Histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

histone deacetylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDK5_LEIBR

TriTrypDb:

LbrM.24.1510 , LBRM2903_240019700

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK5

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	9
GO:0006476	protein deacetylation	6	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0016570	histone modification	5	9
GO:0016575	histone deacetylation	6	9
GO:0019538	protein metabolic process	3	9
GO:0035601	protein deacylation	5	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0098732	macromolecule deacylation	5	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004407	histone deacetylase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	9
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	9
GO:0019213	deacetylase activity	3	9
GO:0033558	protein lysine deacetylase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.536
CLV_NRD_NRD_1	143	145	PF00675	0.287
CLV_NRD_NRD_1	385	387	PF00675	0.509
CLV_PCSK_FUR_1	383	387	PF00082	0.582
CLV_PCSK_KEX2_1	143	145	PF00082	0.287
CLV_PCSK_KEX2_1	329	331	PF00082	0.416
CLV_PCSK_KEX2_1	385	387	PF00082	0.466
CLV_PCSK_KEX2_1	410	412	PF00082	0.692
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.563
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.700
CLV_PCSK_SKI1_1	143	147	PF00082	0.336
CLV_PCSK_SKI1_1	174	178	PF00082	0.263
CLV_PCSK_SKI1_1	223	227	PF00082	0.278
CLV_PCSK_SKI1_1	30	34	PF00082	0.302
CLV_PCSK_SKI1_1	386	390	PF00082	0.510
DEG_APCC_DBOX_1	222	230	PF00400	0.502
DOC_CYCLIN_RxL_1	352	360	PF00134	0.349
DOC_MAPK_gen_1	329	337	PF00069	0.555
DOC_MAPK_MEF2A_6	151	159	PF00069	0.484
DOC_MAPK_MEF2A_6	303	312	PF00069	0.508
DOC_MAPK_MEF2A_6	329	337	PF00069	0.424
DOC_PP2B_LxvP_1	310	313	PF13499	0.480
DOC_PP4_FxxP_1	272	275	PF00568	0.394
DOC_PP4_FxxP_1	336	339	PF00568	0.539
DOC_PP4_FxxP_1	71	74	PF00568	0.478
DOC_USP7_MATH_1	127	131	PF00917	0.481
DOC_USP7_MATH_1	225	229	PF00917	0.536
DOC_USP7_MATH_1	74	78	PF00917	0.536
DOC_USP7_MATH_1	96	100	PF00917	0.462
DOC_WW_Pin1_4	324	329	PF00397	0.594
LIG_14-3-3_CanoR_1	174	179	PF00244	0.478
LIG_14-3-3_CanoR_1	223	233	PF00244	0.502
LIG_14-3-3_CanoR_1	30	37	PF00244	0.478
LIG_14-3-3_CterR_2	429	433	PF00244	0.710
LIG_APCC_ABBA_1	333	338	PF00400	0.420
LIG_BRCT_BRCA1_1	349	353	PF00533	0.538
LIG_BRCT_BRCA1_1	63	67	PF00533	0.536
LIG_BRCT_BRCA1_2	63	69	PF00533	0.536
LIG_CaM_IQ_9	358	374	PF13499	0.474
LIG_FHA_1	175	181	PF00498	0.478
LIG_FHA_1	261	267	PF00498	0.503
LIG_FHA_1	274	280	PF00498	0.429
LIG_FHA_1	330	336	PF00498	0.410
LIG_FHA_1	365	371	PF00498	0.461
LIG_FHA_1	376	382	PF00498	0.495
LIG_FHA_2	31	37	PF00498	0.480
LIG_GBD_Chelix_1	138	146	PF00786	0.278
LIG_GBD_Chelix_1	247	255	PF00786	0.278
LIG_Integrin_RGD_1	108	110	PF01839	0.336
LIG_LIR_Apic_2	271	275	PF02991	0.394
LIG_LIR_Apic_2	70	74	PF02991	0.502
LIG_LIR_Gen_1	130	140	PF02991	0.478
LIG_LIR_Gen_1	87	96	PF02991	0.502
LIG_LIR_Nem_3	130	135	PF02991	0.478
LIG_LIR_Nem_3	316	322	PF02991	0.401
LIG_LIR_Nem_3	87	92	PF02991	0.478
LIG_Pex14_2	183	187	PF04695	0.466
LIG_Pex14_2	67	71	PF04695	0.528
LIG_Pex14_2	85	89	PF04695	0.377
LIG_PTB_Apo_2	182	189	PF02174	0.478
LIG_Rb_LxCxE_1	99	112	PF01857	0.478
LIG_SH2_CRK	149	153	PF00017	0.536
LIG_SH2_PTP2	154	157	PF00017	0.536
LIG_SH2_STAT5	154	157	PF00017	0.478
LIG_SH2_STAT5	218	221	PF00017	0.478
LIG_SH2_STAT5	311	314	PF00017	0.382
LIG_SH2_STAT5	45	48	PF00017	0.478
LIG_SH3_3	204	210	PF00018	0.482
LIG_SH3_3	325	331	PF00018	0.444
LIG_SH3_3	338	344	PF00018	0.406
LIG_SH3_3	403	409	PF00018	0.758
LIG_SH3_3	80	86	PF00018	0.478
LIG_TRAF2_1	33	36	PF00917	0.478
LIG_TRAF2_1	394	397	PF00917	0.578
LIG_TRAF2_1	421	424	PF00917	0.522
LIG_TRAF2_1	76	79	PF00917	0.552
LIG_TYR_ITIM	152	157	PF00017	0.478
LIG_WRC_WIRS_1	219	224	PF05994	0.575
LIG_WRC_WIRS_1	269	274	PF05994	0.394
LIG_WRC_WIRS_1	37	42	PF05994	0.394
MOD_CDK_SPK_2	324	329	PF00069	0.594
MOD_CDK_SPxK_1	324	330	PF00069	0.592
MOD_CK1_1	221	227	PF00069	0.575
MOD_CK1_1	414	420	PF00069	0.732
MOD_CK1_1	90	96	PF00069	0.479
MOD_CK2_1	30	36	PF00069	0.462
MOD_CK2_1	418	424	PF00069	0.635
MOD_GlcNHglycan	129	132	PF01048	0.278
MOD_GlcNHglycan	401	404	PF01048	0.678
MOD_GlcNHglycan	406	409	PF01048	0.698
MOD_GlcNHglycan	413	416	PF01048	0.673
MOD_GlcNHglycan	419	423	PF01048	0.549
MOD_GSK3_1	221	228	PF00069	0.519
MOD_GSK3_1	256	263	PF00069	0.536
MOD_GSK3_1	411	418	PF00069	0.797
MOD_GSK3_1	87	94	PF00069	0.438
MOD_LATS_1	28	34	PF00433	0.536
MOD_NEK2_1	12	17	PF00069	0.478
MOD_NEK2_1	176	181	PF00069	0.478
MOD_NEK2_1	255	260	PF00069	0.471
MOD_NEK2_1	301	306	PF00069	0.563
MOD_NEK2_1	347	352	PF00069	0.432
MOD_NEK2_1	357	362	PF00069	0.333
MOD_NEK2_1	375	380	PF00069	0.449
MOD_NEK2_1	91	96	PF00069	0.478
MOD_NEK2_2	218	223	PF00069	0.575
MOD_PIKK_1	260	266	PF00454	0.536
MOD_PIKK_1	392	398	PF00454	0.615
MOD_PIKK_1	74	80	PF00454	0.562
MOD_PIKK_1	91	97	PF00454	0.378
MOD_PKA_1	329	335	PF00069	0.547
MOD_PKA_2	1	7	PF00069	0.466
MOD_PKA_2	196	202	PF00069	0.536
MOD_PKA_2	273	279	PF00069	0.575
MOD_PKA_2	329	335	PF00069	0.411
MOD_Plk_1	109	115	PF00069	0.575
MOD_Plk_1	61	67	PF00069	0.516
MOD_Plk_4	225	231	PF00069	0.501
MOD_Plk_4	243	249	PF00069	0.397
MOD_Plk_4	273	279	PF00069	0.478
MOD_Plk_4	347	353	PF00069	0.327
MOD_ProDKin_1	324	330	PF00069	0.592
TRG_DiLeu_BaEn_1	87	92	PF01217	0.502
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.478
TRG_ENDOCYTIC_2	149	152	PF00928	0.489
TRG_ENDOCYTIC_2	154	157	PF00928	0.465
TRG_ENDOCYTIC_2	284	287	PF00928	0.478
TRG_ER_diArg_1	142	144	PF00400	0.487
TRG_ER_diArg_1	383	386	PF00400	0.574
TRG_NLS_MonoCore_2	409	414	PF00514	0.763
TRG_NLS_MonoExtN_4	409	414	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD3	Leptomonas seymouri	84%	81%
A0A0N1PD56	Leptomonas seymouri	22%	100%
A0A0N1PFX6	Leptomonas seymouri	37%	100%
A0A1X0NVQ2	Trypanosomatidae	71%	95%
A0A1X0NXU7	Trypanosomatidae	38%	100%
A0A3Q8IC47	Leishmania donovani	93%	81%
A0A3R7L005	Trypanosoma rangeli	39%	100%
A0A3S7WWE6	Leishmania donovani	40%	100%
A0A422N1V5	Trypanosoma rangeli	70%	96%
A4HBR4	Leishmania braziliensis	36%	100%
A4HZ67	Leishmania infantum	40%	100%
A4I0X6	Leishmania infantum	94%	81%
B1H369	Xenopus tropicalis	40%	100%
B1WC68	Rattus norvegicus	37%	100%
D0A1H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AV34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	95%
E9AWY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	79%
O09106	Mus musculus	41%	90%
O13298	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O15379	Homo sapiens	37%	100%
O17695	Caenorhabditis elegans	40%	94%
O22446	Arabidopsis thaliana	41%	86%
O42227	Xenopus laevis	40%	90%
O59702	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O88895	Mus musculus	37%	100%
P32561	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P39067	Bacillus subtilis (strain 168)	32%	100%
P53096	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	96%
P56517	Gallus gallus	42%	90%
P56518	Strongylocentrotus purpuratus	40%	75%
P56519	Gallus gallus	41%	89%
P56520	Gallus gallus	37%	100%
P56521	Zea mays	42%	84%
P64375	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
P64376	Staphylococcus aureus (strain N315)	29%	100%
P70288	Mus musculus	41%	89%
Q09440	Caenorhabditis elegans	39%	85%
Q0VCB2	Bos taurus	36%	100%
Q13547	Homo sapiens	41%	90%
Q28DV3	Xenopus tropicalis	37%	100%
Q32PJ8	Bos taurus	41%	90%
Q4QAJ4	Leishmania major	93%	100%
Q4QCE7	Leishmania major	40%	100%
Q4QQW4	Rattus norvegicus	41%	90%
Q4SFA0	Tetraodon nigroviridis	38%	100%
Q55BW2	Dictyostelium discoideum	40%	100%
Q55FN5	Dictyostelium discoideum	38%	87%
Q56195	Staphylococcus xylosus	29%	100%
Q569C4	Rattus norvegicus	29%	74%
Q5HF39	Staphylococcus aureus (strain COL)	29%	100%
Q5RAG0	Pongo abelii	41%	90%
Q5RB76	Pongo abelii	34%	100%
Q6G8J2	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GFX3	Staphylococcus aureus (strain MRSA252)	29%	100%
Q6GPA7	Xenopus laevis	41%	100%
Q6IRL9	Xenopus laevis	38%	100%
Q6P6W3	Rattus norvegicus	37%	100%
Q6YV04	Oryza sativa subsp. japonica	43%	85%
Q7SXM0	Danio rerio	41%	100%
Q7Y0Y6	Oryza sativa subsp. japonica	42%	85%
Q7Y0Y8	Oryza sativa subsp. japonica	43%	84%
Q803C3	Danio rerio	34%	100%
Q8H0W2	Arabidopsis thaliana	40%	100%
Q8NW34	Staphylococcus aureus (strain MW2)	29%	100%
Q8VH37	Mus musculus	37%	100%
Q91695	Xenopus laevis	40%	90%
Q91WA3	Mus musculus	26%	100%
Q92769	Homo sapiens	41%	89%
Q941D6	Arabidopsis thaliana	26%	100%
Q94517	Drosophila melanogaster	41%	83%
Q9BY41	Homo sapiens	37%	100%
Q9FH09	Arabidopsis thaliana	35%	100%
Q9FML2	Arabidopsis thaliana	39%	92%
Q9I3T5	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	23%	100%
Q9I6H0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	24%	100%