SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HDM6_LEIBR

TriTrypDb:

LbrM.24.1720 , LBRM2903_240024900

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.373
CLV_C14_Caspase3-7	247	251	PF00656	0.578
CLV_C14_Caspase3-7	505	509	PF00656	0.518
CLV_NRD_NRD_1	14	16	PF00675	0.725
CLV_NRD_NRD_1	142	144	PF00675	0.400
CLV_PCSK_KEX2_1	14	16	PF00082	0.719
CLV_PCSK_KEX2_1	202	204	PF00082	0.508
CLV_PCSK_KEX2_1	379	381	PF00082	0.250
CLV_PCSK_KEX2_1	67	69	PF00082	0.695
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.398
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.303
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.745
CLV_PCSK_PC7_1	10	16	PF00082	0.620
CLV_PCSK_SKI1_1	203	207	PF00082	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.600
DEG_SCF_FBW7_2	118	123	PF00400	0.490
DEG_SPOP_SBC_1	174	178	PF00917	0.301
DEG_SPOP_SBC_1	245	249	PF00917	0.515
DEG_SPOP_SBC_1	57	61	PF00917	0.647
DOC_CKS1_1	491	496	PF01111	0.533
DOC_CYCLIN_RxL_1	200	209	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.523
DOC_MAPK_gen_1	165	173	PF00069	0.314
DOC_MAPK_MEF2A_6	277	286	PF00069	0.269
DOC_MAPK_RevD_3	190	203	PF00069	0.487
DOC_PP2B_LxvP_1	231	234	PF13499	0.481
DOC_PP2B_LxvP_1	288	291	PF13499	0.446
DOC_PP2B_LxvP_1	364	367	PF13499	0.446
DOC_PP2B_LxvP_1	408	411	PF13499	0.509
DOC_PP2B_LxvP_1	445	448	PF13499	0.480
DOC_PP4_FxxP_1	218	221	PF00568	0.337
DOC_SPAK_OSR1_1	380	384	PF12202	0.488
DOC_USP7_MATH_1	135	139	PF00917	0.286
DOC_USP7_MATH_1	244	248	PF00917	0.600
DOC_USP7_MATH_1	251	255	PF00917	0.529
DOC_USP7_MATH_1	346	350	PF00917	0.538
DOC_USP7_MATH_1	365	369	PF00917	0.478
DOC_USP7_MATH_1	402	406	PF00917	0.543
DOC_USP7_MATH_1	44	48	PF00917	0.767
DOC_USP7_MATH_1	512	516	PF00917	0.653
DOC_USP7_MATH_1	58	62	PF00917	0.705
DOC_USP7_MATH_1	89	93	PF00917	0.762
DOC_USP7_UBL2_3	140	144	PF12436	0.428
DOC_WW_Pin1_4	116	121	PF00397	0.425
DOC_WW_Pin1_4	194	199	PF00397	0.330
DOC_WW_Pin1_4	329	334	PF00397	0.460
DOC_WW_Pin1_4	391	396	PF00397	0.571
DOC_WW_Pin1_4	490	495	PF00397	0.726
DOC_WW_Pin1_4	77	82	PF00397	0.752
DOC_WW_Pin1_4	92	97	PF00397	0.579
LIG_14-3-3_CanoR_1	159	165	PF00244	0.438
LIG_14-3-3_CanoR_1	324	331	PF00244	0.478
LIG_14-3-3_CanoR_1	88	97	PF00244	0.664
LIG_Actin_WH2_2	283	301	PF00022	0.538
LIG_Actin_WH2_2	96	112	PF00022	0.349
LIG_BIR_III_2	250	254	PF00653	0.493
LIG_eIF4E_1	306	312	PF01652	0.538
LIG_EVH1_2	96	100	PF00568	0.423
LIG_FHA_1	119	125	PF00498	0.465
LIG_FHA_1	131	137	PF00498	0.283
LIG_FHA_1	161	167	PF00498	0.437
LIG_FHA_1	174	180	PF00498	0.424
LIG_FHA_1	189	195	PF00498	0.371
LIG_FHA_1	227	233	PF00498	0.526
LIG_FHA_1	442	448	PF00498	0.560
LIG_FHA_1	475	481	PF00498	0.443
LIG_LIR_Apic_2	217	221	PF02991	0.332
LIG_LIR_Apic_2	433	439	PF02991	0.415
LIG_LIR_Gen_1	303	312	PF02991	0.381
LIG_LIR_Gen_1	474	482	PF02991	0.415
LIG_LIR_Nem_3	303	309	PF02991	0.381
LIG_LIR_Nem_3	474	479	PF02991	0.389
LIG_PDZ_Class_1	512	517	PF00595	0.641
LIG_Pex14_1	436	440	PF04695	0.478
LIG_SH2_CRK	306	310	PF00017	0.460
LIG_SH2_CRK	440	444	PF00017	0.503
LIG_SH2_STAP1	214	218	PF00017	0.368
LIG_SH2_STAP1	306	310	PF00017	0.503
LIG_SH2_STAP1	40	44	PF00017	0.517
LIG_SH2_STAT5	172	175	PF00017	0.348
LIG_SH2_STAT5	359	362	PF00017	0.380
LIG_SH3_1	10	16	PF00018	0.620
LIG_SH3_3	10	16	PF00018	0.688
LIG_SH3_3	168	174	PF00018	0.321
LIG_SH3_3	263	269	PF00018	0.549
LIG_SH3_3	408	414	PF00018	0.460
LIG_SH3_3	440	446	PF00018	0.490
LIG_SH3_3	78	84	PF00018	0.718
LIG_SH3_3	91	97	PF00018	0.564
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.460
LIG_SUMO_SIM_par_1	105	111	PF11976	0.423
LIG_SUMO_SIM_par_1	418	425	PF11976	0.436
LIG_SUMO_SIM_par_1	477	483	PF11976	0.531
LIG_TRAF2_1	120	123	PF00917	0.591
LIG_TRAF2_1	317	320	PF00917	0.538
LIG_TRAF2_1	367	370	PF00917	0.538
LIG_TYR_ITIM	438	443	PF00017	0.503
LIG_WRC_WIRS_1	452	457	PF05994	0.461
MOD_CDK_SPxxK_3	329	336	PF00069	0.460
MOD_CDK_SPxxK_3	391	398	PF00069	0.384
MOD_CK1_1	238	244	PF00069	0.683
MOD_CK1_1	326	332	PF00069	0.503
MOD_CK1_1	349	355	PF00069	0.526
MOD_CK1_1	394	400	PF00069	0.461
MOD_CK1_1	47	53	PF00069	0.704
MOD_CK1_1	471	477	PF00069	0.544
MOD_CK1_1	59	65	PF00069	0.708
MOD_CK1_1	92	98	PF00069	0.580
MOD_CK2_1	251	257	PF00069	0.536
MOD_CK2_1	58	64	PF00069	0.753
MOD_GlcNHglycan	154	157	PF01048	0.360
MOD_GlcNHglycan	206	209	PF01048	0.360
MOD_GlcNHglycan	237	240	PF01048	0.493
MOD_GlcNHglycan	259	262	PF01048	0.627
MOD_GlcNHglycan	406	411	PF01048	0.361
MOD_GlcNHglycan	431	435	PF01048	0.212
MOD_GlcNHglycan	46	49	PF01048	0.759
MOD_GlcNHglycan	470	473	PF01048	0.500
MOD_GlcNHglycan	482	485	PF01048	0.399
MOD_GlcNHglycan	513	517	PF01048	0.489
MOD_GSK3_1	204	211	PF00069	0.503
MOD_GSK3_1	240	247	PF00069	0.778
MOD_GSK3_1	253	260	PF00069	0.521
MOD_GSK3_1	346	353	PF00069	0.491
MOD_GSK3_1	402	409	PF00069	0.558
MOD_GSK3_1	451	458	PF00069	0.472
MOD_N-GLC_1	174	179	PF02516	0.305
MOD_N-GLC_1	455	460	PF02516	0.272
MOD_NEK2_1	2	7	PF00069	0.644
MOD_NEK2_1	350	355	PF00069	0.523
MOD_NEK2_1	451	456	PF00069	0.501
MOD_PIKK_1	118	124	PF00454	0.559
MOD_PIKK_1	315	321	PF00454	0.538
MOD_PIKK_1	365	371	PF00454	0.460
MOD_PKA_2	323	329	PF00069	0.436
MOD_PKA_2	468	474	PF00069	0.414
MOD_Plk_1	174	180	PF00069	0.404
MOD_Plk_1	226	232	PF00069	0.549
MOD_Plk_1	455	461	PF00069	0.488
MOD_Plk_2-3	498	504	PF00069	0.637
MOD_Plk_4	175	181	PF00069	0.483
MOD_Plk_4	188	194	PF00069	0.416
MOD_Plk_4	346	352	PF00069	0.538
MOD_Plk_4	459	465	PF00069	0.462
MOD_ProDKin_1	116	122	PF00069	0.419
MOD_ProDKin_1	194	200	PF00069	0.331
MOD_ProDKin_1	329	335	PF00069	0.460
MOD_ProDKin_1	391	397	PF00069	0.571
MOD_ProDKin_1	490	496	PF00069	0.736
MOD_ProDKin_1	77	83	PF00069	0.751
MOD_ProDKin_1	92	98	PF00069	0.571
TRG_DiLeu_BaEn_1	227	232	PF01217	0.355
TRG_ENDOCYTIC_2	306	309	PF00928	0.380
TRG_ENDOCYTIC_2	440	443	PF00928	0.503
TRG_ER_diArg_1	13	15	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U8	Leptomonas seymouri	63%	100%
A0A0S4JI78	Bodo saltans	43%	100%
A0A1X0NVU0	Trypanosomatidae	45%	100%
A0A3Q8IBF1	Leishmania donovani	79%	100%
A0A3R7R8W6	Trypanosoma rangeli	46%	100%
C9ZWD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AH73	Leishmania infantum	79%	100%
E9AX11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAG5	Leishmania major	81%	100%
V5BFK4	Trypanosoma cruzi	48%	100%