Crossover junction endonuclease MUS81

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ERCC4 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDI9_LEIBR

TriTrypDb:

LbrM.24.1340 , LBRM2903_240022800

Length:

1144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0032991	protein-containing complex	1	1
GO:0048476	Holliday junction resolvase complex	5	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905347	endodeoxyribonuclease complex	4	1
GO:1905348	endonuclease complex	3	1

Expansion

Sequence features

A4HDI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI9

Function

Biological processes
Term	Name	Level	Count
GO:0000737	obsolete DNA catabolic process, endonucleolytic	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	7
GO:0006308	DNA catabolic process	5	7
GO:0006310	DNA recombination	5	3
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0019439	aromatic compound catabolic process	4	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034655	nucleobase-containing compound catabolic process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0044270	cellular nitrogen compound catabolic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046700	heterocycle catabolic process	4	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901361	organic cyclic compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0000712	resolution of meiotic recombination intermediates	4	1
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	7	1
GO:0035556	intracellular signal transduction	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051726	regulation of cell cycle	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0065007	biological regulation	1	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903046	meiotic cell cycle process	2	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	7
GO:0004536	DNA nuclease activity	4	7
GO:0005488	binding	1	7
GO:0008821	crossover junction DNA endonuclease activity	7	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	6	7
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	7
GO:0097159	organic cyclic compound binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0048256	flap endonuclease activity	6	1
GO:0048257	3'-flap endonuclease activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.773
CLV_C14_Caspase3-7	301	305	PF00656	0.480
CLV_C14_Caspase3-7	534	538	PF00656	0.599
CLV_NRD_NRD_1	1066	1068	PF00675	0.328
CLV_NRD_NRD_1	1108	1110	PF00675	0.554
CLV_NRD_NRD_1	184	186	PF00675	0.572
CLV_NRD_NRD_1	317	319	PF00675	0.660
CLV_NRD_NRD_1	343	345	PF00675	0.574
CLV_NRD_NRD_1	404	406	PF00675	0.588
CLV_NRD_NRD_1	711	713	PF00675	0.615
CLV_NRD_NRD_1	769	771	PF00675	0.693
CLV_NRD_NRD_1	779	781	PF00675	0.262
CLV_NRD_NRD_1	848	850	PF00675	0.312
CLV_NRD_NRD_1	868	870	PF00675	0.388
CLV_NRD_NRD_1	983	985	PF00675	0.493
CLV_PCSK_FUR_1	980	984	PF00082	0.481
CLV_PCSK_KEX2_1	1066	1068	PF00082	0.328
CLV_PCSK_KEX2_1	1107	1109	PF00082	0.555
CLV_PCSK_KEX2_1	184	186	PF00082	0.572
CLV_PCSK_KEX2_1	319	321	PF00082	0.652
CLV_PCSK_KEX2_1	343	345	PF00082	0.543
CLV_PCSK_KEX2_1	404	406	PF00082	0.588
CLV_PCSK_KEX2_1	769	771	PF00082	0.689
CLV_PCSK_KEX2_1	868	870	PF00082	0.388
CLV_PCSK_KEX2_1	982	984	PF00082	0.489
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.652
CLV_PCSK_PC7_1	1104	1110	PF00082	0.527
CLV_PCSK_SKI1_1	1071	1075	PF00082	0.497
CLV_PCSK_SKI1_1	209	213	PF00082	0.510
CLV_PCSK_SKI1_1	241	245	PF00082	0.540
CLV_PCSK_SKI1_1	322	326	PF00082	0.575
CLV_PCSK_SKI1_1	35	39	PF00082	0.596
CLV_PCSK_SKI1_1	629	633	PF00082	0.623
CLV_PCSK_SKI1_1	671	675	PF00082	0.545
CLV_PCSK_SKI1_1	868	872	PF00082	0.394
DEG_APCC_DBOX_1	208	216	PF00400	0.529
DEG_APCC_DBOX_1	60	68	PF00400	0.546
DEG_Kelch_Keap1_1	537	542	PF01344	0.497
DEG_SCF_FBW7_1	1049	1056	PF00400	0.341
DEG_SCF_FBW7_1	392	398	PF00400	0.679
DEG_SPOP_SBC_1	336	340	PF00917	0.551
DOC_ANK_TNKS_1	983	990	PF00023	0.572
DOC_CKS1_1	392	397	PF01111	0.674
DOC_CKS1_1	714	719	PF01111	0.539
DOC_CYCLIN_RxL_1	32	42	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.639
DOC_MAPK_gen_1	1128	1134	PF00069	0.423
DOC_MAPK_gen_1	749	758	PF00069	0.479
DOC_PP1_RVXF_1	747	753	PF00149	0.507
DOC_PP1_RVXF_1	875	882	PF00149	0.388
DOC_PP2B_LxvP_1	249	252	PF13499	0.685
DOC_PP4_FxxP_1	108	111	PF00568	0.515
DOC_PP4_FxxP_1	129	132	PF00568	0.516
DOC_PP4_FxxP_1	147	150	PF00568	0.460
DOC_PP4_FxxP_1	588	591	PF00568	0.542
DOC_USP7_MATH_1	1040	1044	PF00917	0.481
DOC_USP7_MATH_1	1087	1091	PF00917	0.413
DOC_USP7_MATH_1	160	164	PF00917	0.684
DOC_USP7_MATH_1	172	176	PF00917	0.600
DOC_USP7_MATH_1	183	187	PF00917	0.726
DOC_USP7_MATH_1	204	208	PF00917	0.723
DOC_USP7_MATH_1	336	340	PF00917	0.712
DOC_USP7_MATH_1	419	423	PF00917	0.540
DOC_USP7_MATH_1	469	473	PF00917	0.605
DOC_USP7_MATH_1	603	607	PF00917	0.543
DOC_USP7_MATH_1	637	641	PF00917	0.575
DOC_USP7_MATH_1	65	69	PF00917	0.676
DOC_USP7_MATH_1	681	685	PF00917	0.702
DOC_USP7_MATH_1	785	789	PF00917	0.330
DOC_USP7_MATH_1	928	932	PF00917	0.303
DOC_USP7_MATH_1	939	943	PF00917	0.315
DOC_USP7_MATH_2	804	810	PF00917	0.219
DOC_USP7_MATH_2	96	102	PF00917	0.628
DOC_WW_Pin1_4	1049	1054	PF00397	0.334
DOC_WW_Pin1_4	107	112	PF00397	0.486
DOC_WW_Pin1_4	155	160	PF00397	0.600
DOC_WW_Pin1_4	195	200	PF00397	0.564
DOC_WW_Pin1_4	295	300	PF00397	0.529
DOC_WW_Pin1_4	327	332	PF00397	0.756
DOC_WW_Pin1_4	337	342	PF00397	0.584
DOC_WW_Pin1_4	376	381	PF00397	0.541
DOC_WW_Pin1_4	388	393	PF00397	0.630
DOC_WW_Pin1_4	508	513	PF00397	0.587
DOC_WW_Pin1_4	597	602	PF00397	0.585
DOC_WW_Pin1_4	623	628	PF00397	0.602
DOC_WW_Pin1_4	633	638	PF00397	0.628
DOC_WW_Pin1_4	683	688	PF00397	0.639
DOC_WW_Pin1_4	698	703	PF00397	0.667
DOC_WW_Pin1_4	713	718	PF00397	0.618
DOC_WW_Pin1_4	726	731	PF00397	0.508
DOC_WW_Pin1_4	8	13	PF00397	0.543
DOC_WW_Pin1_4	800	805	PF00397	0.285
DOC_WW_Pin1_4	871	876	PF00397	0.312
DOC_WW_Pin1_4	88	93	PF00397	0.701
DOC_WW_Pin1_4	919	924	PF00397	0.374
LIG_14-3-3_CanoR_1	1069	1078	PF00244	0.434
LIG_14-3-3_CanoR_1	1082	1091	PF00244	0.458
LIG_14-3-3_CanoR_1	1122	1131	PF00244	0.440
LIG_14-3-3_CanoR_1	113	122	PF00244	0.696
LIG_14-3-3_CanoR_1	128	132	PF00244	0.535
LIG_14-3-3_CanoR_1	184	188	PF00244	0.561
LIG_14-3-3_CanoR_1	322	331	PF00244	0.676
LIG_14-3-3_CanoR_1	437	446	PF00244	0.553
LIG_14-3-3_CanoR_1	470	480	PF00244	0.620
LIG_14-3-3_CanoR_1	510	519	PF00244	0.569
LIG_14-3-3_CanoR_1	553	561	PF00244	0.520
LIG_14-3-3_CanoR_1	622	627	PF00244	0.524
LIG_14-3-3_CanoR_1	658	668	PF00244	0.693
LIG_14-3-3_CanoR_1	671	680	PF00244	0.572
LIG_14-3-3_CanoR_1	849	855	PF00244	0.319
LIG_14-3-3_CanoR_1	919	923	PF00244	0.326
LIG_14-3-3_CanoR_1	954	964	PF00244	0.505
LIG_APCC_ABBA_1	483	488	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_2	1115	1119	PF00653	0.475
LIG_BRCT_BRCA1_1	288	292	PF00533	0.665
LIG_BRCT_BRCA1_1	51	55	PF00533	0.555
LIG_BRCT_BRCA1_1	960	964	PF00533	0.312
LIG_BRCT_BRCA1_2	960	966	PF00533	0.307
LIG_Clathr_ClatBox_1	516	520	PF01394	0.525
LIG_CtBP_PxDLS_1	426	430	PF00389	0.539
LIG_EVH1_2	584	588	PF00568	0.525
LIG_FHA_1	1070	1076	PF00498	0.323
LIG_FHA_1	1133	1139	PF00498	0.435
LIG_FHA_1	116	122	PF00498	0.518
LIG_FHA_1	396	402	PF00498	0.652
LIG_FHA_1	441	447	PF00498	0.646
LIG_FHA_1	475	481	PF00498	0.549
LIG_FHA_1	501	507	PF00498	0.613
LIG_FHA_1	511	517	PF00498	0.508
LIG_FHA_1	610	616	PF00498	0.584
LIG_FHA_1	701	707	PF00498	0.577
LIG_FHA_1	957	963	PF00498	0.388
LIG_FHA_2	166	172	PF00498	0.681
LIG_FHA_2	176	182	PF00498	0.574
LIG_FHA_2	276	282	PF00498	0.580
LIG_FHA_2	299	305	PF00498	0.627
LIG_FHA_2	330	336	PF00498	0.688
LIG_FHA_2	392	398	PF00498	0.679
LIG_FHA_2	445	451	PF00498	0.678
LIG_FHA_2	69	75	PF00498	0.561
LIG_FHA_2	849	855	PF00498	0.312
LIG_LIR_Apic_2	106	111	PF02991	0.616
LIG_LIR_Apic_2	388	392	PF02991	0.548
LIG_LIR_Apic_2	587	591	PF02991	0.543
LIG_LIR_Gen_1	1072	1081	PF02991	0.352
LIG_LIR_Gen_1	123	133	PF02991	0.532
LIG_LIR_Gen_1	298	305	PF02991	0.471
LIG_LIR_Gen_1	490	497	PF02991	0.512
LIG_LIR_Gen_1	961	972	PF02991	0.388
LIG_LIR_LC3C_4	844	847	PF02991	0.312
LIG_LIR_Nem_3	1022	1028	PF02991	0.490
LIG_LIR_Nem_3	123	129	PF02991	0.539
LIG_LIR_Nem_3	490	495	PF02991	0.510
LIG_LIR_Nem_3	874	879	PF02991	0.350
LIG_LIR_Nem_3	961	967	PF02991	0.388
LIG_MYND_1	235	239	PF01753	0.545
LIG_NRBOX	1087	1093	PF00104	0.379
LIG_NRBOX	411	417	PF00104	0.583
LIG_PCNA_yPIPBox_3	404	416	PF02747	0.522
LIG_Pex14_1	754	758	PF04695	0.388
LIG_Pex14_2	705	709	PF04695	0.440
LIG_PTAP_UEV_1	717	722	PF05743	0.543
LIG_SH2_CRK	634	638	PF00017	0.627
LIG_SH2_NCK_1	578	582	PF00017	0.625
LIG_SH2_PTP2	1131	1134	PF00017	0.496
LIG_SH2_STAT3	864	867	PF00017	0.312
LIG_SH2_STAT5	1131	1134	PF00017	0.496
LIG_SH2_STAT5	126	129	PF00017	0.543
LIG_SH2_STAT5	578	581	PF00017	0.458
LIG_SH2_STAT5	903	906	PF00017	0.231
LIG_SH3_1	185	191	PF00018	0.539
LIG_SH3_3	156	162	PF00018	0.709
LIG_SH3_3	185	191	PF00018	0.723
LIG_SH3_3	279	285	PF00018	0.638
LIG_SH3_3	389	395	PF00018	0.605
LIG_SH3_3	579	585	PF00018	0.596
LIG_SH3_3	6	12	PF00018	0.543
LIG_SH3_3	662	668	PF00018	0.824
LIG_SH3_3	696	702	PF00018	0.727
LIG_SH3_3	711	717	PF00018	0.610
LIG_SH3_3	86	92	PF00018	0.731
LIG_SH3_3	97	103	PF00018	0.648
LIG_SUMO_SIM_par_1	1047	1052	PF11976	0.341
LIG_SUMO_SIM_par_1	795	801	PF11976	0.312
LIG_TRAF2_1	167	170	PF00917	0.646
LIG_TRAF2_1	803	806	PF00917	0.315
LIG_WRC_WIRS_1	480	485	PF05994	0.516
LIG_WW_2	159	162	PF00397	0.549
LIG_WW_3	626	630	PF00397	0.606
MOD_CDC14_SPxK_1	110	113	PF00782	0.582
MOD_CDC14_SPxK_1	198	201	PF00782	0.568
MOD_CDC14_SPxK_1	626	629	PF00782	0.604
MOD_CDC14_SPxK_1	874	877	PF00782	0.388
MOD_CDK_SPxK_1	107	113	PF00069	0.584
MOD_CDK_SPxK_1	195	201	PF00069	0.567
MOD_CDK_SPxK_1	337	343	PF00069	0.546
MOD_CDK_SPxK_1	623	629	PF00069	0.605
MOD_CDK_SPxK_1	871	877	PF00069	0.388
MOD_CDK_SPxxK_3	337	344	PF00069	0.547
MOD_CK1_1	117	123	PF00069	0.678
MOD_CK1_1	154	160	PF00069	0.556
MOD_CK1_1	175	181	PF00069	0.742
MOD_CK1_1	259	265	PF00069	0.546
MOD_CK1_1	275	281	PF00069	0.667
MOD_CK1_1	298	304	PF00069	0.480
MOD_CK1_1	330	336	PF00069	0.752
MOD_CK1_1	379	385	PF00069	0.656
MOD_CK1_1	388	394	PF00069	0.557
MOD_CK1_1	505	511	PF00069	0.567
MOD_CK1_1	563	569	PF00069	0.617
MOD_CK1_1	606	612	PF00069	0.664
MOD_CK1_1	638	644	PF00069	0.761
MOD_CK1_1	68	74	PF00069	0.654
MOD_CK1_1	729	735	PF00069	0.696
MOD_CK1_1	829	835	PF00069	0.293
MOD_CK1_1	88	94	PF00069	0.536
MOD_CK1_1	894	900	PF00069	0.296
MOD_CK2_1	1044	1050	PF00069	0.387
MOD_CK2_1	117	123	PF00069	0.521
MOD_CK2_1	149	155	PF00069	0.554
MOD_CK2_1	329	335	PF00069	0.696
MOD_CK2_1	391	397	PF00069	0.676
MOD_CK2_1	444	450	PF00069	0.717
MOD_CK2_1	469	475	PF00069	0.527
MOD_CK2_1	536	542	PF00069	0.557
MOD_CK2_1	800	806	PF00069	0.321
MOD_CK2_1	924	930	PF00069	0.315
MOD_CK2_1	954	960	PF00069	0.291
MOD_Cter_Amidation	767	770	PF01082	0.630
MOD_DYRK1A_RPxSP_1	919	923	PF00069	0.388
MOD_GlcNHglycan	1010	1013	PF01048	0.576
MOD_GlcNHglycan	1042	1045	PF01048	0.471
MOD_GlcNHglycan	1061	1064	PF01048	0.390
MOD_GlcNHglycan	1084	1087	PF01048	0.482
MOD_GlcNHglycan	151	154	PF01048	0.611
MOD_GlcNHglycan	274	277	PF01048	0.704
MOD_GlcNHglycan	281	285	PF01048	0.595
MOD_GlcNHglycan	327	330	PF01048	0.771
MOD_GlcNHglycan	332	335	PF01048	0.677
MOD_GlcNHglycan	420	424	PF01048	0.588
MOD_GlcNHglycan	495	498	PF01048	0.620
MOD_GlcNHglycan	51	54	PF01048	0.501
MOD_GlcNHglycan	533	536	PF01048	0.611
MOD_GlcNHglycan	539	542	PF01048	0.513
MOD_GlcNHglycan	579	582	PF01048	0.633
MOD_GlcNHglycan	608	611	PF01048	0.645
MOD_GlcNHglycan	640	643	PF01048	0.649
MOD_GlcNHglycan	647	650	PF01048	0.653
MOD_GlcNHglycan	67	70	PF01048	0.673
MOD_GlcNHglycan	683	686	PF01048	0.721
MOD_GlcNHglycan	762	765	PF01048	0.634
MOD_GlcNHglycan	828	831	PF01048	0.423
MOD_GlcNHglycan	851	854	PF01048	0.231
MOD_GlcNHglycan	911	914	PF01048	0.310
MOD_GlcNHglycan	930	933	PF01048	0.402
MOD_GlcNHglycan	937	940	PF01048	0.316
MOD_GlcNHglycan	994	997	PF01048	0.558
MOD_GSK3_1	1040	1047	PF00069	0.469
MOD_GSK3_1	1049	1056	PF00069	0.497
MOD_GSK3_1	1087	1094	PF00069	0.462
MOD_GSK3_1	113	120	PF00069	0.553
MOD_GSK3_1	151	158	PF00069	0.628
MOD_GSK3_1	21	28	PF00069	0.656
MOD_GSK3_1	237	244	PF00069	0.648
MOD_GSK3_1	255	262	PF00069	0.571
MOD_GSK3_1	288	295	PF00069	0.569
MOD_GSK3_1	318	325	PF00069	0.800
MOD_GSK3_1	391	398	PF00069	0.753
MOD_GSK3_1	440	447	PF00069	0.759
MOD_GSK3_1	469	476	PF00069	0.673
MOD_GSK3_1	501	508	PF00069	0.619
MOD_GSK3_1	618	625	PF00069	0.595
MOD_GSK3_1	633	640	PF00069	0.656
MOD_GSK3_1	654	661	PF00069	0.791
MOD_GSK3_1	663	670	PF00069	0.557
MOD_GSK3_1	681	688	PF00069	0.524
MOD_GSK3_1	716	723	PF00069	0.628
MOD_GSK3_1	796	803	PF00069	0.388
MOD_GSK3_1	824	831	PF00069	0.268
MOD_GSK3_1	837	844	PF00069	0.322
MOD_GSK3_1	855	862	PF00069	0.225
MOD_GSK3_1	90	97	PF00069	0.723
MOD_GSK3_1	919	926	PF00069	0.259
MOD_GSK3_1	935	942	PF00069	0.454
MOD_GSK3_1	952	959	PF00069	0.315
MOD_N-GLC_1	39	44	PF02516	0.469
MOD_N-GLC_2	1055	1057	PF02516	0.414
MOD_N-GLC_2	30	32	PF02516	0.484
MOD_N-GLC_2	554	556	PF02516	0.376
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	1091	1096	PF00069	0.476
MOD_NEK2_1	292	297	PF00069	0.537
MOD_NEK2_1	440	445	PF00069	0.688
MOD_NEK2_1	462	467	PF00069	0.600
MOD_NEK2_1	473	478	PF00069	0.610
MOD_NEK2_1	49	54	PF00069	0.577
MOD_NEK2_1	502	507	PF00069	0.637
MOD_NEK2_1	531	536	PF00069	0.559
MOD_NEK2_1	545	550	PF00069	0.561
MOD_NEK2_1	552	557	PF00069	0.446
MOD_NEK2_1	561	566	PF00069	0.547
MOD_NEK2_1	576	581	PF00069	0.523
MOD_NEK2_1	645	650	PF00069	0.574
MOD_NEK2_1	826	831	PF00069	0.385
MOD_NEK2_1	855	860	PF00069	0.312
MOD_NEK2_1	967	972	PF00069	0.444
MOD_PIKK_1	1	7	PF00454	0.554
MOD_PIKK_1	160	166	PF00454	0.611
MOD_PIKK_1	183	189	PF00454	0.565
MOD_PIKK_1	39	45	PF00454	0.565
MOD_PIKK_1	635	641	PF00454	0.667
MOD_PIKK_1	700	706	PF00454	0.598
MOD_PIKK_1	90	96	PF00454	0.685
MOD_PIKK_1	967	973	PF00454	0.284
MOD_PKA_1	318	324	PF00069	0.571
MOD_PKA_1	849	855	PF00069	0.231
MOD_PKA_2	1121	1127	PF00069	0.444
MOD_PKA_2	127	133	PF00069	0.584
MOD_PKA_2	183	189	PF00069	0.557
MOD_PKA_2	260	266	PF00069	0.555
MOD_PKA_2	438	444	PF00069	0.545
MOD_PKA_2	469	475	PF00069	0.619
MOD_PKA_2	552	558	PF00069	0.467
MOD_PKA_2	606	612	PF00069	0.574
MOD_PKA_2	760	766	PF00069	0.628
MOD_PKA_2	848	854	PF00069	0.312
MOD_PKA_2	918	924	PF00069	0.231
MOD_PKA_2	955	961	PF00069	0.324
MOD_PKB_1	1067	1075	PF00069	0.317
MOD_PKB_1	316	324	PF00069	0.651
MOD_PKB_1	633	641	PF00069	0.581
MOD_PKB_1	933	941	PF00069	0.388
MOD_PKB_1	954	962	PF00069	0.388
MOD_Plk_1	25	31	PF00069	0.464
MOD_Plk_1	39	45	PF00069	0.439
MOD_Plk_1	441	447	PF00069	0.556
MOD_Plk_1	529	535	PF00069	0.518
MOD_Plk_1	855	861	PF00069	0.312
MOD_Plk_4	1044	1050	PF00069	0.387
MOD_Plk_4	1087	1093	PF00069	0.437
MOD_Plk_4	1095	1101	PF00069	0.424
MOD_Plk_4	292	298	PF00069	0.504
MOD_Plk_4	382	388	PF00069	0.620
MOD_Plk_4	479	485	PF00069	0.559
MOD_Plk_4	720	726	PF00069	0.529
MOD_Plk_4	785	791	PF00069	0.322
MOD_Plk_4	841	847	PF00069	0.312
MOD_ProDKin_1	1049	1055	PF00069	0.339
MOD_ProDKin_1	107	113	PF00069	0.489
MOD_ProDKin_1	155	161	PF00069	0.604
MOD_ProDKin_1	195	201	PF00069	0.562
MOD_ProDKin_1	295	301	PF00069	0.522
MOD_ProDKin_1	327	333	PF00069	0.756
MOD_ProDKin_1	337	343	PF00069	0.584
MOD_ProDKin_1	376	382	PF00069	0.541
MOD_ProDKin_1	388	394	PF00069	0.630
MOD_ProDKin_1	508	514	PF00069	0.586
MOD_ProDKin_1	597	603	PF00069	0.579
MOD_ProDKin_1	623	629	PF00069	0.605
MOD_ProDKin_1	633	639	PF00069	0.627
MOD_ProDKin_1	683	689	PF00069	0.638
MOD_ProDKin_1	698	704	PF00069	0.665
MOD_ProDKin_1	713	719	PF00069	0.619
MOD_ProDKin_1	726	732	PF00069	0.496
MOD_ProDKin_1	8	14	PF00069	0.543
MOD_ProDKin_1	800	806	PF00069	0.285
MOD_ProDKin_1	871	877	PF00069	0.312
MOD_ProDKin_1	88	94	PF00069	0.704
MOD_ProDKin_1	919	925	PF00069	0.374
MOD_SUMO_rev_2	844	852	PF00179	0.312
TRG_DiLeu_BaEn_1	408	413	PF01217	0.579
TRG_DiLeu_BaEn_1	866	871	PF01217	0.312
TRG_DiLeu_BaEn_2	959	965	PF01217	0.312
TRG_DiLeu_LyEn_5	866	871	PF01217	0.312
TRG_ENDOCYTIC_2	1096	1099	PF00928	0.427
TRG_ENDOCYTIC_2	1131	1134	PF00928	0.572
TRG_ENDOCYTIC_2	126	129	PF00928	0.543
TRG_ER_diArg_1	1066	1069	PF00400	0.325
TRG_ER_diArg_1	1106	1109	PF00400	0.535
TRG_ER_diArg_1	228	231	PF00400	0.673
TRG_ER_diArg_1	404	406	PF00400	0.570
TRG_ER_diArg_1	436	439	PF00400	0.539
TRG_ER_diArg_1	749	752	PF00400	0.616
TRG_ER_diArg_1	868	870	PF00400	0.460
TRG_ER_diArg_1	933	936	PF00400	0.388
TRG_ER_diArg_1	953	956	PF00400	0.183
TRG_ER_diArg_1	981	984	PF00400	0.469
TRG_NLS_MonoExtC_3	317	322	PF00514	0.650
TRG_NLS_MonoExtN_4	316	323	PF00514	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEQ9	Leptomonas seymouri	37%	100%
A0A3Q8IEY2	Leishmania donovani	65%	99%
A4I0Z0	Leishmania infantum	65%	99%
E9AWZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QAH9	Leishmania major	65%	100%