Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDJ4_LEIBR

TriTrypDb:

LbrM.24.1390 , LBRM2903_240022100 , LBRM2903_240022200

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.551
CLV_C14_Caspase3-7	432	436	PF00656	0.523
CLV_C14_Caspase3-7	575	579	PF00656	0.527
CLV_C14_Caspase3-7	645	649	PF00656	0.521
CLV_NRD_NRD_1	263	265	PF00675	0.436
CLV_NRD_NRD_1	298	300	PF00675	0.655
CLV_NRD_NRD_1	337	339	PF00675	0.509
CLV_NRD_NRD_1	364	366	PF00675	0.681
CLV_NRD_NRD_1	378	380	PF00675	0.313
CLV_NRD_NRD_1	420	422	PF00675	0.665
CLV_NRD_NRD_1	470	472	PF00675	0.473
CLV_NRD_NRD_1	713	715	PF00675	0.620
CLV_NRD_NRD_1	94	96	PF00675	0.661
CLV_PCSK_KEX2_1	263	265	PF00082	0.462
CLV_PCSK_KEX2_1	298	300	PF00082	0.517
CLV_PCSK_KEX2_1	339	341	PF00082	0.423
CLV_PCSK_KEX2_1	364	366	PF00082	0.681
CLV_PCSK_KEX2_1	378	380	PF00082	0.313
CLV_PCSK_KEX2_1	457	459	PF00082	0.471
CLV_PCSK_KEX2_1	470	472	PF00082	0.473
CLV_PCSK_KEX2_1	71	73	PF00082	0.609
CLV_PCSK_KEX2_1	713	715	PF00082	0.620
CLV_PCSK_KEX2_1	87	89	PF00082	0.670
CLV_PCSK_KEX2_1	93	95	PF00082	0.633
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.423
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.471
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.609
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.616
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.564
CLV_PCSK_PC7_1	259	265	PF00082	0.448
CLV_PCSK_PC7_1	466	472	PF00082	0.493
CLV_PCSK_PC7_1	709	715	PF00082	0.600
CLV_PCSK_SKI1_1	200	204	PF00082	0.596
CLV_PCSK_SKI1_1	236	240	PF00082	0.461
CLV_PCSK_SKI1_1	278	282	PF00082	0.502
CLV_PCSK_SKI1_1	379	383	PF00082	0.442
CLV_PCSK_SKI1_1	441	445	PF00082	0.332
DEG_APCC_DBOX_1	184	192	PF00400	0.512
DEG_APCC_DBOX_1	24	32	PF00400	0.623
DEG_APCC_DBOX_1	339	347	PF00400	0.503
DEG_Nend_UBRbox_1	1	4	PF02207	0.490
DEG_SPOP_SBC_1	556	560	PF00917	0.718
DOC_AGCK_PIF_1	224	229	PF00069	0.464
DOC_CKS1_1	117	122	PF01111	0.742
DOC_CKS1_1	38	43	PF01111	0.542
DOC_CKS1_1	529	534	PF01111	0.530
DOC_CKS1_1	564	569	PF01111	0.531
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.397
DOC_MAPK_DCC_7	493	501	PF00069	0.562
DOC_MAPK_gen_1	108	117	PF00069	0.686
DOC_MAPK_gen_1	267	276	PF00069	0.385
DOC_MAPK_gen_1	338	346	PF00069	0.496
DOC_MAPK_HePTP_8	191	203	PF00069	0.368
DOC_MAPK_MEF2A_6	194	203	PF00069	0.370
DOC_MAPK_MEF2A_6	339	348	PF00069	0.481
DOC_MAPK_MEF2A_6	493	501	PF00069	0.562
DOC_PP1_RVXF_1	343	349	PF00149	0.319
DOC_PP2B_LxvP_1	243	246	PF13499	0.391
DOC_PP2B_LxvP_1	353	356	PF13499	0.373
DOC_SPAK_OSR1_1	259	263	PF12202	0.451
DOC_USP7_MATH_1	10	14	PF00917	0.515
DOC_USP7_MATH_1	128	132	PF00917	0.700
DOC_USP7_MATH_1	16	20	PF00917	0.576
DOC_USP7_MATH_1	161	165	PF00917	0.653
DOC_USP7_MATH_1	555	559	PF00917	0.747
DOC_USP7_MATH_1	56	60	PF00917	0.657
DOC_USP7_MATH_1	574	578	PF00917	0.597
DOC_USP7_MATH_1	637	641	PF00917	0.568
DOC_USP7_MATH_1	74	78	PF00917	0.710
DOC_USP7_MATH_1	80	84	PF00917	0.737
DOC_WW_Pin1_4	116	121	PF00397	0.699
DOC_WW_Pin1_4	12	17	PF00397	0.486
DOC_WW_Pin1_4	126	131	PF00397	0.641
DOC_WW_Pin1_4	23	28	PF00397	0.580
DOC_WW_Pin1_4	289	294	PF00397	0.578
DOC_WW_Pin1_4	305	310	PF00397	0.506
DOC_WW_Pin1_4	315	320	PF00397	0.440
DOC_WW_Pin1_4	37	42	PF00397	0.606
DOC_WW_Pin1_4	525	530	PF00397	0.653
DOC_WW_Pin1_4	536	541	PF00397	0.584
DOC_WW_Pin1_4	54	59	PF00397	0.619
DOC_WW_Pin1_4	563	568	PF00397	0.583
LIG_14-3-3_CanoR_1	108	117	PF00244	0.600
LIG_14-3-3_CanoR_1	182	192	PF00244	0.477
LIG_14-3-3_CanoR_1	251	255	PF00244	0.419
LIG_14-3-3_CanoR_1	32	38	PF00244	0.584
LIG_14-3-3_CanoR_1	345	349	PF00244	0.446
LIG_14-3-3_CanoR_1	406	415	PF00244	0.666
LIG_14-3-3_CanoR_1	43	51	PF00244	0.516
LIG_14-3-3_CanoR_1	452	460	PF00244	0.405
LIG_14-3-3_CanoR_1	585	593	PF00244	0.566
LIG_14-3-3_CanoR_1	655	663	PF00244	0.564
LIG_Actin_WH2_2	621	637	PF00022	0.456
LIG_BIR_III_2	127	131	PF00653	0.693
LIG_BRCT_BRCA1_1	256	260	PF00533	0.448
LIG_BRCT_BRCA1_1	58	62	PF00533	0.525
LIG_deltaCOP1_diTrp_1	462	468	PF00928	0.374
LIG_EH1_1	325	333	PF00400	0.330
LIG_FHA_1	112	118	PF00498	0.641
LIG_FHA_1	306	312	PF00498	0.486
LIG_FHA_1	537	543	PF00498	0.457
LIG_FHA_1	585	591	PF00498	0.522
LIG_FHA_2	117	123	PF00498	0.785
LIG_FHA_2	184	190	PF00498	0.465
LIG_FHA_2	283	289	PF00498	0.618
LIG_FHA_2	361	367	PF00498	0.630
LIG_FHA_2	430	436	PF00498	0.609
LIG_FHA_2	512	518	PF00498	0.619
LIG_FHA_2	564	570	PF00498	0.696
LIG_FHA_2	613	619	PF00498	0.386
LIG_FHA_2	645	651	PF00498	0.690
LIG_GSK3_LRP6_1	563	568	PF00069	0.526
LIG_Integrin_isoDGR_2	336	338	PF01839	0.511
LIG_Integrin_RGD_1	433	435	PF01839	0.494
LIG_LIR_Gen_1	462	468	PF02991	0.480
LIG_LIR_Gen_1	621	632	PF02991	0.446
LIG_LIR_Nem_3	219	224	PF02991	0.402
LIG_LIR_Nem_3	233	238	PF02991	0.336
LIG_LIR_Nem_3	3	7	PF02991	0.537
LIG_LIR_Nem_3	462	467	PF02991	0.488
LIG_LIR_Nem_3	569	573	PF02991	0.537
LIG_LIR_Nem_3	59	65	PF02991	0.538
LIG_LIR_Nem_3	621	627	PF02991	0.456
LIG_PCNA_yPIPBox_3	325	339	PF02747	0.403
LIG_Pex14_1	256	260	PF04695	0.448
LIG_Pex14_1	464	468	PF04695	0.310
LIG_Pex14_2	700	704	PF04695	0.504
LIG_SH2_CRK	235	239	PF00017	0.374
LIG_SH2_CRK	391	395	PF00017	0.470
LIG_SH2_CRK	570	574	PF00017	0.529
LIG_SH2_CRK	629	633	PF00017	0.379
LIG_SH2_NCK_1	646	650	PF00017	0.520
LIG_SH2_STAP1	192	196	PF00017	0.394
LIG_SH2_STAP1	227	231	PF00017	0.458
LIG_SH2_STAT3	227	230	PF00017	0.460
LIG_SH2_STAT5	646	649	PF00017	0.523
LIG_SH2_STAT5	680	683	PF00017	0.423
LIG_SH3_1	391	397	PF00018	0.483
LIG_SH3_1	526	532	PF00018	0.542
LIG_SH3_3	127	133	PF00018	0.618
LIG_SH3_3	205	211	PF00018	0.588
LIG_SH3_3	390	396	PF00018	0.480
LIG_SH3_3	52	58	PF00018	0.656
LIG_SH3_3	526	532	PF00018	0.546
LIG_SH3_3	561	567	PF00018	0.641
LIG_SH3_3	587	593	PF00018	0.794
LIG_SH3_3	657	663	PF00018	0.389
LIG_SUMO_SIM_par_1	308	315	PF11976	0.474
LIG_SUMO_SIM_par_1	476	482	PF11976	0.388
LIG_TRAF2_1	615	618	PF00917	0.403
LIG_TYR_ITIM	627	632	PF00017	0.378
LIG_WW_3	592	596	PF00397	0.516
MOD_CDC14_SPxK_1	129	132	PF00782	0.657
MOD_CDK_SPxK_1	126	132	PF00069	0.655
MOD_CDK_SPxK_1	37	43	PF00069	0.543
MOD_CK1_1	292	298	PF00069	0.598
MOD_CK1_1	318	324	PF00069	0.473
MOD_CK1_1	416	422	PF00069	0.628
MOD_CK1_1	450	456	PF00069	0.488
MOD_CK1_1	476	482	PF00069	0.391
MOD_CK1_1	528	534	PF00069	0.606
MOD_CK1_1	558	564	PF00069	0.686
MOD_CK1_1	644	650	PF00069	0.709
MOD_CK2_1	128	134	PF00069	0.695
MOD_CK2_1	183	189	PF00069	0.530
MOD_CK2_1	282	288	PF00069	0.605
MOD_CK2_1	360	366	PF00069	0.560
MOD_CK2_1	476	482	PF00069	0.329
MOD_CK2_1	511	517	PF00069	0.583
MOD_CK2_1	612	618	PF00069	0.390
MOD_CK2_1	644	650	PF00069	0.692
MOD_Cter_Amidation	336	339	PF01082	0.521
MOD_GlcNHglycan	155	158	PF01048	0.697
MOD_GlcNHglycan	163	166	PF01048	0.577
MOD_GlcNHglycan	18	21	PF01048	0.596
MOD_GlcNHglycan	256	259	PF01048	0.483
MOD_GlcNHglycan	294	297	PF01048	0.616
MOD_GlcNHglycan	406	409	PF01048	0.605
MOD_GlcNHglycan	449	452	PF01048	0.437
MOD_GlcNHglycan	514	517	PF01048	0.821
MOD_GlcNHglycan	543	546	PF01048	0.538
MOD_GlcNHglycan	560	563	PF01048	0.697
MOD_GlcNHglycan	718	723	PF01048	0.688
MOD_GlcNHglycan	725	728	PF01048	0.726
MOD_GlcNHglycan	80	83	PF01048	0.699
MOD_GSK3_1	12	19	PF00069	0.640
MOD_GSK3_1	149	156	PF00069	0.798
MOD_GSK3_1	250	257	PF00069	0.424
MOD_GSK3_1	282	289	PF00069	0.518
MOD_GSK3_1	398	405	PF00069	0.673
MOD_GSK3_1	411	418	PF00069	0.679
MOD_GSK3_1	425	432	PF00069	0.687
MOD_GSK3_1	447	454	PF00069	0.360
MOD_GSK3_1	478	485	PF00069	0.418
MOD_GSK3_1	574	581	PF00069	0.590
MOD_GSK3_1	637	644	PF00069	0.668
MOD_GSK3_1	654	661	PF00069	0.581
MOD_GSK3_1	74	81	PF00069	0.730
MOD_NEK2_1	282	287	PF00069	0.489
MOD_NEK2_1	31	36	PF00069	0.629
MOD_NEK2_1	320	325	PF00069	0.426
MOD_NEK2_1	331	336	PF00069	0.381
MOD_NEK2_1	344	349	PF00069	0.514
MOD_NEK2_1	360	365	PF00069	0.431
MOD_NEK2_1	543	548	PF00069	0.517
MOD_NEK2_1	65	70	PF00069	0.697
MOD_NEK2_1	654	659	PF00069	0.639
MOD_OFUCOSY	30	35	PF10250	0.459
MOD_PIKK_1	183	189	PF00454	0.544
MOD_PIKK_1	584	590	PF00454	0.577
MOD_PIKK_1	80	86	PF00454	0.619
MOD_PKA_2	250	256	PF00069	0.407
MOD_PKA_2	31	37	PF00069	0.536
MOD_PKA_2	344	350	PF00069	0.375
MOD_PKA_2	451	457	PF00069	0.437
MOD_PKA_2	584	590	PF00069	0.563
MOD_PKA_2	65	71	PF00069	0.716
MOD_PKA_2	654	660	PF00069	0.594
MOD_PKB_1	609	617	PF00069	0.408
MOD_Plk_1	618	624	PF00069	0.322
MOD_Plk_1	696	702	PF00069	0.520
MOD_Plk_2-3	134	140	PF00069	0.631
MOD_Plk_2-3	143	149	PF00069	0.677
MOD_Plk_2-3	642	648	PF00069	0.519
MOD_Plk_4	344	350	PF00069	0.499
MOD_Plk_4	473	479	PF00069	0.374
MOD_Plk_4	578	584	PF00069	0.496
MOD_ProDKin_1	116	122	PF00069	0.700
MOD_ProDKin_1	12	18	PF00069	0.485
MOD_ProDKin_1	126	132	PF00069	0.643
MOD_ProDKin_1	23	29	PF00069	0.580
MOD_ProDKin_1	289	295	PF00069	0.584
MOD_ProDKin_1	305	311	PF00069	0.504
MOD_ProDKin_1	315	321	PF00069	0.433
MOD_ProDKin_1	37	43	PF00069	0.608
MOD_ProDKin_1	525	531	PF00069	0.652
MOD_ProDKin_1	536	542	PF00069	0.578
MOD_ProDKin_1	54	60	PF00069	0.624
MOD_ProDKin_1	563	569	PF00069	0.585
TRG_DiLeu_BaEn_4	676	682	PF01217	0.464
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.547
TRG_ENDOCYTIC_2	235	238	PF00928	0.378
TRG_ENDOCYTIC_2	570	573	PF00928	0.535
TRG_ENDOCYTIC_2	629	632	PF00928	0.377
TRG_ER_diArg_1	198	201	PF00400	0.447
TRG_ER_diArg_1	262	264	PF00400	0.437
TRG_ER_diArg_1	297	299	PF00400	0.522
TRG_ER_diArg_1	377	379	PF00400	0.450
TRG_ER_diArg_1	63	66	PF00400	0.623
TRG_ER_diArg_1	683	686	PF00400	0.395
TRG_ER_diArg_1	713	716	PF00400	0.607
TRG_NLS_Bipartite_1	71	90	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	713	718	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM86	Leptomonas seymouri	48%	98%
A0A3Q8IBE1	Leishmania donovani	68%	90%
C9ZWG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AH60	Leishmania infantum	69%	90%
E9AWZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	88%
Q4QAI5	Leishmania major	69%	100%