Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HDJ8_LEIBR

TriTrypDb:

LbrM.24.1440 , LBRM2903_240021400

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.710
CLV_C14_Caspase3-7	299	303	PF00656	0.550
CLV_C14_Caspase3-7	766	770	PF00656	0.783
CLV_NRD_NRD_1	106	108	PF00675	0.586
CLV_NRD_NRD_1	147	149	PF00675	0.600
CLV_NRD_NRD_1	388	390	PF00675	0.768
CLV_NRD_NRD_1	611	613	PF00675	0.613
CLV_NRD_NRD_1	679	681	PF00675	0.769
CLV_NRD_NRD_1	709	711	PF00675	0.556
CLV_NRD_NRD_1	738	740	PF00675	0.787
CLV_NRD_NRD_1	826	828	PF00675	0.566
CLV_NRD_NRD_1	829	831	PF00675	0.546
CLV_NRD_NRD_1	912	914	PF00675	0.772
CLV_PCSK_KEX2_1	611	613	PF00082	0.613
CLV_PCSK_KEX2_1	678	680	PF00082	0.765
CLV_PCSK_KEX2_1	718	720	PF00082	0.554
CLV_PCSK_KEX2_1	738	740	PF00082	0.687
CLV_PCSK_KEX2_1	826	828	PF00082	0.566
CLV_PCSK_KEX2_1	912	914	PF00082	0.806
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.758
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.554
CLV_PCSK_SKI1_1	120	124	PF00082	0.582
CLV_PCSK_SKI1_1	389	393	PF00082	0.667
CLV_PCSK_SKI1_1	497	501	PF00082	0.592
CLV_PCSK_SKI1_1	679	683	PF00082	0.777
CLV_PCSK_SKI1_1	726	730	PF00082	0.780
CLV_PCSK_SKI1_1	863	867	PF00082	0.585
CLV_PCSK_SKI1_1	99	103	PF00082	0.582
DEG_APCC_DBOX_1	496	504	PF00400	0.565
DEG_SPOP_SBC_1	114	118	PF00917	0.575
DEG_SPOP_SBC_1	268	272	PF00917	0.560
DEG_SPOP_SBC_1	291	295	PF00917	0.604
DEG_SPOP_SBC_1	346	350	PF00917	0.688
DEG_SPOP_SBC_1	401	405	PF00917	0.700
DEG_SPOP_SBC_1	79	83	PF00917	0.665
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.561
DOC_MAPK_gen_1	389	395	PF00069	0.771
DOC_MAPK_gen_1	678	688	PF00069	0.584
DOC_MAPK_gen_1	826	836	PF00069	0.569
DOC_MAPK_MEF2A_6	827	836	PF00069	0.577
DOC_MAPK_MEF2A_6	896	905	PF00069	0.570
DOC_PP2B_LxvP_1	360	363	PF13499	0.557
DOC_PP2B_LxvP_1	391	394	PF13499	0.767
DOC_PP2B_LxvP_1	478	481	PF13499	0.742
DOC_PP2B_LxvP_1	624	627	PF13499	0.574
DOC_PP2B_LxvP_1	74	77	PF13499	0.568
DOC_PP4_FxxP_1	106	109	PF00568	0.580
DOC_PP4_FxxP_1	697	700	PF00568	0.550
DOC_USP7_MATH_1	177	181	PF00917	0.573
DOC_USP7_MATH_1	203	207	PF00917	0.723
DOC_USP7_MATH_1	210	214	PF00917	0.743
DOC_USP7_MATH_1	217	221	PF00917	0.658
DOC_USP7_MATH_1	262	266	PF00917	0.666
DOC_USP7_MATH_1	267	271	PF00917	0.653
DOC_USP7_MATH_1	281	285	PF00917	0.584
DOC_USP7_MATH_1	346	350	PF00917	0.792
DOC_USP7_MATH_1	384	388	PF00917	0.547
DOC_USP7_MATH_1	401	405	PF00917	0.706
DOC_USP7_MATH_1	446	450	PF00917	0.678
DOC_USP7_MATH_1	511	515	PF00917	0.719
DOC_USP7_MATH_1	536	540	PF00917	0.597
DOC_USP7_MATH_1	56	60	PF00917	0.634
DOC_USP7_MATH_1	638	642	PF00917	0.750
DOC_USP7_MATH_1	648	652	PF00917	0.590
DOC_USP7_MATH_1	765	769	PF00917	0.636
DOC_USP7_MATH_1	79	83	PF00917	0.652
DOC_USP7_MATH_1	867	871	PF00917	0.660
DOC_USP7_MATH_1	97	101	PF00917	0.613
DOC_USP7_UBL2_3	678	682	PF12436	0.735
DOC_WW_Pin1_4	164	169	PF00397	0.778
DOC_WW_Pin1_4	206	211	PF00397	0.768
DOC_WW_Pin1_4	212	217	PF00397	0.697
DOC_WW_Pin1_4	236	241	PF00397	0.702
DOC_WW_Pin1_4	279	284	PF00397	0.733
DOC_WW_Pin1_4	301	306	PF00397	0.568
DOC_WW_Pin1_4	333	338	PF00397	0.777
DOC_WW_Pin1_4	406	411	PF00397	0.724
DOC_WW_Pin1_4	428	433	PF00397	0.708
DOC_WW_Pin1_4	512	517	PF00397	0.572
DOC_WW_Pin1_4	541	546	PF00397	0.693
DOC_WW_Pin1_4	614	619	PF00397	0.774
DOC_WW_Pin1_4	630	635	PF00397	0.578
DOC_WW_Pin1_4	644	649	PF00397	0.720
DOC_WW_Pin1_4	891	896	PF00397	0.657
DOC_WW_Pin1_4	93	98	PF00397	0.749
LIG_14-3-3_CanoR_1	186	190	PF00244	0.803
LIG_14-3-3_CanoR_1	365	374	PF00244	0.622
LIG_14-3-3_CanoR_1	389	394	PF00244	0.663
LIG_14-3-3_CanoR_1	427	431	PF00244	0.569
LIG_14-3-3_CanoR_1	464	472	PF00244	0.546
LIG_14-3-3_CanoR_1	485	490	PF00244	0.589
LIG_14-3-3_CanoR_1	566	574	PF00244	0.612
LIG_14-3-3_CanoR_1	581	587	PF00244	0.724
LIG_14-3-3_CanoR_1	61	66	PF00244	0.619
LIG_14-3-3_CanoR_1	637	643	PF00244	0.567
LIG_14-3-3_CanoR_1	78	88	PF00244	0.621
LIG_14-3-3_CanoR_1	810	818	PF00244	0.642
LIG_14-3-3_CanoR_1	889	895	PF00244	0.706
LIG_14-3-3_CanoR_1	93	97	PF00244	0.621
LIG_Actin_WH2_2	7	22	PF00022	0.652
LIG_APCC_ABBA_1	667	672	PF00400	0.750
LIG_APCC_ABBA_1	850	855	PF00400	0.573
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_BIR_III_2	302	306	PF00653	0.761
LIG_BRCT_BRCA1_1	495	499	PF00533	0.567
LIG_eIF4E_1	783	789	PF01652	0.558
LIG_FHA_1	213	219	PF00498	0.753
LIG_FHA_1	302	308	PF00498	0.713
LIG_FHA_1	374	380	PF00498	0.755
LIG_FHA_1	390	396	PF00498	0.619
LIG_FHA_1	565	571	PF00498	0.783
LIG_FHA_1	587	593	PF00498	0.582
LIG_FHA_1	604	610	PF00498	0.672
LIG_FHA_1	64	70	PF00498	0.656
LIG_FHA_1	690	696	PF00498	0.633
LIG_FHA_1	784	790	PF00498	0.554
LIG_FHA_1	859	865	PF00498	0.577
LIG_FHA_1	888	894	PF00498	0.595
LIG_FHA_2	179	185	PF00498	0.588
LIG_FHA_2	297	303	PF00498	0.555
LIG_FHA_2	429	435	PF00498	0.680
LIG_FHA_2	866	872	PF00498	0.737
LIG_LIR_Apic_2	105	109	PF02991	0.576
LIG_LIR_Gen_1	230	241	PF02991	0.568
LIG_LIR_Gen_1	250	261	PF02991	0.485
LIG_LIR_Nem_3	230	236	PF02991	0.573
LIG_LIR_Nem_3	250	256	PF02991	0.486
LIG_MYND_1	622	626	PF01753	0.568
LIG_PCNA_yPIPBox_3	810	822	PF02747	0.574
LIG_Pex14_2	249	253	PF04695	0.589
LIG_REV1ctd_RIR_1	230	239	PF16727	0.765
LIG_SH2_CRK	197	201	PF00017	0.557
LIG_SH2_CRK	462	466	PF00017	0.781
LIG_SH2_NCK_1	462	466	PF00017	0.781
LIG_SH2_NCK_1	762	766	PF00017	0.567
LIG_SH2_STAP1	197	201	PF00017	0.557
LIG_SH2_STAP1	670	674	PF00017	0.752
LIG_SH2_STAT5	161	164	PF00017	0.573
LIG_SH2_STAT5	315	318	PF00017	0.790
LIG_SH2_STAT5	704	707	PF00017	0.560
LIG_SH2_STAT5	741	744	PF00017	0.565
LIG_SH3_1	556	562	PF00018	0.800
LIG_SH3_1	612	618	PF00018	0.594
LIG_SH3_2	551	556	PF14604	0.589
LIG_SH3_3	277	283	PF00018	0.670
LIG_SH3_3	285	291	PF00018	0.603
LIG_SH3_3	31	37	PF00018	0.580
LIG_SH3_3	331	337	PF00018	0.753
LIG_SH3_3	338	344	PF00018	0.651
LIG_SH3_3	407	413	PF00018	0.727
LIG_SH3_3	478	484	PF00018	0.783
LIG_SH3_3	500	506	PF00018	0.709
LIG_SH3_3	507	513	PF00018	0.636
LIG_SH3_3	545	551	PF00018	0.680
LIG_SH3_3	556	562	PF00018	0.762
LIG_SH3_3	612	618	PF00018	0.742
LIG_SH3_3	619	625	PF00018	0.794
LIG_SUMO_SIM_anti_2	902	907	PF11976	0.654
LIG_SUMO_SIM_par_1	200	206	PF11976	0.715
LIG_SUMO_SIM_par_1	567	578	PF11976	0.772
LIG_TRAF2_1	181	184	PF00917	0.805
LIG_TRAF2_1	713	716	PF00917	0.555
LIG_TYR_ITIM	460	465	PF00017	0.780
LIG_UBA3_1	705	711	PF00899	0.540
LIG_WRC_WIRS_1	253	258	PF05994	0.554
LIG_WW_2	622	625	PF00397	0.575
LIG_WW_3	139	143	PF00397	0.591
LIG_WW_3	75	79	PF00397	0.741
MOD_CDC14_SPxK_1	167	170	PF00782	0.545
MOD_CDC14_SPxK_1	239	242	PF00782	0.559
MOD_CDC14_SPxK_1	336	339	PF00782	0.542
MOD_CDC14_SPxK_1	96	99	PF00782	0.614
MOD_CDK_SPK_2	891	896	PF00069	0.583
MOD_CDK_SPxK_1	164	170	PF00069	0.553
MOD_CDK_SPxK_1	236	242	PF00069	0.565
MOD_CDK_SPxK_1	333	339	PF00069	0.549
MOD_CDK_SPxK_1	93	99	PF00069	0.613
MOD_CDK_SPxxK_3	630	637	PF00069	0.666
MOD_CK1_1	128	134	PF00069	0.796
MOD_CK1_1	164	170	PF00069	0.693
MOD_CK1_1	175	181	PF00069	0.596
MOD_CK1_1	206	212	PF00069	0.781
MOD_CK1_1	227	233	PF00069	0.710
MOD_CK1_1	252	258	PF00069	0.634
MOD_CK1_1	27	33	PF00069	0.638
MOD_CK1_1	295	301	PF00069	0.664
MOD_CK1_1	348	354	PF00069	0.613
MOD_CK1_1	404	410	PF00069	0.805
MOD_CK1_1	444	450	PF00069	0.694
MOD_CK1_1	491	497	PF00069	0.598
MOD_CK1_1	519	525	PF00069	0.580
MOD_CK1_1	539	545	PF00069	0.756
MOD_CK1_1	584	590	PF00069	0.753
MOD_CK1_1	616	622	PF00069	0.772
MOD_CK1_1	63	69	PF00069	0.717
MOD_CK1_1	743	749	PF00069	0.571
MOD_CK1_1	81	87	PF00069	0.576
MOD_CK1_1	814	820	PF00069	0.766
MOD_CK1_1	870	876	PF00069	0.659
MOD_CK1_1	888	894	PF00069	0.749
MOD_CK1_1	91	97	PF00069	0.625
MOD_CK2_1	177	183	PF00069	0.804
MOD_CK2_1	25	31	PF00069	0.761
MOD_CK2_1	428	434	PF00069	0.676
MOD_CK2_1	473	479	PF00069	0.747
MOD_CK2_1	569	575	PF00069	0.781
MOD_CK2_1	80	86	PF00069	0.752
MOD_Cter_Amidation	716	719	PF01082	0.560
MOD_DYRK1A_RPxSP_1	644	648	PF00069	0.549
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.748
MOD_GlcNHglycan	133	136	PF01048	0.768
MOD_GlcNHglycan	163	166	PF01048	0.747
MOD_GlcNHglycan	205	208	PF01048	0.703
MOD_GlcNHglycan	226	229	PF01048	0.631
MOD_GlcNHglycan	256	259	PF01048	0.699
MOD_GlcNHglycan	283	286	PF01048	0.633
MOD_GlcNHglycan	368	371	PF01048	0.691
MOD_GlcNHglycan	406	409	PF01048	0.585
MOD_GlcNHglycan	444	447	PF01048	0.693
MOD_GlcNHglycan	448	451	PF01048	0.639
MOD_GlcNHglycan	45	48	PF01048	0.745
MOD_GlcNHglycan	454	457	PF01048	0.661
MOD_GlcNHglycan	465	468	PF01048	0.561
MOD_GlcNHglycan	532	535	PF01048	0.649
MOD_GlcNHglycan	567	570	PF01048	0.694
MOD_GlcNHglycan	586	589	PF01048	0.582
MOD_GlcNHglycan	618	621	PF01048	0.607
MOD_GlcNHglycan	652	655	PF01048	0.601
MOD_GlcNHglycan	701	704	PF01048	0.612
MOD_GlcNHglycan	71	74	PF01048	0.646
MOD_GlcNHglycan	742	745	PF01048	0.632
MOD_GlcNHglycan	799	802	PF01048	0.661
MOD_GlcNHglycan	803	807	PF01048	0.611
MOD_GlcNHglycan	838	841	PF01048	0.761
MOD_GlcNHglycan	873	876	PF01048	0.817
MOD_GlcNHglycan	99	102	PF01048	0.668
MOD_GSK3_1	121	128	PF00069	0.630
MOD_GSK3_1	129	136	PF00069	0.733
MOD_GSK3_1	171	178	PF00069	0.692
MOD_GSK3_1	206	213	PF00069	0.743
MOD_GSK3_1	247	254	PF00069	0.677
MOD_GSK3_1	279	286	PF00069	0.669
MOD_GSK3_1	291	298	PF00069	0.583
MOD_GSK3_1	313	320	PF00069	0.737
MOD_GSK3_1	345	352	PF00069	0.787
MOD_GSK3_1	389	396	PF00069	0.650
MOD_GSK3_1	400	407	PF00069	0.543
MOD_GSK3_1	426	433	PF00069	0.664
MOD_GSK3_1	43	50	PF00069	0.747
MOD_GSK3_1	442	449	PF00069	0.624
MOD_GSK3_1	488	495	PF00069	0.611
MOD_GSK3_1	512	519	PF00069	0.690
MOD_GSK3_1	536	543	PF00069	0.792
MOD_GSK3_1	56	63	PF00069	0.592
MOD_GSK3_1	565	572	PF00069	0.708
MOD_GSK3_1	582	589	PF00069	0.611
MOD_GSK3_1	594	601	PF00069	0.616
MOD_GSK3_1	614	621	PF00069	0.748
MOD_GSK3_1	644	651	PF00069	0.736
MOD_GSK3_1	65	72	PF00069	0.685
MOD_GSK3_1	739	746	PF00069	0.566
MOD_GSK3_1	765	772	PF00069	0.838
MOD_GSK3_1	783	790	PF00069	0.804
MOD_GSK3_1	802	809	PF00069	0.539
MOD_GSK3_1	810	817	PF00069	0.682
MOD_GSK3_1	834	841	PF00069	0.573
MOD_GSK3_1	867	874	PF00069	0.766
MOD_GSK3_1	87	94	PF00069	0.740
MOD_GSK3_1	878	885	PF00069	0.697
MOD_GSK3_1	887	894	PF00069	0.577
MOD_N-GLC_1	739	744	PF02516	0.565
MOD_N-GLC_1	777	782	PF02516	0.703
MOD_N-GLC_1	814	819	PF02516	0.709
MOD_NEK2_1	127	132	PF00069	0.775
MOD_NEK2_1	172	177	PF00069	0.715
MOD_NEK2_1	249	254	PF00069	0.645
MOD_NEK2_1	296	301	PF00069	0.561
MOD_NEK2_1	345	350	PF00069	0.581
MOD_NEK2_1	499	504	PF00069	0.563
MOD_NEK2_1	586	591	PF00069	0.564
MOD_NEK2_1	628	633	PF00069	0.567
MOD_NEK2_1	65	70	PF00069	0.641
MOD_NEK2_1	686	691	PF00069	0.550
MOD_NEK2_1	836	841	PF00069	0.578
MOD_NEK2_1	865	870	PF00069	0.634
MOD_NEK2_1	87	92	PF00069	0.748
MOD_NEK2_2	292	297	PF00069	0.574
MOD_NEK2_2	384	389	PF00069	0.652
MOD_OFUCOSY	173	179	PF10250	0.570
MOD_PIKK_1	115	121	PF00454	0.579
MOD_PIKK_1	262	268	PF00454	0.552
MOD_PIKK_1	415	421	PF00454	0.565
MOD_PIKK_1	520	526	PF00454	0.719
MOD_PIKK_1	56	62	PF00454	0.576
MOD_PIKK_1	711	717	PF00454	0.555
MOD_PKA_1	389	395	PF00069	0.666
MOD_PKA_2	128	134	PF00069	0.772
MOD_PKA_2	185	191	PF00069	0.803
MOD_PKA_2	296	302	PF00069	0.559
MOD_PKA_2	426	432	PF00069	0.640
MOD_PKA_2	463	469	PF00069	0.774
MOD_PKA_2	565	571	PF00069	0.601
MOD_PKA_2	60	66	PF00069	0.695
MOD_PKA_2	772	778	PF00069	0.576
MOD_PKA_2	806	812	PF00069	0.658
MOD_PKA_2	888	894	PF00069	0.632
MOD_PKA_2	908	914	PF00069	0.639
MOD_PKA_2	92	98	PF00069	0.749
MOD_PKB_1	483	491	PF00069	0.580
MOD_PKB_1	596	604	PF00069	0.610
MOD_Plk_1	594	600	PF00069	0.566
MOD_Plk_1	777	783	PF00069	0.577
MOD_Plk_1	814	820	PF00069	0.606
MOD_Plk_1	834	840	PF00069	0.576
MOD_Plk_2-3	899	905	PF00069	0.567
MOD_Plk_4	296	302	PF00069	0.585
MOD_Plk_4	356	362	PF00069	0.560
MOD_Plk_4	417	423	PF00069	0.570
MOD_Plk_4	473	479	PF00069	0.747
MOD_Plk_4	499	505	PF00069	0.560
MOD_Plk_4	569	575	PF00069	0.781
MOD_ProDKin_1	164	170	PF00069	0.781
MOD_ProDKin_1	206	212	PF00069	0.769
MOD_ProDKin_1	236	242	PF00069	0.705
MOD_ProDKin_1	279	285	PF00069	0.734
MOD_ProDKin_1	301	307	PF00069	0.568
MOD_ProDKin_1	333	339	PF00069	0.777
MOD_ProDKin_1	406	412	PF00069	0.726
MOD_ProDKin_1	428	434	PF00069	0.711
MOD_ProDKin_1	512	518	PF00069	0.573
MOD_ProDKin_1	541	547	PF00069	0.694
MOD_ProDKin_1	614	620	PF00069	0.777
MOD_ProDKin_1	630	636	PF00069	0.579
MOD_ProDKin_1	644	650	PF00069	0.716
MOD_ProDKin_1	891	897	PF00069	0.654
MOD_ProDKin_1	93	99	PF00069	0.753
TRG_ENDOCYTIC_2	197	200	PF00928	0.557
TRG_ENDOCYTIC_2	462	465	PF00928	0.819
TRG_ER_diArg_1	17	20	PF00400	0.752
TRG_ER_diArg_1	483	486	PF00400	0.578
TRG_ER_diArg_1	596	599	PF00400	0.571
TRG_ER_diArg_1	737	739	PF00400	0.688
TRG_NLS_MonoExtC_3	677	682	PF00514	0.731
TRG_NLS_MonoExtN_4	675	682	PF00514	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID28	Leishmania donovani	56%	100%
A4I0Y3	Leishmania infantum	56%	100%
E9ACS9	Leishmania major	55%	99%
E9AWY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%