LeishMANIAdb
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Putative IgE-dependent histamine-releasing factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative IgE-dependent histamine-releasing factor
Gene product:
translationally controlled tumor protein (TCTP), putative
Species:
Leishmania braziliensis
UniProt:
A4HDJ0_LEIBR
TriTrypDb:
LbrM.24.1350 , LBRM2903_240022700
Length:
170

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. yes yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HDJ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDJ0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005509 calcium ion binding 5 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 139 143 PF00656 0.542
CLV_PCSK_SKI1_1 108 112 PF00082 0.331
CLV_PCSK_SKI1_1 120 124 PF00082 0.323
CLV_PCSK_SKI1_1 2 6 PF00082 0.345
CLV_PCSK_SKI1_1 96 100 PF00082 0.347
DEG_Nend_UBRbox_1 1 4 PF02207 0.542
DOC_CYCLIN_RxL_1 90 103 PF00134 0.550
DOC_PP4_FxxP_1 131 134 PF00568 0.542
DOC_USP7_UBL2_3 120 124 PF12436 0.542
DOC_USP7_UBL2_3 162 166 PF12436 0.550
DOC_WW_Pin1_4 152 157 PF00397 0.598
LIG_14-3-3_CanoR_1 76 82 PF00244 0.542
LIG_APCC_ABBA_1 1 6 PF00400 0.542
LIG_FHA_1 56 62 PF00498 0.598
LIG_FHA_2 7 13 PF00498 0.542
LIG_FHA_2 78 84 PF00498 0.542
LIG_LIR_Apic_2 128 134 PF02991 0.542
LIG_LIR_Gen_1 127 134 PF02991 0.550
LIG_LIR_Gen_1 26 36 PF02991 0.593
LIG_LIR_Nem_3 127 132 PF02991 0.542
LIG_LIR_Nem_3 26 32 PF02991 0.593
LIG_PDZ_Class_3 165 170 PF00595 0.721
LIG_PTB_Apo_2 71 78 PF02174 0.542
LIG_PTB_Phospho_1 71 77 PF10480 0.542
LIG_SH2_NCK_1 82 86 PF00017 0.583
LIG_SH2_PTP2 29 32 PF00017 0.549
LIG_SH2_PTP2 35 38 PF00017 0.536
LIG_SH2_SRC 35 38 PF00017 0.542
LIG_SH2_STAT3 94 97 PF00017 0.560
LIG_SH2_STAT5 159 162 PF00017 0.586
LIG_SH2_STAT5 29 32 PF00017 0.549
LIG_SH2_STAT5 35 38 PF00017 0.532
LIG_SH2_STAT5 77 80 PF00017 0.542
LIG_TYR_ITIM 27 32 PF00017 0.477
MOD_CDK_SPK_2 152 157 PF00069 0.646
MOD_CK2_1 6 12 PF00069 0.542
MOD_GlcNHglycan 45 48 PF01048 0.350
MOD_PKA_2 75 81 PF00069 0.542
MOD_Plk_1 78 84 PF00069 0.598
MOD_Plk_4 83 89 PF00069 0.550
MOD_ProDKin_1 152 158 PF00069 0.598
MOD_SUMO_for_1 165 168 PF00179 0.727
MOD_SUMO_rev_2 103 111 PF00179 0.565
TRG_ENDOCYTIC_2 129 132 PF00928 0.550
TRG_ENDOCYTIC_2 29 32 PF00928 0.549
TRG_ENDOCYTIC_2 35 38 PF00928 0.536
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.370

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7U9 Leptomonas seymouri 91% 100%
A0A0S4IX73 Bodo saltans 70% 99%
A0A1X0NX45 Trypanosomatidae 81% 100%
A0A1X0NXD1 Trypanosomatidae 82% 100%
A0A3S7WYJ2 Leishmania donovani 91% 100%
A0A422N031 Trypanosoma rangeli 81% 100%
A1KXP4 Davidiella tassiana 38% 100%
A4I0Y8 Leishmania infantum 91% 100%
A5A6K2 Pan troglodytes 34% 99%
C9ZWG0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 82% 100%
C9ZWG1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 82% 100%
D0MQ50 Alternaria alternata 40% 100%
E8NHJ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
G3LU44 Loxosceles intermedia 36% 99%
J3SFJ3 Crotalus adamanteus 35% 99%
M5B4R7 Grammostola rosea 33% 98%
O03992 Fragaria ananassa 30% 100%
O18477 Lumbricus rubellus 37% 100%
P0CR82 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 40% 100%
P0CR83 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 40% 100%
P13693 Homo sapiens 34% 99%
P28014 Medicago sativa 29% 100%
P31265 Arabidopsis thaliana 33% 100%
P35681 Oryza sativa subsp. japonica 30% 100%
P35691 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P43347 Gallus gallus 34% 99%
P43348 Oryctolagus cuniculus 33% 99%
P43349 Solanum tuberosum 32% 100%
P50906 Pisum sativum 31% 100%
P61288 Sus scrofa 34% 99%
P63028 Mus musculus 34% 99%
P63029 Rattus norvegicus 34% 99%
P84152 Plasmodium knowlesi 32% 99%
P91800 Schistosoma japonicum 36% 100%
Q10344 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 100%
Q1HR79 Aedes aegypti 30% 99%
Q202I6 Scophthalmus maximus 34% 100%
Q293Y0 Drosophila pseudoobscura pseudoobscura 35% 99%
Q2PS27 Cucurbita maxima 32% 100%
Q2UR29 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 34% 98%
Q4IJT5 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 37% 100%
Q4N938 Theileria parva 31% 98%
Q4PF30 Ustilago maydis (strain 521 / FGSC 9021) 37% 100%
Q4PLZ3 Ixodes scapularis 31% 98%
Q4QAI0 Leishmania major 92% 100%
Q4UGL5 Theileria annulata 29% 98%
Q4WRB8 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 29% 95%
Q4XFJ8 Plasmodium chabaudi 33% 99%
Q4YZC6 Plasmodium berghei (strain Anka) 33% 99%
Q54RX1 Dictyostelium discoideum 27% 88%
Q54RX6 Dictyostelium discoideum 33% 98%
Q56UQ5 Homo sapiens 33% 100%
Q5A860 Candida albicans (strain SC5314 / ATCC MYA-2876) 37% 100%
Q5BFN9 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 27% 95%
Q5E984 Bos taurus 33% 99%
Q5J907 Elaeis guineensis var. tenera 29% 100%
Q5MGM6 Lonomia obliqua 32% 99%
Q5MIP6 Aedes albopictus 31% 99%
Q60FS1 Plutella xylostella 32% 99%
Q622B7 Caenorhabditis briggsae 30% 94%
Q66JC5 Xenopus tropicalis 36% 99%
Q6BP09 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 34% 100%
Q6C4G1 Yarrowia lipolytica (strain CLIB 122 / E 150) 39% 100%
Q6CTH3 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 37% 100%
Q6DUX3 Solanum lycopersicum 33% 100%
Q6FKB6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 35% 100%
Q6XIN1 Drosophila yakuba 32% 99%
Q6XSH4 Lateolabrax japonicus 35% 100%
Q75VN3 Bombyx mori 34% 99%
Q7QCK2 Anopheles gambiae 33% 99%
Q7RYV5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 37% 100%
Q7ZYF2 Xenopus laevis 34% 99%
Q8H6A5 Zea mays 28% 100%
Q8I3Z5 Plasmodium falciparum (isolate 3D7) 35% 99%
Q8I8A2 Schistosoma haematobium 26% 100%
Q8LRM8 Triticum aestivum 28% 100%
Q93573 Caenorhabditis elegans 29% 94%
Q944T2 Glycine max 30% 100%
Q944W6 Brassica oleracea 33% 100%
Q95VY2 Branchiostoma belcheri 34% 100%
Q95WA2 Schistosoma mansoni 33% 100%
Q98SJ7 Labeo rohita 40% 99%
Q9DGK4 Danio rerio 40% 99%
Q9M5G3 Hordeum vulgare 33% 100%
Q9M5I8 Cucumis melo 31% 100%
Q9M9V9 Arabidopsis thaliana 24% 100%
Q9VGS2 Drosophila melanogaster 33% 99%
Q9XHL7 Nicotiana tabacum 33% 100%
Q9XYU2 Plasmodium yoelii yoelii 32% 99%
Q9ZRX0 Pseudotsuga menziesii 32% 100%
T1DKS4 Crotalus horridus 35% 99%
U3EQ60 Micrurus fulvius 34% 99%
V5DBM6 Trypanosoma cruzi 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS