Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDJ2_LEIBR

TriTrypDb:

LbrM.24.1370 , LBRM2903_240022400

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.550
CLV_NRD_NRD_1	272	274	PF00675	0.596
CLV_NRD_NRD_1	367	369	PF00675	0.608
CLV_NRD_NRD_1	37	39	PF00675	0.706
CLV_NRD_NRD_1	464	466	PF00675	0.678
CLV_NRD_NRD_1	529	531	PF00675	0.408
CLV_NRD_NRD_1	578	580	PF00675	0.594
CLV_NRD_NRD_1	623	625	PF00675	0.586
CLV_PCSK_KEX2_1	272	274	PF00082	0.596
CLV_PCSK_KEX2_1	367	369	PF00082	0.608
CLV_PCSK_KEX2_1	37	39	PF00082	0.706
CLV_PCSK_KEX2_1	464	466	PF00082	0.661
CLV_PCSK_KEX2_1	623	625	PF00082	0.586
CLV_PCSK_SKI1_1	273	277	PF00082	0.647
CLV_Separin_Metazoa	163	167	PF03568	0.405
DEG_APCC_DBOX_1	165	173	PF00400	0.424
DEG_SCF_FBW7_1	415	422	PF00400	0.360
DEG_SCF_FBW7_2	229	236	PF00400	0.315
DEG_SPOP_SBC_1	205	209	PF00917	0.440
DEG_SPOP_SBC_1	326	330	PF00917	0.544
DOC_CKS1_1	230	235	PF01111	0.494
DOC_CKS1_1	407	412	PF01111	0.417
DOC_CKS1_1	416	421	PF01111	0.474
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.411
DOC_MAPK_gen_1	423	431	PF00069	0.388
DOC_MAPK_MEF2A_6	446	453	PF00069	0.294
DOC_PP2B_LxvP_1	201	204	PF13499	0.623
DOC_PP2B_LxvP_1	280	283	PF13499	0.440
DOC_PP4_FxxP_1	407	410	PF00568	0.369
DOC_USP7_MATH_1	114	118	PF00917	0.549
DOC_USP7_MATH_1	327	331	PF00917	0.565
DOC_USP7_MATH_1	343	347	PF00917	0.621
DOC_USP7_MATH_1	356	360	PF00917	0.435
DOC_USP7_MATH_1	419	423	PF00917	0.474
DOC_USP7_MATH_1	475	479	PF00917	0.588
DOC_USP7_MATH_1	601	605	PF00917	0.806
DOC_USP7_MATH_1	83	87	PF00917	0.487
DOC_WW_Pin1_4	108	113	PF00397	0.572
DOC_WW_Pin1_4	120	125	PF00397	0.481
DOC_WW_Pin1_4	174	179	PF00397	0.438
DOC_WW_Pin1_4	206	211	PF00397	0.597
DOC_WW_Pin1_4	229	234	PF00397	0.480
DOC_WW_Pin1_4	248	253	PF00397	0.219
DOC_WW_Pin1_4	278	283	PF00397	0.517
DOC_WW_Pin1_4	375	380	PF00397	0.425
DOC_WW_Pin1_4	406	411	PF00397	0.405
DOC_WW_Pin1_4	415	420	PF00397	0.470
DOC_WW_Pin1_4	572	577	PF00397	0.753
DOC_WW_Pin1_4	604	609	PF00397	0.778
LIG_14-3-3_CanoR_1	119	124	PF00244	0.525
LIG_14-3-3_CanoR_1	272	280	PF00244	0.508
LIG_14-3-3_CanoR_1	309	315	PF00244	0.644
LIG_14-3-3_CanoR_1	37	43	PF00244	0.537
LIG_14-3-3_CanoR_1	617	622	PF00244	0.608
LIG_EVH1_1	169	173	PF00568	0.474
LIG_EVH1_1	201	205	PF00568	0.450
LIG_FHA_1	347	353	PF00498	0.462
LIG_FHA_1	607	613	PF00498	0.838
LIG_FHA_2	230	236	PF00498	0.500
LIG_FHA_2	584	590	PF00498	0.674
LIG_LIR_Apic_2	228	233	PF02991	0.402
LIG_LIR_Gen_1	157	165	PF02991	0.397
LIG_LIR_Gen_1	358	364	PF02991	0.410
LIG_LIR_Gen_1	385	396	PF02991	0.388
LIG_LIR_Nem_3	157	161	PF02991	0.398
LIG_LIR_Nem_3	358	363	PF02991	0.523
LIG_LIR_Nem_3	385	391	PF02991	0.394
LIG_LIR_Nem_3	502	506	PF02991	0.362
LIG_PCNA_yPIPBox_3	496	504	PF02747	0.272
LIG_PDZ_Class_1	628	633	PF00595	0.735
LIG_RPA_C_Fungi	612	624	PF08784	0.518
LIG_SH2_CRK	230	234	PF00017	0.502
LIG_SH2_CRK	245	249	PF00017	0.455
LIG_SH2_CRK	413	417	PF00017	0.552
LIG_SH2_PTP2	503	506	PF00017	0.411
LIG_SH2_SRC	362	365	PF00017	0.589
LIG_SH2_STAP1	10	14	PF00017	0.459
LIG_SH2_STAP1	152	156	PF00017	0.589
LIG_SH2_STAT5	133	136	PF00017	0.577
LIG_SH2_STAT5	3	6	PF00017	0.662
LIG_SH2_STAT5	362	365	PF00017	0.580
LIG_SH2_STAT5	424	427	PF00017	0.471
LIG_SH2_STAT5	498	501	PF00017	0.441
LIG_SH2_STAT5	503	506	PF00017	0.411
LIG_SH3_1	413	419	PF00018	0.567
LIG_SH3_3	121	127	PF00018	0.716
LIG_SH3_3	165	171	PF00018	0.516
LIG_SH3_3	197	203	PF00018	0.748
LIG_SH3_3	207	213	PF00018	0.771
LIG_SH3_3	246	252	PF00018	0.459
LIG_SH3_3	342	348	PF00018	0.793
LIG_SH3_3	413	419	PF00018	0.567
LIG_SH3_3	432	438	PF00018	0.445
LIG_SH3_3	444	450	PF00018	0.492
LIG_SH3_3	489	495	PF00018	0.625
LIG_SH3_3	546	552	PF00018	0.533
LIG_SUMO_SIM_par_1	427	432	PF11976	0.450
LIG_TRAF2_1	233	236	PF00917	0.407
LIG_TRAF2_1	561	564	PF00917	0.734
LIG_TYR_ITIM	156	161	PF00017	0.467
LIG_TYR_ITIM	501	506	PF00017	0.411
LIG_WRC_WIRS_1	357	362	PF05994	0.429
MOD_CDK_SPxxK_3	572	579	PF00069	0.788
MOD_CK1_1	106	112	PF00069	0.743
MOD_CK1_1	209	215	PF00069	0.644
MOD_CK1_1	228	234	PF00069	0.594
MOD_CK1_1	298	304	PF00069	0.726
MOD_CK1_1	315	321	PF00069	0.599
MOD_CK1_1	329	335	PF00069	0.823
MOD_CK1_1	346	352	PF00069	0.486
MOD_CK1_1	476	482	PF00069	0.665
MOD_CK1_1	48	54	PF00069	0.670
MOD_CK1_1	568	574	PF00069	0.711
MOD_CK1_1	587	593	PF00069	0.761
MOD_CK1_1	604	610	PF00069	0.801
MOD_CK1_1	61	67	PF00069	0.744
MOD_CK1_1	616	622	PF00069	0.644
MOD_CK2_1	229	235	PF00069	0.612
MOD_CK2_1	278	284	PF00069	0.571
MOD_CK2_1	310	316	PF00069	0.574
MOD_CK2_1	583	589	PF00069	0.656
MOD_Cter_Amidation	129	132	PF01082	0.531
MOD_GlcNHglycan	105	108	PF01048	0.785
MOD_GlcNHglycan	127	130	PF01048	0.571
MOD_GlcNHglycan	273	276	PF01048	0.634
MOD_GlcNHglycan	341	344	PF01048	0.795
MOD_GlcNHglycan	431	434	PF01048	0.434
MOD_GlcNHglycan	475	478	PF01048	0.766
MOD_GlcNHglycan	481	484	PF01048	0.687
MOD_GlcNHglycan	522	525	PF01048	0.484
MOD_GlcNHglycan	589	592	PF01048	0.742
MOD_GlcNHglycan	603	606	PF01048	0.735
MOD_GlcNHglycan	61	64	PF01048	0.749
MOD_GlcNHglycan	69	73	PF01048	0.676
MOD_GlcNHglycan	89	92	PF01048	0.750
MOD_GlcNHglycan	98	102	PF01048	0.678
MOD_GSK3_1	205	212	PF00069	0.623
MOD_GSK3_1	225	232	PF00069	0.574
MOD_GSK3_1	294	301	PF00069	0.692
MOD_GSK3_1	325	332	PF00069	0.757
MOD_GSK3_1	339	346	PF00069	0.793
MOD_GSK3_1	415	422	PF00069	0.562
MOD_GSK3_1	475	482	PF00069	0.689
MOD_GSK3_1	565	572	PF00069	0.706
MOD_GSK3_1	579	586	PF00069	0.705
MOD_GSK3_1	613	620	PF00069	0.743
MOD_GSK3_1	68	75	PF00069	0.800
MOD_GSK3_1	83	90	PF00069	0.727
MOD_N-GLC_1	114	119	PF02516	0.592
MOD_N-GLC_1	333	338	PF02516	0.570
MOD_NEK2_1	134	139	PF00069	0.506
MOD_NEK2_1	295	300	PF00069	0.640
MOD_NEK2_1	398	403	PF00069	0.546
MOD_NEK2_1	4	9	PF00069	0.754
MOD_NEK2_1	520	525	PF00069	0.521
MOD_NEK2_1	565	570	PF00069	0.662
MOD_NEK2_1	613	618	PF00069	0.695
MOD_NEK2_1	68	73	PF00069	0.589
MOD_NEK2_2	540	545	PF00069	0.639
MOD_PIKK_1	134	140	PF00454	0.502
MOD_PIKK_1	45	51	PF00454	0.711
MOD_PIKK_1	534	540	PF00454	0.607
MOD_PK_1	38	44	PF00069	0.459
MOD_PKA_1	579	585	PF00069	0.807
MOD_PKA_2	271	277	PF00069	0.552
MOD_PKA_2	293	299	PF00069	0.741
MOD_PKA_2	330	336	PF00069	0.753
MOD_PKA_2	460	466	PF00069	0.446
MOD_PKA_2	51	57	PF00069	0.718
MOD_PKA_2	587	593	PF00069	0.674
MOD_PKA_2	616	622	PF00069	0.500
MOD_PKB_1	264	272	PF00069	0.615
MOD_PKB_1	323	331	PF00069	0.801
MOD_Plk_4	30	36	PF00069	0.530
MOD_Plk_4	38	44	PF00069	0.584
MOD_Plk_4	617	623	PF00069	0.621
MOD_ProDKin_1	108	114	PF00069	0.728
MOD_ProDKin_1	120	126	PF00069	0.597
MOD_ProDKin_1	174	180	PF00069	0.535
MOD_ProDKin_1	206	212	PF00069	0.753
MOD_ProDKin_1	229	235	PF00069	0.612
MOD_ProDKin_1	248	254	PF00069	0.237
MOD_ProDKin_1	278	284	PF00069	0.660
MOD_ProDKin_1	375	381	PF00069	0.528
MOD_ProDKin_1	406	412	PF00069	0.503
MOD_ProDKin_1	415	421	PF00069	0.579
MOD_ProDKin_1	572	578	PF00069	0.705
MOD_ProDKin_1	604	610	PF00069	0.735
TRG_DiLeu_BaEn_1	502	507	PF01217	0.411
TRG_DiLeu_BaEn_2	97	103	PF01217	0.646
TRG_ENDOCYTIC_2	158	161	PF00928	0.577
TRG_ENDOCYTIC_2	245	248	PF00928	0.456
TRG_ENDOCYTIC_2	498	501	PF00928	0.441
TRG_ENDOCYTIC_2	503	506	PF00928	0.411
TRG_ER_diArg_1	263	266	PF00400	0.619
TRG_ER_diArg_1	271	273	PF00400	0.474
TRG_ER_diArg_1	36	38	PF00400	0.600
TRG_ER_diArg_1	367	369	PF00400	0.497
TRG_ER_diArg_1	544	547	PF00400	0.698
TRG_ER_diArg_1	622	624	PF00400	0.756
TRG_PTS1	630	633	PF00515	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM15	Leptomonas seymouri	46%	98%
A0A3S7WYF8	Leishmania donovani	70%	100%
A4I0Y6	Leishmania infantum	71%	100%
E9AWZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QAI3	Leishmania major	71%	99%