Chromosome partition protein Smc

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDK2_LEIBR

TriTrypDb:

LbrM.24.1480 , LBRM2903_240020900

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.514
CLV_NRD_NRD_1	115	117	PF00675	0.581
CLV_NRD_NRD_1	27	29	PF00675	0.494
CLV_NRD_NRD_1	61	63	PF00675	0.515
CLV_PCSK_KEX2_1	114	116	PF00082	0.588
CLV_PCSK_KEX2_1	159	161	PF00082	0.502
CLV_PCSK_KEX2_1	27	29	PF00082	0.473
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.525
CLV_PCSK_SKI1_1	106	110	PF00082	0.544
CLV_PCSK_SKI1_1	133	137	PF00082	0.552
DOC_USP7_MATH_1	189	193	PF00917	0.544
DOC_USP7_MATH_1	29	33	PF00917	0.519
DOC_USP7_MATH_1	54	58	PF00917	0.621
DOC_USP7_MATH_1	68	72	PF00917	0.402
DOC_USP7_UBL2_3	69	73	PF12436	0.477
LIG_14-3-3_CanoR_1	13	17	PF00244	0.527
LIG_14-3-3_CanoR_1	28	38	PF00244	0.510
LIG_14-3-3_CanoR_1	83	87	PF00244	0.641
LIG_Actin_WH2_2	80	97	PF00022	0.428
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_FHA_1	107	113	PF00498	0.571
LIG_FHA_1	13	19	PF00498	0.612
LIG_FHA_1	163	169	PF00498	0.516
LIG_FHA_2	119	125	PF00498	0.588
LIG_FHA_2	186	192	PF00498	0.570
LIG_FHA_2	95	101	PF00498	0.614
LIG_LIR_Nem_3	5	10	PF02991	0.556
LIG_PDZ_Class_3	195	200	PF00595	0.712
LIG_RPA_C_Fungi	23	35	PF08784	0.578
LIG_SH2_STAT5	194	197	PF00017	0.682
LIG_SH3_1	171	177	PF00018	0.672
LIG_SH3_3	171	177	PF00018	0.593
LIG_SUMO_SIM_par_1	14	19	PF11976	0.621
LIG_TRAF2_1	135	138	PF00917	0.556
LIG_TRAF2_1	151	154	PF00917	0.592
LIG_TRAF2_1	47	50	PF00917	0.592
MOD_CK1_1	2	8	PF00069	0.664
MOD_CK2_1	185	191	PF00069	0.572
MOD_CK2_1	68	74	PF00069	0.551
MOD_CK2_1	82	88	PF00069	0.624
MOD_CK2_1	94	100	PF00069	0.398
MOD_GlcNHglycan	180	184	PF01048	0.611
MOD_GSK3_1	181	188	PF00069	0.597
MOD_GSK3_1	2	9	PF00069	0.589
MOD_GSK3_1	68	75	PF00069	0.382
MOD_N-GLC_1	94	99	PF02516	0.360
MOD_NEK2_1	118	123	PF00069	0.570
MOD_NEK2_1	185	190	PF00069	0.561
MOD_NEK2_1	94	99	PF00069	0.594
MOD_NEK2_2	189	194	PF00069	0.676
MOD_PIKK_1	76	82	PF00454	0.551
MOD_PKA_2	12	18	PF00069	0.501
MOD_PKA_2	82	88	PF00069	0.613
MOD_Plk_1	118	124	PF00069	0.567
MOD_Plk_1	2	8	PF00069	0.597
MOD_Plk_1	54	60	PF00069	0.589
MOD_Plk_1	94	100	PF00069	0.453
MOD_Plk_4	12	18	PF00069	0.501
MOD_Plk_4	189	195	PF00069	0.555
MOD_SUMO_rev_2	137	144	PF00179	0.536
MOD_SUMO_rev_2	55	65	PF00179	0.521
TRG_DiLeu_BaEn_1	191	196	PF01217	0.566
TRG_DiLeu_BaEn_4	89	95	PF01217	0.613
TRG_ER_diArg_1	114	116	PF00400	0.587
TRG_ER_diArg_1	56	59	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N4	Leptomonas seymouri	69%	99%
A0A0S4JQL1	Bodo saltans	29%	98%
A0A1X0NLU8	Trypanosomatidae	41%	100%
A0A3R7MNC1	Trypanosoma rangeli	45%	93%
A0A3S7WYE8	Leishmania donovani	88%	100%
A4I0X9	Leishmania infantum	88%	100%
C9ZUU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AWY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAJ1	Leishmania major	86%	100%