Zinc finger, C3HC4 type (RING finger) protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative

Species:

Leishmania braziliensis

UniProt:

A4HDK4_LEIBR

TriTrypDb:

LbrM.24.1500 , LBRM2903_240019500 , LBRM2903_240019600

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HDK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	20
GO:0005509	calcium ion binding	5	17
GO:0043167	ion binding	2	20
GO:0043169	cation binding	3	20
GO:0046872	metal ion binding	4	20
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.396
CLV_NRD_NRD_1	50	52	PF00675	0.194
CLV_PCSK_SKI1_1	287	291	PF00082	0.414
DEG_SCF_FBW7_1	56	63	PF00400	0.312
DOC_CKS1_1	57	62	PF01111	0.460
DOC_CYCLIN_RxL_1	272	282	PF00134	0.341
DOC_MAPK_gen_1	376	384	PF00069	0.267
DOC_PP1_RVXF_1	273	280	PF00149	0.347
DOC_PP4_FxxP_1	123	126	PF00568	0.563
DOC_USP7_MATH_1	163	167	PF00917	0.755
DOC_USP7_MATH_1	180	184	PF00917	0.526
DOC_USP7_MATH_1	95	99	PF00917	0.708
DOC_USP7_UBL2_3	314	318	PF12436	0.465
DOC_WW_Pin1_4	101	106	PF00397	0.618
DOC_WW_Pin1_4	122	127	PF00397	0.575
DOC_WW_Pin1_4	135	140	PF00397	0.622
DOC_WW_Pin1_4	218	223	PF00397	0.668
DOC_WW_Pin1_4	27	32	PF00397	0.194
DOC_WW_Pin1_4	279	284	PF00397	0.376
DOC_WW_Pin1_4	56	61	PF00397	0.453
LIG_14-3-3_CanoR_1	235	240	PF00244	0.573
LIG_14-3-3_CanoR_1	300	304	PF00244	0.384
LIG_APCC_ABBA_1	253	258	PF00400	0.397
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_CtBP_PxDLS_1	26	30	PF00389	0.354
LIG_FHA_1	126	132	PF00498	0.732
LIG_FHA_1	13	19	PF00498	0.416
LIG_FHA_1	350	356	PF00498	0.270
LIG_FHA_2	338	344	PF00498	0.326
LIG_LIR_Apic_2	134	139	PF02991	0.511
LIG_LIR_Apic_2	21	26	PF02991	0.353
LIG_LIR_Gen_1	224	234	PF02991	0.400
LIG_LIR_Gen_1	246	255	PF02991	0.322
LIG_LIR_Gen_1	326	335	PF02991	0.367
LIG_LIR_Gen_1	350	358	PF02991	0.319
LIG_LIR_Gen_1	386	392	PF02991	0.398
LIG_LIR_Nem_3	206	212	PF02991	0.501
LIG_LIR_Nem_3	224	229	PF02991	0.573
LIG_LIR_Nem_3	246	250	PF02991	0.483
LIG_LIR_Nem_3	252	257	PF02991	0.335
LIG_LIR_Nem_3	326	331	PF02991	0.413
LIG_LIR_Nem_3	350	354	PF02991	0.332
LIG_LIR_Nem_3	386	390	PF02991	0.355
LIG_Pex14_2	10	14	PF04695	0.283
LIG_SH2_CRK	136	140	PF00017	0.522
LIG_SH2_CRK	247	251	PF00017	0.365
LIG_SH2_CRK	328	332	PF00017	0.250
LIG_SH2_STAP1	127	131	PF00017	0.634
LIG_SH2_STAP1	247	251	PF00017	0.365
LIG_SH2_STAT3	127	130	PF00017	0.629
LIG_SH2_STAT3	201	204	PF00017	0.711
LIG_SH2_STAT3	212	215	PF00017	0.596
LIG_SH2_STAT5	127	130	PF00017	0.617
LIG_SH2_STAT5	209	212	PF00017	0.524
LIG_SH3_3	156	162	PF00018	0.818
LIG_SH3_3	225	231	PF00018	0.597
LIG_SH3_3	97	103	PF00018	0.555
LIG_SH3_4	314	321	PF00018	0.579
LIG_SUMO_SIM_par_1	25	30	PF11976	0.255
LIG_TYR_ITSM	222	229	PF00017	0.445
MOD_CDK_SPxK_1	56	62	PF00069	0.460
MOD_CDK_SPxxK_3	218	225	PF00069	0.495
MOD_CK1_1	107	113	PF00069	0.724
MOD_CK1_1	125	131	PF00069	0.704
MOD_CK1_1	149	155	PF00069	0.658
MOD_CK1_1	183	189	PF00069	0.637
MOD_CK1_1	221	227	PF00069	0.563
MOD_CK1_1	98	104	PF00069	0.554
MOD_CK2_1	200	206	PF00069	0.495
MOD_CK2_1	299	305	PF00069	0.339
MOD_CK2_1	380	386	PF00069	0.399
MOD_GlcNHglycan	133	136	PF01048	0.632
MOD_GlcNHglycan	155	158	PF01048	0.668
MOD_GlcNHglycan	165	168	PF01048	0.674
MOD_GlcNHglycan	185	188	PF01048	0.582
MOD_GlcNHglycan	258	264	PF01048	0.334
MOD_GlcNHglycan	296	300	PF01048	0.341
MOD_GlcNHglycan	95	98	PF01048	0.572
MOD_GSK3_1	101	108	PF00069	0.642
MOD_GSK3_1	131	138	PF00069	0.692
MOD_GSK3_1	149	156	PF00069	0.573
MOD_GSK3_1	163	170	PF00069	0.735
MOD_GSK3_1	295	302	PF00069	0.311
MOD_GSK3_1	323	330	PF00069	0.530
MOD_GSK3_1	56	63	PF00069	0.608
MOD_N-GLC_1	149	154	PF02516	0.515
MOD_N-GLC_1	60	65	PF02516	0.530
MOD_N-GLC_1	93	98	PF02516	0.605
MOD_NEK2_1	153	158	PF00069	0.706
MOD_NEK2_1	295	300	PF00069	0.288
MOD_NEK2_1	323	328	PF00069	0.566
MOD_NEK2_1	337	342	PF00069	0.414
MOD_NEK2_2	380	385	PF00069	0.415
MOD_OFUCOSY	11	16	PF10250	0.194
MOD_PIKK_1	108	114	PF00454	0.796
MOD_PIKK_1	125	131	PF00454	0.504
MOD_PIKK_1	157	163	PF00454	0.626
MOD_PIKK_1	200	206	PF00454	0.530
MOD_PIKK_1	321	327	PF00454	0.497
MOD_PIKK_1	98	104	PF00454	0.507
MOD_PKA_2	299	305	PF00069	0.199
MOD_PKA_2	361	367	PF00069	0.206
MOD_Plk_1	149	155	PF00069	0.518
MOD_Plk_1	205	211	PF00069	0.780
MOD_Plk_1	349	355	PF00069	0.356
MOD_Plk_1	60	66	PF00069	0.510
MOD_Plk_4	149	155	PF00069	0.559
MOD_Plk_4	249	255	PF00069	0.314
MOD_Plk_4	305	311	PF00069	0.339
MOD_Plk_4	316	322	PF00069	0.525
MOD_Plk_4	327	333	PF00069	0.325
MOD_ProDKin_1	101	107	PF00069	0.622
MOD_ProDKin_1	122	128	PF00069	0.585
MOD_ProDKin_1	135	141	PF00069	0.626
MOD_ProDKin_1	218	224	PF00069	0.667
MOD_ProDKin_1	27	33	PF00069	0.194
MOD_ProDKin_1	279	285	PF00069	0.376
MOD_ProDKin_1	56	62	PF00069	0.460
TRG_DiLeu_BaEn_1	350	355	PF01217	0.394
TRG_ENDOCYTIC_2	226	229	PF00928	0.556
TRG_ENDOCYTIC_2	247	250	PF00928	0.511
TRG_ENDOCYTIC_2	328	331	PF00928	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P229	Leptomonas seymouri	57%	100%
A0A0N1ILD7	Leptomonas seymouri	22%	87%
A0A0S4JBP2	Bodo saltans	23%	88%
A0A1X0NCU6	Trypanosomatidae	33%	100%
A0A3Q8IMS6	Leishmania donovani	75%	100%
A0A3S5H5B1	Leishmania donovani	27%	67%
A0A3S7WWY0	Leishmania donovani	24%	88%
A0A3S7WYG1	Leishmania donovani	61%	85%
A4HDK3	Leishmania braziliensis	100%	100%
A4HS49	Leishmania infantum	27%	67%
A4HZP7	Leishmania infantum	24%	88%
A4I0X7	Leishmania infantum	75%	100%
A4I0X8	Leishmania infantum	60%	100%
E9AK36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AWY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
O97201	Leishmania major	29%	100%
Q4QAJ2	Leishmania major	59%	85%
Q4QAJ3	Leishmania major	73%	100%
Q8HZJ4	Bos taurus	21%	100%