LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HDJ5_LEIBR
TriTrypDb:
LbrM.24.1410 , LBRM2903_240021900 *
Length:
543

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HDJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016310 phosphorylation 5 9
GO:0019538 protein metabolic process 3 9
GO:0036211 protein modification process 4 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
GO:0007165 signal transduction 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0004672 protein kinase activity 3 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0016301 kinase activity 4 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140096 catalytic activity, acting on a protein 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9
GO:0004674 protein serine/threonine kinase activity 4 2
GO:0004707 MAP kinase activity 5 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 148 152 PF00656 0.512
CLV_C14_Caspase3-7 445 449 PF00656 0.254
CLV_NRD_NRD_1 106 108 PF00675 0.533
CLV_NRD_NRD_1 34 36 PF00675 0.567
CLV_NRD_NRD_1 423 425 PF00675 0.294
CLV_PCSK_KEX2_1 105 107 PF00082 0.533
CLV_PCSK_KEX2_1 34 36 PF00082 0.661
CLV_PCSK_KEX2_1 423 425 PF00082 0.294
CLV_PCSK_KEX2_1 525 527 PF00082 0.290
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.613
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.289
CLV_PCSK_PC7_1 521 527 PF00082 0.262
CLV_PCSK_SKI1_1 361 365 PF00082 0.282
CLV_PCSK_SKI1_1 393 397 PF00082 0.463
CLV_PCSK_SKI1_1 423 427 PF00082 0.258
DEG_SPOP_SBC_1 168 172 PF00917 0.522
DOC_CKS1_1 436 441 PF01111 0.258
DOC_CKS1_1 68 73 PF01111 0.676
DOC_MAPK_gen_1 393 402 PF00069 0.322
DOC_PP1_RVXF_1 413 420 PF00149 0.258
DOC_PP2B_PxIxI_1 535 541 PF00149 0.240
DOC_PP4_FxxP_1 59 62 PF00568 0.556
DOC_USP7_MATH_1 113 117 PF00917 0.529
DOC_USP7_MATH_1 122 126 PF00917 0.617
DOC_USP7_MATH_1 154 158 PF00917 0.522
DOC_USP7_MATH_1 189 193 PF00917 0.516
DOC_USP7_MATH_1 195 199 PF00917 0.570
DOC_USP7_MATH_1 284 288 PF00917 0.289
DOC_USP7_MATH_1 3 7 PF00917 0.616
DOC_USP7_MATH_1 52 56 PF00917 0.534
DOC_USP7_MATH_1 8 12 PF00917 0.664
DOC_USP7_MATH_2 62 68 PF00917 0.605
DOC_USP7_UBL2_3 34 38 PF12436 0.600
DOC_WW_Pin1_4 169 174 PF00397 0.524
DOC_WW_Pin1_4 203 208 PF00397 0.543
DOC_WW_Pin1_4 241 246 PF00397 0.483
DOC_WW_Pin1_4 435 440 PF00397 0.258
DOC_WW_Pin1_4 505 510 PF00397 0.287
DOC_WW_Pin1_4 67 72 PF00397 0.703
DOC_WW_Pin1_4 75 80 PF00397 0.592
LIG_14-3-3_CanoR_1 167 173 PF00244 0.591
LIG_14-3-3_CanoR_1 256 264 PF00244 0.367
LIG_14-3-3_CanoR_1 327 333 PF00244 0.250
LIG_14-3-3_CanoR_1 35 45 PF00244 0.513
LIG_14-3-3_CanoR_1 372 379 PF00244 0.296
LIG_14-3-3_CanoR_1 74 81 PF00244 0.618
LIG_APCC_ABBA_1 344 349 PF00400 0.258
LIG_BIR_III_4 448 452 PF00653 0.254
LIG_CtBP_PxDLS_1 46 50 PF00389 0.499
LIG_FHA_1 169 175 PF00498 0.628
LIG_FHA_1 218 224 PF00498 0.477
LIG_FHA_1 373 379 PF00498 0.258
LIG_FHA_1 424 430 PF00498 0.396
LIG_FHA_1 76 82 PF00498 0.516
LIG_FHA_2 195 201 PF00498 0.497
LIG_FHA_2 402 408 PF00498 0.262
LIG_FHA_2 466 472 PF00498 0.258
LIG_Integrin_RGD_1 217 219 PF01839 0.482
LIG_LIR_Apic_2 438 444 PF02991 0.305
LIG_LIR_Apic_2 58 62 PF02991 0.556
LIG_LIR_Gen_1 285 296 PF02991 0.296
LIG_LIR_Nem_3 238 243 PF02991 0.523
LIG_LIR_Nem_3 274 278 PF02991 0.299
LIG_LIR_Nem_3 285 291 PF02991 0.258
LIG_LIR_Nem_3 331 335 PF02991 0.264
LIG_PTAP_UEV_1 482 487 PF05743 0.192
LIG_SH2_CRK 275 279 PF00017 0.258
LIG_SH2_SRC 384 387 PF00017 0.296
LIG_SH2_STAP1 456 460 PF00017 0.258
LIG_SH2_STAT3 456 459 PF00017 0.192
LIG_SH2_STAT5 237 240 PF00017 0.526
LIG_SH2_STAT5 279 282 PF00017 0.258
LIG_SH2_STAT5 350 353 PF00017 0.269
LIG_SH2_STAT5 384 387 PF00017 0.305
LIG_SH3_1 362 368 PF00018 0.231
LIG_SH3_2 477 482 PF14604 0.258
LIG_SH3_3 116 122 PF00018 0.547
LIG_SH3_3 156 162 PF00018 0.622
LIG_SH3_3 201 207 PF00018 0.549
LIG_SH3_3 362 368 PF00018 0.231
LIG_SH3_3 41 47 PF00018 0.690
LIG_SH3_3 474 480 PF00018 0.327
LIG_SH3_3 537 543 PF00018 0.331
LIG_SH3_3 9 15 PF00018 0.595
LIG_SUMO_SIM_par_1 307 313 PF11976 0.250
LIG_TRAF2_1 230 233 PF00917 0.625
LIG_TRAF2_1 503 506 PF00917 0.258
LIG_TRAF2_1 96 99 PF00917 0.452
LIG_WRC_WIRS_1 329 334 PF05994 0.258
MOD_CDK_SPK_2 67 72 PF00069 0.591
MOD_CDK_SPxxK_3 67 74 PF00069 0.632
MOD_CK1_1 13 19 PF00069 0.561
MOD_CK1_1 40 46 PF00069 0.514
MOD_CK1_1 430 436 PF00069 0.258
MOD_CK1_1 454 460 PF00069 0.275
MOD_CK1_1 484 490 PF00069 0.290
MOD_CK1_1 63 69 PF00069 0.595
MOD_CK2_1 135 141 PF00069 0.563
MOD_CK2_1 194 200 PF00069 0.515
MOD_CK2_1 227 233 PF00069 0.463
MOD_CK2_1 45 51 PF00069 0.575
MOD_CK2_1 465 471 PF00069 0.258
MOD_CK2_1 52 58 PF00069 0.565
MOD_CK2_1 93 99 PF00069 0.508
MOD_GlcNHglycan 115 118 PF01048 0.494
MOD_GlcNHglycan 12 15 PF01048 0.676
MOD_GlcNHglycan 122 125 PF01048 0.501
MOD_GlcNHglycan 197 200 PF01048 0.521
MOD_GlcNHglycan 229 232 PF01048 0.450
MOD_GlcNHglycan 356 359 PF01048 0.226
MOD_GlcNHglycan 379 382 PF01048 0.407
MOD_GlcNHglycan 39 42 PF01048 0.623
MOD_GlcNHglycan 448 452 PF01048 0.258
MOD_GlcNHglycan 453 456 PF01048 0.266
MOD_GlcNHglycan 483 486 PF01048 0.264
MOD_GlcNHglycan 493 496 PF01048 0.308
MOD_GlcNHglycan 86 89 PF01048 0.644
MOD_GSK3_1 10 17 PF00069 0.630
MOD_GSK3_1 143 150 PF00069 0.512
MOD_GSK3_1 223 230 PF00069 0.576
MOD_GSK3_1 235 242 PF00069 0.401
MOD_GSK3_1 252 259 PF00069 0.552
MOD_GSK3_1 36 43 PF00069 0.611
MOD_GSK3_1 366 373 PF00069 0.296
MOD_GSK3_1 423 430 PF00069 0.302
MOD_GSK3_1 431 438 PF00069 0.312
MOD_GSK3_1 447 454 PF00069 0.350
MOD_GSK3_1 461 468 PF00069 0.319
MOD_GSK3_1 47 54 PF00069 0.523
MOD_GSK3_1 493 500 PF00069 0.305
MOD_GSK3_1 60 67 PF00069 0.583
MOD_GSK3_1 89 96 PF00069 0.563
MOD_N-GLC_1 256 261 PF02516 0.373
MOD_N-GLC_2 328 330 PF02516 0.258
MOD_NEK2_1 194 199 PF00069 0.487
MOD_NEK2_1 252 257 PF00069 0.390
MOD_NEK2_1 401 406 PF00069 0.297
MOD_NEK2_1 491 496 PF00069 0.286
MOD_NEK2_2 284 289 PF00069 0.258
MOD_PIKK_1 372 378 PF00454 0.333
MOD_PIKK_1 384 390 PF00454 0.207
MOD_PIKK_1 409 415 PF00454 0.255
MOD_PIKK_1 427 433 PF00454 0.226
MOD_PK_1 107 113 PF00069 0.472
MOD_PKA_1 106 112 PF00069 0.470
MOD_PKA_1 36 42 PF00069 0.611
MOD_PKA_1 423 429 PF00069 0.258
MOD_PKA_1 525 531 PF00069 0.258
MOD_PKA_2 106 112 PF00069 0.719
MOD_PKA_2 227 233 PF00069 0.502
MOD_PKA_2 265 271 PF00069 0.299
MOD_PKA_2 36 42 PF00069 0.646
MOD_PKA_2 423 429 PF00069 0.258
MOD_PKA_2 481 487 PF00069 0.239
MOD_PKA_2 525 531 PF00069 0.305
MOD_PKA_2 73 79 PF00069 0.626
MOD_PKB_1 105 113 PF00069 0.470
MOD_PKB_1 35 43 PF00069 0.518
MOD_Plk_1 154 160 PF00069 0.609
MOD_Plk_1 63 69 PF00069 0.616
MOD_Plk_4 107 113 PF00069 0.472
MOD_Plk_4 265 271 PF00069 0.249
MOD_Plk_4 274 280 PF00069 0.274
MOD_Plk_4 366 372 PF00069 0.322
MOD_Plk_4 40 46 PF00069 0.512
MOD_Plk_4 431 437 PF00069 0.305
MOD_Plk_4 52 58 PF00069 0.483
MOD_ProDKin_1 169 175 PF00069 0.522
MOD_ProDKin_1 203 209 PF00069 0.543
MOD_ProDKin_1 241 247 PF00069 0.481
MOD_ProDKin_1 435 441 PF00069 0.258
MOD_ProDKin_1 505 511 PF00069 0.287
MOD_ProDKin_1 67 73 PF00069 0.704
MOD_ProDKin_1 75 81 PF00069 0.593
TRG_ENDOCYTIC_2 275 278 PF00928 0.258
TRG_ENDOCYTIC_2 279 282 PF00928 0.258
TRG_ER_diArg_1 105 107 PF00400 0.517
TRG_ER_diArg_1 324 327 PF00400 0.261
TRG_ER_diArg_1 423 425 PF00400 0.258
TRG_NES_CRM1_1 304 317 PF08389 0.258
TRG_NLS_MonoCore_2 33 38 PF00514 0.506
TRG_NLS_MonoExtC_3 33 38 PF00514 0.506
TRG_NLS_MonoExtC_3 360 365 PF00514 0.258
TRG_NLS_MonoExtN_4 34 40 PF00514 0.510
TRG_Pf-PMV_PEXEL_1 423 427 PF00026 0.258

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTF0 Leptomonas seymouri 62% 86%
A0A3Q8ICW9 Leishmania donovani 80% 90%
A0A3Q8IH39 Leishmania donovani 22% 100%
A0A3Q8IIG1 Leishmania donovani 28% 100%
A0A3Q8ITZ9 Leishmania donovani 26% 100%
A0A3Q8IVR8 Leishmania donovani 26% 100%
A0A3R7JV29 Trypanosoma rangeli 29% 100%
A0A3S5H5G0 Leishmania donovani 25% 100%
A0A3S5H789 Leishmania donovani 24% 100%
A0A3S7WRG1 Leishmania donovani 24% 100%
A0A3S7WTN9 Leishmania donovani 25% 100%
A0A3S7X2W3 Leishmania donovani 29% 100%
A0A3S7X7Y2 Leishmania donovani 29% 100%
A0A3S7XA45 Leishmania donovani 27% 100%
A4H3J3 Leishmania braziliensis 26% 100%
A4H459 Leishmania braziliensis 26% 100%
A4H601 Leishmania braziliensis 23% 100%
A4H8C4 Leishmania braziliensis 25% 100%
A4HA94 Leishmania braziliensis 26% 100%
A4HAS1 Leishmania braziliensis 28% 100%
A4HFA1 Leishmania braziliensis 26% 100%
A4HH03 Leishmania braziliensis 29% 100%
A4HHN1 Leishmania braziliensis 28% 100%
A4HLJ9 Leishmania braziliensis 25% 100%
A4HNG3 Leishmania braziliensis 26% 100%
A4HNT2 Leishmania braziliensis 25% 100%
A4HSE2 Leishmania infantum 25% 100%
A4HUC8 Leishmania infantum 22% 100%
A4HUS3 Leishmania infantum 24% 100%
A4HWP5 Leishmania infantum 25% 100%
A4HYH4 Leishmania infantum 28% 100%
A4HYX6 Leishmania infantum 24% 100%
A4I0Y4 Leishmania infantum 80% 90%
A4I435 Leishmania infantum 28% 100%
A4I4U6 Leishmania infantum 30% 100%
A4I910 Leishmania infantum 26% 100%
A4I9Y5 Leishmania infantum 29% 100%
A4IC54 Leishmania infantum 27% 100%
A4ICR2 Leishmania infantum 26% 100%
A7A1P0 Saccharomyces cerevisiae (strain YJM789) 29% 76%
B5VNQ3 Saccharomyces cerevisiae (strain AWRI1631) 30% 76%
E9AFX4 Leishmania major 27% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9ANF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AS98 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AWZ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 90%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B727 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P23561 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 76%
P36507 Homo sapiens 26% 100%
Q4Q204 Leishmania major 26% 100%
Q4Q2Z2 Leishmania major 29% 100%
Q4Q449 Leishmania major 26% 100%
Q4Q7W2 Leishmania major 27% 100%
Q4QAI6 Leishmania major 79% 100%
Q4QD66 Leishmania major 28% 100%
Q4QF23 Leishmania major 24% 100%
Q4QH69 Leishmania major 24% 100%
Q4QHJ8 Leishmania major 22% 100%
Q4QJJ0 Leishmania major 25% 100%
Q6BVA0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 27% 100%
Q6F3A6 Oryza sativa subsp. japonica 26% 91%
Q9U6V4 Leishmania donovani 28% 100%
Q9Y077 Leishmania major 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS