Putative cyclophilin 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 8, putative

Species:

Leishmania braziliensis

UniProt:

A4HDL1_LEIBR

TriTrypDb:

LbrM.24.1570 , LBRM2903_240020300

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDL1

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018208	peptidyl-proline modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	10
GO:0003824	catalytic activity	1	10
GO:0016853	isomerase activity	2	10
GO:0016859	cis-trans isomerase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	48	50	PF00675	0.692
CLV_PCSK_KEX2_1	33	35	PF00082	0.630
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.608
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.447
DOC_MAPK_DCC_7	12	20	PF00069	0.428
DOC_PP1_RVXF_1	10	17	PF00149	0.428
DOC_PP1_RVXF_1	193	200	PF00149	0.284
DOC_PP2B_LxvP_1	44	47	PF13499	0.545
DOC_USP7_MATH_1	141	145	PF00917	0.255
DOC_USP7_MATH_1	211	215	PF00917	0.387
DOC_USP7_UBL2_3	112	116	PF12436	0.290
DOC_USP7_UBL2_3	50	54	PF12436	0.589
DOC_WW_Pin1_4	3	8	PF00397	0.434
DOC_WW_Pin1_4	90	95	PF00397	0.340
LIG_14-3-3_CanoR_1	168	174	PF00244	0.350
LIG_BRCT_BRCA1_1	12	16	PF00533	0.431
LIG_BRCT_BRCA1_1	169	173	PF00533	0.266
LIG_BRCT_BRCA1_1	175	179	PF00533	0.252
LIG_Clathr_ClatBox_1	71	75	PF01394	0.386
LIG_FHA_1	133	139	PF00498	0.375
LIG_FHA_1	236	242	PF00498	0.272
LIG_FHA_2	61	67	PF00498	0.497
LIG_LIR_Gen_1	176	187	PF02991	0.375
LIG_LIR_Gen_1	22	31	PF02991	0.485
LIG_LIR_Gen_1	229	240	PF02991	0.384
LIG_LIR_Nem_3	13	19	PF02991	0.538
LIG_LIR_Nem_3	176	182	PF02991	0.316
LIG_LIR_Nem_3	22	28	PF02991	0.423
LIG_LIR_Nem_3	78	84	PF02991	0.318
LIG_MLH1_MIPbox_1	175	179	PF16413	0.260
LIG_PTB_Apo_2	119	126	PF02174	0.375
LIG_SH2_CRK	161	165	PF00017	0.340
LIG_SH2_CRK	81	85	PF00017	0.375
LIG_SH2_STAT5	196	199	PF00017	0.177
LIG_SUMO_SIM_par_1	82	87	PF11976	0.340
LIG_UBA3_1	71	76	PF00899	0.391
LIG_WW_3	46	50	PF00397	0.626
MOD_CDK_SPK_2	90	95	PF00069	0.340
MOD_CK1_1	107	113	PF00069	0.185
MOD_CK1_1	169	175	PF00069	0.381
MOD_CK1_1	26	32	PF00069	0.683
MOD_CK1_1	60	66	PF00069	0.689
MOD_CK1_1	90	96	PF00069	0.423
MOD_CK2_1	26	32	PF00069	0.683
MOD_GlcNHglycan	169	172	PF01048	0.255
MOD_GlcNHglycan	185	188	PF01048	0.237
MOD_GlcNHglycan	218	222	PF01048	0.435
MOD_GlcNHglycan	25	28	PF01048	0.484
MOD_GlcNHglycan	89	92	PF01048	0.329
MOD_GSK3_1	106	113	PF00069	0.385
MOD_GSK3_1	162	169	PF00069	0.321
MOD_GSK3_1	19	26	PF00069	0.433
MOD_N-GLC_1	107	112	PF02516	0.321
MOD_NEK2_1	166	171	PF00069	0.275
MOD_NEK2_1	173	178	PF00069	0.282
MOD_NEK2_1	19	24	PF00069	0.476
MOD_NEK2_1	235	240	PF00069	0.503
MOD_PIKK_1	173	179	PF00454	0.319
MOD_PKA_2	126	132	PF00069	0.316
MOD_PKA_2	167	173	PF00069	0.307
MOD_PKA_2	183	189	PF00069	0.265
MOD_Plk_1	235	241	PF00069	0.411
MOD_Plk_4	10	16	PF00069	0.541
MOD_ProDKin_1	3	9	PF00069	0.429
MOD_ProDKin_1	90	96	PF00069	0.340
TRG_ENDOCYTIC_2	161	164	PF00928	0.340
TRG_ENDOCYTIC_2	196	199	PF00928	0.177
TRG_ENDOCYTIC_2	232	235	PF00928	0.414
TRG_ENDOCYTIC_2	239	242	PF00928	0.570
TRG_ENDOCYTIC_2	25	28	PF00928	0.484
TRG_ENDOCYTIC_2	81	84	PF00928	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D1	Leptomonas seymouri	64%	100%
A0A1X0ND98	Trypanosomatidae	41%	100%
A0A1X0NJS0	Trypanosomatidae	27%	100%
A0A3S7WYD9	Leishmania donovani	80%	100%
A4I0X0	Leishmania infantum	80%	100%
C9ZT99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	80%
C9ZWH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
P30405	Homo sapiens	27%	100%
Q4QAK0	Leishmania major	79%	100%
V5B2A0	Trypanosoma cruzi	29%	94%
V5D532	Trypanosoma cruzi	27%	100%