UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDL8_LEIBR

TriTrypDb:

LbrM.24.1640 , LBRM2903_240023600

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HDL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.702
CLV_NRD_NRD_1	321	323	PF00675	0.468
CLV_NRD_NRD_1	345	347	PF00675	0.566
CLV_NRD_NRD_1	85	87	PF00675	0.364
CLV_PCSK_FUR_1	319	323	PF00082	0.511
CLV_PCSK_KEX2_1	191	193	PF00082	0.702
CLV_PCSK_KEX2_1	321	323	PF00082	0.469
CLV_PCSK_KEX2_1	345	347	PF00082	0.571
CLV_PCSK_KEX2_1	51	53	PF00082	0.602
CLV_PCSK_KEX2_1	85	87	PF00082	0.361
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.647
CLV_PCSK_PC7_1	317	323	PF00082	0.530
CLV_PCSK_PC7_1	81	87	PF00082	0.342
CLV_PCSK_SKI1_1	176	180	PF00082	0.301
CLV_PCSK_SKI1_1	237	241	PF00082	0.376
CLV_PCSK_SKI1_1	244	248	PF00082	0.360
CLV_PCSK_SKI1_1	51	55	PF00082	0.645
DEG_APCC_DBOX_1	203	211	PF00400	0.376
DEG_APCC_DBOX_1	236	244	PF00400	0.574
DEG_APCC_DBOX_1	51	59	PF00400	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.453
DEG_SCF_FBW7_1	40	46	PF00400	0.223
DOC_CDC14_PxL_1	169	177	PF14671	0.358
DOC_CKS1_1	40	45	PF01111	0.223
DOC_CYCLIN_RxL_1	26	39	PF00134	0.522
DOC_CYCLIN_RxL_1	48	57	PF00134	0.535
DOC_MAPK_DCC_7	167	177	PF00069	0.307
DOC_MAPK_gen_1	191	199	PF00069	0.366
DOC_MAPK_HePTP_8	230	242	PF00069	0.603
DOC_MAPK_MEF2A_6	167	174	PF00069	0.260
DOC_MAPK_MEF2A_6	191	199	PF00069	0.359
DOC_MAPK_MEF2A_6	233	242	PF00069	0.567
DOC_MAPK_NFAT4_5	167	175	PF00069	0.223
DOC_PP1_RVXF_1	29	36	PF00149	0.527
DOC_PP4_FxxP_1	242	245	PF00568	0.591
DOC_USP7_MATH_1	43	47	PF00917	0.350
DOC_WW_Pin1_4	131	136	PF00397	0.223
DOC_WW_Pin1_4	327	332	PF00397	0.597
DOC_WW_Pin1_4	345	350	PF00397	0.772
DOC_WW_Pin1_4	39	44	PF00397	0.371
LIG_14-3-3_CanoR_1	125	133	PF00244	0.332
LIG_14-3-3_CanoR_1	150	154	PF00244	0.715
LIG_14-3-3_CanoR_1	225	231	PF00244	0.611
LIG_14-3-3_CanoR_1	244	253	PF00244	0.628
LIG_14-3-3_CanoR_1	345	349	PF00244	0.690
LIG_Actin_WH2_2	132	147	PF00022	0.432
LIG_eIF4E_1	234	240	PF01652	0.633
LIG_FHA_1	10	16	PF00498	0.354
LIG_FHA_1	139	145	PF00498	0.344
LIG_FHA_1	245	251	PF00498	0.570
LIG_FHA_2	161	167	PF00498	0.520
LIG_FHA_2	308	314	PF00498	0.701
LIG_FHA_2	359	365	PF00498	0.516
LIG_IRF3_LxIS_1	11	16	PF10401	0.449
LIG_IRF3_LxIS_1	59	66	PF10401	0.449
LIG_LIR_Gen_1	203	214	PF02991	0.385
LIG_LIR_Gen_1	69	78	PF02991	0.450
LIG_LIR_Gen_1	89	100	PF02991	0.478
LIG_LIR_Nem_3	203	209	PF02991	0.376
LIG_LIR_Nem_3	229	234	PF02991	0.659
LIG_LIR_Nem_3	28	33	PF02991	0.636
LIG_LIR_Nem_3	69	74	PF02991	0.437
LIG_LIR_Nem_3	89	95	PF02991	0.476
LIG_Pex14_1	227	231	PF04695	0.563
LIG_Pex14_2	251	255	PF04695	0.700
LIG_PTB_Apo_2	29	36	PF02174	0.680
LIG_SH2_CRK	30	34	PF00017	0.522
LIG_SH2_STAT5	143	146	PF00017	0.470
LIG_SH2_STAT5	27	30	PF00017	0.654
LIG_SH2_STAT5	300	303	PF00017	0.653
LIG_SH3_3	175	181	PF00018	0.397
LIG_SH3_3	56	62	PF00018	0.360
LIG_SUMO_SIM_anti_2	9	17	PF11976	0.439
LIG_SUMO_SIM_par_1	11	17	PF11976	0.418
LIG_TRAF2_1	310	313	PF00917	0.714
LIG_TRAF2_1	348	351	PF00917	0.744
LIG_TRAF2_1	361	364	PF00917	0.677
LIG_UBA3_1	169	176	PF00899	0.410
LIG_WRC_WIRS_1	187	192	PF05994	0.352
LIG_WRC_WIRS_1	44	49	PF05994	0.223
LIG_WW_3	147	151	PF00397	0.508
MOD_CDK_SPK_2	327	332	PF00069	0.597
MOD_CK1_1	16	22	PF00069	0.375
MOD_CK1_1	215	221	PF00069	0.452
MOD_CK2_1	160	166	PF00069	0.456
MOD_CK2_1	307	313	PF00069	0.640
MOD_CK2_1	345	351	PF00069	0.779
MOD_CK2_1	358	364	PF00069	0.503
MOD_CK2_1	367	373	PF00069	0.664
MOD_GlcNHglycan	113	116	PF01048	0.619
MOD_GlcNHglycan	127	130	PF01048	0.347
MOD_GlcNHglycan	136	139	PF01048	0.330
MOD_GlcNHglycan	19	22	PF01048	0.356
MOD_GlcNHglycan	263	266	PF01048	0.452
MOD_GlcNHglycan	280	283	PF01048	0.477
MOD_GlcNHglycan	98	101	PF01048	0.364
MOD_GSK3_1	113	120	PF00069	0.415
MOD_GSK3_1	125	132	PF00069	0.288
MOD_GSK3_1	134	141	PF00069	0.331
MOD_GSK3_1	212	219	PF00069	0.245
MOD_GSK3_1	303	310	PF00069	0.738
MOD_GSK3_1	39	46	PF00069	0.315
MOD_GSK3_1	9	16	PF00069	0.367
MOD_LATS_1	259	265	PF00433	0.606
MOD_N-GLC_1	160	165	PF02516	0.345
MOD_N-GLC_1	367	372	PF02516	0.507
MOD_NEK2_1	13	18	PF00069	0.379
MOD_NEK2_1	216	221	PF00069	0.375
MOD_NEK2_1	378	383	PF00069	0.672
MOD_NEK2_1	54	59	PF00069	0.425
MOD_NEK2_1	63	68	PF00069	0.349
MOD_NEK2_1	95	100	PF00069	0.328
MOD_NEK2_2	138	143	PF00069	0.475
MOD_NEK2_2	226	231	PF00069	0.617
MOD_PIKK_1	180	186	PF00454	0.448
MOD_PK_1	117	123	PF00069	0.482
MOD_PKA_2	149	155	PF00069	0.718
MOD_PKA_2	344	350	PF00069	0.759
MOD_Plk_1	160	166	PF00069	0.497
MOD_Plk_1	307	313	PF00069	0.660
MOD_Plk_4	226	232	PF00069	0.626
MOD_Plk_4	88	94	PF00069	0.486
MOD_Plk_4	9	15	PF00069	0.391
MOD_ProDKin_1	131	137	PF00069	0.223
MOD_ProDKin_1	327	333	PF00069	0.600
MOD_ProDKin_1	345	351	PF00069	0.769
MOD_ProDKin_1	39	45	PF00069	0.371
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.291
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.609
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.633
TRG_ENDOCYTIC_2	30	33	PF00928	0.697
TRG_ENDOCYTIC_2	92	95	PF00928	0.455
TRG_ER_diArg_1	190	192	PF00400	0.504
TRG_ER_diArg_1	314	317	PF00400	0.701
TRG_ER_diArg_1	318	321	PF00400	0.693
TRG_ER_diArg_1	85	87	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM84	Leptomonas seymouri	58%	100%
A0A0S4JKW6	Bodo saltans	24%	97%
A0A1X0NVU5	Trypanosomatidae	34%	100%
A0A3S7WYG8	Leishmania donovani	84%	100%
A0A422N8E9	Trypanosoma rangeli	33%	100%
C9ZWE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AH65	Leishmania infantum	84%	100%
E9AX03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAH3	Leishmania major	83%	100%
V5AVK1	Trypanosoma cruzi	34%	100%