Histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

histone deacetylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDK5_LEIBR

TriTrypDb:

LbrM.24.1510 , LBRM2903_240019700

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK5

Function

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Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	9
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	9
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004407	histone deacetylase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	9
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	9
GO:0019213	deacetylase activity	3	9
GO:0033558	protein lysine deacetylase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.536
CLV_NRD_NRD_1	143	145	PF00675	0.287
CLV_NRD_NRD_1	385	387	PF00675	0.509
CLV_PCSK_FUR_1	383	387	PF00082	0.582
CLV_PCSK_KEX2_1	143	145	PF00082	0.287
CLV_PCSK_KEX2_1	329	331	PF00082	0.416
CLV_PCSK_KEX2_1	385	387	PF00082	0.466
CLV_PCSK_KEX2_1	410	412	PF00082	0.692
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.563
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.700

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD3	Leptomonas seymouri	84%	81%
A0A0N1PD56	Leptomonas seymouri	22%	100%
A0A0N1PFX6	Leptomonas seymouri	37%	100%
A0A1X0NVQ2	Trypanosomatidae	71%	95%
A0A1X0NXU7	Trypanosomatidae	38%	100%
A0A3Q8IC47	Leishmania donovani	93%	81%
A0A3R7L005	Trypanosoma rangeli	39%	100%
A0A3S7WWE6	Leishmania donovani	40%	100%
A0A422N1V5	Trypanosoma rangeli	70%	96%
A4HBR4	Leishmania braziliensis	36%	100%

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