Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDI5_LEIBR

TriTrypDb:

LbrM.24.1300 , LBRM2903_240023200

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4HDI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.342
CLV_C14_Caspase3-7	311	315	PF00656	0.488
CLV_C14_Caspase3-7	396	400	PF00656	0.485
CLV_NRD_NRD_1	219	221	PF00675	0.450
CLV_NRD_NRD_1	486	488	PF00675	0.550
CLV_NRD_NRD_1	80	82	PF00675	0.336
CLV_PCSK_FUR_1	484	488	PF00082	0.475
CLV_PCSK_KEX2_1	221	223	PF00082	0.424
CLV_PCSK_KEX2_1	486	488	PF00082	0.548
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.414
CLV_PCSK_SKI1_1	178	182	PF00082	0.376
CLV_PCSK_SKI1_1	213	217	PF00082	0.462
CLV_PCSK_SKI1_1	266	270	PF00082	0.405
CLV_PCSK_SKI1_1	36	40	PF00082	0.293
CLV_PCSK_SKI1_1	375	379	PF00082	0.452
CLV_PCSK_SKI1_1	59	63	PF00082	0.452
CLV_Separin_Metazoa	405	409	PF03568	0.534
DEG_APCC_DBOX_1	131	139	PF00400	0.262
DEG_APCC_KENBOX_2	465	469	PF00400	0.301
DEG_COP1_1	396	406	PF00400	0.542
DEG_SPOP_SBC_1	75	79	PF00917	0.259
DOC_CYCLIN_RxL_1	173	185	PF00134	0.473
DOC_CYCLIN_RxL_1	56	64	PF00134	0.428
DOC_CYCLIN_yClb5_NLxxxL_5	158	167	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.405
DOC_MAPK_gen_1	220	229	PF00069	0.391
DOC_MAPK_MEF2A_6	343	350	PF00069	0.504
DOC_PP2B_LxvP_1	381	384	PF13499	0.412
DOC_PP2B_PxIxI_1	71	77	PF00149	0.463
DOC_PP4_FxxP_1	450	453	PF00568	0.499
DOC_USP7_MATH_1	19	23	PF00917	0.420
DOC_USP7_MATH_1	388	392	PF00917	0.514
DOC_USP7_MATH_1	425	429	PF00917	0.489
DOC_USP7_MATH_1	430	434	PF00917	0.542
DOC_USP7_MATH_1	440	444	PF00917	0.535
DOC_USP7_UBL2_3	217	221	PF12436	0.479
DOC_USP7_UBL2_3	466	470	PF12436	0.438
DOC_USP7_UBL2_3	489	493	PF12436	0.541
DOC_WW_Pin1_4	15	20	PF00397	0.401
DOC_WW_Pin1_4	361	366	PF00397	0.539
DOC_WW_Pin1_4	479	484	PF00397	0.483
LIG_14-3-3_CanoR_1	220	229	PF00244	0.434
LIG_14-3-3_CanoR_1	412	417	PF00244	0.638
LIG_14-3-3_CanoR_1	448	453	PF00244	0.350
LIG_14-3-3_CanoR_1	554	559	PF00244	0.437
LIG_14-3-3_CanoR_1	81	86	PF00244	0.393
LIG_Actin_WH2_2	255	272	PF00022	0.322
LIG_Actin_WH2_2	94	111	PF00022	0.484
LIG_BIR_III_4	185	189	PF00653	0.510
LIG_BRCT_BRCA1_1	256	260	PF00533	0.261
LIG_BRCT_BRCA1_1	390	394	PF00533	0.588
LIG_BRCT_BRCA1_1	410	414	PF00533	0.354
LIG_BRCT_BRCA1_1	419	423	PF00533	0.553
LIG_BRCT_BRCA1_1	502	506	PF00533	0.454
LIG_BRCT_BRCA1_1	90	94	PF00533	0.463
LIG_eIF4E_1	522	528	PF01652	0.561
LIG_EVH1_2	446	450	PF00568	0.466
LIG_FHA_1	187	193	PF00498	0.530
LIG_FHA_1	224	230	PF00498	0.385
LIG_FHA_1	362	368	PF00498	0.438
LIG_FHA_1	502	508	PF00498	0.329
LIG_FHA_1	52	58	PF00498	0.442
LIG_FHA_1	531	537	PF00498	0.410
LIG_FHA_2	240	246	PF00498	0.385
LIG_FHA_2	251	257	PF00498	0.404
LIG_FHA_2	394	400	PF00498	0.553
LIG_FHA_2	433	439	PF00498	0.594
LIG_FHA_2	483	489	PF00498	0.491
LIG_FHA_2	506	512	PF00498	0.268
LIG_FHA_2	533	539	PF00498	0.363
LIG_LIR_Gen_1	189	199	PF02991	0.374
LIG_LIR_Gen_1	231	240	PF02991	0.346
LIG_LIR_Gen_1	37	47	PF02991	0.500
LIG_LIR_Gen_1	592	600	PF02991	0.614
LIG_LIR_Nem_3	189	194	PF02991	0.387
LIG_LIR_Nem_3	21	26	PF02991	0.454
LIG_LIR_Nem_3	231	235	PF02991	0.347
LIG_LIR_Nem_3	286	292	PF02991	0.634
LIG_LIR_Nem_3	37	42	PF02991	0.379
LIG_LIR_Nem_3	391	395	PF02991	0.547
LIG_LIR_Nem_3	520	525	PF02991	0.337
LIG_LIR_Nem_3	592	597	PF02991	0.613
LIG_LYPXL_yS_3	203	206	PF13949	0.462
LIG_PCNA_yPIPBox_3	160	173	PF02747	0.479
LIG_Pex14_1	49	53	PF04695	0.445
LIG_PTB_Apo_2	197	204	PF02174	0.388
LIG_PTB_Phospho_1	197	203	PF10480	0.468
LIG_REV1ctd_RIR_1	461	470	PF16727	0.387
LIG_SH2_CRK	23	27	PF00017	0.389
LIG_SH2_CRK	289	293	PF00017	0.337
LIG_SH2_CRK	525	529	PF00017	0.370
LIG_SH2_GRB2like	237	240	PF00017	0.338
LIG_SH2_SRC	306	309	PF00017	0.258
LIG_SH2_STAP1	170	174	PF00017	0.420
LIG_SH2_STAP1	53	57	PF00017	0.443
LIG_SH2_STAT5	174	177	PF00017	0.379
LIG_SH2_STAT5	258	261	PF00017	0.469
LIG_SH2_STAT5	306	309	PF00017	0.433
LIG_SH2_STAT5	395	398	PF00017	0.515
LIG_SH2_STAT5	402	405	PF00017	0.391
LIG_SH2_STAT5	53	56	PF00017	0.458
LIG_SH2_STAT5	547	550	PF00017	0.278
LIG_SH3_3	289	295	PF00018	0.478
LIG_SH3_3	379	385	PF00018	0.475
LIG_SH3_3	40	46	PF00018	0.512
LIG_SH3_3	477	483	PF00018	0.552
LIG_Sin3_3	313	320	PF02671	0.379
LIG_SUMO_SIM_anti_2	369	374	PF11976	0.312
LIG_SUMO_SIM_par_1	117	123	PF11976	0.363
LIG_SUMO_SIM_par_1	223	231	PF11976	0.392
LIG_SUMO_SIM_par_1	364	369	PF11976	0.307
LIG_SUMO_SIM_par_1	53	58	PF11976	0.515
LIG_SUMO_SIM_par_1	530	538	PF11976	0.406
LIG_SUMO_SIM_par_1	553	560	PF11976	0.518
LIG_SUMO_SIM_par_1	72	79	PF11976	0.305
LIG_TRAF2_1	535	538	PF00917	0.360
LIG_TRAF2_2	291	296	PF00917	0.483
LIG_UBA3_1	235	241	PF00899	0.254
LIG_UBA3_1	38	45	PF00899	0.282
LIG_WRC_WIRS_1	229	234	PF05994	0.363
LIG_WRC_WIRS_1	498	503	PF05994	0.457
LIG_WW_3	445	449	PF00397	0.367
MOD_CDK_SPK_2	15	20	PF00069	0.381
MOD_CDK_SPK_2	479	484	PF00069	0.472
MOD_CDK_SPxxK_3	479	486	PF00069	0.604
MOD_CK1_1	107	113	PF00069	0.412
MOD_CK1_1	223	229	PF00069	0.419
MOD_CK1_1	335	341	PF00069	0.457
MOD_CK1_1	361	367	PF00069	0.371
MOD_CK1_1	433	439	PF00069	0.592
MOD_CK1_1	482	488	PF00069	0.470
MOD_CK1_1	84	90	PF00069	0.488
MOD_CK2_1	111	117	PF00069	0.476
MOD_CK2_1	239	245	PF00069	0.386
MOD_CK2_1	250	256	PF00069	0.389
MOD_CK2_1	505	511	PF00069	0.369
MOD_CK2_1	532	538	PF00069	0.372
MOD_CK2_1	556	562	PF00069	0.287
MOD_CK2_1	586	592	PF00069	0.606
MOD_GlcNHglycan	122	125	PF01048	0.346
MOD_GlcNHglycan	325	329	PF01048	0.577
MOD_GlcNHglycan	385	388	PF01048	0.413
MOD_GlcNHglycan	423	426	PF01048	0.533
MOD_GlcNHglycan	435	438	PF01048	0.578
MOD_GSK3_1	107	114	PF00069	0.362
MOD_GSK3_1	15	22	PF00069	0.495
MOD_GSK3_1	250	257	PF00069	0.299
MOD_GSK3_1	408	415	PF00069	0.488
MOD_GSK3_1	417	424	PF00069	0.471
MOD_GSK3_1	432	439	PF00069	0.584
MOD_GSK3_1	448	455	PF00069	0.485
MOD_GSK3_1	497	504	PF00069	0.330
MOD_GSK3_1	57	64	PF00069	0.497
MOD_GSK3_1	84	91	PF00069	0.242
MOD_N-GLC_1	408	413	PF02516	0.672
MOD_N-GLC_1	425	430	PF02516	0.474
MOD_N-GLC_1	441	446	PF02516	0.557
MOD_N-GLC_2	276	278	PF02516	0.313
MOD_NEK2_1	193	198	PF00069	0.361
MOD_NEK2_1	324	329	PF00069	0.518
MOD_NEK2_1	366	371	PF00069	0.285
MOD_NEK2_1	57	62	PF00069	0.451
MOD_PK_1	412	418	PF00069	0.516
MOD_PK_1	474	480	PF00069	0.530
MOD_PKA_1	220	226	PF00069	0.410
MOD_PKA_1	474	480	PF00069	0.522
MOD_PKA_1	81	87	PF00069	0.388
MOD_PKA_2	19	25	PF00069	0.472
MOD_PKA_2	417	423	PF00069	0.598
MOD_Plk_1	223	229	PF00069	0.525
MOD_Plk_1	254	260	PF00069	0.494
MOD_Plk_1	285	291	PF00069	0.529
MOD_Plk_1	425	431	PF00069	0.534
MOD_Plk_1	569	575	PF00069	0.505
MOD_Plk_1	57	63	PF00069	0.431
MOD_Plk_1	586	592	PF00069	0.530
MOD_Plk_1	7	13	PF00069	0.465
MOD_Plk_2-3	505	511	PF00069	0.447
MOD_Plk_2-3	586	592	PF00069	0.636
MOD_Plk_4	117	123	PF00069	0.393
MOD_Plk_4	193	199	PF00069	0.516
MOD_Plk_4	228	234	PF00069	0.364
MOD_Plk_4	254	260	PF00069	0.266
MOD_Plk_4	377	383	PF00069	0.547
MOD_Plk_4	452	458	PF00069	0.426
MOD_Plk_4	474	480	PF00069	0.615
MOD_Plk_4	497	503	PF00069	0.460
MOD_Plk_4	57	63	PF00069	0.480
MOD_ProDKin_1	15	21	PF00069	0.402
MOD_ProDKin_1	361	367	PF00069	0.530
MOD_ProDKin_1	479	485	PF00069	0.479
TRG_DiLeu_BaLyEn_6	513	518	PF01217	0.308
TRG_DiLeu_LyEn_5	362	367	PF01217	0.357
TRG_ENDOCYTIC_2	174	177	PF00928	0.402
TRG_ENDOCYTIC_2	203	206	PF00928	0.509
TRG_ENDOCYTIC_2	23	26	PF00928	0.375
TRG_ENDOCYTIC_2	289	292	PF00928	0.337
TRG_ENDOCYTIC_2	525	528	PF00928	0.563
TRG_ER_diArg_1	219	222	PF00400	0.449
TRG_ER_diArg_1	301	304	PF00400	0.365
TRG_ER_diArg_1	483	486	PF00400	0.624
TRG_NES_CRM1_1	538	549	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU8	Leptomonas seymouri	64%	100%
A0A0S4JJW4	Bodo saltans	30%	100%
A0A1X0NW77	Trypanosomatidae	39%	89%
A0A3S7WYG2	Leishmania donovani	80%	100%
A0A422N8J0	Trypanosoma rangeli	42%	97%
C9ZWF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9AH63	Leishmania infantum	80%	100%
E9AX01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAH5	Leishmania major	80%	100%
V5BK17	Trypanosoma cruzi	40%	100%