Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDL9_LEIBR

TriTrypDb:

LbrM.24.1650 , LBRM2903_240023700

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.588
CLV_C14_Caspase3-7	413	417	PF00656	0.712
CLV_NRD_NRD_1	267	269	PF00675	0.632
CLV_NRD_NRD_1	289	291	PF00675	0.695
CLV_NRD_NRD_1	381	383	PF00675	0.833
CLV_NRD_NRD_1	435	437	PF00675	0.593
CLV_PCSK_FUR_1	378	382	PF00082	0.850
CLV_PCSK_KEX2_1	267	269	PF00082	0.608
CLV_PCSK_KEX2_1	377	379	PF00082	0.851
CLV_PCSK_KEX2_1	380	382	PF00082	0.799
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.851
CLV_PCSK_PC7_1	373	379	PF00082	0.850
CLV_PCSK_SKI1_1	145	149	PF00082	0.349
CLV_PCSK_SKI1_1	24	28	PF00082	0.779
CLV_PCSK_SKI1_1	279	283	PF00082	0.744
CLV_Separin_Metazoa	162	166	PF03568	0.575
DEG_APCC_DBOX_1	111	119	PF00400	0.569
DEG_APCC_DBOX_1	547	555	PF00400	0.512
DEG_APCC_DBOX_1	8	16	PF00400	0.612
DEG_Nend_UBRbox_2	1	3	PF02207	0.465
DEG_SPOP_SBC_1	426	430	PF00917	0.673
DOC_CYCLIN_RxL_1	140	151	PF00134	0.432
DOC_MAPK_gen_1	143	152	PF00069	0.494
DOC_MAPK_MEF2A_6	143	152	PF00069	0.502
DOC_MAPK_NFAT4_5	143	151	PF00069	0.564
DOC_PP2B_LxvP_1	34	37	PF13499	0.825
DOC_USP7_MATH_1	136	140	PF00917	0.379
DOC_USP7_MATH_1	29	33	PF00917	0.620
DOC_USP7_MATH_1	299	303	PF00917	0.695
DOC_USP7_MATH_1	37	41	PF00917	0.708
DOC_USP7_MATH_1	425	429	PF00917	0.665
DOC_USP7_MATH_1	517	521	PF00917	0.601
DOC_WW_Pin1_4	295	300	PF00397	0.727
DOC_WW_Pin1_4	305	310	PF00397	0.786
DOC_WW_Pin1_4	495	500	PF00397	0.670
LIG_14-3-3_CanoR_1	122	131	PF00244	0.421
LIG_14-3-3_CanoR_1	132	136	PF00244	0.471
LIG_14-3-3_CanoR_1	149	153	PF00244	0.503
LIG_14-3-3_CanoR_1	254	264	PF00244	0.460
LIG_14-3-3_CanoR_1	331	336	PF00244	0.692
LIG_14-3-3_CanoR_1	527	531	PF00244	0.477
LIG_14-3-3_CanoR_1	546	552	PF00244	0.521
LIG_Actin_WH2_2	8	26	PF00022	0.667
LIG_deltaCOP1_diTrp_1	205	210	PF00928	0.578
LIG_FHA_1	101	107	PF00498	0.664
LIG_FHA_1	142	148	PF00498	0.304
LIG_FHA_1	416	422	PF00498	0.792
LIG_FHA_1	482	488	PF00498	0.555
LIG_FHA_1	60	66	PF00498	0.578
LIG_FHA_2	386	392	PF00498	0.596
LIG_FHA_2	537	543	PF00498	0.704
LIG_FHA_2	548	554	PF00498	0.570
LIG_GBD_Chelix_1	50	58	PF00786	0.619
LIG_LIR_Gen_1	204	215	PF02991	0.615
LIG_LIR_Nem_3	17	22	PF02991	0.533
LIG_LIR_Nem_3	204	210	PF02991	0.614
LIG_LYPXL_yS_3	19	22	PF13949	0.703
LIG_NRBOX	11	17	PF00104	0.618
LIG_NRBOX	353	359	PF00104	0.564
LIG_PCNA_yPIPBox_3	70	80	PF02747	0.365
LIG_Pex14_1	531	535	PF04695	0.460
LIG_SH2_CRK	257	261	PF00017	0.443
LIG_SH2_NCK_1	257	261	PF00017	0.695
LIG_SH2_SRC	263	266	PF00017	0.489
LIG_SH2_STAT3	256	259	PF00017	0.685
LIG_SH2_STAT5	129	132	PF00017	0.573
LIG_SH2_STAT5	257	260	PF00017	0.531
LIG_SH2_STAT5	263	266	PF00017	0.593
LIG_SH3_3	214	220	PF00018	0.611
LIG_SH3_3	23	29	PF00018	0.594
LIG_SH3_3	266	272	PF00018	0.755
LIG_SH3_3	303	309	PF00018	0.592
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.559
LIG_SUMO_SIM_par_1	78	84	PF11976	0.573
LIG_TRAF2_1	114	117	PF00917	0.446
LIG_TRAF2_1	420	423	PF00917	0.573
LIG_TRAF2_1	444	447	PF00917	0.571
MOD_CDC14_SPxK_1	298	301	PF00782	0.584
MOD_CDK_SPxK_1	295	301	PF00069	0.585
MOD_CK1_1	190	196	PF00069	0.671
MOD_CK1_1	250	256	PF00069	0.634
MOD_CK1_1	295	301	PF00069	0.585
MOD_CK1_1	347	353	PF00069	0.810
MOD_CK1_1	363	369	PF00069	0.568
MOD_CK1_1	384	390	PF00069	0.850
MOD_CK1_1	415	421	PF00069	0.767
MOD_CK1_1	495	501	PF00069	0.650
MOD_CK1_1	521	527	PF00069	0.552
MOD_CK1_1	547	553	PF00069	0.499
MOD_CK2_1	297	303	PF00069	0.841
MOD_CK2_1	385	391	PF00069	0.703
MOD_CK2_1	417	423	PF00069	0.830
MOD_CK2_1	536	542	PF00069	0.703
MOD_CK2_1	75	81	PF00069	0.571
MOD_CMANNOS	531	534	PF00535	0.709
MOD_Cter_Amidation	265	268	PF01082	0.513
MOD_GlcNHglycan	201	204	PF01048	0.422
MOD_GlcNHglycan	243	246	PF01048	0.573
MOD_GlcNHglycan	247	252	PF01048	0.605
MOD_GlcNHglycan	272	275	PF01048	0.719
MOD_GlcNHglycan	294	297	PF01048	0.676
MOD_GlcNHglycan	405	408	PF01048	0.618
MOD_GlcNHglycan	46	50	PF01048	0.709
MOD_GlcNHglycan	514	517	PF01048	0.697
MOD_GSK3_1	183	190	PF00069	0.515
MOD_GSK3_1	246	253	PF00069	0.594
MOD_GSK3_1	255	262	PF00069	0.491
MOD_GSK3_1	295	302	PF00069	0.679
MOD_GSK3_1	305	312	PF00069	0.819
MOD_GSK3_1	344	351	PF00069	0.823
MOD_GSK3_1	353	360	PF00069	0.669
MOD_GSK3_1	381	388	PF00069	0.635
MOD_GSK3_1	403	410	PF00069	0.794
MOD_GSK3_1	411	418	PF00069	0.747
MOD_GSK3_1	421	428	PF00069	0.567
MOD_GSK3_1	472	479	PF00069	0.671
MOD_GSK3_1	517	524	PF00069	0.608
MOD_GSK3_1	536	543	PF00069	0.596
MOD_GSK3_1	59	66	PF00069	0.583
MOD_GSK3_1	94	101	PF00069	0.576
MOD_N-GLC_1	344	349	PF02516	0.824
MOD_N-GLC_1	411	416	PF02516	0.791
MOD_N-GLC_1	426	431	PF02516	0.554
MOD_N-GLC_1	495	500	PF02516	0.617
MOD_N-GLC_2	417	419	PF02516	0.621
MOD_NEK2_1	148	153	PF00069	0.339
MOD_NEK2_1	241	246	PF00069	0.528
MOD_NEK2_1	357	362	PF00069	0.567
MOD_NEK2_1	501	506	PF00069	0.609
MOD_NEK2_1	511	516	PF00069	0.656
MOD_NEK2_1	526	531	PF00069	0.448
MOD_PIKK_1	122	128	PF00454	0.578
MOD_PIKK_1	255	261	PF00454	0.691
MOD_PIKK_1	357	363	PF00454	0.725
MOD_PIKK_1	37	43	PF00454	0.666
MOD_PIKK_1	98	104	PF00454	0.469
MOD_PK_1	63	69	PF00069	0.592
MOD_PKA_1	267	273	PF00069	0.497
MOD_PKA_1	381	387	PF00069	0.596
MOD_PKA_2	131	137	PF00069	0.412
MOD_PKA_2	148	154	PF00069	0.508
MOD_PKA_2	267	273	PF00069	0.749
MOD_PKA_2	372	378	PF00069	0.595
MOD_PKA_2	381	387	PF00069	0.561
MOD_PKA_2	526	532	PF00069	0.473
MOD_PKA_2	547	553	PF00069	0.596
MOD_PKB_1	120	128	PF00069	0.584
MOD_PKB_1	379	387	PF00069	0.847
MOD_Plk_1	344	350	PF00069	0.822
MOD_Plk_1	421	427	PF00069	0.565
MOD_Plk_1	544	550	PF00069	0.482
MOD_Plk_1	59	65	PF00069	0.403
MOD_Plk_2-3	483	489	PF00069	0.549
MOD_Plk_4	14	20	PF00069	0.505
MOD_Plk_4	183	189	PF00069	0.513
MOD_Plk_4	206	212	PF00069	0.615
MOD_Plk_4	259	265	PF00069	0.533
MOD_Plk_4	29	35	PF00069	0.525
MOD_Plk_4	353	359	PF00069	0.617
MOD_Plk_4	427	433	PF00069	0.814
MOD_Plk_4	526	532	PF00069	0.473
MOD_ProDKin_1	295	301	PF00069	0.727
MOD_ProDKin_1	305	311	PF00069	0.786
MOD_ProDKin_1	495	501	PF00069	0.672
TRG_ENDOCYTIC_2	19	22	PF00928	0.703
TRG_ENDOCYTIC_2	257	260	PF00928	0.687
TRG_ER_diArg_1	142	145	PF00400	0.542
TRG_ER_diArg_1	267	269	PF00400	0.493
TRG_ER_diArg_1	378	381	PF00400	0.850
TRG_ER_diArg_1	546	549	PF00400	0.589
TRG_ER_diArg_1	6	9	PF00400	0.371
TRG_NLS_MonoCore_2	375	380	PF00514	0.848
TRG_NLS_MonoExtC_3	375	380	PF00514	0.848
TRG_NLS_MonoExtN_4	373	380	PF00514	0.848

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYG0	Leishmania donovani	69%	100%
E9AH66	Leishmania infantum	69%	100%
E9AX04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QAH2	Leishmania major	66%	100%