Fatty acyl-CoA reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Male sterility protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDM4_LEIBR

TriTrypDb:

LbrM.24.1700 , LBRM2903_240024200

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HDM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035336	long-chain fatty-acyl-CoA metabolic process	6	1
GO:0035337	fatty-acyl-CoA metabolic process	5	1
GO:0035383	thioester metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901568	fatty acid derivative metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12
GO:0080019	alcohol-forming very long-chain fatty acyl-CoA reductase activity	5	12
GO:0102965	alcohol-forming long-chain fatty acyl-CoA reductase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.449
CLV_NRD_NRD_1	490	492	PF00675	0.402
CLV_NRD_NRD_1	51	53	PF00675	0.346
CLV_NRD_NRD_1	525	527	PF00675	0.443
CLV_PCSK_FUR_1	46	50	PF00082	0.449
CLV_PCSK_KEX2_1	172	174	PF00082	0.449
CLV_PCSK_KEX2_1	196	198	PF00082	0.449
CLV_PCSK_KEX2_1	48	50	PF00082	0.361
CLV_PCSK_KEX2_1	490	492	PF00082	0.397
CLV_PCSK_KEX2_1	51	53	PF00082	0.338
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.449
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.383
CLV_PCSK_SKI1_1	111	115	PF00082	0.305
CLV_PCSK_SKI1_1	12	16	PF00082	0.351
CLV_PCSK_SKI1_1	147	151	PF00082	0.358
CLV_PCSK_SKI1_1	196	200	PF00082	0.328
CLV_PCSK_SKI1_1	25	29	PF00082	0.337
CLV_PCSK_SKI1_1	30	34	PF00082	0.309
CLV_PCSK_SKI1_1	306	310	PF00082	0.355
CLV_PCSK_SKI1_1	51	55	PF00082	0.363
CLV_PCSK_SKI1_1	526	530	PF00082	0.274
CLV_Separin_Metazoa	74	78	PF03568	0.449
DEG_APCC_DBOX_1	61	69	PF00400	0.449
DEG_SPOP_SBC_1	377	381	PF00917	0.498
DEG_SPOP_SBC_1	403	407	PF00917	0.426
DOC_CYCLIN_RxL_1	303	311	PF00134	0.362
DOC_MAPK_DCC_7	236	246	PF00069	0.449
DOC_MAPK_gen_1	236	245	PF00069	0.348
DOC_MAPK_HePTP_8	233	245	PF00069	0.413
DOC_MAPK_MEF2A_6	133	140	PF00069	0.390
DOC_MAPK_MEF2A_6	236	245	PF00069	0.388
DOC_MAPK_MEF2A_6	342	350	PF00069	0.741
DOC_MAPK_MEF2A_6	432	441	PF00069	0.528
DOC_MAPK_MEF2A_6	456	465	PF00069	0.516
DOC_MAPK_NFAT4_5	133	141	PF00069	0.378
DOC_MAPK_RevD_3	160	173	PF00069	0.449
DOC_PP1_RVXF_1	409	415	PF00149	0.497
DOC_PP2B_LxvP_1	469	472	PF13499	0.490
DOC_PP4_FxxP_1	560	563	PF00568	0.456
DOC_USP7_MATH_1	403	407	PF00917	0.423
DOC_USP7_UBL2_3	306	310	PF12436	0.356
DOC_USP7_UBL2_3	428	432	PF12436	0.490
DOC_WW_Pin1_4	329	334	PF00397	0.739
DOC_WW_Pin1_4	432	437	PF00397	0.479
DOC_WW_Pin1_4	472	477	PF00397	0.548
DOC_WW_Pin1_4	67	72	PF00397	0.363
LIG_14-3-3_CanoR_1	147	152	PF00244	0.335
LIG_14-3-3_CanoR_1	411	415	PF00244	0.524
LIG_14-3-3_CanoR_1	416	422	PF00244	0.497
LIG_14-3-3_CanoR_1	526	532	PF00244	0.383
LIG_14-3-3_CterR_2	575	579	PF00244	0.554
LIG_AP2alpha_2	257	259	PF02296	0.449
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_4	351	355	PF00653	0.506
LIG_BRCT_BRCA1_1	255	259	PF00533	0.223
LIG_BRCT_BRCA1_1	69	73	PF00533	0.344
LIG_CaM_IQ_9	308	323	PF13499	0.480
LIG_CaM_NSCaTE_8	262	269	PF13499	0.328
LIG_FHA_1	11	17	PF00498	0.454
LIG_FHA_1	164	170	PF00498	0.328
LIG_FHA_1	224	230	PF00498	0.337
LIG_FHA_1	273	279	PF00498	0.344
LIG_FHA_1	369	375	PF00498	0.752
LIG_FHA_2	379	385	PF00498	0.521
LIG_FHA_2	389	395	PF00498	0.631
LIG_FHA_2	501	507	PF00498	0.363
LIG_GBD_Chelix_1	300	308	PF00786	0.344
LIG_LIR_Apic_2	254	258	PF02991	0.363
LIG_LIR_Apic_2	557	563	PF02991	0.455
LIG_LIR_Gen_1	413	422	PF02991	0.288
LIG_LIR_Gen_1	496	504	PF02991	0.434
LIG_LIR_Gen_1	506	517	PF02991	0.381
LIG_LIR_Nem_3	165	171	PF02991	0.342
LIG_LIR_Nem_3	413	417	PF02991	0.430
LIG_LIR_Nem_3	444	450	PF02991	0.340
LIG_LIR_Nem_3	496	502	PF02991	0.434
LIG_LIR_Nem_3	506	512	PF02991	0.381
LIG_LIR_Nem_3	530	534	PF02991	0.419
LIG_LIR_Nem_3	535	541	PF02991	0.390
LIG_LIR_Nem_3	70	76	PF02991	0.352
LIG_LIR_Nem_3	82	88	PF02991	0.328
LIG_PCNA_yPIPBox_3	302	316	PF02747	0.416
LIG_PDZ_Class_1	574	579	PF00595	0.570
LIG_SH2_CRK	29	33	PF00017	0.449
LIG_SH2_CRK	509	513	PF00017	0.475
LIG_SH2_CRK	541	545	PF00017	0.382
LIG_SH2_GRB2like	168	171	PF00017	0.328
LIG_SH2_GRB2like	56	59	PF00017	0.413
LIG_SH2_NCK_1	255	259	PF00017	0.223
LIG_SH2_NCK_1	509	513	PF00017	0.223
LIG_SH2_NCK_1	541	545	PF00017	0.363
LIG_SH2_PTP2	460	463	PF00017	0.533
LIG_SH2_SRC	545	548	PF00017	0.391
LIG_SH2_SRC	56	59	PF00017	0.413
LIG_SH2_STAP1	524	528	PF00017	0.433
LIG_SH2_STAP1	534	538	PF00017	0.372
LIG_SH2_STAP1	541	545	PF00017	0.306
LIG_SH2_STAT5	168	171	PF00017	0.326
LIG_SH2_STAT5	223	226	PF00017	0.319
LIG_SH2_STAT5	299	302	PF00017	0.475
LIG_SH2_STAT5	42	45	PF00017	0.330
LIG_SH2_STAT5	453	456	PF00017	0.481
LIG_SH2_STAT5	460	463	PF00017	0.441
LIG_SH2_STAT5	541	544	PF00017	0.406
LIG_SH2_STAT5	56	59	PF00017	0.363
LIG_SH3_3	560	566	PF00018	0.451
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.475
LIG_SUMO_SIM_par_1	344	349	PF11976	0.675
LIG_TYR_ITIM	27	32	PF00017	0.445
LIG_TYR_ITIM	450	455	PF00017	0.463
LIG_UBA3_1	27	33	PF00899	0.329
LIG_UBA3_1	304	310	PF00899	0.348
MOD_CDC14_SPxK_1	435	438	PF00782	0.349
MOD_CDC14_SPxK_1	475	478	PF00782	0.566
MOD_CDK_SPK_2	472	477	PF00069	0.549
MOD_CDK_SPxK_1	432	438	PF00069	0.349
MOD_CDK_SPxK_1	472	478	PF00069	0.555
MOD_CK1_1	10	16	PF00069	0.390
MOD_CK1_1	237	243	PF00069	0.431
MOD_CK1_1	344	350	PF00069	0.577
MOD_CK1_1	379	385	PF00069	0.702
MOD_CK2_1	201	207	PF00069	0.358
MOD_CK2_1	403	409	PF00069	0.556
MOD_CK2_1	500	506	PF00069	0.363
MOD_CK2_1	565	571	PF00069	0.587
MOD_Cter_Amidation	46	49	PF01082	0.413
MOD_GlcNHglycan	19	22	PF01048	0.243
MOD_GlcNHglycan	209	212	PF01048	0.417
MOD_GlcNHglycan	383	388	PF01048	0.728
MOD_GlcNHglycan	567	570	PF01048	0.621
MOD_GSK3_1	10	17	PF00069	0.371
MOD_GSK3_1	147	154	PF00069	0.386
MOD_GSK3_1	219	226	PF00069	0.317
MOD_GSK3_1	379	386	PF00069	0.661
MOD_GSK3_1	437	444	PF00069	0.535
MOD_N-GLC_1	10	15	PF02516	0.497
MOD_NEK2_1	124	129	PF00069	0.353
MOD_NEK2_1	151	156	PF00069	0.439
MOD_NEK2_1	272	277	PF00069	0.328
MOD_NEK2_1	308	313	PF00069	0.374
MOD_NEK2_1	417	422	PF00069	0.418
MOD_NEK2_1	437	442	PF00069	0.490
MOD_NEK2_1	500	505	PF00069	0.393
MOD_PIKK_1	308	314	PF00454	0.397
MOD_PIKK_1	441	447	PF00454	0.402
MOD_PIKK_1	539	545	PF00454	0.390
MOD_PKA_2	246	252	PF00069	0.328
MOD_PKA_2	341	347	PF00069	0.743
MOD_PKA_2	410	416	PF00069	0.533
MOD_PKA_2	554	560	PF00069	0.489
MOD_Plk_1	10	16	PF00069	0.470
MOD_Plk_1	500	506	PF00069	0.449
MOD_Plk_1	97	103	PF00069	0.445
MOD_Plk_2-3	493	499	PF00069	0.475
MOD_Plk_4	246	252	PF00069	0.355
MOD_Plk_4	341	347	PF00069	0.593
MOD_ProDKin_1	329	335	PF00069	0.740
MOD_ProDKin_1	432	438	PF00069	0.484
MOD_ProDKin_1	472	478	PF00069	0.549
MOD_ProDKin_1	67	73	PF00069	0.363
MOD_SUMO_rev_2	34	41	PF00179	0.433
TRG_DiLeu_BaEn_2	394	400	PF01217	0.577
TRG_DiLeu_BaEn_3	108	114	PF01217	0.223
TRG_ENDOCYTIC_2	29	32	PF00928	0.413
TRG_ENDOCYTIC_2	42	45	PF00928	0.145
TRG_ENDOCYTIC_2	447	450	PF00928	0.452
TRG_ENDOCYTIC_2	452	455	PF00928	0.422
TRG_ENDOCYTIC_2	460	463	PF00928	0.335
TRG_ENDOCYTIC_2	509	512	PF00928	0.475
TRG_ENDOCYTIC_2	541	544	PF00928	0.383
TRG_ENDOCYTIC_2	547	550	PF00928	0.372
TRG_ER_diArg_1	171	173	PF00400	0.449
TRG_ER_diArg_1	448	451	PF00400	0.494
TRG_ER_diArg_1	489	491	PF00400	0.387
TRG_ER_diArg_1	49	52	PF00400	0.371
TRG_NES_CRM1_1	493	506	PF08389	0.415
TRG_NLS_MonoExtC_3	47	52	PF00514	0.413
TRG_NLS_MonoExtN_4	172	177	PF00514	0.475
TRG_NLS_MonoExtN_4	46	52	PF00514	0.412
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	515	520	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I721	Leptomonas seymouri	70%	100%
A0A0S4ILT5	Bodo saltans	42%	100%
A0A1X0NVR7	Trypanosomatidae	49%	100%
A0A3Q8ICX8	Leishmania donovani	86%	100%
A0A422N8G4	Trypanosoma rangeli	48%	98%
C9ZWE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	93%
E9AH71	Leishmania infantum	86%	100%
E9AX09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAG7	Leishmania major	86%	100%
V5AVK6	Trypanosoma cruzi	49%	98%