Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDL5_LEIBR

TriTrypDb:

LbrM.24.1610 , LBRM2903_240020600

Length:

308

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4HDL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.467
CLV_PCSK_KEX2_1	190	192	PF00082	0.465
DEG_APCC_DBOX_1	33	41	PF00400	0.571
DEG_Nend_UBRbox_3	1	3	PF02207	0.563
DOC_CKS1_1	149	154	PF01111	0.476
DOC_CKS1_1	156	161	PF01111	0.325
DOC_CKS1_1	55	60	PF01111	0.562
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.552
DOC_MAPK_gen_1	295	305	PF00069	0.529
DOC_MAPK_MEF2A_6	298	305	PF00069	0.536
DOC_PP2B_LxvP_1	108	111	PF13499	0.559
DOC_PP2B_LxvP_1	112	115	PF13499	0.544
DOC_PP2B_LxvP_1	9	12	PF13499	0.575
DOC_PP4_FxxP_1	156	159	PF00568	0.250
DOC_PP4_FxxP_1	55	58	PF00568	0.555
DOC_WW_Pin1_4	148	153	PF00397	0.508
DOC_WW_Pin1_4	155	160	PF00397	0.340
DOC_WW_Pin1_4	54	59	PF00397	0.573
DOC_WW_Pin1_4	71	76	PF00397	0.567
DOC_WW_Pin1_4	93	98	PF00397	0.582
LIG_14-3-3_CanoR_1	190	196	PF00244	0.228
LIG_14-3-3_CanoR_1	34	38	PF00244	0.569
LIG_BRCT_BRCA1_1	4	8	PF00533	0.581
LIG_eIF4E_1	45	51	PF01652	0.557
LIG_eIF4E_1	64	70	PF01652	0.535
LIG_FHA_1	45	51	PF00498	0.562
LIG_FHA_1	98	104	PF00498	0.585
LIG_LIR_Apic_2	153	159	PF02991	0.248
LIG_LIR_Apic_2	291	296	PF02991	0.487
LIG_LIR_Apic_2	52	58	PF02991	0.557
LIG_LIR_Gen_1	135	143	PF02991	0.249
LIG_LIR_Gen_1	244	252	PF02991	0.245
LIG_LIR_Gen_1	268	276	PF02991	0.342
LIG_LIR_Gen_1	5	14	PF02991	0.575
LIG_LIR_LC3C_4	98	103	PF02991	0.582
LIG_LIR_Nem_3	135	139	PF02991	0.256
LIG_LIR_Nem_3	244	248	PF02991	0.221
LIG_LIR_Nem_3	250	255	PF02991	0.219
LIG_LIR_Nem_3	5	11	PF02991	0.582
LIG_LYPXL_yS_3	65	68	PF13949	0.543
LIG_MYND_1	110	114	PF01753	0.541
LIG_Pex14_1	144	148	PF04695	0.212
LIG_Pex14_2	51	55	PF04695	0.556
LIG_SH2_CRK	252	256	PF00017	0.204
LIG_SH2_STAT5	130	133	PF00017	0.407
LIG_SH2_STAT5	164	167	PF00017	0.242
LIG_SH2_STAT5	267	270	PF00017	0.242
LIG_SH3_3	107	113	PF00018	0.567
LIG_SH3_3	146	152	PF00018	0.354
LIG_SH3_3	233	239	PF00018	0.211
LIG_SUMO_SIM_anti_2	98	105	PF11976	0.580
LIG_SUMO_SIM_par_1	225	230	PF11976	0.406
LIG_SUMO_SIM_par_1	271	277	PF11976	0.211
LIG_SUMO_SIM_par_1	281	286	PF11976	0.216
LIG_TRAF2_1	297	300	PF00917	0.602
LIG_TYR_ITIM	63	68	PF00017	0.548
LIG_WRC_WIRS_1	169	174	PF05994	0.204
LIG_WRC_WIRS_1	228	233	PF05994	0.216
LIG_WW_2	110	113	PF00397	0.541
LIG_WW_3	295	299	PF00397	0.519
MOD_CK1_1	43	49	PF00069	0.558
MOD_CK1_1	96	102	PF00069	0.588
MOD_GlcNHglycan	205	208	PF01048	0.224
MOD_GSK3_1	128	135	PF00069	0.404
MOD_GSK3_1	40	47	PF00069	0.570
MOD_GSK3_1	93	100	PF00069	0.571
MOD_N-GLC_1	291	296	PF02516	0.362
MOD_NEK2_1	134	139	PF00069	0.273
MOD_NEK2_1	218	223	PF00069	0.469
MOD_NEK2_1	274	279	PF00069	0.234
MOD_NEK2_1	288	293	PF00069	0.360
MOD_NEK2_1	78	83	PF00069	0.540
MOD_NEK2_1	88	93	PF00069	0.564
MOD_NEK2_2	247	252	PF00069	0.222
MOD_OFUCOSY	38	44	PF10250	0.370
MOD_PIKK_1	218	224	PF00454	0.212
MOD_PIKK_1	91	97	PF00454	0.573
MOD_PKA_1	190	196	PF00069	0.207
MOD_PKA_2	189	195	PF00069	0.242
MOD_PKA_2	33	39	PF00069	0.570
MOD_PKA_2	40	46	PF00069	0.561
MOD_Plk_1	97	103	PF00069	0.577
MOD_Plk_4	162	168	PF00069	0.410
MOD_Plk_4	247	253	PF00069	0.295
MOD_Plk_4	283	289	PF00069	0.278
MOD_Plk_4	46	52	PF00069	0.560
MOD_Plk_4	97	103	PF00069	0.585
MOD_ProDKin_1	148	154	PF00069	0.508
MOD_ProDKin_1	155	161	PF00069	0.340
MOD_ProDKin_1	54	60	PF00069	0.575
MOD_ProDKin_1	71	77	PF00069	0.566
MOD_ProDKin_1	93	99	PF00069	0.583
TRG_ENDOCYTIC_2	169	172	PF00928	0.240
TRG_ENDOCYTIC_2	252	255	PF00928	0.204
TRG_ENDOCYTIC_2	65	68	PF00928	0.549
TRG_ER_diArg_1	39	42	PF00400	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A381MTC7	Leishmania infantum	28%	100%
A0A3Q8IFH7	Leishmania donovani	28%	100%
A0A3Q8IHZ6	Leishmania donovani	25%	100%
A0A3S7X7E5	Leishmania donovani	26%	100%
A0A3S7X7M4	Leishmania donovani	25%	100%
A0A3S7X7U1	Leishmania donovani	25%	100%
A0A3S7X7W2	Leishmania donovani	27%	100%
A4HDI3	Leishmania braziliensis	39%	100%
A4I0W6	Leishmania infantum	60%	100%
A4I9X0	Leishmania infantum	27%	100%
D0A843	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	68%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AHT2	Leishmania infantum	26%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q325	Leishmania major	23%	100%
Q4Q397	Leishmania major	27%	100%
Q4Q3F7	Leishmania major	25%	100%