Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDI3_LEIBR

TriTrypDb:

LbrM.24.1280 , LBRM2903_240019000

Length:

242

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 178
NetGPI	no	yes: 0, no: 184

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	162
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	162

Previous1Next

Expansion

Sequence features

A4HDI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDI3

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.524
CLV_NRD_NRD_1	33	35	PF00675	0.372
CLV_PCSK_KEX2_1	138	140	PF00082	0.523
CLV_PCSK_KEX2_1	33	35	PF00082	0.374
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DOC_CKS1_1	95	100	PF01111	0.386
DOC_MAPK_DCC_7	60	70	PF00069	0.561
DOC_MAPK_gen_1	33	41	PF00069	0.575
DOC_MAPK_MEF2A_6	33	41	PF00069	0.575
DOC_MAPK_NFAT4_5	34	42	PF00069	0.576

Previous1 2 3 4 5…9Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	56%	100%
A0A0N0P6P9	Leptomonas seymouri	21%	100%
A0A0N0P7I8	Leptomonas seymouri	27%	71%
A0A1X0NQ58	Trypanosomatidae	40%	100%
A0A1X0NUH1	Trypanosomatidae	29%	100%
A0A1X0NYN9	Trypanosomatidae	25%	73%
A0A1X0P2R3	Trypanosomatidae	28%	100%
A0A1X0P988	Trypanosomatidae	34%	100%
A0A381MTA7	Leishmania infantum	33%	100%
A0A381MTB8	Leishmania infantum	30%	100%

Previous1 2 3 4 5…19Next