HpcH_HpaI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HpcH/HpaI aldolase/citrate lyase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HDJ6_LEIBR

TriTrypDb:

LbrM.24.1420 , LBRM2903_240021700 , LBRM2903_240021800

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ6

Function

Biological processes
Term	Name	Level	Count
GO:0019222	regulation of metabolic process	3	1
GO:0030656	regulation of vitamin metabolic process	5	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0106064	regulation of cobalamin metabolic process	6	1
GO:1901401	regulation of tetrapyrrole metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016833	oxo-acid-lyase activity	4	1
GO:0047777	(S)-citramalyl-CoA lyase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.438
CLV_NRD_NRD_1	143	145	PF00675	0.614
CLV_NRD_NRD_1	2	4	PF00675	0.615
CLV_NRD_NRD_1	397	399	PF00675	0.316
CLV_NRD_NRD_1	404	406	PF00675	0.316
CLV_NRD_NRD_1	47	49	PF00675	0.614
CLV_NRD_NRD_1	522	524	PF00675	0.618
CLV_NRD_NRD_1	82	84	PF00675	0.395
CLV_PCSK_KEX2_1	143	145	PF00082	0.618
CLV_PCSK_KEX2_1	196	198	PF00082	0.313
CLV_PCSK_KEX2_1	2	4	PF00082	0.626
CLV_PCSK_KEX2_1	397	399	PF00082	0.316
CLV_PCSK_KEX2_1	404	406	PF00082	0.330
CLV_PCSK_KEX2_1	444	446	PF00082	0.395
CLV_PCSK_KEX2_1	47	49	PF00082	0.604
CLV_PCSK_KEX2_1	522	524	PF00082	0.618
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.313
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.452
CLV_PCSK_SKI1_1	159	163	PF00082	0.249
CLV_PCSK_SKI1_1	3	7	PF00082	0.429
CLV_PCSK_SKI1_1	467	471	PF00082	0.483
CLV_PCSK_SKI1_1	498	502	PF00082	0.522
CLV_PCSK_SKI1_1	76	80	PF00082	0.499
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DOC_CDC14_PxL_1	172	180	PF14671	0.495
DOC_CKS1_1	27	32	PF01111	0.555
DOC_CYCLIN_RxL_1	80	88	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.437
DOC_MAPK_gen_1	464	472	PF00069	0.530
DOC_PP1_RVXF_1	157	164	PF00149	0.377
DOC_PP1_RVXF_1	81	88	PF00149	0.360
DOC_PP2B_LxvP_1	162	165	PF13499	0.449
DOC_PP2B_LxvP_1	25	28	PF13499	0.464
DOC_PP2B_LxvP_1	330	333	PF13499	0.473
DOC_PP4_FxxP_1	298	301	PF00568	0.449
DOC_PP4_FxxP_1	387	390	PF00568	0.516
DOC_USP7_MATH_1	124	128	PF00917	0.504
DOC_USP7_MATH_1	28	32	PF00917	0.436
DOC_USP7_MATH_1	352	356	PF00917	0.420
DOC_USP7_MATH_1	492	496	PF00917	0.796
DOC_USP7_MATH_1	70	74	PF00917	0.660
DOC_WW_Pin1_4	144	149	PF00397	0.664
DOC_WW_Pin1_4	243	248	PF00397	0.449
DOC_WW_Pin1_4	26	31	PF00397	0.665
DOC_WW_Pin1_4	297	302	PF00397	0.449
DOC_WW_Pin1_4	42	47	PF00397	0.660
DOC_WW_Pin1_4	424	429	PF00397	0.425
DOC_WW_Pin1_4	521	526	PF00397	0.677
DOC_WW_Pin1_4	61	66	PF00397	0.572
LIG_14-3-3_CanoR_1	2	12	PF00244	0.427
LIG_14-3-3_CanoR_1	36	46	PF00244	0.467
LIG_14-3-3_CanoR_1	397	401	PF00244	0.516
LIG_14-3-3_CanoR_1	47	57	PF00244	0.686
LIG_14-3-3_CterR_2	529	532	PF00244	0.692
LIG_APCC_ABBA_1	89	94	PF00400	0.483
LIG_BRCT_BRCA1_1	159	163	PF00533	0.516
LIG_BRCT_BRCA1_1	30	34	PF00533	0.545
LIG_CaM_IQ_9	207	223	PF13499	0.516
LIG_CaM_NSCaTE_8	14	21	PF13499	0.440
LIG_FHA_1	19	25	PF00498	0.699
LIG_FHA_1	251	257	PF00498	0.516
LIG_FHA_1	278	284	PF00498	0.473
LIG_FHA_1	357	363	PF00498	0.524
LIG_FHA_1	366	372	PF00498	0.511
LIG_FHA_1	464	470	PF00498	0.355
LIG_FHA_2	227	233	PF00498	0.471
LIG_FHA_2	342	348	PF00498	0.449
LIG_FHA_2	425	431	PF00498	0.499
LIG_FHA_2	449	455	PF00498	0.484
LIG_LIR_Apic_2	286	290	PF02991	0.451
LIG_LIR_Apic_2	384	390	PF02991	0.516
LIG_LIR_Gen_1	280	289	PF02991	0.385
LIG_LIR_Nem_3	235	240	PF02991	0.556
LIG_LIR_Nem_3	280	284	PF02991	0.385
LIG_LIR_Nem_3	88	92	PF02991	0.620
LIG_LYPXL_yS_3	237	240	PF13949	0.377
LIG_MYND_1	154	158	PF01753	0.522
LIG_NRBOX	259	265	PF00104	0.473
LIG_SH2_NCK_1	249	253	PF00017	0.495
LIG_SH2_NCK_1	426	430	PF00017	0.457
LIG_SH2_PTP2	287	290	PF00017	0.473
LIG_SH2_SRC	249	252	PF00017	0.495
LIG_SH2_SRC	287	290	PF00017	0.449
LIG_SH2_SRC	316	319	PF00017	0.533
LIG_SH2_STAT5	183	186	PF00017	0.387
LIG_SH2_STAT5	287	290	PF00017	0.449
LIG_SH2_STAT5	357	360	PF00017	0.387
LIG_SH2_STAT5	426	429	PF00017	0.476
LIG_SH2_STAT5	86	89	PF00017	0.501
LIG_SH3_3	27	33	PF00018	0.483
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.469
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.425
LIG_SUMO_SIM_anti_2	299	306	PF11976	0.516
LIG_SUMO_SIM_par_1	183	190	PF11976	0.476
LIG_SUMO_SIM_par_1	253	259	PF11976	0.387
LIG_TRAF2_1	101	104	PF00917	0.543
LIG_TRAF2_1	399	402	PF00917	0.525
MOD_CDC14_SPxK_1	64	67	PF00782	0.503
MOD_CDK_SPK_2	42	47	PF00069	0.549
MOD_CDK_SPxK_1	42	48	PF00069	0.554
MOD_CDK_SPxK_1	521	527	PF00069	0.680
MOD_CDK_SPxK_1	61	67	PF00069	0.469
MOD_CK1_1	120	126	PF00069	0.527
MOD_CK1_1	127	133	PF00069	0.661
MOD_CK1_1	300	306	PF00069	0.377
MOD_CK1_1	338	344	PF00069	0.273
MOD_CK1_1	51	57	PF00069	0.692
MOD_CK1_1	58	64	PF00069	0.696
MOD_CK1_1	69	75	PF00069	0.451
MOD_CK2_1	226	232	PF00069	0.474
MOD_CK2_1	396	402	PF00069	0.349
MOD_CK2_1	424	430	PF00069	0.406
MOD_CK2_1	453	459	PF00069	0.475
MOD_GlcNHglycan	223	226	PF01048	0.480
MOD_GlcNHglycan	325	329	PF01048	0.428
MOD_GlcNHglycan	340	343	PF01048	0.283
MOD_GlcNHglycan	474	477	PF01048	0.717
MOD_GlcNHglycan	493	497	PF01048	0.524
MOD_GlcNHglycan	58	61	PF01048	0.800
MOD_GlcNHglycan	68	71	PF01048	0.659
MOD_GSK3_1	120	127	PF00069	0.692
MOD_GSK3_1	144	151	PF00069	0.708
MOD_GSK3_1	164	171	PF00069	0.209
MOD_GSK3_1	273	280	PF00069	0.377
MOD_GSK3_1	332	339	PF00069	0.286
MOD_GSK3_1	352	359	PF00069	0.275
MOD_GSK3_1	478	485	PF00069	0.654
MOD_GSK3_1	488	495	PF00069	0.587
MOD_GSK3_1	51	58	PF00069	0.763
MOD_GSK3_1	66	73	PF00069	0.591
MOD_N-GLC_1	36	41	PF02516	0.462
MOD_NEK2_1	18	23	PF00069	0.624
MOD_NEK2_1	187	192	PF00069	0.289
MOD_NEK2_1	356	361	PF00069	0.293
MOD_NEK2_1	364	369	PF00069	0.363
MOD_NEK2_1	396	401	PF00069	0.302
MOD_NEK2_1	50	55	PF00069	0.715
MOD_NEK2_2	117	122	PF00069	0.443
MOD_NEK2_2	124	129	PF00069	0.471
MOD_NEK2_2	274	279	PF00069	0.290
MOD_NEK2_2	352	357	PF00069	0.328
MOD_PIKK_1	213	219	PF00454	0.290
MOD_PKA_2	396	402	PF00069	0.349
MOD_PKA_2	463	469	PF00069	0.461
MOD_PKA_2	66	72	PF00069	0.563
MOD_Plk_1	187	193	PF00069	0.377
MOD_Plk_1	227	233	PF00069	0.471
MOD_Plk_1	448	454	PF00069	0.590
MOD_Plk_1	478	484	PF00069	0.650
MOD_Plk_1	70	76	PF00069	0.545
MOD_Plk_4	117	123	PF00069	0.447
MOD_Plk_4	20	26	PF00069	0.635
MOD_Plk_4	300	306	PF00069	0.366
MOD_Plk_4	352	358	PF00069	0.197
MOD_Plk_4	409	415	PF00069	0.377
MOD_Plk_4	453	459	PF00069	0.347
MOD_Plk_4	74	80	PF00069	0.483
MOD_ProDKin_1	144	150	PF00069	0.653
MOD_ProDKin_1	243	249	PF00069	0.283
MOD_ProDKin_1	26	32	PF00069	0.661
MOD_ProDKin_1	297	303	PF00069	0.283
MOD_ProDKin_1	42	48	PF00069	0.665
MOD_ProDKin_1	424	430	PF00069	0.431
MOD_ProDKin_1	521	527	PF00069	0.680
MOD_ProDKin_1	61	67	PF00069	0.574
MOD_SUMO_rev_2	345	355	PF00179	0.273
TRG_DiLeu_BaEn_1	259	264	PF01217	0.207
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.644
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.377
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.349
TRG_ENDOCYTIC_2	237	240	PF00928	0.377
TRG_ENDOCYTIC_2	281	284	PF00928	0.220
TRG_ENDOCYTIC_2	318	321	PF00928	0.283
TRG_ENDOCYTIC_2	323	326	PF00928	0.283
TRG_ENDOCYTIC_2	86	89	PF00928	0.530
TRG_ER_diArg_1	1	3	PF00400	0.629
TRG_ER_diArg_1	143	146	PF00400	0.637
TRG_ER_diArg_1	396	398	PF00400	0.377
TRG_ER_diArg_1	404	406	PF00400	0.377
TRG_ER_diArg_1	46	48	PF00400	0.598
TRG_ER_diArg_1	521	523	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHZ0	Leptomonas seymouri	56%	99%
A0A1X0NVS5	Trypanosomatidae	31%	100%
A0A3S7WYJ5	Leishmania donovani	74%	99%
E9AH59	Leishmania infantum	74%	99%
E9AWY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QAI7	Leishmania major	74%	100%
V5DBJ5	Trypanosoma cruzi	35%	100%