LeishMANIAdb
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Stability determinant

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Stability determinant
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HDM0_LEIBR
TriTrypDb:
LbrM.24.1660 , LBRM2903_240023800
Length:
66

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDM0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDM0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 19 23 PF00656 0.456
CLV_C14_Caspase3-7 6 10 PF00656 0.433
CLV_NRD_NRD_1 16 18 PF00675 0.665
CLV_NRD_NRD_1 54 56 PF00675 0.651
CLV_PCSK_KEX2_1 16 18 PF00082 0.607
CLV_PCSK_KEX2_1 54 56 PF00082 0.599
LIG_BIR_II_1 1 5 PF00653 0.615
LIG_FHA_2 59 65 PF00498 0.698
LIG_LIR_Gen_1 25 33 PF02991 0.506
LIG_LIR_Nem_3 25 30 PF02991 0.511
LIG_PDZ_Class_3 61 66 PF00595 0.508
LIG_SH2_STAT5 60 63 PF00017 0.625
LIG_SH3_3 27 33 PF00018 0.504
MOD_CK1_1 35 41 PF00069 0.621
MOD_CK2_1 7 13 PF00069 0.646
MOD_GlcNHglycan 9 12 PF01048 0.638
MOD_N-GLC_1 7 12 PF02516 0.554
MOD_PIKK_1 1 7 PF00454 0.609
TRG_ER_diArg_1 15 17 PF00400 0.608
TRG_ER_diArg_1 53 55 PF00400 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WYK1 Leishmania donovani 74% 100%
E9AH67 Leishmania infantum 74% 100%
E9AX05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
Q4QAH1 Leishmania major 74% 95%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS