Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDM5_LEIBR

TriTrypDb:

LbrM.24.1710 , LBRM2903_240024800

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.564
CLV_NRD_NRD_1	14	16	PF00675	0.776
CLV_NRD_NRD_1	248	250	PF00675	0.453
CLV_NRD_NRD_1	65	67	PF00675	0.793
CLV_NRD_NRD_1	82	84	PF00675	0.504
CLV_PCSK_KEX2_1	82	84	PF00082	0.533
CLV_PCSK_SKI1_1	126	130	PF00082	0.652
CLV_PCSK_SKI1_1	249	253	PF00082	0.522
CLV_PCSK_SKI1_1	271	275	PF00082	0.521
CLV_PCSK_SKI1_1	358	362	PF00082	0.339
CLV_PCSK_SKI1_1	404	408	PF00082	0.603
CLV_PCSK_SKI1_1	517	521	PF00082	0.467
CLV_Separin_Metazoa	181	185	PF03568	0.608
DEG_APCC_DBOX_1	396	404	PF00400	0.522
DEG_SPOP_SBC_1	490	494	PF00917	0.744
DOC_MAPK_gen_1	249	256	PF00069	0.460
DOC_MAPK_gen_1	341	350	PF00069	0.603
DOC_MAPK_gen_1	515	524	PF00069	0.465
DOC_PP1_RVXF_1	518	525	PF00149	0.472
DOC_USP7_MATH_1	476	480	PF00917	0.567
DOC_USP7_MATH_1	489	493	PF00917	0.701
DOC_USP7_MATH_1	540	544	PF00917	0.633
DOC_USP7_MATH_1	78	82	PF00917	0.676
DOC_USP7_UBL2_3	513	517	PF12436	0.547
DOC_USP7_UBL2_3	52	56	PF12436	0.511
DOC_WW_Pin1_4	1	6	PF00397	0.668
DOC_WW_Pin1_4	20	25	PF00397	0.472
DOC_WW_Pin1_4	472	477	PF00397	0.612
DOC_WW_Pin1_4	485	490	PF00397	0.769
DOC_WW_Pin1_4	532	537	PF00397	0.636
LIG_14-3-3_CanoR_1	15	19	PF00244	0.731
LIG_14-3-3_CanoR_1	192	197	PF00244	0.606
LIG_14-3-3_CanoR_1	390	394	PF00244	0.543
LIG_14-3-3_CanoR_1	404	411	PF00244	0.503
LIG_14-3-3_CanoR_1	44	48	PF00244	0.602
LIG_14-3-3_CanoR_1	66	76	PF00244	0.804
LIG_14-3-3_CanoR_1	82	86	PF00244	0.638
LIG_Actin_WH2_2	133	150	PF00022	0.356
LIG_BIR_II_1	1	5	PF00653	0.764
LIG_BRCT_BRCA1_1	502	506	PF00533	0.690
LIG_Clathr_ClatBox_1	253	257	PF01394	0.458
LIG_EH1_1	298	306	PF00400	0.620
LIG_FHA_1	160	166	PF00498	0.548
LIG_FHA_1	195	201	PF00498	0.542
LIG_FHA_1	216	222	PF00498	0.562
LIG_FHA_1	285	291	PF00498	0.539
LIG_FHA_1	296	302	PF00498	0.420
LIG_FHA_1	306	312	PF00498	0.494
LIG_FHA_1	359	365	PF00498	0.446
LIG_FHA_1	405	411	PF00498	0.600
LIG_FHA_1	5	11	PF00498	0.772
LIG_FHA_1	71	77	PF00498	0.690
LIG_FHA_1	92	98	PF00498	0.623
LIG_FHA_2	224	230	PF00498	0.482
LIG_FHA_2	307	313	PF00498	0.619
LIG_FHA_2	473	479	PF00498	0.791
LIG_FHA_2	70	76	PF00498	0.793
LIG_GBD_Chelix_1	139	147	PF00786	0.506
LIG_LIR_Gen_1	191	200	PF02991	0.387
LIG_LIR_Gen_1	263	272	PF02991	0.552
LIG_LIR_Gen_1	277	284	PF02991	0.493
LIG_LIR_LC3C_4	229	233	PF02991	0.608
LIG_LIR_Nem_3	109	115	PF02991	0.590
LIG_LIR_Nem_3	191	196	PF02991	0.387
LIG_LIR_Nem_3	263	267	PF02991	0.552
LIG_LIR_Nem_3	277	283	PF02991	0.493
LIG_PCNA_TLS_4	414	421	PF02747	0.519
LIG_PCNA_yPIPBox_3	225	237	PF02747	0.607
LIG_PTB_Apo_2	524	531	PF02174	0.581
LIG_PTB_Phospho_1	524	530	PF10480	0.576
LIG_SH2_CRK	193	197	PF00017	0.468
LIG_SH2_CRK	531	535	PF00017	0.444
LIG_SH2_GRB2like	111	114	PF00017	0.543
LIG_SH2_NCK_1	193	197	PF00017	0.550
LIG_SH2_STAT3	111	114	PF00017	0.679
LIG_SH2_STAT3	210	213	PF00017	0.563
LIG_SH2_STAT5	210	213	PF00017	0.546
LIG_SUMO_SIM_anti_2	377	385	PF11976	0.376
LIG_SUMO_SIM_par_1	252	257	PF11976	0.459
LIG_TRAF2_1	171	174	PF00917	0.630
LIG_TRAF2_1	275	278	PF00917	0.538
LIG_TRAF2_1	475	478	PF00917	0.788
LIG_TYR_ITSM	189	196	PF00017	0.439
LIG_UBA3_1	253	258	PF00899	0.595
MOD_CDK_SPxxK_3	20	27	PF00069	0.536
MOD_CK1_1	195	201	PF00069	0.524
MOD_CK1_1	374	380	PF00069	0.618
MOD_CK1_1	388	394	PF00069	0.600
MOD_CK1_1	4	10	PF00069	0.645
MOD_CK1_1	472	478	PF00069	0.688
MOD_CK1_1	479	485	PF00069	0.688
MOD_CK1_1	492	498	PF00069	0.588
MOD_CK1_1	59	65	PF00069	0.574
MOD_CK1_1	68	74	PF00069	0.617
MOD_CK1_1	81	87	PF00069	0.651
MOD_CK1_1	95	101	PF00069	0.532
MOD_CK2_1	223	229	PF00069	0.495
MOD_CK2_1	412	418	PF00069	0.513
MOD_CK2_1	472	478	PF00069	0.762
MOD_CK2_1	69	75	PF00069	0.758
MOD_GlcNHglycan	20	23	PF01048	0.666
MOD_GlcNHglycan	37	40	PF01048	0.646
MOD_GlcNHglycan	435	438	PF01048	0.771
MOD_GlcNHglycan	445	448	PF01048	0.711
MOD_GlcNHglycan	464	467	PF01048	0.711
MOD_GlcNHglycan	502	505	PF01048	0.698
MOD_GlcNHglycan	542	545	PF01048	0.629
MOD_GlcNHglycan	58	61	PF01048	0.744
MOD_GSK3_1	10	17	PF00069	0.736
MOD_GSK3_1	188	195	PF00069	0.501
MOD_GSK3_1	381	388	PF00069	0.585
MOD_GSK3_1	43	50	PF00069	0.649
MOD_GSK3_1	439	446	PF00069	0.648
MOD_GSK3_1	472	479	PF00069	0.601
MOD_GSK3_1	485	492	PF00069	0.667
MOD_GSK3_1	496	503	PF00069	0.705
MOD_GSK3_1	52	59	PF00069	0.730
MOD_GSK3_1	532	539	PF00069	0.699
MOD_GSK3_1	61	68	PF00069	0.723
MOD_GSK3_1	81	88	PF00069	0.444
MOD_GSK3_1	91	98	PF00069	0.639
MOD_LATS_1	402	408	PF00433	0.404
MOD_NEK2_1	101	106	PF00069	0.557
MOD_NEK2_1	14	19	PF00069	0.748
MOD_NEK2_1	142	147	PF00069	0.602
MOD_NEK2_1	256	261	PF00069	0.491
MOD_NEK2_1	284	289	PF00069	0.591
MOD_NEK2_1	35	40	PF00069	0.718
MOD_NEK2_1	371	376	PF00069	0.498
MOD_NEK2_1	386	391	PF00069	0.506
MOD_NEK2_1	420	425	PF00069	0.604
MOD_NEK2_1	496	501	PF00069	0.707
MOD_NEK2_1	65	70	PF00069	0.743
MOD_NEK2_1	92	97	PF00069	0.641
MOD_PIKK_1	151	157	PF00454	0.566
MOD_PIKK_1	159	165	PF00454	0.559
MOD_PIKK_1	223	229	PF00454	0.357
MOD_PIKK_1	284	290	PF00454	0.511
MOD_PIKK_1	313	319	PF00454	0.482
MOD_PK_1	192	198	PF00069	0.606
MOD_PKA_2	107	113	PF00069	0.534
MOD_PKA_2	14	20	PF00069	0.786
MOD_PKA_2	389	395	PF00069	0.578
MOD_PKA_2	43	49	PF00069	0.541
MOD_PKA_2	65	71	PF00069	0.737
MOD_PKA_2	81	87	PF00069	0.593
MOD_PKB_1	356	364	PF00069	0.432
MOD_Plk_1	188	194	PF00069	0.354
MOD_Plk_1	215	221	PF00069	0.565
MOD_Plk_1	256	262	PF00069	0.536
MOD_Plk_1	313	319	PF00069	0.370
MOD_Plk_4	107	113	PF00069	0.682
MOD_Plk_4	30	36	PF00069	0.538
MOD_Plk_4	43	49	PF00069	0.461
MOD_Plk_4	476	482	PF00069	0.709
MOD_Plk_4	92	98	PF00069	0.679
MOD_ProDKin_1	1	7	PF00069	0.669
MOD_ProDKin_1	20	26	PF00069	0.471
MOD_ProDKin_1	472	478	PF00069	0.612
MOD_ProDKin_1	485	491	PF00069	0.764
MOD_ProDKin_1	532	538	PF00069	0.638
MOD_SUMO_rev_2	291	296	PF00179	0.640
MOD_SUMO_rev_2	344	350	PF00179	0.517
MOD_SUMO_rev_2	380	389	PF00179	0.561
TRG_DiLeu_BaEn_1	263	268	PF01217	0.496
TRG_ENDOCYTIC_2	179	182	PF00928	0.473
TRG_ENDOCYTIC_2	193	196	PF00928	0.469
TRG_ENDOCYTIC_2	531	534	PF00928	0.462
TRG_NES_CRM1_1	141	153	PF08389	0.353
TRG_NES_CRM1_1	222	236	PF08389	0.609
TRG_NES_CRM1_1	359	370	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	358	363	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM1	Leptomonas seymouri	60%	100%
A0A3Q8ICZ4	Leishmania donovani	78%	100%
A0A422NQP6	Trypanosoma rangeli	33%	99%
D0A6S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9AH72	Leishmania infantum	78%	100%
E9AX10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAG6	Leishmania major	75%	97%