Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HDJ1_LEIBR

TriTrypDb:

LbrM.24.1360 , LBRM2903_240022500

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A4HDJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.354
CLV_C14_Caspase3-7	213	217	PF00656	0.375
CLV_C14_Caspase3-7	387	391	PF00656	0.495
CLV_NRD_NRD_1	195	197	PF00675	0.509
CLV_PCSK_KEX2_1	195	197	PF00082	0.569
CLV_PCSK_KEX2_1	206	208	PF00082	0.471
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.589
CLV_PCSK_SKI1_1	202	206	PF00082	0.485
CLV_PCSK_SKI1_1	207	211	PF00082	0.431
CLV_PCSK_SKI1_1	48	52	PF00082	0.480
DEG_APCC_DBOX_1	296	304	PF00400	0.474
DEG_MDM2_SWIB_1	172	180	PF02201	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.321
DEG_SCF_FBW7_1	13	20	PF00400	0.521
DOC_MAPK_gen_1	401	411	PF00069	0.409
DOC_MAPK_JIP1_4	108	114	PF00069	0.517
DOC_MAPK_MEF2A_6	343	352	PF00069	0.372
DOC_MAPK_MEF2A_6	404	413	PF00069	0.400
DOC_PP2B_PxIxI_1	170	176	PF00149	0.415
DOC_USP7_MATH_1	150	154	PF00917	0.466
DOC_USP7_MATH_1	232	236	PF00917	0.449
DOC_USP7_MATH_1	311	315	PF00917	0.521
DOC_USP7_MATH_1	316	320	PF00917	0.580
DOC_USP7_MATH_1	325	329	PF00917	0.371
DOC_USP7_MATH_1	423	427	PF00917	0.295
DOC_USP7_UBL2_3	10	14	PF12436	0.398
DOC_USP7_UBL2_3	202	206	PF12436	0.597
DOC_USP7_UBL2_3	48	52	PF12436	0.441
DOC_WW_Pin1_4	13	18	PF00397	0.508
DOC_WW_Pin1_4	414	419	PF00397	0.385
LIG_APCC_ABBA_1	128	133	PF00400	0.380
LIG_APCC_ABBA_1	138	143	PF00400	0.397
LIG_APCC_ABBA_1	169	174	PF00400	0.342
LIG_BRCT_BRCA1_1	275	279	PF00533	0.337
LIG_BRCT_BRCA1_1	409	413	PF00533	0.362
LIG_deltaCOP1_diTrp_1	329	335	PF00928	0.400
LIG_FHA_1	108	114	PF00498	0.412
LIG_FHA_1	14	20	PF00498	0.474
LIG_FHA_1	213	219	PF00498	0.518
LIG_FHA_1	237	243	PF00498	0.531
LIG_FHA_1	403	409	PF00498	0.387
LIG_FHA_1	434	440	PF00498	0.371
LIG_FHA_1	76	82	PF00498	0.732
LIG_FHA_2	252	258	PF00498	0.392
LIG_FHA_2	54	60	PF00498	0.595
LIG_FHA_2	71	77	PF00498	0.678
LIG_LIR_Apic_2	254	258	PF02991	0.370
LIG_LIR_Gen_1	220	231	PF02991	0.533
LIG_LIR_Gen_1	3	13	PF02991	0.332
LIG_LIR_Gen_1	329	340	PF02991	0.357
LIG_LIR_Nem_3	220	226	PF02991	0.533
LIG_LIR_Nem_3	3	8	PF02991	0.303
LIG_LIR_Nem_3	329	335	PF02991	0.332
LIG_Pex14_2	172	176	PF04695	0.325
LIG_SH2_CRK	298	302	PF00017	0.440
LIG_SH2_NCK_1	131	135	PF00017	0.414
LIG_SH2_NCK_1	255	259	PF00017	0.396
LIG_SH2_SRC	131	134	PF00017	0.405
LIG_SH2_SRC	139	142	PF00017	0.393
LIG_SH2_STAP1	200	204	PF00017	0.632
LIG_SH2_STAT3	200	203	PF00017	0.379
LIG_SH2_STAT5	129	132	PF00017	0.373
LIG_SH2_STAT5	139	142	PF00017	0.393
LIG_SH2_STAT5	38	41	PF00017	0.581
LIG_SH2_STAT5	433	436	PF00017	0.366
LIG_SH3_3	345	351	PF00018	0.503
LIG_SH3_3	412	418	PF00018	0.377
LIG_SUMO_SIM_par_1	162	168	PF11976	0.473
LIG_SUMO_SIM_par_1	407	412	PF11976	0.507
LIG_WRC_WIRS_1	2	7	PF05994	0.301
MOD_CK1_1	154	160	PF00069	0.486
MOD_CK1_1	20	26	PF00069	0.531
MOD_CK1_1	402	408	PF00069	0.378
MOD_CK2_1	251	257	PF00069	0.384
MOD_CK2_1	323	329	PF00069	0.252
MOD_CK2_1	93	99	PF00069	0.630
MOD_GlcNHglycan	145	149	PF01048	0.417
MOD_GlcNHglycan	232	235	PF01048	0.299
MOD_GlcNHglycan	275	278	PF01048	0.327
MOD_GlcNHglycan	311	314	PF01048	0.571
MOD_GlcNHglycan	318	321	PF01048	0.565
MOD_GlcNHglycan	426	429	PF01048	0.521
MOD_GSK3_1	103	110	PF00069	0.509
MOD_GSK3_1	13	20	PF00069	0.521
MOD_GSK3_1	150	157	PF00069	0.360
MOD_GSK3_1	194	201	PF00069	0.595
MOD_GSK3_1	232	239	PF00069	0.299
MOD_GSK3_1	334	341	PF00069	0.555
MOD_GSK3_1	360	367	PF00069	0.324
MOD_N-GLC_1	198	203	PF02516	0.615
MOD_NEK2_1	1	6	PF00069	0.293
MOD_NEK2_1	102	107	PF00069	0.585
MOD_NEK2_1	112	117	PF00069	0.423
MOD_NEK2_1	144	149	PF00069	0.424
MOD_NEK2_1	151	156	PF00069	0.415
MOD_NEK2_1	273	278	PF00069	0.331
MOD_NEK2_1	279	284	PF00069	0.359
MOD_NEK2_1	339	344	PF00069	0.524
MOD_NEK2_1	362	367	PF00069	0.423
MOD_NEK2_1	373	378	PF00069	0.364
MOD_NEK2_1	397	402	PF00069	0.541
MOD_NEK2_1	409	414	PF00069	0.429
MOD_NEK2_1	431	436	PF00069	0.371
MOD_NEK2_2	217	222	PF00069	0.373
MOD_NEK2_2	236	241	PF00069	0.161
MOD_PIKK_1	118	124	PF00454	0.377
MOD_PK_1	389	395	PF00069	0.488
MOD_PK_1	404	410	PF00069	0.444
MOD_PKA_2	194	200	PF00069	0.556
MOD_PKA_2	388	394	PF00069	0.501
MOD_PKA_2	53	59	PF00069	0.567
MOD_Plk_1	102	108	PF00069	0.533
MOD_Plk_1	144	150	PF00069	0.328
MOD_Plk_1	236	242	PF00069	0.299
MOD_Plk_1	279	285	PF00069	0.394
MOD_Plk_1	360	366	PF00069	0.354
MOD_Plk_1	389	395	PF00069	0.392
MOD_Plk_1	75	81	PF00069	0.706
MOD_Plk_2-3	93	99	PF00069	0.707
MOD_Plk_4	151	157	PF00069	0.450
MOD_Plk_4	159	165	PF00069	0.405
MOD_Plk_4	279	285	PF00069	0.416
MOD_Plk_4	404	410	PF00069	0.456
MOD_ProDKin_1	13	19	PF00069	0.520
MOD_ProDKin_1	414	420	PF00069	0.380
MOD_SUMO_rev_2	43	53	PF00179	0.674
TRG_DiLeu_BaEn_1	270	275	PF01217	0.359
TRG_DiLeu_BaEn_2	304	310	PF01217	0.435
TRG_NLS_MonoExtN_4	48	55	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A8	Leptomonas seymouri	79%	100%
A0A0S4IX69	Bodo saltans	55%	100%
A0A1X0NW69	Trypanosomatidae	58%	100%
A0A3Q8IBY9	Leishmania donovani	91%	100%
A0A3R7K1J8	Trypanosoma rangeli	57%	100%
A1Z8D0	Drosophila melanogaster	29%	97%
A4I0Y7	Leishmania infantum	91%	100%
C9ZWG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AWZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P21304	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	77%
Q13610	Homo sapiens	31%	89%
Q2HJ56	Bos taurus	32%	89%
Q4QAI2	Leishmania major	90%	100%
Q99LL5	Mus musculus	31%	89%
Q9P775	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	86%
V5BFJ2	Trypanosoma cruzi	56%	100%