HpcH_HpaI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HpcH/HpaI aldolase/citrate lyase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HDJ6_LEIBR

TriTrypDb:

LbrM.24.1420 , LBRM2903_240021700 , LBRM2903_240021800

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ6

Function

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Biological processes
Term	Name	Level	Count
GO:0019222	regulation of metabolic process	3	1
GO:0030656	regulation of vitamin metabolic process	5	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0106064	regulation of cobalamin metabolic process	6	1
GO:1901401	regulation of tetrapyrrole metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016833	oxo-acid-lyase activity	4	1
GO:0047777	(S)-citramalyl-CoA lyase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.438
CLV_NRD_NRD_1	143	145	PF00675	0.614
CLV_NRD_NRD_1	2	4	PF00675	0.615
CLV_NRD_NRD_1	397	399	PF00675	0.316
CLV_NRD_NRD_1	404	406	PF00675	0.316
CLV_NRD_NRD_1	47	49	PF00675	0.614
CLV_NRD_NRD_1	522	524	PF00675	0.618
CLV_NRD_NRD_1	82	84	PF00675	0.395
CLV_PCSK_KEX2_1	143	145	PF00082	0.618
CLV_PCSK_KEX2_1	196	198	PF00082	0.313

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHZ0	Leptomonas seymouri	56%	99%
A0A1X0NVS5	Trypanosomatidae	31%	100%
A0A3S7WYJ5	Leishmania donovani	74%	99%
E9AH59	Leishmania infantum	74%	99%
E9AWY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QAI7	Leishmania major	74%	100%
V5DBJ5	Trypanosoma cruzi	35%	100%

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