Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDI6_LEIBR

TriTrypDb:

LbrM.24.1310 , LBRM2903_240023100

Length:

995

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	861	865	PF00656	0.547
CLV_NRD_NRD_1	131	133	PF00675	0.802
CLV_NRD_NRD_1	201	203	PF00675	0.678
CLV_NRD_NRD_1	420	422	PF00675	0.718
CLV_NRD_NRD_1	571	573	PF00675	0.716
CLV_NRD_NRD_1	647	649	PF00675	0.767
CLV_NRD_NRD_1	73	75	PF00675	0.606
CLV_NRD_NRD_1	772	774	PF00675	0.760
CLV_NRD_NRD_1	917	919	PF00675	0.662
CLV_NRD_NRD_1	96	98	PF00675	0.595
CLV_NRD_NRD_1	976	978	PF00675	0.501
CLV_PCSK_KEX2_1	131	133	PF00082	0.802
CLV_PCSK_KEX2_1	201	203	PF00082	0.678
CLV_PCSK_KEX2_1	23	25	PF00082	0.447
CLV_PCSK_KEX2_1	570	572	PF00082	0.717
CLV_PCSK_KEX2_1	647	649	PF00082	0.665
CLV_PCSK_KEX2_1	674	676	PF00082	0.627
CLV_PCSK_KEX2_1	73	75	PF00082	0.606
CLV_PCSK_KEX2_1	772	774	PF00082	0.758
CLV_PCSK_KEX2_1	917	919	PF00082	0.662
CLV_PCSK_KEX2_1	95	97	PF00082	0.601
CLV_PCSK_KEX2_1	976	978	PF00082	0.501
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.447
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.569
CLV_PCSK_PC7_1	197	203	PF00082	0.616
CLV_PCSK_SKI1_1	160	164	PF00082	0.709
CLV_PCSK_SKI1_1	185	189	PF00082	0.725
CLV_PCSK_SKI1_1	23	27	PF00082	0.417
CLV_PCSK_SKI1_1	571	575	PF00082	0.719
CLV_PCSK_SKI1_1	629	633	PF00082	0.609
CLV_PCSK_SKI1_1	63	67	PF00082	0.632
CLV_PCSK_SKI1_1	772	776	PF00082	0.580
CLV_PCSK_SKI1_1	83	87	PF00082	0.376
CLV_PCSK_SKI1_1	966	970	PF00082	0.675
CLV_PCSK_SKI1_1	976	980	PF00082	0.615
CLV_Separin_Metazoa	611	615	PF03568	0.595
DEG_APCC_DBOX_1	184	192	PF00400	0.731
DEG_APCC_DBOX_1	975	983	PF00400	0.757
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DEG_SCF_FBW7_1	291	296	PF00400	0.846
DEG_SPOP_SBC_1	857	861	PF00917	0.518
DOC_ANK_TNKS_1	111	118	PF00023	0.659
DOC_CDC14_PxL_1	477	485	PF14671	0.682
DOC_CYCLIN_RxL_1	182	190	PF00134	0.740
DOC_CYCLIN_RxL_1	80	88	PF00134	0.452
DOC_CYCLIN_RxL_1	974	983	PF00134	0.505
DOC_MAPK_gen_1	614	621	PF00069	0.573
DOC_MAPK_gen_1	647	654	PF00069	0.664
DOC_MAPK_gen_1	976	982	PF00069	0.506
DOC_MAPK_MEF2A_6	10	18	PF00069	0.506
DOC_MAPK_MEF2A_6	647	654	PF00069	0.756
DOC_MAPK_MEF2A_6	736	744	PF00069	0.698
DOC_PP2B_LxvP_1	389	392	PF13499	0.688
DOC_PP2B_LxvP_1	478	481	PF13499	0.681
DOC_PP2B_LxvP_1	689	692	PF13499	0.647
DOC_PP4_MxPP_1	471	474	PF00568	0.681
DOC_USP7_MATH_1	212	216	PF00917	0.707
DOC_USP7_MATH_1	221	225	PF00917	0.793
DOC_USP7_MATH_1	228	232	PF00917	0.731
DOC_USP7_MATH_1	238	242	PF00917	0.603
DOC_USP7_MATH_1	293	297	PF00917	0.761
DOC_USP7_MATH_1	484	488	PF00917	0.671
DOC_USP7_MATH_1	573	577	PF00917	0.483
DOC_USP7_MATH_1	777	781	PF00917	0.530
DOC_USP7_MATH_1	858	862	PF00917	0.784
DOC_USP7_MATH_1	865	869	PF00917	0.692
DOC_USP7_MATH_2	441	447	PF00917	0.811
DOC_WW_Pin1_4	208	213	PF00397	0.738
DOC_WW_Pin1_4	219	224	PF00397	0.738
DOC_WW_Pin1_4	287	292	PF00397	0.752
DOC_WW_Pin1_4	366	371	PF00397	0.747
DOC_WW_Pin1_4	462	467	PF00397	0.789
DOC_WW_Pin1_4	674	679	PF00397	0.810
DOC_WW_Pin1_4	773	778	PF00397	0.798
DOC_WW_Pin1_4	940	945	PF00397	0.590
DOC_WW_Pin1_4	989	994	PF00397	0.571
LIG_14-3-3_CanoR_1	24	32	PF00244	0.414
LIG_14-3-3_CanoR_1	276	284	PF00244	0.734
LIG_14-3-3_CanoR_1	571	579	PF00244	0.604
LIG_14-3-3_CanoR_1	629	636	PF00244	0.716
LIG_14-3-3_CanoR_1	73	78	PF00244	0.609
LIG_14-3-3_CanoR_1	795	800	PF00244	0.693
LIG_14-3-3_CanoR_1	829	833	PF00244	0.521
LIG_14-3-3_CanoR_1	925	929	PF00244	0.658
LIG_BRCT_BRCA1_1	640	644	PF00533	0.740
LIG_CaM_IQ_9	88	104	PF13499	0.644
LIG_CtBP_PxDLS_1	910	914	PF00389	0.604
LIG_deltaCOP1_diTrp_1	154	163	PF00928	0.590
LIG_FHA_1	300	306	PF00498	0.598
LIG_FHA_1	60	66	PF00498	0.623
LIG_FHA_1	630	636	PF00498	0.704
LIG_FHA_1	683	689	PF00498	0.706
LIG_FHA_1	712	718	PF00498	0.485
LIG_FHA_1	86	92	PF00498	0.697
LIG_FHA_1	861	867	PF00498	0.550
LIG_FHA_1	962	968	PF00498	0.582
LIG_FHA_2	156	162	PF00498	0.706
LIG_FHA_2	24	30	PF00498	0.626
LIG_LIR_Apic_2	458	464	PF02991	0.802
LIG_LIR_Gen_1	154	163	PF02991	0.701
LIG_LIR_Gen_1	386	396	PF02991	0.680
LIG_LIR_Gen_1	552	563	PF02991	0.602
LIG_LIR_Gen_1	607	617	PF02991	0.531
LIG_LIR_Gen_1	850	858	PF02991	0.683
LIG_LIR_LC3C_4	850	855	PF02991	0.552
LIG_LIR_Nem_3	154	159	PF02991	0.704
LIG_LIR_Nem_3	386	391	PF02991	0.698
LIG_LIR_Nem_3	552	558	PF02991	0.552
LIG_LIR_Nem_3	607	612	PF02991	0.534
LIG_LIR_Nem_3	850	854	PF02991	0.636
LIG_NRBOX	183	189	PF00104	0.737
LIG_NRBOX	256	262	PF00104	0.643
LIG_NRBOX	81	87	PF00104	0.451
LIG_Pex14_1	802	806	PF04695	0.594
LIG_SH2_GRB2like	328	331	PF00017	0.566
LIG_SH2_PTP2	461	464	PF00017	0.800
LIG_SH2_PTP2	851	854	PF00017	0.671
LIG_SH2_SRC	31	34	PF00017	0.632
LIG_SH2_STAP1	263	267	PF00017	0.597
LIG_SH2_STAP1	328	332	PF00017	0.565
LIG_SH2_STAP1	617	621	PF00017	0.580
LIG_SH2_STAT3	2	5	PF00017	0.790
LIG_SH2_STAT3	263	266	PF00017	0.750
LIG_SH2_STAT5	2	5	PF00017	0.790
LIG_SH2_STAT5	31	34	PF00017	0.632
LIG_SH2_STAT5	400	403	PF00017	0.733
LIG_SH2_STAT5	415	418	PF00017	0.725
LIG_SH2_STAT5	434	437	PF00017	0.523
LIG_SH2_STAT5	461	464	PF00017	0.800
LIG_SH2_STAT5	477	480	PF00017	0.515
LIG_SH2_STAT5	699	702	PF00017	0.625
LIG_SH2_STAT5	703	706	PF00017	0.620
LIG_SH2_STAT5	810	813	PF00017	0.625
LIG_SH2_STAT5	847	850	PF00017	0.570
LIG_SH2_STAT5	851	854	PF00017	0.621
LIG_SH3_3	170	176	PF00018	0.646
LIG_SH3_3	285	291	PF00018	0.663
LIG_SH3_3	559	565	PF00018	0.713
LIG_SH3_3	74	80	PF00018	0.601
LIG_SH3_3	852	858	PF00018	0.622
LIG_SH3_3	945	951	PF00018	0.521
LIG_SH3_3	987	993	PF00018	0.564
LIG_Sin3_3	935	942	PF02671	0.712
LIG_SUMO_SIM_anti_2	850	856	PF11976	0.675
LIG_SUMO_SIM_par_1	318	324	PF11976	0.553
LIG_SUMO_SIM_par_1	740	745	PF11976	0.703
LIG_SUMO_SIM_par_1	909	915	PF11976	0.630
LIG_TRAF2_1	530	533	PF00917	0.788
LIG_TRAF2_1	600	603	PF00917	0.625
LIG_TRAF2_1	786	789	PF00917	0.695
MOD_CDK_SPxxK_3	219	226	PF00069	0.683
MOD_CK1_1	222	228	PF00069	0.837
MOD_CK1_1	243	249	PF00069	0.759
MOD_CK1_1	286	292	PF00069	0.861
MOD_CK1_1	446	452	PF00069	0.577
MOD_CK1_1	487	493	PF00069	0.757
MOD_CK1_1	575	581	PF00069	0.585
MOD_CK1_1	638	644	PF00069	0.709
MOD_CK1_1	711	717	PF00069	0.482
MOD_CK1_1	765	771	PF00069	0.557
MOD_CK1_1	831	837	PF00069	0.633
MOD_CK1_1	860	866	PF00069	0.546
MOD_CK1_1	882	888	PF00069	0.545
MOD_CK1_1	912	918	PF00069	0.488
MOD_CK1_1	940	946	PF00069	0.585
MOD_CK2_1	155	161	PF00069	0.705
MOD_CK2_1	23	29	PF00069	0.472
MOD_CK2_1	48	54	PF00069	0.456
MOD_CK2_1	490	496	PF00069	0.786
MOD_CK2_1	527	533	PF00069	0.762
MOD_GlcNHglycan	124	127	PF01048	0.713
MOD_GlcNHglycan	136	139	PF01048	0.656
MOD_GlcNHglycan	179	182	PF01048	0.738
MOD_GlcNHglycan	239	243	PF01048	0.822
MOD_GlcNHglycan	277	280	PF01048	0.728
MOD_GlcNHglycan	285	288	PF01048	0.812
MOD_GlcNHglycan	295	298	PF01048	0.733
MOD_GlcNHglycan	307	310	PF01048	0.694
MOD_GlcNHglycan	364	367	PF01048	0.707
MOD_GlcNHglycan	375	378	PF01048	0.734
MOD_GlcNHglycan	425	428	PF01048	0.562
MOD_GlcNHglycan	445	448	PF01048	0.817
MOD_GlcNHglycan	486	489	PF01048	0.727
MOD_GlcNHglycan	492	495	PF01048	0.683
MOD_GlcNHglycan	50	53	PF01048	0.611
MOD_GlcNHglycan	529	532	PF01048	0.771
MOD_GlcNHglycan	547	550	PF01048	0.438
MOD_GlcNHglycan	579	582	PF01048	0.658
MOD_GlcNHglycan	592	595	PF01048	0.782
MOD_GlcNHglycan	659	662	PF01048	0.679
MOD_GlcNHglycan	68	71	PF01048	0.562
MOD_GlcNHglycan	719	722	PF01048	0.537
MOD_GlcNHglycan	777	780	PF01048	0.732
MOD_GlcNHglycan	819	822	PF01048	0.665
MOD_GlcNHglycan	825	828	PF01048	0.642
MOD_GlcNHglycan	868	871	PF01048	0.681
MOD_GlcNHglycan	982	985	PF01048	0.778
MOD_GSK3_1	122	129	PF00069	0.668
MOD_GSK3_1	208	215	PF00069	0.795
MOD_GSK3_1	217	224	PF00069	0.749
MOD_GSK3_1	283	290	PF00069	0.829
MOD_GSK3_1	293	300	PF00069	0.809
MOD_GSK3_1	362	369	PF00069	0.807
MOD_GSK3_1	371	378	PF00069	0.618
MOD_GSK3_1	379	386	PF00069	0.572
MOD_GSK3_1	490	497	PF00069	0.710
MOD_GSK3_1	573	580	PF00069	0.604
MOD_GSK3_1	711	718	PF00069	0.531
MOD_GSK3_1	773	780	PF00069	0.541
MOD_GSK3_1	813	820	PF00069	0.558
MOD_GSK3_1	828	835	PF00069	0.646
MOD_GSK3_1	856	863	PF00069	0.521
MOD_GSK3_1	881	888	PF00069	0.540
MOD_GSK3_1	950	957	PF00069	0.647
MOD_NEK2_1	136	141	PF00069	0.773
MOD_NEK2_1	152	157	PF00069	0.468
MOD_NEK2_1	299	304	PF00069	0.598
MOD_NEK2_1	344	349	PF00069	0.570
MOD_NEK2_1	66	71	PF00069	0.610
MOD_NEK2_1	684	689	PF00069	0.683
MOD_NEK2_1	72	77	PF00069	0.611
MOD_NEK2_1	85	90	PF00069	0.595
MOD_NEK2_1	866	871	PF00069	0.548
MOD_NEK2_1	937	942	PF00069	0.640
MOD_NEK2_1	968	973	PF00069	0.711
MOD_NEK2_1	980	985	PF00069	0.599
MOD_NEK2_2	828	833	PF00069	0.523
MOD_PIKK_1	212	218	PF00454	0.601
MOD_PIKK_1	23	29	PF00454	0.500
MOD_PIKK_1	344	350	PF00454	0.570
MOD_PIKK_1	604	610	PF00454	0.697
MOD_PIKK_1	777	783	PF00454	0.594
MOD_PIKK_1	882	888	PF00454	0.557
MOD_PKA_1	23	29	PF00069	0.417
MOD_PKA_1	73	79	PF00069	0.707
MOD_PKA_2	152	158	PF00069	0.656
MOD_PKA_2	216	222	PF00069	0.636
MOD_PKA_2	23	29	PF00069	0.663
MOD_PKA_2	275	281	PF00069	0.705
MOD_PKA_2	413	419	PF00069	0.741
MOD_PKA_2	72	78	PF00069	0.611
MOD_PKA_2	765	771	PF00069	0.745
MOD_PKA_2	828	834	PF00069	0.565
MOD_PKA_2	886	892	PF00069	0.574
MOD_PKA_2	924	930	PF00069	0.627
MOD_PKB_1	570	578	PF00069	0.631
MOD_Plk_1	344	350	PF00069	0.570
MOD_Plk_1	534	540	PF00069	0.653
MOD_Plk_1	558	564	PF00069	0.710
MOD_Plk_1	581	587	PF00069	0.518
MOD_Plk_1	638	644	PF00069	0.731
MOD_Plk_4	36	42	PF00069	0.549
MOD_Plk_4	383	389	PF00069	0.808
MOD_Plk_4	494	500	PF00069	0.773
MOD_Plk_4	558	564	PF00069	0.710
MOD_Plk_4	638	644	PF00069	0.731
MOD_Plk_4	684	690	PF00069	0.644
MOD_Plk_4	73	79	PF00069	0.707
MOD_Plk_4	828	834	PF00069	0.686
MOD_Plk_4	924	930	PF00069	0.596
MOD_Plk_4	943	949	PF00069	0.647
MOD_ProDKin_1	208	214	PF00069	0.743
MOD_ProDKin_1	219	225	PF00069	0.738
MOD_ProDKin_1	287	293	PF00069	0.751
MOD_ProDKin_1	366	372	PF00069	0.748
MOD_ProDKin_1	462	468	PF00069	0.787
MOD_ProDKin_1	674	680	PF00069	0.809
MOD_ProDKin_1	773	779	PF00069	0.797
MOD_ProDKin_1	940	946	PF00069	0.592
MOD_ProDKin_1	989	995	PF00069	0.576
MOD_SUMO_rev_2	15	25	PF00179	0.468
MOD_SUMO_rev_2	446	455	PF00179	0.607
TRG_DiLeu_BaEn_1	934	939	PF01217	0.703
TRG_DiLeu_BaEn_2	872	878	PF01217	0.529
TRG_DiLeu_BaEn_4	750	756	PF01217	0.582
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.700
TRG_ENDOCYTIC_2	841	844	PF00928	0.692
TRG_ENDOCYTIC_2	851	854	PF00928	0.544
TRG_ER_diArg_1	130	132	PF00400	0.807
TRG_ER_diArg_1	201	203	PF00400	0.678
TRG_ER_diArg_1	570	572	PF00400	0.717
TRG_ER_diArg_1	613	616	PF00400	0.575
TRG_ER_diArg_1	647	649	PF00400	0.767
TRG_ER_diArg_1	72	74	PF00400	0.623
TRG_ER_diArg_1	771	773	PF00400	0.751
TRG_ER_diArg_1	917	919	PF00400	0.588
TRG_ER_diArg_1	95	97	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.762
TRG_Pf-PMV_PEXEL_1	977	981	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I728	Leptomonas seymouri	38%	100%
A0A3S7WYF6	Leishmania donovani	75%	100%
E9AH62	Leishmania infantum	74%	100%
E9AX00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAH6	Leishmania major	74%	96%