Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDL2_LEIBR

TriTrypDb:

LbrM.24.1580 , LBRM2903_240020400

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.431
CLV_NRD_NRD_1	3	5	PF00675	0.698
CLV_PCSK_KEX2_1	190	192	PF00082	0.405
CLV_PCSK_KEX2_1	52	54	PF00082	0.601
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.601
CLV_PCSK_SKI1_1	106	110	PF00082	0.458
CLV_PCSK_SKI1_1	127	131	PF00082	0.543
CLV_PCSK_SKI1_1	192	196	PF00082	0.476
CLV_PCSK_SKI1_1	44	48	PF00082	0.472
DEG_MDM2_SWIB_1	56	63	PF02201	0.464
DEG_SPOP_SBC_1	121	125	PF00917	0.288
DOC_MAPK_MEF2A_6	19	27	PF00069	0.649
DOC_MAPK_MEF2A_6	205	212	PF00069	0.490
DOC_PP1_RVXF_1	125	131	PF00149	0.495
DOC_PP4_FxxP_1	232	235	PF00568	0.507
DOC_USP7_MATH_1	8	12	PF00917	0.668
DOC_USP7_UBL2_3	205	209	PF12436	0.490
LIG_14-3-3_CanoR_1	19	23	PF00244	0.409
LIG_14-3-3_CanoR_1	190	195	PF00244	0.519
LIG_14-3-3_CanoR_1	53	57	PF00244	0.564
LIG_AP2alpha_1	228	232	PF02296	0.545
LIG_APCC_ABBAyCdc20_2	191	197	PF00400	0.403
LIG_BRCT_BRCA1_1	218	222	PF00533	0.432
LIG_EH_1	74	78	PF12763	0.607
LIG_FHA_1	121	127	PF00498	0.503
LIG_FHA_1	153	159	PF00498	0.555
LIG_FHA_1	169	175	PF00498	0.491
LIG_FHA_1	247	253	PF00498	0.597
LIG_FHA_2	142	148	PF00498	0.511
LIG_FHA_2	160	166	PF00498	0.563
LIG_FHA_2	222	228	PF00498	0.381
LIG_LIR_Apic_2	230	235	PF02991	0.589
LIG_LIR_Gen_1	57	67	PF02991	0.564
LIG_LIR_Gen_1	95	101	PF02991	0.442
LIG_LIR_Nem_3	219	225	PF02991	0.407
LIG_LIR_Nem_3	57	63	PF02991	0.572
LIG_LIR_Nem_3	92	96	PF02991	0.411
LIG_MYND_1	204	208	PF01753	0.428
LIG_NRBOX	42	48	PF00104	0.292
LIG_Pex14_2	228	232	PF04695	0.518
LIG_Pex14_2	56	60	PF04695	0.531
LIG_SH2_NCK_1	35	39	PF00017	0.607
LIG_SH2_STAP1	35	39	PF00017	0.575
LIG_SH2_STAT3	39	42	PF00017	0.328
LIG_SH2_STAT3	96	99	PF00017	0.495
LIG_SH2_STAT5	107	110	PF00017	0.359
LIG_SH2_STAT5	216	219	PF00017	0.404
LIG_SH2_STAT5	96	99	PF00017	0.407
LIG_SH3_3	198	204	PF00018	0.498
LIG_SH3_3	245	251	PF00018	0.497
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.442
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.432
LIG_SUMO_SIM_par_1	175	182	PF11976	0.509
LIG_WRC_WIRS_1	229	234	PF05994	0.310
LIG_WW_3	1	5	PF00397	0.726
MOD_CK1_1	141	147	PF00069	0.471
MOD_CK1_1	152	158	PF00069	0.312
MOD_CK1_1	182	188	PF00069	0.384
MOD_CK1_1	193	199	PF00069	0.535
MOD_CK1_1	221	227	PF00069	0.544
MOD_CK1_1	81	87	PF00069	0.590
MOD_CK2_1	159	165	PF00069	0.534
MOD_CK2_1	173	179	PF00069	0.524
MOD_CK2_1	221	227	PF00069	0.392
MOD_CK2_1	8	14	PF00069	0.619
MOD_Cter_Amidation	188	191	PF01082	0.375
MOD_Cter_Amidation	48	51	PF01082	0.421
MOD_GlcNHglycan	10	13	PF01048	0.517
MOD_GlcNHglycan	140	143	PF01048	0.498
MOD_GSK3_1	14	21	PF00069	0.541
MOD_GSK3_1	168	175	PF00069	0.528
MOD_GSK3_1	179	186	PF00069	0.428
MOD_GSK3_1	81	88	PF00069	0.525
MOD_NEK2_1	228	233	PF00069	0.456
MOD_NEK2_1	78	83	PF00069	0.528
MOD_PIKK_1	179	185	PF00454	0.452
MOD_PIKK_1	78	84	PF00454	0.661
MOD_PK_1	190	196	PF00069	0.562
MOD_PKA_1	190	196	PF00069	0.559
MOD_PKA_1	51	57	PF00069	0.571
MOD_PKA_2	18	24	PF00069	0.625
MOD_PKA_2	190	196	PF00069	0.428
MOD_PKA_2	52	58	PF00069	0.567
MOD_Plk_1	121	127	PF00069	0.279
MOD_Plk_1	159	165	PF00069	0.599
MOD_Plk_1	172	178	PF00069	0.511
MOD_Plk_2-3	173	179	PF00069	0.379
MOD_Plk_2-3	18	24	PF00069	0.566
MOD_Plk_4	173	179	PF00069	0.524
MOD_Plk_4	18	24	PF00069	0.514
MOD_Plk_4	190	196	PF00069	0.395
MOD_Plk_4	218	224	PF00069	0.538
MOD_Plk_4	85	91	PF00069	0.489
MOD_SUMO_for_1	208	211	PF00179	0.485
MOD_SUMO_rev_2	113	118	PF00179	0.529
MOD_SUMO_rev_2	61	69	PF00179	0.572
TRG_NLS_MonoCore_2	49	54	PF00514	0.570
TRG_NLS_MonoExtN_4	50	55	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY5	Leptomonas seymouri	53%	100%
A0A0S4J677	Bodo saltans	24%	77%
A0A0S4JEV4	Bodo saltans	24%	77%
A0A1X0NX29	Trypanosomatidae	33%	96%
A0A3S7WYF1	Leishmania donovani	79%	100%
A4I0W9	Leishmania infantum	79%	100%
C9ZWH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9AWX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QAK1	Leishmania major	81%	100%
V5BAW4	Trypanosoma cruzi	36%	81%