200	202	PF00082	0.522
CLV_PCSK_KEX2_1	205	207	PF00082	0.531
CLV_PCSK_KEX2_1	48	50	PF00082	0.477
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.536
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.522
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.447
CLV_PCSK_PC7_1	201	207	PF00082	0.524
CLV_PCSK_SKI1_1	129	133	PF00082	0.474
CLV_PCSK_SKI1_1	238	242	PF00082	0.500
CLV_PCSK_SKI1_1	9	13	PF00082	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_MAPK_gen_1	180	189	PF00069	0.492
DOC_PP1_RVXF_1	75	81	PF00149	0.279
DOC_PP4_FxxP_1	87	90	PF00568	0.365
DOC_USP7_MATH_1	216	220	PF00917	0.601
DOC_USP7_UBL2_3	149	153	PF12436	0.468
DOC_USP7_UBL2_3	176	180	PF12436	0.484
DOC_WW_Pin1_4	16	21	PF00397	0.548
LIG_14-3-3_CanoR_1	152	158	PF00244	0.487
LIG_14-3-3_CanoR_1	265	271	PF00244	0.615
LIG_14-3-3_CanoR_1	9	18	PF00244	0.554
LIG_Actin_WH2_2	225	240	PF00022	0.525
LIG_Actin_WH2_2	30	47	PF00022	0.317
LIG_Actin_WH2_2	95	111	PF00022	0.394
LIG_BRCT_BRCA1_1	46	50	PF00533	0.538
LIG_deltaCOP1_diTrp_1	222	228	PF00928	0.493
LIG_deltaCOP1_diTrp_1	79	87	PF00928	0.399
LIG_FHA_1	13	19	PF00498	0.417
LIG_FHA_1	227	233	PF00498	0.506
LIG_FHA_1	39	45	PF00498	0.553
LIG_LIR_Apic_2	84	90	PF02991	0.377
LIG_LIR_Gen_1	140	147	PF02991	0.453
LIG_LIR_Gen_1	222	233	PF02991	0.479
LIG_LIR_Gen_1	47	57	PF02991	0.471
LIG_LIR_Gen_1	79	90	PF02991	0.348
LIG_LIR_Nem_3	140	146	PF02991	0.449
LIG_LIR_Nem_3	222	228	PF02991	0.474
LIG_LIR_Nem_3	47	53	PF02991	0.493
LIG_LIR_Nem_3	79	85	PF02991	0.367
LIG_SH2_GRB2like	101	104	PF00017	0.356
LIG_SH2_STAT5	171	174	PF00017	0.535
LIG_SH2_STAT5	31	34	PF00017	0.473
LIG_SH2_STAT5	59	62	PF00017	0.439
LIG_SH2_STAT5	82	85	PF00017	0.356
LIG_SUMO_SIM_par_1	12	19	PF11976	0.421
LIG_TRFH_1	87	91	PF08558	0.371
MOD_CK1_1	21	27	PF00069	0.415
MOD_CK1_1	266	272	PF00069	0.612
MOD_CK2_1	216	222	PF00069	0.496
MOD_GlcNHglycan	12	15	PF01048	0.647
MOD_GlcNHglycan	218	221	PF01048	0.534
MOD_GSK3_1	113	120	PF00069	0.493
MOD_GSK3_1	18	25	PF00069	0.380
MOD_GSK3_1	216	223	PF00069	0.525
MOD_GSK3_1	251	258	PF00069	0.561
MOD_GSK3_1	5	12	PF00069	0.568
MOD_GSK3_1	85	92	PF00069	0.432
MOD_N-GLC_1	113	118	PF02516	0.468
MOD_N-GLC_2	54	56	PF02516	0.296
MOD_NEK2_1	10	15	PF00069	0.570
MOD_NEK2_1	158	163	PF00069	0.462
MOD_NEK2_1	44	49	PF00069	0.490
MOD_NEK2_1	85	90	PF00069	0.398
MOD_NEK2_2	263	268	PF00069	0.717
MOD_PKA_2	151	157	PF00069	0.492
MOD_PKA_2	174	180	PF00069	0.484
MOD_PKA_2	2	8	PF00069	0.644
MOD_PKA_2	220	226	PF00069	0.542
MOD_PKA_2	242	248	PF00069	0.536
MOD_PKA_2	251	257	PF00069	0.548
MOD_PKA_2	44	50	PF00069	0.347
MOD_Plk_1	185	191	PF00069	0.484
MOD_Plk_1	83	89	PF00069	0.471
MOD_Plk_4	158	164	PF00069	0.456
MOD_Plk_4	33	39	PF00069	0.450
MOD_ProDKin_1	16	22	PF00069	0.539
MOD_SUMO_rev_2	70	75	PF00179	0.486
TRG_ENDOCYTIC_2	59	62	PF00928	0.326
TRG_ENDOCYTIC_2	82	85	PF00928	0.358
TRG_ER_diArg_1	199	202	PF00400	0.482
TRG_ER_diArg_1	205	207	PF00400	0.483
TRG_NLS_MonoExtN_4	199	204	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U3	Leptomonas seymouri	83%	100%
A0A0S4JQ00	Bodo saltans	53%	100%
A0A1X0NW91	Trypanosomatidae	76%	100%
A0A3S7WYJ0	Leishmania donovani	94%	100%
C9ZWD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AH74	Leishmania infantum	94%	100%
E9AX12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAG4	Leishmania major	92%	100%
V5BK26	Trypanosoma cruzi	73%	99%