TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDK7_LEIBR

TriTrypDb:

LbrM.24.1530 , LBRM2903_240020000

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.407
CLV_C14_Caspase3-7	479	483	PF00656	0.659
CLV_C14_Caspase3-7	79	83	PF00656	0.581
CLV_C14_Caspase3-7	87	91	PF00656	0.393
CLV_NRD_NRD_1	167	169	PF00675	0.404
CLV_NRD_NRD_1	297	299	PF00675	0.695
CLV_NRD_NRD_1	445	447	PF00675	0.674
CLV_NRD_NRD_1	573	575	PF00675	0.591
CLV_NRD_NRD_1	590	592	PF00675	0.363
CLV_NRD_NRD_1	600	602	PF00675	0.419
CLV_NRD_NRD_1	604	606	PF00675	0.415
CLV_NRD_NRD_1	621	623	PF00675	0.400
CLV_NRD_NRD_1	635	637	PF00675	0.420
CLV_NRD_NRD_1	745	747	PF00675	0.286
CLV_NRD_NRD_1	771	773	PF00675	0.683
CLV_NRD_NRD_1	806	808	PF00675	0.499
CLV_PCSK_FUR_1	742	746	PF00082	0.299
CLV_PCSK_KEX2_1	297	299	PF00082	0.658
CLV_PCSK_KEX2_1	536	538	PF00082	0.479
CLV_PCSK_KEX2_1	559	561	PF00082	0.409
CLV_PCSK_KEX2_1	572	574	PF00082	0.576
CLV_PCSK_KEX2_1	590	592	PF00082	0.355
CLV_PCSK_KEX2_1	600	602	PF00082	0.425
CLV_PCSK_KEX2_1	604	606	PF00082	0.428
CLV_PCSK_KEX2_1	620	622	PF00082	0.266
CLV_PCSK_KEX2_1	635	637	PF00082	0.441
CLV_PCSK_KEX2_1	696	698	PF00082	0.233
CLV_PCSK_KEX2_1	744	746	PF00082	0.297
CLV_PCSK_KEX2_1	771	773	PF00082	0.710
CLV_PCSK_KEX2_1	805	807	PF00082	0.542
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.400
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.406
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.276
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.644
CLV_PCSK_PC7_1	555	561	PF00082	0.497
CLV_PCSK_PC7_1	600	606	PF00082	0.455
CLV_PCSK_SKI1_1	120	124	PF00082	0.539
CLV_PCSK_SKI1_1	168	172	PF00082	0.570
CLV_PCSK_SKI1_1	419	423	PF00082	0.651
CLV_PCSK_SKI1_1	531	535	PF00082	0.466
CLV_PCSK_SKI1_1	611	615	PF00082	0.436
CLV_PCSK_SKI1_1	699	703	PF00082	0.296
CLV_PCSK_SKI1_1	93	97	PF00082	0.419
CLV_Separin_Metazoa	597	601	PF03568	0.503
DEG_APCC_DBOX_1	167	175	PF00400	0.601
DEG_APCC_DBOX_1	418	426	PF00400	0.596
DEG_APCC_DBOX_1	698	706	PF00400	0.405
DEG_COP1_1	81	92	PF00400	0.432
DEG_Nend_UBRbox_1	1	4	PF02207	0.466
DOC_ANK_TNKS_1	108	115	PF00023	0.569
DOC_CKS1_1	174	179	PF01111	0.434
DOC_CKS1_1	318	323	PF01111	0.564
DOC_CKS1_1	415	420	PF01111	0.573
DOC_CYCLIN_RxL_1	166	176	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.355
DOC_MAPK_gen_1	116	123	PF00069	0.307
DOC_MAPK_gen_1	251	258	PF00069	0.459
DOC_MAPK_gen_1	455	463	PF00069	0.563
DOC_MAPK_gen_1	542	551	PF00069	0.517
DOC_MAPK_gen_1	696	705	PF00069	0.492
DOC_MAPK_HePTP_8	693	705	PF00069	0.405
DOC_MAPK_MEF2A_6	251	258	PF00069	0.537
DOC_MAPK_MEF2A_6	542	551	PF00069	0.557
DOC_MAPK_MEF2A_6	696	705	PF00069	0.405
DOC_MAPK_MEF2A_6	93	100	PF00069	0.498
DOC_MAPK_NFAT4_5	93	101	PF00069	0.281
DOC_MIT_MIM_1	486	495	PF04212	0.601
DOC_PP2B_LxvP_1	463	466	PF13499	0.588
DOC_PP2B_LxvP_1	66	69	PF13499	0.624
DOC_PP4_FxxP_1	464	467	PF00568	0.622
DOC_USP7_MATH_1	232	236	PF00917	0.578
DOC_USP7_MATH_1	245	249	PF00917	0.476
DOC_USP7_MATH_1	293	297	PF00917	0.691
DOC_USP7_MATH_1	319	323	PF00917	0.352
DOC_USP7_MATH_1	380	384	PF00917	0.609
DOC_USP7_MATH_1	437	441	PF00917	0.546
DOC_USP7_MATH_1	450	454	PF00917	0.458
DOC_USP7_MATH_1	477	481	PF00917	0.500
DOC_USP7_MATH_1	76	80	PF00917	0.603
DOC_USP7_MATH_1	760	764	PF00917	0.490
DOC_USP7_MATH_1	791	795	PF00917	0.468
DOC_USP7_MATH_2	177	183	PF00917	0.489
DOC_WW_Pin1_4	173	178	PF00397	0.413
DOC_WW_Pin1_4	317	322	PF00397	0.577
DOC_WW_Pin1_4	36	41	PF00397	0.537
DOC_WW_Pin1_4	390	395	PF00397	0.372
DOC_WW_Pin1_4	414	419	PF00397	0.461
LIG_14-3-3_CanoR_1	138	143	PF00244	0.382
LIG_14-3-3_CanoR_1	307	317	PF00244	0.723
LIG_14-3-3_CanoR_1	438	445	PF00244	0.459
LIG_14-3-3_CanoR_1	560	564	PF00244	0.475
LIG_APCC_ABBA_1	254	259	PF00400	0.536
LIG_APCC_ABBAyCdc20_2	253	259	PF00400	0.537
LIG_APCC_ABBAyCdc20_2	560	566	PF00400	0.359
LIG_CaM_IQ_9	582	598	PF13499	0.427
LIG_CaM_IQ_9	612	628	PF13499	0.456
LIG_CaM_IQ_9	652	667	PF13499	0.486
LIG_CaM_IQ_9	691	706	PF13499	0.482
LIG_CaM_IQ_9	721	737	PF13499	0.392
LIG_CaM_IQ_9	792	808	PF13499	0.499
LIG_CSL_BTD_1	415	418	PF09270	0.476
LIG_DLG_GKlike_1	342	349	PF00625	0.310
LIG_FHA_1	139	145	PF00498	0.501
LIG_FHA_1	192	198	PF00498	0.601
LIG_FHA_1	208	214	PF00498	0.434
LIG_FHA_1	318	324	PF00498	0.564
LIG_FHA_1	335	341	PF00498	0.357
LIG_FHA_1	396	402	PF00498	0.518
LIG_FHA_1	496	502	PF00498	0.504
LIG_FHA_1	507	513	PF00498	0.454
LIG_FHA_1	776	782	PF00498	0.466
LIG_FHA_1	83	89	PF00498	0.622
LIG_FHA_1	831	837	PF00498	0.712
LIG_FHA_2	154	160	PF00498	0.492
LIG_FHA_2	174	180	PF00498	0.607
LIG_FHA_2	216	222	PF00498	0.548
LIG_FHA_2	372	378	PF00498	0.563
LIG_FHA_2	69	75	PF00498	0.659
LIG_GBD_Chelix_1	484	492	PF00786	0.520
LIG_LIR_Gen_1	19	29	PF02991	0.521
LIG_LIR_Gen_1	382	392	PF02991	0.491
LIG_LIR_Gen_1	54	63	PF02991	0.463
LIG_LIR_Nem_3	141	145	PF02991	0.558
LIG_LIR_Nem_3	17	21	PF02991	0.464
LIG_LIR_Nem_3	382	388	PF02991	0.459
LIG_LIR_Nem_3	46	50	PF02991	0.408
LIG_LIR_Nem_3	54	58	PF02991	0.422
LIG_NRBOX	491	497	PF00104	0.518
LIG_PCNA_yPIPBox_3	695	709	PF02747	0.558
LIG_Pex14_2	385	389	PF04695	0.533
LIG_Pex14_2	502	506	PF04695	0.502
LIG_PTB_Apo_2	57	64	PF02174	0.334
LIG_REV1ctd_RIR_1	551	559	PF16727	0.458
LIG_SH2_CRK	21	25	PF00017	0.245
LIG_SH2_CRK	690	694	PF00017	0.355
LIG_SH2_CRK	757	761	PF00017	0.496
LIG_SH2_NCK_1	59	63	PF00017	0.334
LIG_SH2_STAP1	227	231	PF00017	0.552
LIG_SH2_STAP1	350	354	PF00017	0.564
LIG_SH2_STAP1	690	694	PF00017	0.360
LIG_SH2_STAT3	722	725	PF00017	0.644
LIG_SH2_STAT5	209	212	PF00017	0.385
LIG_SH2_STAT5	21	24	PF00017	0.486
LIG_SH2_STAT5	257	260	PF00017	0.555
LIG_SH2_STAT5	330	333	PF00017	0.493
LIG_SH2_STAT5	47	50	PF00017	0.460
LIG_SH2_STAT5	588	591	PF00017	0.503
LIG_SH2_STAT5	608	611	PF00017	0.253
LIG_SH3_3	318	324	PF00018	0.513
LIG_SH3_3	412	418	PF00018	0.607
LIG_SH3_3	431	437	PF00018	0.449
LIG_SH3_3	58	64	PF00018	0.585
LIG_SH3_3	745	751	PF00018	0.576
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.606
LIG_SUMO_SIM_anti_2	610	617	PF11976	0.462
LIG_SUMO_SIM_par_1	482	489	PF11976	0.406
LIG_SUMO_SIM_par_1	610	617	PF11976	0.462
LIG_TRAF2_1	268	271	PF00917	0.464
LIG_TRAF2_1	594	597	PF00917	0.532
LIG_TYR_ITIM	206	211	PF00017	0.392
LIG_TYR_ITSM	17	24	PF00017	0.243
LIG_UBA3_1	525	531	PF00899	0.376
MOD_CDK_SPK_2	414	419	PF00069	0.614
MOD_CK1_1	182	188	PF00069	0.724
MOD_CK1_1	214	220	PF00069	0.473
MOD_CK1_1	414	420	PF00069	0.510
MOD_CK1_1	480	486	PF00069	0.459
MOD_CK1_1	763	769	PF00069	0.734
MOD_CK2_1	173	179	PF00069	0.512
MOD_CK2_1	187	193	PF00069	0.732
MOD_CK2_1	215	221	PF00069	0.487
MOD_CK2_1	265	271	PF00069	0.526
MOD_CK2_1	306	312	PF00069	0.688
MOD_CK2_1	326	332	PF00069	0.394
MOD_CK2_1	371	377	PF00069	0.607
MOD_CK2_1	480	486	PF00069	0.415
MOD_CK2_1	559	565	PF00069	0.496
MOD_GlcNHglycan	181	184	PF01048	0.679
MOD_GlcNHglycan	2	5	PF01048	0.700
MOD_GlcNHglycan	267	270	PF01048	0.394
MOD_GlcNHglycan	439	442	PF01048	0.582
MOD_GlcNHglycan	451	455	PF01048	0.565
MOD_GlcNHglycan	513	516	PF01048	0.568
MOD_GlcNHglycan	757	760	PF01048	0.610
MOD_GlcNHglycan	762	765	PF01048	0.616
MOD_GlcNHglycan	8	11	PF01048	0.537
MOD_GSK3_1	130	137	PF00069	0.635
MOD_GSK3_1	187	194	PF00069	0.625
MOD_GSK3_1	2	9	PF00069	0.559
MOD_GSK3_1	207	214	PF00069	0.496
MOD_GSK3_1	215	222	PF00069	0.542
MOD_GSK3_1	232	239	PF00069	0.652
MOD_GSK3_1	245	252	PF00069	0.544
MOD_GSK3_1	407	414	PF00069	0.465
MOD_GSK3_1	74	81	PF00069	0.531
MOD_NEK2_1	122	127	PF00069	0.528
MOD_NEK2_1	16	21	PF00069	0.517
MOD_NEK2_1	247	252	PF00069	0.512
MOD_NEK2_1	353	358	PF00069	0.497
MOD_NEK2_1	371	376	PF00069	0.405
MOD_NEK2_1	388	393	PF00069	0.344
MOD_NEK2_1	395	400	PF00069	0.491
MOD_NEK2_1	411	416	PF00069	0.469
MOD_NEK2_1	614	619	PF00069	0.508
MOD_NEK2_1	683	688	PF00069	0.639
MOD_NEK2_1	721	726	PF00069	0.475
MOD_NEK2_1	798	803	PF00069	0.637
MOD_NEK2_1	96	101	PF00069	0.409
MOD_NEK2_2	380	385	PF00069	0.584
MOD_NEK2_2	469	474	PF00069	0.474
MOD_PIKK_1	245	251	PF00454	0.329
MOD_PIKK_1	306	312	PF00454	0.769
MOD_PIKK_1	531	537	PF00454	0.358
MOD_PIKK_1	721	727	PF00454	0.642
MOD_PK_1	2	8	PF00069	0.428
MOD_PKA_1	559	565	PF00069	0.434
MOD_PKA_2	265	271	PF00069	0.554
MOD_PKA_2	306	312	PF00069	0.682
MOD_PKA_2	437	443	PF00069	0.722
MOD_PKA_2	559	565	PF00069	0.477
MOD_PKA_2	683	689	PF00069	0.589
MOD_PKA_2	830	836	PF00069	0.715
MOD_Plk_1	16	22	PF00069	0.534
MOD_Plk_1	197	203	PF00069	0.516
MOD_Plk_1	220	226	PF00069	0.518
MOD_Plk_1	53	59	PF00069	0.578
MOD_Plk_1	543	549	PF00069	0.544
MOD_Plk_4	198	204	PF00069	0.483
MOD_Plk_4	220	226	PF00069	0.551
MOD_Plk_4	366	372	PF00069	0.574
MOD_Plk_4	380	386	PF00069	0.384
MOD_Plk_4	411	417	PF00069	0.657
MOD_Plk_4	421	427	PF00069	0.517
MOD_Plk_4	480	486	PF00069	0.545
MOD_Plk_4	689	695	PF00069	0.335
MOD_Plk_4	830	836	PF00069	0.462
MOD_ProDKin_1	173	179	PF00069	0.426
MOD_ProDKin_1	317	323	PF00069	0.566
MOD_ProDKin_1	36	42	PF00069	0.528
MOD_ProDKin_1	390	396	PF00069	0.373
MOD_ProDKin_1	414	420	PF00069	0.455
MOD_SUMO_for_1	496	499	PF00179	0.596
TRG_DiLeu_BaEn_1	198	203	PF01217	0.332
TRG_DiLeu_BaEn_1	565	570	PF01217	0.371
TRG_DiLeu_BaEn_1	610	615	PF01217	0.462
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.530
TRG_ENDOCYTIC_2	208	211	PF00928	0.284
TRG_ENDOCYTIC_2	21	24	PF00928	0.486
TRG_ENDOCYTIC_2	350	353	PF00928	0.566
TRG_ENDOCYTIC_2	47	50	PF00928	0.512
TRG_ENDOCYTIC_2	595	598	PF00928	0.467
TRG_ENDOCYTIC_2	690	693	PF00928	0.355
TRG_ENDOCYTIC_2	813	816	PF00928	0.607
TRG_ER_diArg_1	251	254	PF00400	0.463
TRG_ER_diArg_1	297	299	PF00400	0.649
TRG_ER_diArg_1	572	574	PF00400	0.564
TRG_ER_diArg_1	589	591	PF00400	0.298
TRG_ER_diArg_1	599	601	PF00400	0.414
TRG_ER_diArg_1	620	622	PF00400	0.550
TRG_ER_diArg_1	634	636	PF00400	0.438
TRG_ER_diArg_1	741	744	PF00400	0.376
TRG_ER_diArg_1	745	747	PF00400	0.353
TRG_ER_diArg_1	770	772	PF00400	0.728
TRG_ER_diArg_1	806	808	PF00400	0.515
TRG_NES_CRM1_1	510	524	PF08389	0.608
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSD4	Leptomonas seymouri	47%	100%
A0A1X0NVS1	Trypanosomatidae	28%	98%
A0A3Q8IBX8	Leishmania donovani	76%	95%
A0A422NP16	Trypanosoma rangeli	28%	100%
A4I0X4	Leishmania infantum	76%	95%
C9ZWH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AWX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	95%
Q4QAJ6	Leishmania major	75%	100%
V5AVI0	Trypanosoma cruzi	29%	100%