Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDI3_LEIBR

TriTrypDb:

LbrM.24.1280 , LBRM2903_240019000

Length:

242

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 178
NetGPI	no	yes: 0, no: 184

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	162
GO:0110165	cellular anatomical entity	1	162
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4HDI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.524
CLV_NRD_NRD_1	33	35	PF00675	0.372
CLV_PCSK_KEX2_1	138	140	PF00082	0.523
CLV_PCSK_KEX2_1	33	35	PF00082	0.374
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DOC_CKS1_1	95	100	PF01111	0.386
DOC_MAPK_DCC_7	60	70	PF00069	0.561
DOC_MAPK_gen_1	33	41	PF00069	0.575
DOC_MAPK_MEF2A_6	33	41	PF00069	0.575
DOC_MAPK_NFAT4_5	34	42	PF00069	0.576
DOC_PP2B_LxvP_1	168	171	PF13499	0.455
DOC_PP4_FxxP_1	41	44	PF00568	0.570
DOC_WW_Pin1_4	14	19	PF00397	0.571
DOC_WW_Pin1_4	27	32	PF00397	0.615
DOC_WW_Pin1_4	46	51	PF00397	0.607
DOC_WW_Pin1_4	94	99	PF00397	0.398
LIG_14-3-3_CanoR_1	25	31	PF00244	0.565
LIG_BRCT_BRCA1_1	16	20	PF00533	0.549
LIG_BRCT_BRCA1_1	37	41	PF00533	0.580
LIG_deltaCOP1_diTrp_1	206	211	PF00928	0.197
LIG_FHA_1	185	191	PF00498	0.375
LIG_LIR_Apic_2	38	44	PF02991	0.574
LIG_LIR_Gen_1	152	162	PF02991	0.284
LIG_LIR_Gen_1	184	193	PF02991	0.365
LIG_LIR_Gen_1	206	215	PF02991	0.337
LIG_LIR_Gen_1	23	31	PF02991	0.570
LIG_LIR_Nem_3	112	116	PF02991	0.235
LIG_LIR_Nem_3	152	157	PF02991	0.291
LIG_LIR_Nem_3	184	189	PF02991	0.357
LIG_LIR_Nem_3	191	195	PF02991	0.341
LIG_LIR_Nem_3	206	211	PF02991	0.285
LIG_LIR_Nem_3	23	29	PF02991	0.567
LIG_MLH1_MIPbox_1	16	20	PF16413	0.549
LIG_MLH1_MIPbox_1	37	41	PF16413	0.580
LIG_Pex14_2	176	180	PF04695	0.399
LIG_REV1ctd_RIR_1	111	121	PF16727	0.194
LIG_SH2_NCK_1	26	30	PF00017	0.565
LIG_SH2_STAT5	19	22	PF00017	0.638
LIG_SH2_STAT5	26	29	PF00017	0.638
LIG_SH3_1	12	18	PF00018	0.544
LIG_SH3_3	102	108	PF00018	0.353
LIG_SH3_3	12	18	PF00018	0.557
LIG_SH3_3	42	48	PF00018	0.610
LIG_SH3_3	92	98	PF00018	0.413
LIG_Sin3_3	158	165	PF02671	0.195
LIG_SUMO_SIM_par_1	149	156	PF11976	0.347
LIG_SUMO_SIM_par_1	186	191	PF11976	0.251
LIG_SUMO_SIM_par_1	232	237	PF11976	0.351
LIG_TYR_ITSM	22	29	PF00017	0.566
MOD_CDK_SPxK_1	27	33	PF00069	0.561
MOD_CDK_SPxxK_3	27	34	PF00069	0.562
MOD_CK1_1	118	124	PF00069	0.294
MOD_CK1_1	152	158	PF00069	0.276
MOD_CK1_1	184	190	PF00069	0.263
MOD_CK2_1	97	103	PF00069	0.337
MOD_GlcNHglycan	70	73	PF01048	0.351
MOD_GSK3_1	115	122	PF00069	0.290
MOD_GSK3_1	149	156	PF00069	0.304
MOD_GSK3_1	184	191	PF00069	0.296
MOD_GSK3_1	20	27	PF00069	0.624
MOD_GSK3_1	97	104	PF00069	0.313
MOD_NEK2_1	153	158	PF00069	0.257
MOD_NEK2_1	20	25	PF00069	0.567
MOD_NEK2_1	221	226	PF00069	0.288
MOD_NEK2_2	109	114	PF00069	0.200
MOD_NEK2_2	149	154	PF00069	0.416
MOD_NEK2_2	181	186	PF00069	0.453
MOD_NEK2_2	197	202	PF00069	0.364
MOD_PIKK_1	60	66	PF00454	0.669
MOD_PIKK_1	97	103	PF00454	0.279
MOD_PKA_2	206	212	PF00069	0.216
MOD_PKA_2	24	30	PF00069	0.694
MOD_Plk_1	35	41	PF00069	0.635
MOD_Plk_4	101	107	PF00069	0.352
MOD_Plk_4	181	187	PF00069	0.305
MOD_Plk_4	234	240	PF00069	0.289
MOD_Plk_4	35	41	PF00069	0.577
MOD_ProDKin_1	14	20	PF00069	0.573
MOD_ProDKin_1	27	33	PF00069	0.616
MOD_ProDKin_1	46	52	PF00069	0.611
MOD_ProDKin_1	94	100	PF00069	0.398
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.482
TRG_ENDOCYTIC_2	26	29	PF00928	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	56%	100%
A0A0N0P6P9	Leptomonas seymouri	21%	100%
A0A0N0P7I8	Leptomonas seymouri	27%	71%
A0A1X0NQ58	Trypanosomatidae	40%	100%
A0A1X0NUH1	Trypanosomatidae	29%	100%
A0A1X0NYN9	Trypanosomatidae	25%	73%
A0A1X0P2R3	Trypanosomatidae	28%	100%
A0A1X0P988	Trypanosomatidae	34%	100%
A0A381MTA7	Leishmania infantum	33%	100%
A0A381MTB8	Leishmania infantum	30%	100%
A0A381MTC7	Leishmania infantum	33%	100%
A0A381MVY0	Leishmania infantum	35%	100%
A0A3Q8ID16	Leishmania donovani	60%	100%
A0A3Q8IEC2	Leishmania donovani	33%	100%
A0A3Q8IEI1	Leishmania donovani	34%	100%
A0A3Q8IF65	Leishmania donovani	32%	100%
A0A3Q8IFH7	Leishmania donovani	33%	100%
A0A3Q8IFI8	Leishmania donovani	25%	100%
A0A3Q8IH65	Leishmania donovani	31%	100%
A0A3Q8IHN2	Leishmania donovani	33%	100%
A0A3Q8IHW7	Leishmania donovani	37%	100%
A0A3Q8IHZ6	Leishmania donovani	31%	100%
A0A3Q8IIH1	Leishmania donovani	32%	100%
A0A3Q8IL03	Leishmania donovani	32%	100%
A0A3Q8IMR4	Leishmania donovani	39%	100%
A0A3Q8IUK8	Leishmania donovani	30%	100%
A0A3S5H662	Leishmania donovani	31%	100%
A0A3S5H663	Leishmania donovani	31%	100%
A0A3S5H665	Leishmania donovani	31%	100%
A0A3S5H666	Leishmania donovani	33%	100%
A0A3S5H667	Leishmania donovani	31%	100%
A0A3S5H7D2	Leishmania donovani	60%	100%
A0A3S5H7L2	Leishmania donovani	29%	100%
A0A3S5H7V9	Leishmania donovani	30%	100%
A0A3S5H7W6	Leishmania donovani	33%	100%
A0A3S7WQA0	Leishmania donovani	31%	100%
A0A3S7WQA8	Leishmania donovani	28%	100%
A0A3S7WQC1	Leishmania donovani	30%	100%
A0A3S7X1H6	Leishmania donovani	26%	71%
A0A3S7X2E6	Leishmania donovani	29%	100%
A0A3S7X357	Leishmania donovani	24%	100%
A0A3S7X381	Leishmania donovani	25%	100%
A0A3S7X453	Leishmania donovani	32%	100%
A0A3S7X472	Leishmania donovani	30%	100%
A0A3S7X7E5	Leishmania donovani	36%	97%
A0A3S7X7M4	Leishmania donovani	31%	100%
A0A3S7X7U1	Leishmania donovani	29%	100%
A0A3S7X7U4	Leishmania donovani	35%	93%
A0A3S7X7W2	Leishmania donovani	33%	100%
A0A3S7X7Y0	Leishmania donovani	31%	100%
A0A422MVP4	Trypanosoma rangeli	24%	82%
A4H596	Leishmania braziliensis	30%	100%
A4H5D1	Leishmania braziliensis	35%	100%
A4H5G0	Leishmania braziliensis	31%	100%
A4H5G9	Leishmania braziliensis	33%	100%
A4H5H0	Leishmania braziliensis	31%	100%
A4H5H1	Leishmania braziliensis	30%	100%
A4H5H2	Leishmania braziliensis	31%	100%
A4H6C8	Leishmania braziliensis	29%	100%
A4H7D7	Leishmania braziliensis	33%	100%
A4H9E9	Leishmania braziliensis	33%	100%
A4HAJ4	Leishmania braziliensis	25%	100%
A4HAM2	Leishmania braziliensis	32%	100%
A4HAM4	Leishmania braziliensis	35%	100%
A4HAR1	Leishmania braziliensis	29%	100%
A4HAZ8	Leishmania braziliensis	38%	100%
A4HB00	Leishmania braziliensis	33%	100%
A4HB02	Leishmania braziliensis	34%	100%
A4HBJ0	Leishmania braziliensis	31%	100%
A4HBJ1	Leishmania braziliensis	33%	100%
A4HBJ2	Leishmania braziliensis	33%	100%
A4HDI2	Leishmania braziliensis	40%	100%
A4HDI4	Leishmania braziliensis	60%	100%
A4HDL3	Leishmania braziliensis	67%	100%
A4HDL4	Leishmania braziliensis	60%	100%
A4HDL5	Leishmania braziliensis	39%	79%
A4HGJ1	Leishmania braziliensis	28%	71%
A4HI41	Leishmania braziliensis	26%	100%
A4HTM3	Leishmania infantum	31%	100%
A4HTM4	Leishmania infantum	27%	100%
A4HTM5	Leishmania infantum	31%	100%
A4I0W3	Leishmania infantum	39%	100%
A4I0W4	Leishmania infantum	59%	100%
A4I0W5	Leishmania infantum	60%	100%
A4I0W6	Leishmania infantum	39%	82%
A4I3L8	Leishmania infantum	26%	71%
A4I4J2	Leishmania infantum	28%	100%
A4I4J3	Leishmania infantum	24%	94%
A4I5B8	Leishmania infantum	25%	100%
A4I5B9	Leishmania infantum	24%	100%
A4I6E5	Leishmania infantum	28%	100%
A4I9Q4	Leishmania infantum	30%	100%
A4I9R7	Leishmania infantum	34%	100%
A4I9W8	Leishmania infantum	33%	93%
A4I9X0	Leishmania infantum	33%	100%
A4IAL7	Leishmania infantum	36%	100%
A4IAM1	Leishmania infantum	30%	100%
A4IAM2	Leishmania infantum	33%	100%
C6K3X5	Leptomonas seymouri	27%	100%
C6K3X9	Leptomonas seymouri	35%	100%
D0A842	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%
E8NHC3	Leishmania infantum	31%	100%
E8NHD3	Leishmania infantum	28%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	71%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	78%
E9AG81	Leishmania infantum	31%	100%
E9AG82	Leishmania infantum	30%	100%
E9AG83	Leishmania infantum	33%	100%
E9AG85	Leishmania infantum	30%	100%
E9AHI9	Leishmania infantum	28%	100%
E9AHT2	Leishmania infantum	34%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AZV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	72%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q305	Leishmania major	30%	100%
Q4Q313	Leishmania major	30%	100%
Q4Q317	Leishmania major	29%	100%
Q4Q325	Leishmania major	31%	100%
Q4Q329	Leishmania major	31%	100%
Q4Q333	Leishmania major	30%	100%
Q4Q335	Leishmania major	30%	100%
Q4Q339	Leishmania major	30%	100%
Q4Q341	Leishmania major	33%	100%
Q4Q397	Leishmania major	31%	100%
Q4Q3A9	Leishmania major	33%	100%
Q4Q3F7	Leishmania major	35%	100%
Q4Q6L8	Leishmania major	31%	100%
Q4Q7L6	Leishmania major	24%	100%
Q4Q7L7	Leishmania major	25%	100%
Q4Q7L8	Leishmania major	25%	100%
Q4Q8C7	Leishmania major	26%	71%
Q4QAK4	Leishmania major	37%	100%
Q4QAK5	Leishmania major	59%	100%
Q4QAK6	Leishmania major	61%	99%
Q4QAK7	Leishmania major	37%	100%
Q4QI84	Leishmania major	29%	100%
Q4QI85	Leishmania major	27%	100%
Q4QI86	Leishmania major	27%	100%
Q4QI87	Leishmania major	31%	100%
Q4QI88	Leishmania major	29%	100%
Q4QI92	Leishmania major	27%	100%
Q4QI93	Leishmania major	27%	100%
Q4QI95	Leishmania major	27%	100%
Q4QI97	Leishmania major	27%	100%
V5AQB9	Trypanosoma cruzi	27%	84%