Putative DNAJ-domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDL7_LEIBR

TriTrypDb:

LbrM.24.1630 , LBRM2903_240020800

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.466
CLV_C14_Caspase3-7	486	490	PF00656	0.575
CLV_C14_Caspase3-7	491	495	PF00656	0.591
CLV_C14_Caspase3-7	652	656	PF00656	0.586
CLV_C14_Caspase3-7	746	750	PF00656	0.538
CLV_C14_Caspase3-7	774	778	PF00656	0.433
CLV_NRD_NRD_1	156	158	PF00675	0.573
CLV_NRD_NRD_1	163	165	PF00675	0.535
CLV_NRD_NRD_1	215	217	PF00675	0.510
CLV_NRD_NRD_1	222	224	PF00675	0.459
CLV_NRD_NRD_1	3	5	PF00675	0.718
CLV_NRD_NRD_1	746	748	PF00675	0.639
CLV_NRD_NRD_1	752	754	PF00675	0.466
CLV_NRD_NRD_1	85	87	PF00675	0.764
CLV_PCSK_FUR_1	555	559	PF00082	0.293
CLV_PCSK_KEX2_1	156	158	PF00082	0.573
CLV_PCSK_KEX2_1	163	165	PF00082	0.535
CLV_PCSK_KEX2_1	215	217	PF00082	0.586
CLV_PCSK_KEX2_1	221	223	PF00082	0.553
CLV_PCSK_KEX2_1	3	5	PF00082	0.718
CLV_PCSK_KEX2_1	547	549	PF00082	0.502
CLV_PCSK_KEX2_1	557	559	PF00082	0.473
CLV_PCSK_KEX2_1	85	87	PF00082	0.764
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.356
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.336
CLV_PCSK_PC7_1	543	549	PF00082	0.446
CLV_PCSK_SKI1_1	14	18	PF00082	0.422
CLV_PCSK_SKI1_1	216	220	PF00082	0.599
CLV_PCSK_SKI1_1	513	517	PF00082	0.533
CLV_PCSK_SKI1_1	536	540	PF00082	0.384
CLV_PCSK_SKI1_1	543	547	PF00082	0.372
CLV_PCSK_SKI1_1	557	561	PF00082	0.515
CLV_PCSK_SKI1_1	569	573	PF00082	0.369
CLV_PCSK_SKI1_1	67	71	PF00082	0.407
CLV_PCSK_SKI1_1	742	746	PF00082	0.439
CLV_PCSK_SKI1_1	86	90	PF00082	0.483
CLV_PCSK_SKI1_1	9	13	PF00082	0.482
DEG_APCC_DBOX_1	13	21	PF00400	0.445
DEG_APCC_DBOX_1	535	543	PF00400	0.521
DEG_APCC_DBOX_1	66	74	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DOC_CDC14_PxL_1	365	373	PF14671	0.333
DOC_CKS1_1	10	15	PF01111	0.583
DOC_CKS1_1	143	148	PF01111	0.589
DOC_CKS1_1	434	439	PF01111	0.425
DOC_CYCLIN_RxL_1	14	25	PF00134	0.335
DOC_CYCLIN_yClb1_LxF_4	726	732	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	682	688	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	781	787	PF00134	0.365
DOC_MAPK_gen_1	332	339	PF00069	0.429
DOC_MAPK_gen_1	501	510	PF00069	0.558
DOC_MAPK_gen_1	533	542	PF00069	0.249
DOC_MAPK_MEF2A_6	205	214	PF00069	0.486
DOC_MAPK_MEF2A_6	332	339	PF00069	0.383
DOC_MAPK_NFAT4_5	332	340	PF00069	0.386
DOC_PP2B_LxvP_1	781	784	PF13499	0.351
DOC_PP4_FxxP_1	123	126	PF00568	0.495
DOC_PP4_FxxP_1	143	146	PF00568	0.556
DOC_PP4_FxxP_1	263	266	PF00568	0.495
DOC_USP7_MATH_1	101	105	PF00917	0.664
DOC_USP7_MATH_1	311	315	PF00917	0.477
DOC_USP7_MATH_1	430	434	PF00917	0.530
DOC_WW_Pin1_4	122	127	PF00397	0.654
DOC_WW_Pin1_4	142	147	PF00397	0.585
DOC_WW_Pin1_4	20	25	PF00397	0.285
DOC_WW_Pin1_4	26	31	PF00397	0.242
DOC_WW_Pin1_4	418	423	PF00397	0.417
DOC_WW_Pin1_4	433	438	PF00397	0.443
DOC_WW_Pin1_4	478	483	PF00397	0.729
DOC_WW_Pin1_4	503	508	PF00397	0.595
DOC_WW_Pin1_4	584	589	PF00397	0.526
DOC_WW_Pin1_4	755	760	PF00397	0.502
DOC_WW_Pin1_4	766	771	PF00397	0.450
DOC_WW_Pin1_4	9	14	PF00397	0.491
LIG_14-3-3_CanoR_1	163	169	PF00244	0.549
LIG_14-3-3_CanoR_1	18	23	PF00244	0.386
LIG_14-3-3_CanoR_1	300	308	PF00244	0.566
LIG_14-3-3_CanoR_1	444	450	PF00244	0.347
LIG_14-3-3_CanoR_1	60	68	PF00244	0.313
LIG_14-3-3_CanoR_1	650	655	PF00244	0.660
LIG_14-3-3_CanoR_1	753	759	PF00244	0.588
LIG_14-3-3_CanoR_1	85	95	PF00244	0.721
LIG_Actin_WH2_2	528	545	PF00022	0.383
LIG_APCC_ABBA_1	616	621	PF00400	0.542
LIG_APCC_ABBA_1	633	638	PF00400	0.374
LIG_BIR_III_2	479	483	PF00653	0.482
LIG_BRCT_BRCA1_1	62	66	PF00533	0.378
LIG_CtBP_PxDLS_1	484	488	PF00389	0.494
LIG_FHA_1	143	149	PF00498	0.642
LIG_FHA_1	191	197	PF00498	0.540
LIG_FHA_1	23	29	PF00498	0.363
LIG_FHA_1	434	440	PF00498	0.560
LIG_FHA_1	465	471	PF00498	0.489
LIG_FHA_1	530	536	PF00498	0.451
LIG_FHA_1	687	693	PF00498	0.486
LIG_FHA_1	763	769	PF00498	0.336
LIG_FHA_1	88	94	PF00498	0.489
LIG_FHA_2	145	151	PF00498	0.642
LIG_FHA_2	604	610	PF00498	0.396
LIG_FHA_2	755	761	PF00498	0.459
LIG_HP1_1	254	258	PF01393	0.495
LIG_LIR_Apic_2	120	126	PF02991	0.570
LIG_LIR_Gen_1	226	236	PF02991	0.557
LIG_LIR_Gen_1	272	282	PF02991	0.474
LIG_LIR_Gen_1	329	338	PF02991	0.405
LIG_LIR_Gen_1	573	579	PF02991	0.543
LIG_LIR_Nem_3	226	232	PF02991	0.546
LIG_LIR_Nem_3	272	277	PF02991	0.474
LIG_LIR_Nem_3	329	333	PF02991	0.401
LIG_LIR_Nem_3	57	62	PF02991	0.273
LIG_LIR_Nem_3	573	578	PF02991	0.596
LIG_LIR_Nem_3	611	616	PF02991	0.339
LIG_LYPXL_L_2	309	318	PF13949	0.479
LIG_MYND_1	46	50	PF01753	0.271
LIG_NRBOX	791	797	PF00104	0.424
LIG_PDZ_Class_2	802	807	PF00595	0.581
LIG_Pex14_1	613	617	PF04695	0.422
LIG_Pex14_2	636	640	PF04695	0.502
LIG_Pex14_2	731	735	PF04695	0.328
LIG_REV1ctd_RIR_1	188	198	PF16727	0.493
LIG_REV1ctd_RIR_1	507	517	PF16727	0.361
LIG_SH2_CRK	591	595	PF00017	0.490
LIG_SH2_SRC	195	198	PF00017	0.483
LIG_SH2_STAT3	37	40	PF00017	0.289
LIG_SH2_STAT3	96	99	PF00017	0.539
LIG_SH2_STAT5	195	198	PF00017	0.495
LIG_SH2_STAT5	224	227	PF00017	0.488
LIG_SH2_STAT5	229	232	PF00017	0.520
LIG_SH2_STAT5	37	40	PF00017	0.271
LIG_SH2_STAT5	617	620	PF00017	0.430
LIG_SH2_STAT5	622	625	PF00017	0.391
LIG_SH2_STAT5	716	719	PF00017	0.375
LIG_SH2_STAT5	728	731	PF00017	0.368
LIG_SH3_3	124	130	PF00018	0.573
LIG_SH3_3	47	53	PF00018	0.289
LIG_SH3_3	638	644	PF00018	0.508
LIG_SH3_3	7	13	PF00018	0.619
LIG_SH3_3	718	724	PF00018	0.381
LIG_SH3_3	796	802	PF00018	0.412
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.454
LIG_SUMO_SIM_anti_2	788	794	PF11976	0.352
LIG_SUMO_SIM_par_1	18	23	PF11976	0.470
LIG_SUMO_SIM_par_1	764	769	PF11976	0.299
LIG_TRAF2_1	408	411	PF00917	0.333
LIG_TRFH_1	561	565	PF08558	0.444
LIG_UBA3_1	539	547	PF00899	0.377
LIG_WRC_WIRS_1	165	170	PF05994	0.610
LIG_WRC_WIRS_1	728	733	PF05994	0.332
MOD_CDC14_SPxK_1	769	772	PF00782	0.467
MOD_CDK_SPK_2	9	14	PF00069	0.474
MOD_CDK_SPxK_1	766	772	PF00069	0.445
MOD_CK1_1	125	131	PF00069	0.717
MOD_CK1_1	284	290	PF00069	0.692
MOD_CK1_1	358	364	PF00069	0.629
MOD_CK1_1	372	378	PF00069	0.323
MOD_CK1_1	418	424	PF00069	0.471
MOD_CK1_1	433	439	PF00069	0.434
MOD_CK1_1	503	509	PF00069	0.391
MOD_CK1_1	519	525	PF00069	0.282
MOD_CK1_1	666	672	PF00069	0.542
MOD_CK1_1	87	93	PF00069	0.769
MOD_CK2_1	515	521	PF00069	0.522
MOD_CK2_1	603	609	PF00069	0.403
MOD_CK2_1	754	760	PF00069	0.456
MOD_Cter_Amidation	83	86	PF01082	0.629
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.516
MOD_GlcNHglycan	180	183	PF01048	0.559
MOD_GlcNHglycan	199	202	PF01048	0.360
MOD_GlcNHglycan	283	286	PF01048	0.725
MOD_GlcNHglycan	346	349	PF01048	0.405
MOD_GlcNHglycan	354	360	PF01048	0.555
MOD_GlcNHglycan	373	377	PF01048	0.490
MOD_GlcNHglycan	518	521	PF01048	0.503
MOD_GlcNHglycan	665	668	PF01048	0.490
MOD_GlcNHglycan	86	89	PF01048	0.719
MOD_GSK3_1	121	128	PF00069	0.730
MOD_GSK3_1	18	25	PF00069	0.311
MOD_GSK3_1	281	288	PF00069	0.635
MOD_GSK3_1	354	361	PF00069	0.608
MOD_GSK3_1	488	495	PF00069	0.718
MOD_GSK3_1	515	522	PF00069	0.515
MOD_GSK3_1	523	530	PF00069	0.389
MOD_GSK3_1	549	556	PF00069	0.476
MOD_GSK3_1	573	580	PF00069	0.650
MOD_GSK3_1	727	734	PF00069	0.371
MOD_GSK3_1	762	769	PF00069	0.556
MOD_N-GLC_1	553	558	PF02516	0.434
MOD_N-GLC_1	60	65	PF02516	0.421
MOD_NEK2_1	176	181	PF00069	0.628
MOD_NEK2_1	190	195	PF00069	0.551
MOD_NEK2_1	515	520	PF00069	0.500
MOD_NEK2_1	523	528	PF00069	0.340
MOD_NEK2_1	731	736	PF00069	0.364
MOD_NEK2_2	101	106	PF00069	0.630
MOD_PIKK_1	488	494	PF00454	0.640
MOD_PKA_1	753	759	PF00069	0.387
MOD_PKA_2	299	305	PF00069	0.531
MOD_PKA_2	450	456	PF00069	0.373
MOD_PKA_2	649	655	PF00069	0.671
MOD_PKA_2	702	708	PF00069	0.539
MOD_PKA_2	84	90	PF00069	0.626
MOD_Plk_1	149	155	PF00069	0.594
MOD_Plk_1	278	284	PF00069	0.600
MOD_Plk_1	409	415	PF00069	0.483
MOD_Plk_1	573	579	PF00069	0.530
MOD_Plk_1	696	702	PF00069	0.372
MOD_Plk_2-3	326	332	PF00069	0.417
MOD_Plk_4	171	177	PF00069	0.389
MOD_Plk_4	435	441	PF00069	0.454
MOD_Plk_4	483	489	PF00069	0.494
MOD_Plk_4	519	525	PF00069	0.574
MOD_Plk_4	727	733	PF00069	0.335
MOD_Plk_4	762	768	PF00069	0.405
MOD_ProDKin_1	122	128	PF00069	0.658
MOD_ProDKin_1	142	148	PF00069	0.585
MOD_ProDKin_1	20	26	PF00069	0.285
MOD_ProDKin_1	418	424	PF00069	0.405
MOD_ProDKin_1	433	439	PF00069	0.434
MOD_ProDKin_1	478	484	PF00069	0.735
MOD_ProDKin_1	503	509	PF00069	0.579
MOD_ProDKin_1	584	590	PF00069	0.529
MOD_ProDKin_1	755	761	PF00069	0.500
MOD_ProDKin_1	766	772	PF00069	0.459
MOD_ProDKin_1	9	15	PF00069	0.488
MOD_SUMO_for_1	333	336	PF00179	0.435
MOD_SUMO_for_1	571	574	PF00179	0.496
MOD_SUMO_rev_2	298	308	PF00179	0.416
MOD_SUMO_rev_2	652	661	PF00179	0.407
TRG_DiLeu_BaEn_1	435	440	PF01217	0.415
TRG_DiLeu_BaEn_4	410	416	PF01217	0.355
TRG_ENDOCYTIC_2	229	232	PF00928	0.560
TRG_ENDOCYTIC_2	637	640	PF00928	0.532
TRG_ENDOCYTIC_2	728	731	PF00928	0.371
TRG_ER_diArg_1	162	164	PF00400	0.544
TRG_ER_diArg_1	2	4	PF00400	0.712
TRG_ER_diArg_1	214	216	PF00400	0.589
TRG_ER_diArg_1	221	223	PF00400	0.547
TRG_ER_diArg_1	540	543	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JIX4	Bodo saltans	28%	75%
A0A1X0NVN0	Trypanosomatidae	41%	97%
A0A3Q8ICX0	Leishmania donovani	88%	100%
A0A422NQ56	Trypanosoma rangeli	40%	96%
A4I0W8	Leishmania infantum	88%	100%
D0A799	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9AWX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAK2	Leishmania major	87%	100%
V5BAJ1	Trypanosoma cruzi	40%	96%