Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDM2_LEIBR

TriTrypDb:

LbrM.24.1680 , LBRM2903_240024000

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	7
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HDM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM2

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.423
CLV_NRD_NRD_1	24	26	PF00675	0.369
CLV_NRD_NRD_1	39	41	PF00675	0.438
CLV_NRD_NRD_1	51	53	PF00675	0.444
CLV_NRD_NRD_1	80	82	PF00675	0.498
CLV_PCSK_KEX2_1	150	152	PF00082	0.448
CLV_PCSK_KEX2_1	188	190	PF00082	0.409
CLV_PCSK_KEX2_1	239	241	PF00082	0.596
CLV_PCSK_KEX2_1	272	274	PF00082	0.557
CLV_PCSK_KEX2_1	326	328	PF00082	0.513
CLV_PCSK_KEX2_1	367	369	PF00082	0.566
CLV_PCSK_KEX2_1	51	53	PF00082	0.423
CLV_PCSK_KEX2_1	79	81	PF00082	0.501
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.448
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.498
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.557
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.513
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.566
CLV_PCSK_SKI1_1	201	205	PF00082	0.486
CLV_PCSK_SKI1_1	26	30	PF00082	0.374
CLV_PCSK_SKI1_1	273	277	PF00082	0.443
CLV_PCSK_SKI1_1	326	330	PF00082	0.475
CLV_PCSK_SKI1_1	72	76	PF00082	0.563
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DOC_ANK_TNKS_1	50	57	PF00023	0.409
DOC_CYCLIN_RxL_1	270	279	PF00134	0.293
DOC_CYCLIN_RxL_1	323	332	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.319
DOC_MAPK_MEF2A_6	92	100	PF00069	0.324
DOC_MAPK_RevD_3	226	239	PF00069	0.291
DOC_PP1_RVXF_1	199	205	PF00149	0.248
DOC_PP1_RVXF_1	338	344	PF00149	0.452
DOC_PP2B_LxvP_1	137	140	PF13499	0.209
DOC_PP2B_LxvP_1	291	294	PF13499	0.276
DOC_PP4_FxxP_1	99	102	PF00568	0.259
DOC_USP7_MATH_1	248	252	PF00917	0.395
DOC_USP7_MATH_1	372	376	PF00917	0.547
DOC_USP7_UBL2_3	34	38	PF12436	0.703
DOC_WW_Pin1_4	101	106	PF00397	0.306
DOC_WW_Pin1_4	108	113	PF00397	0.283
DOC_WW_Pin1_4	40	45	PF00397	0.733
LIG_14-3-3_CanoR_1	188	192	PF00244	0.294
LIG_14-3-3_CanoR_1	240	249	PF00244	0.370
LIG_14-3-3_CanoR_1	273	281	PF00244	0.336
LIG_14-3-3_CanoR_1	327	336	PF00244	0.357
LIG_14-3-3_CanoR_1	340	344	PF00244	0.475
LIG_14-3-3_CanoR_1	72	77	PF00244	0.414
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.283
LIG_BRCT_BRCA1_1	70	74	PF00533	0.399
LIG_FHA_2	113	119	PF00498	0.307
LIG_FHA_2	169	175	PF00498	0.154
LIG_FHA_2	280	286	PF00498	0.229
LIG_FHA_2	30	36	PF00498	0.663
LIG_FHA_2	356	362	PF00498	0.522
LIG_FHA_2	37	43	PF00498	0.599
LIG_IRF3_LxIS_1	215	222	PF10401	0.374
LIG_LIR_Gen_1	305	316	PF02991	0.355
LIG_LIR_Gen_1	65	74	PF02991	0.367
LIG_LIR_Gen_1	94	105	PF02991	0.278
LIG_LIR_Nem_3	143	149	PF02991	0.297
LIG_LIR_Nem_3	244	249	PF02991	0.335
LIG_LIR_Nem_3	305	311	PF02991	0.325
LIG_LIR_Nem_3	4	9	PF02991	0.517
LIG_LIR_Nem_3	65	70	PF02991	0.383
LIG_LIR_Nem_3	71	77	PF02991	0.383
LIG_LIR_Nem_3	94	100	PF02991	0.370
LIG_MYND_1	108	112	PF01753	0.294
LIG_MYND_1	44	48	PF01753	0.490
LIG_PCNA_PIPBox_1	180	189	PF02747	0.147
LIG_PCNA_yPIPBox_3	178	187	PF02747	0.277
LIG_Pex14_2	6	10	PF04695	0.583
LIG_SH2_CRK	200	204	PF00017	0.248
LIG_SH2_CRK	246	250	PF00017	0.311
LIG_SH2_CRK	289	293	PF00017	0.238
LIG_SH2_CRK	308	312	PF00017	0.277
LIG_SH2_CRK	67	71	PF00017	0.392
LIG_SH2_GRB2like	254	257	PF00017	0.197
LIG_SH2_NCK_1	308	312	PF00017	0.360
LIG_SH2_STAP1	233	237	PF00017	0.308
LIG_SH2_STAP1	254	258	PF00017	0.243
LIG_SH2_STAP1	284	288	PF00017	0.209
LIG_SH2_STAP1	289	293	PF00017	0.210
LIG_SH2_STAP1	308	312	PF00017	0.309
LIG_SH2_STAT3	149	152	PF00017	0.248
LIG_SH2_STAT5	274	277	PF00017	0.308
LIG_SH2_STAT5	297	300	PF00017	0.239
LIG_SH2_STAT5	320	323	PF00017	0.271
LIG_SH2_STAT5	67	70	PF00017	0.316
LIG_SH3_3	342	348	PF00018	0.309
LIG_SH3_3	99	105	PF00018	0.325
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.180
LIG_TRAF2_1	362	365	PF00917	0.480
LIG_TYR_ITIM	126	131	PF00017	0.318
LIG_UBA3_1	317	326	PF00899	0.351
MOD_CDK_SPK_2	40	45	PF00069	0.531
MOD_CDK_SPxxK_3	44	51	PF00069	0.581
MOD_CK1_1	346	352	PF00069	0.431
MOD_CK2_1	1	7	PF00069	0.607
MOD_CK2_1	112	118	PF00069	0.326
MOD_CK2_1	29	35	PF00069	0.631
MOD_CK2_1	355	361	PF00069	0.527
MOD_CK2_1	36	42	PF00069	0.580
MOD_GlcNHglycan	304	307	PF01048	0.586
MOD_GlcNHglycan	333	336	PF01048	0.597
MOD_GlcNHglycan	348	351	PF01048	0.654
MOD_GlcNHglycan	361	364	PF01048	0.565
MOD_GSK3_1	108	115	PF00069	0.330
MOD_GSK3_1	13	20	PF00069	0.648
MOD_GSK3_1	168	175	PF00069	0.218
MOD_GSK3_1	187	194	PF00069	0.279
MOD_GSK3_1	276	283	PF00069	0.258
MOD_GSK3_1	302	309	PF00069	0.380
MOD_GSK3_1	327	334	PF00069	0.367
MOD_GSK3_1	339	346	PF00069	0.397
MOD_GSK3_1	355	362	PF00069	0.522
MOD_GSK3_1	36	43	PF00069	0.546
MOD_GSK3_1	62	69	PF00069	0.381
MOD_N-GLC_1	168	173	PF02516	0.533
MOD_N-GLC_1	279	284	PF02516	0.439
MOD_NEK2_1	1	6	PF00069	0.603
MOD_NEK2_1	172	177	PF00069	0.264
MOD_NEK2_1	219	224	PF00069	0.413
MOD_NEK2_1	241	246	PF00069	0.377
MOD_NEK2_1	276	281	PF00069	0.273
MOD_NEK2_1	304	309	PF00069	0.273
MOD_NEK2_1	329	334	PF00069	0.356
MOD_NEK2_1	343	348	PF00069	0.513
MOD_PIKK_1	46	52	PF00454	0.506
MOD_PKA_2	187	193	PF00069	0.294
MOD_PKA_2	322	328	PF00069	0.258
MOD_PKA_2	339	345	PF00069	0.379
MOD_PKA_2	91	97	PF00069	0.345
MOD_Plk_1	168	174	PF00069	0.359
MOD_Plk_1	191	197	PF00069	0.177
MOD_Plk_1	279	285	PF00069	0.268
MOD_Plk_1	299	305	PF00069	0.203
MOD_Plk_1	355	361	PF00069	0.556
MOD_Plk_4	287	293	PF00069	0.177
MOD_Plk_4	299	305	PF00069	0.258
MOD_Plk_4	312	318	PF00069	0.207
MOD_Plk_4	355	361	PF00069	0.368
MOD_Plk_4	55	61	PF00069	0.218
MOD_ProDKin_1	101	107	PF00069	0.305
MOD_ProDKin_1	108	114	PF00069	0.282
MOD_ProDKin_1	40	46	PF00069	0.726
TRG_DiLeu_BaEn_1	143	148	PF01217	0.248
TRG_DiLeu_BaEn_2	92	98	PF01217	0.289
TRG_ENDOCYTIC_2	128	131	PF00928	0.300
TRG_ENDOCYTIC_2	200	203	PF00928	0.332
TRG_ENDOCYTIC_2	246	249	PF00928	0.299
TRG_ENDOCYTIC_2	289	292	PF00928	0.210
TRG_ENDOCYTIC_2	308	311	PF00928	0.246
TRG_ENDOCYTIC_2	67	70	PF00928	0.280
TRG_ER_diArg_1	151	154	PF00400	0.248
TRG_ER_diArg_1	187	189	PF00400	0.224
TRG_ER_diArg_1	224	227	PF00400	0.322
TRG_ER_diArg_1	51	53	PF00400	0.651
TRG_ER_diArg_1	79	81	PF00400	0.320
TRG_NLS_MonoExtC_3	149	155	PF00514	0.248
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM13	Leptomonas seymouri	60%	85%
A0A0N1PD54	Leptomonas seymouri	30%	100%
A0A0S4JQS8	Bodo saltans	30%	100%
A0A1X0NVT0	Trypanosomatidae	26%	81%
A0A3S5H7D4	Leishmania donovani	81%	100%
A0A422N8G9	Trypanosoma rangeli	29%	100%
A0A422N8I7	Trypanosoma rangeli	30%	93%
E9AH69	Leishmania infantum	81%	100%
E9AX07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4QAG9	Leishmania major	78%	100%
Q95RI5	Drosophila melanogaster	22%	90%
V5BK31	Trypanosoma cruzi	28%	100%
V5DBK9	Trypanosoma cruzi	30%	92%