Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDK1_LEIBR

TriTrypDb:

LbrM.24.1470 , LBRM2903_240021000

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HDK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.350
CLV_C14_Caspase3-7	534	538	PF00656	0.363
CLV_C14_Caspase3-7	553	557	PF00656	0.355
CLV_NRD_NRD_1	220	222	PF00675	0.552
CLV_NRD_NRD_1	451	453	PF00675	0.569
CLV_NRD_NRD_1	5	7	PF00675	0.660
CLV_NRD_NRD_1	636	638	PF00675	0.657
CLV_NRD_NRD_1	797	799	PF00675	0.728
CLV_NRD_NRD_1	866	868	PF00675	0.492
CLV_PCSK_FUR_1	795	799	PF00082	0.649
CLV_PCSK_KEX2_1	220	222	PF00082	0.552
CLV_PCSK_KEX2_1	451	453	PF00082	0.531
CLV_PCSK_KEX2_1	5	7	PF00082	0.660
CLV_PCSK_KEX2_1	636	638	PF00082	0.621
CLV_PCSK_KEX2_1	797	799	PF00082	0.674
CLV_PCSK_KEX2_1	866	868	PF00082	0.492
CLV_PCSK_SKI1_1	324	328	PF00082	0.625
CLV_PCSK_SKI1_1	665	669	PF00082	0.598
CLV_PCSK_SKI1_1	949	953	PF00082	0.497
DEG_SPOP_SBC_1	677	681	PF00917	0.355
DEG_SPOP_SBC_1	807	811	PF00917	0.403
DOC_CDC14_PxL_1	713	721	PF14671	0.274
DOC_CKS1_1	55	60	PF01111	0.336
DOC_CKS1_1	629	634	PF01111	0.420
DOC_CYCLIN_RxL_1	321	331	PF00134	0.377
DOC_MAPK_gen_1	451	457	PF00069	0.375
DOC_MAPK_gen_1	5	13	PF00069	0.611
DOC_MAPK_gen_1	866	875	PF00069	0.387
DOC_MAPK_MEF2A_6	818	825	PF00069	0.313
DOC_MAPK_MEF2A_6	866	875	PF00069	0.344
DOC_PP1_RVXF_1	322	329	PF00149	0.400
DOC_PP2B_LxvP_1	455	458	PF13499	0.431
DOC_PP4_FxxP_1	68	71	PF00568	0.318
DOC_PP4_FxxP_1	775	778	PF00568	0.387
DOC_USP7_MATH_1	176	180	PF00917	0.389
DOC_USP7_MATH_1	31	35	PF00917	0.622
DOC_USP7_MATH_1	560	564	PF00917	0.310
DOC_USP7_MATH_1	575	579	PF00917	0.317
DOC_USP7_MATH_1	730	734	PF00917	0.448
DOC_USP7_MATH_1	807	811	PF00917	0.466
DOC_USP7_MATH_1	858	862	PF00917	0.405
DOC_USP7_MATH_1	883	887	PF00917	0.359
DOC_WW_Pin1_4	54	59	PF00397	0.387
DOC_WW_Pin1_4	564	569	PF00397	0.454
DOC_WW_Pin1_4	576	581	PF00397	0.490
DOC_WW_Pin1_4	628	633	PF00397	0.390
DOC_WW_Pin1_4	842	847	PF00397	0.435
LIG_14-3-3_CanoR_1	253	263	PF00244	0.369
LIG_14-3-3_CanoR_1	304	314	PF00244	0.423
LIG_14-3-3_CanoR_1	419	425	PF00244	0.284
LIG_14-3-3_CanoR_1	487	492	PF00244	0.475
LIG_14-3-3_CanoR_1	6	12	PF00244	0.562
LIG_14-3-3_CanoR_1	636	644	PF00244	0.438
LIG_14-3-3_CanoR_1	665	670	PF00244	0.340
LIG_14-3-3_CanoR_1	700	706	PF00244	0.442
LIG_14-3-3_CanoR_1	749	757	PF00244	0.366
LIG_14-3-3_CanoR_1	866	872	PF00244	0.363
LIG_APCC_ABBAyCdc20_2	274	280	PF00400	0.237
LIG_BIR_III_2	945	949	PF00653	0.646
LIG_BIR_III_4	167	171	PF00653	0.504
LIG_Clathr_ClatBox_1	374	378	PF01394	0.217
LIG_CtBP_PxDLS_1	718	722	PF00389	0.374
LIG_FHA_1	247	253	PF00498	0.422
LIG_FHA_1	255	261	PF00498	0.366
LIG_FHA_1	345	351	PF00498	0.404
LIG_FHA_1	460	466	PF00498	0.437
LIG_FHA_1	565	571	PF00498	0.466
LIG_FHA_1	598	604	PF00498	0.453
LIG_FHA_1	624	630	PF00498	0.342
LIG_FHA_1	672	678	PF00498	0.260
LIG_FHA_1	689	695	PF00498	0.403
LIG_FHA_1	786	792	PF00498	0.520
LIG_FHA_1	8	14	PF00498	0.500
LIG_FHA_1	807	813	PF00498	0.410
LIG_FHA_1	902	908	PF00498	0.289
LIG_FHA_2	114	120	PF00498	0.349
LIG_FHA_2	551	557	PF00498	0.331
LIG_FHA_2	666	672	PF00498	0.374
LIG_FHA_2	734	740	PF00498	0.400
LIG_FHA_2	817	823	PF00498	0.428
LIG_GBD_Chelix_1	13	21	PF00786	0.562
LIG_LIR_Apic_2	279	284	PF02991	0.368
LIG_LIR_Apic_2	67	71	PF02991	0.365
LIG_LIR_Gen_1	265	276	PF02991	0.336
LIG_LIR_Gen_1	320	327	PF02991	0.395
LIG_LIR_Gen_1	403	412	PF02991	0.342
LIG_LIR_Gen_1	548	559	PF02991	0.433
LIG_LIR_Gen_1	607	615	PF02991	0.437
LIG_LIR_Gen_1	709	718	PF02991	0.416
LIG_LIR_Gen_1	882	892	PF02991	0.263
LIG_LIR_Nem_3	119	125	PF02991	0.377
LIG_LIR_Nem_3	265	271	PF02991	0.341
LIG_LIR_Nem_3	273	278	PF02991	0.283
LIG_LIR_Nem_3	320	325	PF02991	0.335
LIG_LIR_Nem_3	403	408	PF02991	0.308
LIG_LIR_Nem_3	468	474	PF02991	0.345
LIG_LIR_Nem_3	511	516	PF02991	0.440
LIG_LIR_Nem_3	548	554	PF02991	0.392
LIG_LIR_Nem_3	607	612	PF02991	0.435
LIG_LIR_Nem_3	663	669	PF02991	0.425
LIG_LIR_Nem_3	709	713	PF02991	0.405
LIG_LIR_Nem_3	82	88	PF02991	0.340
LIG_LIR_Nem_3	882	887	PF02991	0.328
LIG_NRBOX	926	932	PF00104	0.386
LIG_NRBOX	936	942	PF00104	0.328
LIG_PCNA_yPIPBox_3	324	337	PF02747	0.379
LIG_PDZ_Class_2	948	953	PF00595	0.659
LIG_Pex14_1	422	426	PF04695	0.341
LIG_SH2_CRK	268	272	PF00017	0.392
LIG_SH2_CRK	322	326	PF00017	0.333
LIG_SH2_CRK	857	861	PF00017	0.404
LIG_SH2_GRB2like	857	860	PF00017	0.351
LIG_SH2_NCK_1	857	861	PF00017	0.355
LIG_SH2_PTP2	551	554	PF00017	0.275
LIG_SH2_PTP2	85	88	PF00017	0.457
LIG_SH2_SRC	857	860	PF00017	0.333
LIG_SH2_SRC	895	898	PF00017	0.388
LIG_SH2_STAP1	268	272	PF00017	0.312
LIG_SH2_STAP1	322	326	PF00017	0.392
LIG_SH2_STAP1	426	430	PF00017	0.334
LIG_SH2_STAP1	669	673	PF00017	0.397
LIG_SH2_STAT3	646	649	PF00017	0.328
LIG_SH2_STAT5	204	207	PF00017	0.412
LIG_SH2_STAT5	276	279	PF00017	0.374
LIG_SH2_STAT5	551	554	PF00017	0.358
LIG_SH2_STAT5	609	612	PF00017	0.346
LIG_SH2_STAT5	85	88	PF00017	0.414
LIG_SH2_STAT5	863	866	PF00017	0.331
LIG_SH2_STAT5	916	919	PF00017	0.337
LIG_SH2_STAT5	939	942	PF00017	0.429
LIG_SH3_3	352	358	PF00018	0.405
LIG_SH3_3	428	434	PF00018	0.420
LIG_SH3_3	52	58	PF00018	0.378
LIG_SH3_3	592	598	PF00018	0.285
LIG_SH3_3	626	632	PF00018	0.397
LIG_SH3_3	711	717	PF00018	0.365
LIG_SH3_3	724	730	PF00018	0.344
LIG_Sin3_3	95	102	PF02671	0.338
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.328
LIG_SUMO_SIM_par_1	111	117	PF11976	0.365
LIG_SUMO_SIM_par_1	625	631	PF11976	0.255
LIG_SUMO_SIM_par_1	673	681	PF11976	0.304
LIG_SUMO_SIM_par_1	689	697	PF11976	0.430
LIG_TRAF2_1	244	247	PF00917	0.423
LIG_TRAF2_1	886	889	PF00917	0.331
LIG_TRAF2_1	908	911	PF00917	0.330
LIG_TYR_ITIM	937	942	PF00017	0.423
LIG_UBA3_1	388	393	PF00899	0.270
LIG_WW_1	58	61	PF00397	0.323
MOD_CDK_SPxxK_3	564	571	PF00069	0.413
MOD_CK1_1	188	194	PF00069	0.458
MOD_CK1_1	299	305	PF00069	0.562
MOD_CK1_1	332	338	PF00069	0.412
MOD_CK1_1	381	387	PF00069	0.424
MOD_CK1_1	398	404	PF00069	0.376
MOD_CK1_1	639	645	PF00069	0.457
MOD_CK1_1	676	682	PF00069	0.256
MOD_CK1_1	693	699	PF00069	0.247
MOD_CK1_1	701	707	PF00069	0.295
MOD_CK1_1	733	739	PF00069	0.404
MOD_CK1_1	811	817	PF00069	0.443
MOD_CK1_1	861	867	PF00069	0.259
MOD_CK1_1	87	93	PF00069	0.482
MOD_CK2_1	241	247	PF00069	0.405
MOD_CK2_1	398	404	PF00069	0.408
MOD_CK2_1	474	480	PF00069	0.429
MOD_CK2_1	665	671	PF00069	0.377
MOD_CK2_1	733	739	PF00069	0.477
MOD_CK2_1	816	822	PF00069	0.432
MOD_CK2_1	883	889	PF00069	0.407
MOD_CMANNOS	26	29	PF00535	0.643
MOD_GlcNHglycan	127	131	PF01048	0.641
MOD_GlcNHglycan	178	181	PF01048	0.770
MOD_GlcNHglycan	187	190	PF01048	0.720
MOD_GlcNHglycan	196	199	PF01048	0.588
MOD_GlcNHglycan	264	267	PF01048	0.576
MOD_GlcNHglycan	293	296	PF01048	0.660
MOD_GlcNHglycan	301	304	PF01048	0.789
MOD_GlcNHglycan	307	310	PF01048	0.719
MOD_GlcNHglycan	33	36	PF01048	0.636
MOD_GlcNHglycan	495	499	PF01048	0.711
MOD_GlcNHglycan	546	550	PF01048	0.530
MOD_GlcNHglycan	562	565	PF01048	0.570
MOD_GlcNHglycan	583	586	PF01048	0.693
MOD_GlcNHglycan	605	609	PF01048	0.609
MOD_GlcNHglycan	680	683	PF01048	0.453
MOD_GlcNHglycan	732	735	PF01048	0.683
MOD_GlcNHglycan	736	739	PF01048	0.609
MOD_GlcNHglycan	753	756	PF01048	0.526
MOD_GlcNHglycan	798	801	PF01048	0.750
MOD_GlcNHglycan	826	830	PF01048	0.646
MOD_GlcNHglycan	836	839	PF01048	0.529
MOD_GlcNHglycan	880	884	PF01048	0.537
MOD_GlcNHglycan	913	916	PF01048	0.663
MOD_GlcNHglycan	95	98	PF01048	0.734
MOD_GSK3_1	171	178	PF00069	0.413
MOD_GSK3_1	181	188	PF00069	0.500
MOD_GSK3_1	215	222	PF00069	0.360
MOD_GSK3_1	238	245	PF00069	0.502
MOD_GSK3_1	262	269	PF00069	0.402
MOD_GSK3_1	331	338	PF00069	0.388
MOD_GSK3_1	340	347	PF00069	0.390
MOD_GSK3_1	394	401	PF00069	0.405
MOD_GSK3_1	461	468	PF00069	0.476
MOD_GSK3_1	560	567	PF00069	0.443
MOD_GSK3_1	671	678	PF00069	0.312
MOD_GSK3_1	684	691	PF00069	0.286
MOD_GSK3_1	694	701	PF00069	0.355
MOD_GSK3_1	730	737	PF00069	0.434
MOD_GSK3_1	807	814	PF00069	0.476
MOD_GSK3_1	821	828	PF00069	0.427
MOD_GSK3_1	84	91	PF00069	0.490
MOD_GSK3_1	875	882	PF00069	0.387
MOD_N-GLC_1	297	302	PF02516	0.651
MOD_N-GLC_1	329	334	PF02516	0.576
MOD_N-GLC_1	459	464	PF02516	0.681
MOD_N-GLC_1	586	591	PF02516	0.588
MOD_N-GLC_1	616	621	PF02516	0.643
MOD_N-GLC_1	671	676	PF02516	0.472
MOD_N-GLC_1	719	724	PF02516	0.538
MOD_N-GLC_1	858	863	PF02516	0.607
MOD_N-GLC_1	93	98	PF02516	0.674
MOD_NEK2_1	121	126	PF00069	0.394
MOD_NEK2_1	215	220	PF00069	0.369
MOD_NEK2_1	340	345	PF00069	0.339
MOD_NEK2_1	350	355	PF00069	0.335
MOD_NEK2_1	394	399	PF00069	0.395
MOD_NEK2_1	473	478	PF00069	0.418
MOD_NEK2_1	481	486	PF00069	0.420
MOD_NEK2_1	550	555	PF00069	0.397
MOD_NEK2_1	673	678	PF00069	0.306
MOD_NEK2_1	690	695	PF00069	0.255
MOD_NEK2_1	698	703	PF00069	0.369
MOD_NEK2_1	719	724	PF00069	0.400
MOD_NEK2_1	751	756	PF00069	0.490
MOD_NEK2_1	808	813	PF00069	0.399
MOD_NEK2_1	825	830	PF00069	0.395
MOD_NEK2_2	779	784	PF00069	0.469
MOD_NEK2_2	836	841	PF00069	0.258
MOD_NEK2_2	858	863	PF00069	0.247
MOD_PIKK_1	660	666	PF00454	0.406
MOD_PIKK_1	785	791	PF00454	0.460
MOD_PKA_1	636	642	PF00069	0.438
MOD_PKA_2	219	225	PF00069	0.363
MOD_PKA_2	254	260	PF00069	0.373
MOD_PKA_2	493	499	PF00069	0.494
MOD_PKA_2	636	642	PF00069	0.505
MOD_PKA_2	660	666	PF00069	0.311
MOD_PKA_2	699	705	PF00069	0.401
MOD_PKA_2	796	802	PF00069	0.456
MOD_Plk_1	182	188	PF00069	0.481
MOD_Plk_1	215	221	PF00069	0.425
MOD_Plk_1	246	252	PF00069	0.296
MOD_Plk_1	329	335	PF00069	0.433
MOD_Plk_1	378	384	PF00069	0.387
MOD_Plk_1	545	551	PF00069	0.386
MOD_Plk_1	586	592	PF00069	0.495
MOD_Plk_1	671	677	PF00069	0.250
MOD_Plk_1	821	827	PF00069	0.399
MOD_Plk_1	858	864	PF00069	0.360
MOD_Plk_1	879	885	PF00069	0.337
MOD_Plk_1	93	99	PF00069	0.472
MOD_Plk_4	19	25	PF00069	0.521
MOD_Plk_4	332	338	PF00069	0.312
MOD_Plk_4	395	401	PF00069	0.376
MOD_Plk_4	465	471	PF00069	0.353
MOD_Plk_4	508	514	PF00069	0.416
MOD_Plk_4	623	629	PF00069	0.380
MOD_Plk_4	639	645	PF00069	0.449
MOD_Plk_4	779	785	PF00069	0.387
MOD_Plk_4	858	864	PF00069	0.244
MOD_Plk_4	921	927	PF00069	0.297
MOD_ProDKin_1	54	60	PF00069	0.386
MOD_ProDKin_1	564	570	PF00069	0.450
MOD_ProDKin_1	576	582	PF00069	0.489
MOD_ProDKin_1	628	634	PF00069	0.394
MOD_ProDKin_1	842	848	PF00069	0.436
TRG_DiLeu_BaEn_1	247	252	PF01217	0.407
TRG_DiLeu_BaEn_2	63	69	PF01217	0.267
TRG_DiLeu_BaEn_4	247	253	PF01217	0.404
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.401
TRG_DiLeu_LyEn_5	247	252	PF01217	0.407
TRG_ENDOCYTIC_2	268	271	PF00928	0.319
TRG_ENDOCYTIC_2	275	278	PF00928	0.302
TRG_ENDOCYTIC_2	322	325	PF00928	0.406
TRG_ENDOCYTIC_2	470	473	PF00928	0.365
TRG_ENDOCYTIC_2	551	554	PF00928	0.394
TRG_ENDOCYTIC_2	609	612	PF00928	0.346
TRG_ENDOCYTIC_2	781	784	PF00928	0.321
TRG_ENDOCYTIC_2	85	88	PF00928	0.340
TRG_ENDOCYTIC_2	857	860	PF00928	0.398
TRG_ENDOCYTIC_2	939	942	PF00928	0.423
TRG_ER_diArg_1	212	215	PF00400	0.322
TRG_ER_diArg_1	219	221	PF00400	0.342
TRG_ER_diArg_1	252	255	PF00400	0.425
TRG_ER_diArg_1	416	419	PF00400	0.277
TRG_ER_diArg_1	450	452	PF00400	0.328
TRG_ER_diArg_1	486	489	PF00400	0.557
TRG_ER_diArg_1	5	7	PF00400	0.579
TRG_ER_diArg_1	795	798	PF00400	0.455
TRG_ER_diArg_1	865	867	PF00400	0.329
TRG_ER_diArg_1	871	874	PF00400	0.392
TRG_NES_CRM1_1	364	378	PF08389	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L3	Leptomonas seymouri	48%	100%
A0A1X0PBB4	Trypanosomatidae	25%	98%
A0A3R7KLJ4	Trypanosoma rangeli	26%	99%
A0A3S5H7D3	Leishmania donovani	75%	100%
A4I0Y0	Leishmania infantum	76%	100%
C9ZLZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AWY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QAJ0	Leishmania major	77%	100%
V5BQI0	Trypanosoma cruzi	24%	100%