LeishMANIAdb
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Putative translation initiation factor IF-2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative translation initiation factor IF-2
Gene product:
translation initiation factor IF-2, putative
Species:
Leishmania braziliensis
UniProt:
A4HDK8_LEIBR
TriTrypDb:
LbrM.24.1540 , LBRM2903_240020100 *
Length:
892

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HDK8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK8

Function

Biological processes
Term Name Level Count
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003676 nucleic acid binding 3 11
GO:0003743 translation initiation factor activity 4 11
GO:0003824 catalytic activity 1 11
GO:0003924 GTPase activity 7 11
GO:0005488 binding 1 11
GO:0005525 GTP binding 5 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0019001 guanyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032561 guanyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.428
CLV_C14_Caspase3-7 795 799 PF00656 0.472
CLV_C14_Caspase3-7 835 839 PF00656 0.677
CLV_C14_Caspase3-7 842 846 PF00656 0.708
CLV_MEL_PAP_1 762 768 PF00089 0.362
CLV_NRD_NRD_1 167 169 PF00675 0.582
CLV_NRD_NRD_1 176 178 PF00675 0.493
CLV_NRD_NRD_1 179 181 PF00675 0.310
CLV_NRD_NRD_1 19 21 PF00675 0.516
CLV_NRD_NRD_1 380 382 PF00675 0.480
CLV_NRD_NRD_1 448 450 PF00675 0.579
CLV_NRD_NRD_1 638 640 PF00675 0.530
CLV_NRD_NRD_1 711 713 PF00675 0.475
CLV_NRD_NRD_1 754 756 PF00675 0.372
CLV_NRD_NRD_1 875 877 PF00675 0.532
CLV_PCSK_FUR_1 17 21 PF00082 0.408
CLV_PCSK_FUR_1 177 181 PF00082 0.469
CLV_PCSK_KEX2_1 167 169 PF00082 0.601
CLV_PCSK_KEX2_1 176 178 PF00082 0.497
CLV_PCSK_KEX2_1 179 181 PF00082 0.321
CLV_PCSK_KEX2_1 19 21 PF00082 0.563
CLV_PCSK_KEX2_1 372 374 PF00082 0.603
CLV_PCSK_KEX2_1 450 452 PF00082 0.577
CLV_PCSK_KEX2_1 471 473 PF00082 0.667
CLV_PCSK_KEX2_1 638 640 PF00082 0.615
CLV_PCSK_KEX2_1 686 688 PF00082 0.690
CLV_PCSK_KEX2_1 711 713 PF00082 0.475
CLV_PCSK_KEX2_1 86 88 PF00082 0.596
CLV_PCSK_KEX2_1 874 876 PF00082 0.558
CLV_PCSK_PC1ET2_1 372 374 PF00082 0.628
CLV_PCSK_PC1ET2_1 450 452 PF00082 0.578
CLV_PCSK_PC1ET2_1 471 473 PF00082 0.654
CLV_PCSK_PC1ET2_1 686 688 PF00082 0.690
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.596
CLV_PCSK_PC7_1 172 178 PF00082 0.538
CLV_PCSK_PC7_1 446 452 PF00082 0.570
CLV_PCSK_SKI1_1 104 108 PF00082 0.446
CLV_PCSK_SKI1_1 133 137 PF00082 0.543
CLV_PCSK_SKI1_1 194 198 PF00082 0.391
CLV_PCSK_SKI1_1 219 223 PF00082 0.245
CLV_PCSK_SKI1_1 230 234 PF00082 0.250
CLV_PCSK_SKI1_1 277 281 PF00082 0.240
CLV_PCSK_SKI1_1 307 311 PF00082 0.361
CLV_PCSK_SKI1_1 437 441 PF00082 0.441
CLV_PCSK_SKI1_1 475 479 PF00082 0.429
CLV_PCSK_SKI1_1 65 69 PF00082 0.524
CLV_PCSK_SKI1_1 686 690 PF00082 0.638
CLV_PCSK_SKI1_1 712 716 PF00082 0.524
CLV_PCSK_SKI1_1 875 879 PF00082 0.564
DEG_APCC_DBOX_1 166 174 PF00400 0.546
DEG_APCC_DBOX_1 306 314 PF00400 0.561
DEG_APCC_DBOX_1 875 883 PF00400 0.451
DEG_Nend_UBRbox_1 1 4 PF02207 0.605
DOC_CKS1_1 236 241 PF01111 0.453
DOC_CKS1_1 787 792 PF01111 0.376
DOC_CYCLIN_RxL_1 395 408 PF00134 0.408
DOC_CYCLIN_RxL_1 871 883 PF00134 0.593
DOC_MAPK_gen_1 17 26 PF00069 0.565
DOC_MAPK_gen_1 176 183 PF00069 0.476
DOC_MAPK_gen_1 369 379 PF00069 0.552
DOC_MAPK_gen_1 381 388 PF00069 0.337
DOC_MAPK_gen_1 536 546 PF00069 0.492
DOC_MAPK_gen_1 580 589 PF00069 0.479
DOC_MAPK_gen_1 598 606 PF00069 0.436
DOC_MAPK_gen_1 871 879 PF00069 0.557
DOC_MAPK_HePTP_8 39 51 PF00069 0.430
DOC_MAPK_MEF2A_6 372 379 PF00069 0.526
DOC_MAPK_MEF2A_6 381 390 PF00069 0.353
DOC_MAPK_MEF2A_6 42 51 PF00069 0.435
DOC_MAPK_MEF2A_6 539 548 PF00069 0.482
DOC_MAPK_MEF2A_6 598 606 PF00069 0.450
DOC_PP1_RVXF_1 150 157 PF00149 0.383
DOC_PP1_RVXF_1 399 406 PF00149 0.233
DOC_PP1_RVXF_1 580 586 PF00149 0.410
DOC_PP1_RVXF_1 753 760 PF00149 0.355
DOC_PP2B_LxvP_1 78 81 PF13499 0.474
DOC_PP2B_PxIxI_1 284 290 PF00149 0.535
DOC_PP2B_PxIxI_1 850 856 PF00149 0.663
DOC_PP4_FxxP_1 221 224 PF00568 0.463
DOC_PP4_FxxP_1 25 28 PF00568 0.429
DOC_PP4_FxxP_1 787 790 PF00568 0.499
DOC_SPAK_OSR1_1 248 252 PF12202 0.492
DOC_USP7_MATH_1 141 145 PF00917 0.529
DOC_USP7_MATH_1 645 649 PF00917 0.719
DOC_USP7_MATH_1 867 871 PF00917 0.764
DOC_USP7_MATH_2 867 873 PF00917 0.485
DOC_USP7_UBL2_3 34 38 PF12436 0.504
DOC_WW_Pin1_4 143 148 PF00397 0.538
DOC_WW_Pin1_4 235 240 PF00397 0.440
DOC_WW_Pin1_4 470 475 PF00397 0.655
DOC_WW_Pin1_4 56 61 PF00397 0.502
DOC_WW_Pin1_4 786 791 PF00397 0.362
LIG_14-3-3_CanoR_1 381 385 PF00244 0.550
LIG_14-3-3_CanoR_1 491 501 PF00244 0.630
LIG_14-3-3_CanoR_1 551 555 PF00244 0.326
LIG_14-3-3_CanoR_1 687 693 PF00244 0.641
LIG_14-3-3_CanoR_1 711 720 PF00244 0.543
LIG_14-3-3_CanoR_1 788 797 PF00244 0.470
LIG_14-3-3_CanoR_1 97 105 PF00244 0.457
LIG_APCC_ABBA_1 49 54 PF00400 0.477
LIG_BRCT_BRCA1_1 296 300 PF00533 0.437
LIG_BRCT_BRCA1_1 32 36 PF00533 0.440
LIG_BRCT_BRCA1_1 63 67 PF00533 0.460
LIG_BRCT_BRCA1_2 32 38 PF00533 0.442
LIG_Clathr_ClatBox_1 733 737 PF01394 0.342
LIG_DLG_GKlike_1 128 135 PF00625 0.489
LIG_eIF4E_1 374 380 PF01652 0.399
LIG_FHA_1 105 111 PF00498 0.432
LIG_FHA_1 193 199 PF00498 0.477
LIG_FHA_1 213 219 PF00498 0.438
LIG_FHA_1 273 279 PF00498 0.482
LIG_FHA_1 495 501 PF00498 0.413
LIG_FHA_1 589 595 PF00498 0.498
LIG_FHA_1 683 689 PF00498 0.754
LIG_FHA_1 752 758 PF00498 0.352
LIG_FHA_2 16 22 PF00498 0.502
LIG_FHA_2 232 238 PF00498 0.447
LIG_FHA_2 545 551 PF00498 0.373
LIG_GBD_Chelix_1 617 625 PF00786 0.400
LIG_IRF3_LxIS_1 257 263 PF10401 0.492
LIG_LIR_Apic_2 356 360 PF02991 0.602
LIG_LIR_Gen_1 231 239 PF02991 0.530
LIG_LIR_Gen_1 33 40 PF02991 0.417
LIG_LIR_Gen_1 603 612 PF02991 0.486
LIG_LIR_Gen_1 704 710 PF02991 0.317
LIG_LIR_Gen_1 811 821 PF02991 0.469
LIG_LIR_Nem_3 231 236 PF02991 0.530
LIG_LIR_Nem_3 33 39 PF02991 0.462
LIG_LIR_Nem_3 371 377 PF02991 0.641
LIG_LIR_Nem_3 397 403 PF02991 0.251
LIG_LIR_Nem_3 480 485 PF02991 0.575
LIG_LIR_Nem_3 603 609 PF02991 0.481
LIG_LIR_Nem_3 611 615 PF02991 0.469
LIG_LIR_Nem_3 704 708 PF02991 0.315
LIG_LIR_Nem_3 719 723 PF02991 0.305
LIG_LIR_Nem_3 811 817 PF02991 0.487
LIG_LYPXL_yS_3 374 377 PF13949 0.498
LIG_LYPXL_yS_3 541 544 PF13949 0.485
LIG_NRBOX 398 404 PF00104 0.322
LIG_PCNA_yPIPBox_3 425 437 PF02747 0.525
LIG_Pex14_1 153 157 PF04695 0.498
LIG_Pex14_2 465 469 PF04695 0.412
LIG_PTB_Apo_2 476 483 PF02174 0.432
LIG_RPA_C_Fungi 15 27 PF08784 0.369
LIG_SH2_CRK 612 616 PF00017 0.484
LIG_SH2_CRK 627 631 PF00017 0.542
LIG_SH2_NCK_1 52 56 PF00017 0.310
LIG_SH2_PTP2 457 460 PF00017 0.379
LIG_SH2_PTP2 586 589 PF00017 0.310
LIG_SH2_SRC 52 55 PF00017 0.452
LIG_SH2_SRC 586 589 PF00017 0.532
LIG_SH2_STAP1 157 161 PF00017 0.493
LIG_SH2_STAP1 720 724 PF00017 0.417
LIG_SH2_STAT3 723 726 PF00017 0.306
LIG_SH2_STAT3 776 779 PF00017 0.471
LIG_SH2_STAT5 169 172 PF00017 0.495
LIG_SH2_STAT5 357 360 PF00017 0.540
LIG_SH2_STAT5 457 460 PF00017 0.382
LIG_SH2_STAT5 586 589 PF00017 0.467
LIG_SH2_STAT5 596 599 PF00017 0.457
LIG_SH2_STAT5 657 660 PF00017 0.520
LIG_SH2_STAT5 723 726 PF00017 0.306
LIG_SH2_STAT5 758 761 PF00017 0.481
LIG_SH2_STAT5 776 779 PF00017 0.530
LIG_SH2_STAT5 8 11 PF00017 0.720
LIG_SH2_STAT5 800 803 PF00017 0.393
LIG_SH3_1 627 633 PF00018 0.627
LIG_SH3_2 147 152 PF14604 0.508
LIG_SH3_3 144 150 PF00018 0.593
LIG_SH3_3 279 285 PF00018 0.320
LIG_SH3_3 627 633 PF00018 0.627
LIG_SH3_3 675 681 PF00018 0.620
LIG_SUMO_SIM_anti_2 256 263 PF11976 0.277
LIG_SUMO_SIM_par_1 256 263 PF11976 0.267
LIG_TRAF2_1 633 636 PF00917 0.755
LIG_TRAF2_2 768 773 PF00917 0.491
LIG_UBA3_1 119 126 PF00899 0.510
LIG_UBA3_1 774 782 PF00899 0.453
LIG_Vh1_VBS_1 261 279 PF01044 0.404
LIG_WRC_WIRS_1 232 237 PF05994 0.409
MOD_CDK_SPK_2 470 475 PF00069 0.655
MOD_CDK_SPxxK_3 235 242 PF00069 0.266
MOD_CK1_1 343 349 PF00069 0.600
MOD_CK1_1 389 395 PF00069 0.578
MOD_CK1_1 473 479 PF00069 0.663
MOD_CK1_1 484 490 PF00069 0.583
MOD_CK1_1 496 502 PF00069 0.422
MOD_CK1_1 552 558 PF00069 0.531
MOD_CK1_1 648 654 PF00069 0.641
MOD_CK1_1 665 671 PF00069 0.718
MOD_CK1_1 738 744 PF00069 0.353
MOD_CK1_1 792 798 PF00069 0.480
MOD_CK1_1 844 850 PF00069 0.634
MOD_CK2_1 128 134 PF00069 0.549
MOD_CK2_1 15 21 PF00069 0.484
MOD_CK2_1 260 266 PF00069 0.330
MOD_CK2_1 464 470 PF00069 0.464
MOD_CK2_1 713 719 PF00069 0.573
MOD_CK2_1 796 802 PF00069 0.461
MOD_CMANNOS 153 156 PF00535 0.484
MOD_Cter_Amidation 165 168 PF01082 0.567
MOD_GlcNHglycan 143 146 PF01048 0.579
MOD_GlcNHglycan 300 303 PF01048 0.271
MOD_GlcNHglycan 554 557 PF01048 0.489
MOD_GlcNHglycan 56 59 PF01048 0.382
MOD_GlcNHglycan 647 650 PF01048 0.649
MOD_GlcNHglycan 666 670 PF01048 0.473
MOD_GlcNHglycan 791 794 PF01048 0.498
MOD_GlcNHglycan 863 866 PF01048 0.685
MOD_GSK3_1 231 238 PF00069 0.328
MOD_GSK3_1 26 33 PF00069 0.536
MOD_GSK3_1 294 301 PF00069 0.369
MOD_GSK3_1 331 338 PF00069 0.527
MOD_GSK3_1 339 346 PF00069 0.519
MOD_GSK3_1 415 422 PF00069 0.511
MOD_GSK3_1 473 480 PF00069 0.603
MOD_GSK3_1 492 499 PF00069 0.382
MOD_GSK3_1 565 572 PF00069 0.439
MOD_GSK3_1 644 651 PF00069 0.554
MOD_GSK3_1 670 677 PF00069 0.643
MOD_GSK3_1 682 689 PF00069 0.572
MOD_GSK3_1 747 754 PF00069 0.402
MOD_GSK3_1 792 799 PF00069 0.556
MOD_GSK3_1 808 815 PF00069 0.298
MOD_N-GLC_1 424 429 PF02516 0.460
MOD_N-GLC_1 478 483 PF02516 0.536
MOD_N-GLC_1 492 497 PF02516 0.598
MOD_NEK2_1 201 206 PF00069 0.349
MOD_NEK2_1 244 249 PF00069 0.296
MOD_NEK2_1 260 265 PF00069 0.269
MOD_NEK2_1 380 385 PF00069 0.413
MOD_NEK2_1 433 438 PF00069 0.314
MOD_NEK2_1 478 483 PF00069 0.542
MOD_NEK2_1 500 505 PF00069 0.372
MOD_NEK2_1 544 549 PF00069 0.426
MOD_NEK2_1 602 607 PF00069 0.497
MOD_NEK2_1 670 675 PF00069 0.703
MOD_NEK2_1 701 706 PF00069 0.428
MOD_NEK2_1 9 14 PF00069 0.630
MOD_NEK2_2 81 86 PF00069 0.502
MOD_OFUCOSY 409 414 PF10250 0.466
MOD_PIKK_1 212 218 PF00454 0.277
MOD_PIKK_1 267 273 PF00454 0.295
MOD_PIKK_1 484 490 PF00454 0.613
MOD_PIKK_1 686 692 PF00454 0.638
MOD_PIKK_1 713 719 PF00454 0.471
MOD_PIKK_1 869 875 PF00454 0.637
MOD_PK_1 415 421 PF00069 0.504
MOD_PKA_1 686 692 PF00069 0.668
MOD_PKA_2 141 147 PF00069 0.650
MOD_PKA_2 171 177 PF00069 0.603
MOD_PKA_2 380 386 PF00069 0.548
MOD_PKA_2 493 499 PF00069 0.619
MOD_PKA_2 550 556 PF00069 0.317
MOD_PKA_2 662 668 PF00069 0.590
MOD_PKA_2 686 692 PF00069 0.668
MOD_Plk_1 128 134 PF00069 0.592
MOD_Plk_1 424 430 PF00069 0.526
MOD_Plk_1 478 484 PF00069 0.511
MOD_Plk_1 549 555 PF00069 0.444
MOD_Plk_1 602 608 PF00069 0.496
MOD_Plk_1 747 753 PF00069 0.441
MOD_Plk_1 90 96 PF00069 0.478
MOD_Plk_2-3 134 140 PF00069 0.505
MOD_Plk_2-3 231 237 PF00069 0.409
MOD_Plk_2-3 796 802 PF00069 0.461
MOD_Plk_4 26 32 PF00069 0.399
MOD_Plk_4 343 349 PF00069 0.524
MOD_Plk_4 496 502 PF00069 0.415
MOD_Plk_4 544 550 PF00069 0.366
MOD_Plk_4 670 676 PF00069 0.752
MOD_Plk_4 796 802 PF00069 0.444
MOD_ProDKin_1 143 149 PF00069 0.536
MOD_ProDKin_1 235 241 PF00069 0.277
MOD_ProDKin_1 470 476 PF00069 0.653
MOD_ProDKin_1 56 62 PF00069 0.506
MOD_ProDKin_1 786 792 PF00069 0.368
MOD_SUMO_for_1 135 138 PF00179 0.450
MOD_SUMO_for_1 45 48 PF00179 0.441
MOD_SUMO_for_1 85 88 PF00179 0.435
MOD_SUMO_rev_2 129 137 PF00179 0.528
MOD_SUMO_rev_2 29 36 PF00179 0.437
MOD_SUMO_rev_2 864 872 PF00179 0.671
TRG_DiLeu_BaEn_2 20 26 PF01217 0.397
TRG_DiLeu_BaEn_2 512 518 PF01217 0.493
TRG_DiLeu_BaEn_4 442 448 PF01217 0.622
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.427
TRG_DiLeu_BaLyEn_6 873 878 PF01217 0.592
TRG_ENDOCYTIC_2 374 377 PF00928 0.498
TRG_ENDOCYTIC_2 457 460 PF00928 0.379
TRG_ENDOCYTIC_2 52 55 PF00928 0.516
TRG_ENDOCYTIC_2 541 544 PF00928 0.450
TRG_ENDOCYTIC_2 586 589 PF00928 0.486
TRG_ENDOCYTIC_2 612 615 PF00928 0.480
TRG_ENDOCYTIC_2 758 761 PF00928 0.436
TRG_ER_diArg_1 1 4 PF00400 0.605
TRG_ER_diArg_1 16 19 PF00400 0.490
TRG_ER_diArg_1 167 169 PF00400 0.522
TRG_ER_diArg_1 176 179 PF00400 0.478
TRG_ER_diArg_1 573 576 PF00400 0.431
TRG_ER_diArg_1 579 582 PF00400 0.378
TRG_ER_diArg_1 597 600 PF00400 0.351
TRG_ER_diArg_1 638 640 PF00400 0.530
TRG_ER_diArg_1 710 712 PF00400 0.454
TRG_ER_diArg_1 874 876 PF00400 0.616
TRG_NES_CRM1_1 312 326 PF08389 0.493
TRG_NLS_MonoExtN_4 446 453 PF00514 0.569
TRG_Pf-PMV_PEXEL_1 133 138 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 712 717 PF00026 0.497
TRG_Pf-PMV_PEXEL_1 743 748 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 876 881 PF00026 0.615

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IH60 Leptomonas seymouri 65% 100%
A0A1X0NVX3 Trypanosomatidae 47% 100%
A0A3Q8IG60 Leishmania donovani 89% 100%
A0A3R7MK23 Trypanosoma rangeli 45% 100%
A4I0X3 Leishmania infantum 89% 100%
C9ZWH4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AWX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QAJ7 Leishmania major 89% 100%
V5BFL2 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS